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We began analyzing https://pmc.ncbi.nlm.nih.gov/articles/PMC165842/, but it redirected us to https://pmc.ncbi.nlm.nih.gov/articles/PMC165842/. The analysis below is for the second page.
Title[redir]:
Retinoid activation of retinoic acid receptor but not retinoid X receptor is sufficient to rescue lethal defect in retinoic acid synthesis - PMC
Description:
Two isomers of retinoic acid (RA) may be necessary as ligands for retinoid signaling: all-trans-RA for RA receptors (RARs) and 9-cis-RA for retinoid X receptors (RXRs). This was explored by using retinaldehyde dehydrogenase (Raldh)2-/- mouse embryos ...
Title[redir]:
Retinoid activation of retinoic acid receptor but not retinoid X receptor is sufficient to rescue lethal defect in retinoic acid synthesis - PMC
Description:
Two isomers of retinoic acid (RA) may be necessary as ligands for retinoid signaling: all-trans-RA for RA receptors (RARs) and 9-cis-RA for retinoid X receptors (RXRs). This was explored by using retinaldehyde dehydrogenase (Raldh)2-/- mouse embryos ...
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Keywords {🔍}
cisra, alltransra, embryos, raldh, doi, rxr, pubmed, google, scholar, mgkg, ngg, rescue, retinoid, treatment, wildtype, ligand, tissues, maternal, mouse, fig, signaling, rescued, development, serum, table, binding, mice, shet, pmc, undetectable, physiological, detection, rarelacz, synthesis, rxrs, rar, studies, embryonic, ohet, nature, rars, retinoids, sheta, observed, detected, function, untreated, receptor, receptors, levels,
Topics {✒️}
rare-lacz ra-reporter gene wild-type 9-cis-ra-treated embryos microsomal short-chain dehydrogenases pmc beta search cancer-chemoprevention agents warrants potential long-term administration rare-lacz expression phenotype rxrα ligand-binding domain rare-lacz transgene expression timed-pregnant raldh2-/+ mice providing rare-lacz mice pregnant wild-type mice raldh2-/- 9-cis-ra-treated embryos hplc/photodiode array detector vestigial retinoid-binding domain growth-retarded forelimb buds retinoid-treated pregnant mice rxr functions ligand-independently reversed-phase hplc analysis endogenous 9-cis-ra exists 9-cis-ra transactivation ranging 9-cis-ra gained access rxr ligand-binding domain 5 mg/kg 9-cis-ra 10 mg/kg 9-cis-ra untreated wild-type embryos rare-lacz reporter tissues producing 9-cis-ra wild-type embryos due receptor-specific synthetic retinoids rare-lacz expression publisher site pdf rxr ligand 9-cis-ra 9-cis-ra remained undetectable 9-cis-ra-treated mutants license information pmcid cytosolic alcohol dehydrogenases photodiode array detector dorsal spinal cord rare-lacz transgene rxr binds 9-cis-ra rare-lacz data binary reporter assay pregnant mice treated specific structural alterations undergo axial rotation wild-type littermates wild-type mice rar-specific ligand lateral plate mesoderm
Questions {❓}
- Is 9-cis-RA Normally Present in Embryos at a Concentration High Enough to Transactivate RXRs?
- What is the function of the RXR ligand-binding domain if it does not bind 9-cis-RA?
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