Here's how NATURE.COM makes money* and how much!

*Please read our disclaimer before using our estimates.
Loading...

NATURE . COM {}

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Nature.com Make Money
  6. How Much Does Nature.com Make
  7. Keywords
  8. Topics
  9. Questions
  10. Schema
  11. Social Networks
  12. External Links
  13. Analytics And Tracking
  14. Libraries
  15. Hosting Providers
  16. CDN Services

We are analyzing https://www.nature.com/articles/nrg2340.

Title:
Retinoic acid in development: towards an integrated view | Nature Reviews Genetics
Description:
How are the complex and varied roles of retinoic acid orchestrated at multiple developmental stages? Recent studies have highlighted the importance of tightly regulating its distribution, of switching the activities of its nuclear receptors, and of interactions with other key developmental signalling molecules. Retinoic acid (RA) has complex and pleiotropic functions during vertebrate development. Recent work in several species has increased our understanding of the roles of RA as a signalling molecule. These functions rely on a tight control of RA distribution within embryonic tissues through the combined action of synthesizing and metabolizing enzymes, possibly leading to diffusion gradients. Also important is the switching of nuclear receptors from a transcriptionally repressing state to an activating state. In addition, cross-talk with other key embryonic signals, especially fibroblast growth factors (FGFs) and sonic hedgehog (SHH), is being uncovered. Some of these functions could be maintained throughout the life of an organism to regulate cell-lineage decisions and/or the differentiation of stem cell populations, highlighting possibilities for regenerative medicine.
Website Age:
30 years and 10 months (reg. 1994-08-11).

Matching Content Categories {📚}

  • Education
  • Science
  • Environment

Content Management System {📝}

What CMS is nature.com built with?

Custom-built

No common CMS systems were detected on Nature.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of nature.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Nature.com Make Money? {💸}


Display Ads {🎯}


The website utilizes display ads within its content to generate revenue. Check the next section for further revenue estimates.

Ads are managed by yourbow.com. Particular relationships are as follows:

Direct Advertisers (10)
google.com, pmc.com, doceree.com, yourbow.com, audienciad.com, onlinemediasolutions.com, advibe.media, aps.amazon.com, getmediamx.com, onomagic.com

Reseller Advertisers (38)
conversantmedia.com, rubiconproject.com, pubmatic.com, appnexus.com, openx.com, smartadserver.com, lijit.com, sharethrough.com, video.unrulymedia.com, google.com, yahoo.com, triplelift.com, onetag.com, sonobi.com, contextweb.com, 33across.com, indexexchange.com, media.net, themediagrid.com, adform.com, richaudience.com, sovrn.com, improvedigital.com, freewheel.tv, smaato.com, yieldmo.com, amxrtb.com, adyoulike.com, adpone.com, criteo.com, smilewanted.com, 152media.info, e-planning.net, smartyads.com, loopme.com, opera.com, mediafuse.com, betweendigital.com

How Much Does Nature.com Make? {💰}


Display Ads {🎯}

$63,100 per month
Our estimates place Nature.com's monthly online earnings from display ads at $42,042 to $115,616.

Keywords {🔍}

pubmed, google, scholar, cas, article, retinoic, acid, development, nature, dev, embryonic, mouse, cell, cells, patterning, signaling, central, retinoid, embryo, biol, neural, signalling, heart, hindbrain, dollé, receptors, fgf, formation, essential, niederreither, genes, early, expression, raldh, forebrain, vertebrate, gene, axis, chambon, genet, synthesis, cypa, zebrafish, developing, differentiation, access, receptor, beta, function, stem,

Topics {✒️}

nature portfolio permissions reprints privacy policy tissue research author information authors advertising research regional pattern social media nature cell biol retinoic acid-metabolizing enzyme wnt/β-catenin promotes coactivator/corepressor/epigenetic code trans-retinoic acid 4-hydroxylase regulate cell-lineage decisions nature rev nature protoc nature genet integrating signal-dependent programs retinoic acid-induced downregulation controls epithelial/mesenchymal interactions nature neurosci central nervous system personal data springerlink instant access nature 327 nature 340 nature 435 nature 366 nature data protection permissions specific retinol dehydrogenase sex-specific regulation retinoic acid synthesis retinoic acid receptor article niederreither ra-dependent meiosis onset cardiac progenitor pool cardiac progenitor population embryonic retinoic acid tissue-specific catabolism karen niederreither retinoic acid signaling mesenchymal cell populations tissue-specific expression retinoic acid controls retinoic acid-inducible key embryonic signals integrated view

Questions {❓}

  • Carotenoid and retinoid transport to fish oocytes and eggs: what is the role of retinol binding protein?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Retinoic acid in development: towards an integrated view
         description: How are the complex and varied roles of retinoic acid orchestrated at multiple developmental stages? Recent studies have highlighted the importance of tightly regulating its distribution, of switching the activities of its nuclear receptors, and of interactions with other key developmental signalling molecules. Retinoic acid (RA) has complex and pleiotropic functions during vertebrate development. Recent work in several species has increased our understanding of the roles of RA as a signalling molecule. These functions rely on a tight control of RA distribution within embryonic tissues through the combined action of synthesizing and metabolizing enzymes, possibly leading to diffusion gradients. Also important is the switching of nuclear receptors from a transcriptionally repressing state to an activating state. In addition, cross-talk with other key embryonic signals, especially fibroblast growth factors (FGFs) and sonic hedgehog (SHH), is being uncovered. Some of these functions could be maintained throughout the life of an organism to regulate cell-lineage decisions and/or the differentiation of stem cell populations, highlighting possibilities for regenerative medicine.
         datePublished:2008-06-10T00:00:00Z
         dateModified:2008-06-10T00:00:00Z
         pageStart:541
         pageEnd:553
         sameAs:https://doi.org/10.1038/nrg2340
         keywords:
            Biomedicine
            general
            Human Genetics
            Cancer Research
            Agriculture
            Gene Function
            Animal Genetics and Genomics
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnrg2340/MediaObjects/41576_2008_Article_BFnrg2340_Fig1_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnrg2340/MediaObjects/41576_2008_Article_BFnrg2340_Fig2_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnrg2340/MediaObjects/41576_2008_Article_BFnrg2340_Fig3_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnrg2340/MediaObjects/41576_2008_Article_BFnrg2340_Fig4_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnrg2340/MediaObjects/41576_2008_Article_BFnrg2340_Figa_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnrg2340/MediaObjects/41576_2008_Article_BFnrg2340_Figb_HTML.jpg
         isPartOf:
            name:Nature Reviews Genetics
            issn:
               1471-0064
               1471-0056
            volumeNumber:9
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Nature Publishing Group UK
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Karen Niederreither
               affiliation:
                     name:Baylor College of Medicine, One Baylor Plaza
                     address:
                        name:Department of Medicine, Baylor College of Medicine, One Baylor Plaza, Houston, USA
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:Pascal Dollé
               affiliation:
                     name:Institut de Génétique et de Biologie Moléculaire et Cellulaire, UMR 7104 CNRS, U 596 INSERM, Université Louis Pasteur, BP 10142
                     address:
                        name:Institut de Génétique et de Biologie Moléculaire et Cellulaire, UMR 7104 CNRS, U 596 INSERM, Université Louis Pasteur, BP 10142, Illkirch, France
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Retinoic acid in development: towards an integrated view
      description: How are the complex and varied roles of retinoic acid orchestrated at multiple developmental stages? Recent studies have highlighted the importance of tightly regulating its distribution, of switching the activities of its nuclear receptors, and of interactions with other key developmental signalling molecules. Retinoic acid (RA) has complex and pleiotropic functions during vertebrate development. Recent work in several species has increased our understanding of the roles of RA as a signalling molecule. These functions rely on a tight control of RA distribution within embryonic tissues through the combined action of synthesizing and metabolizing enzymes, possibly leading to diffusion gradients. Also important is the switching of nuclear receptors from a transcriptionally repressing state to an activating state. In addition, cross-talk with other key embryonic signals, especially fibroblast growth factors (FGFs) and sonic hedgehog (SHH), is being uncovered. Some of these functions could be maintained throughout the life of an organism to regulate cell-lineage decisions and/or the differentiation of stem cell populations, highlighting possibilities for regenerative medicine.
      datePublished:2008-06-10T00:00:00Z
      dateModified:2008-06-10T00:00:00Z
      pageStart:541
      pageEnd:553
      sameAs:https://doi.org/10.1038/nrg2340
      keywords:
         Biomedicine
         general
         Human Genetics
         Cancer Research
         Agriculture
         Gene Function
         Animal Genetics and Genomics
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnrg2340/MediaObjects/41576_2008_Article_BFnrg2340_Fig1_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnrg2340/MediaObjects/41576_2008_Article_BFnrg2340_Fig2_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnrg2340/MediaObjects/41576_2008_Article_BFnrg2340_Fig3_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnrg2340/MediaObjects/41576_2008_Article_BFnrg2340_Fig4_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnrg2340/MediaObjects/41576_2008_Article_BFnrg2340_Figa_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnrg2340/MediaObjects/41576_2008_Article_BFnrg2340_Figb_HTML.jpg
      isPartOf:
         name:Nature Reviews Genetics
         issn:
            1471-0064
            1471-0056
         volumeNumber:9
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Nature Publishing Group UK
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Karen Niederreither
            affiliation:
                  name:Baylor College of Medicine, One Baylor Plaza
                  address:
                     name:Department of Medicine, Baylor College of Medicine, One Baylor Plaza, Houston, USA
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Pascal Dollé
            affiliation:
                  name:Institut de Génétique et de Biologie Moléculaire et Cellulaire, UMR 7104 CNRS, U 596 INSERM, Université Louis Pasteur, BP 10142
                  address:
                     name:Institut de Génétique et de Biologie Moléculaire et Cellulaire, UMR 7104 CNRS, U 596 INSERM, Université Louis Pasteur, BP 10142, Illkirch, France
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Nature Reviews Genetics
      issn:
         1471-0064
         1471-0056
      volumeNumber:9
Organization:
      name:Nature Publishing Group UK
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Baylor College of Medicine, One Baylor Plaza
      address:
         name:Department of Medicine, Baylor College of Medicine, One Baylor Plaza, Houston, USA
         type:PostalAddress
      name:Institut de Génétique et de Biologie Moléculaire et Cellulaire, UMR 7104 CNRS, U 596 INSERM, Université Louis Pasteur, BP 10142
      address:
         name:Institut de Génétique et de Biologie Moléculaire et Cellulaire, UMR 7104 CNRS, U 596 INSERM, Université Louis Pasteur, BP 10142, Illkirch, France
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Karen Niederreither
      affiliation:
            name:Baylor College of Medicine, One Baylor Plaza
            address:
               name:Department of Medicine, Baylor College of Medicine, One Baylor Plaza, Houston, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Pascal Dollé
      affiliation:
            name:Institut de Génétique et de Biologie Moléculaire et Cellulaire, UMR 7104 CNRS, U 596 INSERM, Université Louis Pasteur, BP 10142
            address:
               name:Institut de Génétique et de Biologie Moléculaire et Cellulaire, UMR 7104 CNRS, U 596 INSERM, Université Louis Pasteur, BP 10142, Illkirch, France
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Department of Medicine, Baylor College of Medicine, One Baylor Plaza, Houston, USA
      name:Institut de Génétique et de Biologie Moléculaire et Cellulaire, UMR 7104 CNRS, U 596 INSERM, Université Louis Pasteur, BP 10142, Illkirch, France
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

Social Networks {👍}(2)

External Links {🔗}(396)

Analytics and Tracking {📊}

  • Google Tag Manager

Libraries {📚}

  • Prism.js
  • Zoom.js

Emails and Hosting {✉️}

Mail Servers:

  • mxa-002c5801.gslb.pphosted.com
  • mxb-002c5801.gslb.pphosted.com

Name Servers:

  • pdns1.ultradns.net
  • pdns2.ultradns.net
  • pdns3.ultradns.org
  • pdns4.ultradns.org
  • pdns5.ultradns.info
  • pdns6.ultradns.co.uk

CDN Services {📦}

  • Crossref

5.2s.