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We are analyzing https://www.nature.com/articles/nrg2340.

Title:
Retinoic acid in development: towards an integrated view | Nature Reviews Genetics
Description:
How are the complex and varied roles of retinoic acid orchestrated at multiple developmental stages? Recent studies have highlighted the importance of tightly regulating its distribution, of switching the activities of its nuclear receptors, and of interactions with other key developmental signalling molecules. Retinoic acid (RA) has complex and pleiotropic functions during vertebrate development. Recent work in several species has increased our understanding of the roles of RA as a signalling molecule. These functions rely on a tight control of RA distribution within embryonic tissues through the combined action of synthesizing and metabolizing enzymes, possibly leading to diffusion gradients. Also important is the switching of nuclear receptors from a transcriptionally repressing state to an activating state. In addition, cross-talk with other key embryonic signals, especially fibroblast growth factors (FGFs) and sonic hedgehog (SHH), is being uncovered. Some of these functions could be maintained throughout the life of an organism to regulate cell-lineage decisions and/or the differentiation of stem cell populations, highlighting possibilities for regenerative medicine.
Website Age:
30 years and 10 months (reg. 1994-08-11).

Matching Content Categories {📚}

  • Education
  • Science
  • Environment

Content Management System {📝}

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Custom-built

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🌠 Phenomenal Traffic: 5M - 10M visitors per month


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How Much Does Nature.com Make? {💰}


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$63,100 per month
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Keywords {🔍}

pubmed, google, scholar, cas, article, retinoic, acid, development, nature, dev, embryonic, mouse, cell, cells, patterning, signaling, central, retinoid, embryo, biol, neural, signalling, heart, hindbrain, dollé, receptors, fgf, formation, essential, niederreither, genes, early, expression, raldh, forebrain, vertebrate, gene, axis, chambon, genet, synthesis, cypa, zebrafish, developing, differentiation, access, receptor, beta, function, stem,

Topics {✒️}

nature portfolio permissions reprints privacy policy tissue research author information authors advertising research regional pattern social media nature cell biol retinoic acid-metabolizing enzyme wnt/β-catenin promotes coactivator/corepressor/epigenetic code trans-retinoic acid 4-hydroxylase regulate cell-lineage decisions nature rev nature protoc nature genet integrating signal-dependent programs retinoic acid-induced downregulation controls epithelial/mesenchymal interactions nature neurosci central nervous system personal data springerlink instant access nature 327 nature 340 nature 435 nature 366 nature data protection permissions specific retinol dehydrogenase sex-specific regulation retinoic acid synthesis retinoic acid receptor article niederreither ra-dependent meiosis onset cardiac progenitor pool cardiac progenitor population embryonic retinoic acid tissue-specific catabolism karen niederreither retinoic acid signaling mesenchymal cell populations tissue-specific expression retinoic acid controls retinoic acid-inducible key embryonic signals integrated view

Questions {❓}

  • Carotenoid and retinoid transport to fish oocytes and eggs: what is the role of retinol binding protein?

Schema {🗺️}

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