
DOI . ORG {
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Title[redir]:
Insulin and insulin-like growth factor signalling in neoplasia | Nature Reviews Cancer
Description:
Insulin and insulin-like growth factors (IGFs) are well-known as key regulators of energy metabolism and growth and have important roles in neoplasia. This Review documents the various methods are being used to investigate novel cancer prevention and treatment strategies related to insulin and IGF signalling. Insulin and insulin-like growth factors (IGFs) are well known as key regulators of energy metabolism and growth. There is now considerable evidence that these hormones and the signal transduction networks they regulate have important roles in neoplasia. Epidermiological, clinical and laboratory research methods are being used to investigate novel cancer prevention and treatment strategies related to insulin and IGF signalling. Pharmacological strategies under study include the use of novel receptor-specific antibodies, receptor kinase inhibitors and AMP-activated protein kinase activators such as metformin. There is evidence that insulin and IGF signalling may also be relevant to dietary and lifestyle factors that influence cancer risk and cancer prognosis. Recent results are encouraging and have justified the expansion of many translational research programmes.
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pubmed, google, scholar, cancer, article, cas, growth, insulinlike, insulin, receptor, factor, res, breast, clin, nature, igf, central, human, protein, study, prostate, risk, antibody, cell, cells, patients, factori, oncol, pollak, metformin, evidence, binding, monoclonal, kinase, tumor, natl, suppl, phase, levels, activity, energy, signaling, receptors, type, biol, plasma, med, signalling, gene, mammary,
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delayed 2-deoxy-2-[f-18]fluoro-d-glucose injection nature portfolio prediagnostic body-mass index permissions reprints privacy policy advertising anti-igf-ir antibody cp-751 benzimidazole-based igf-ir inhibitors anti-igf-ir targeted therapy received research support social media vitamin-d-related compounds translational research programmes ncic-ctg ma14 trial author information authors laboratory research methods nature cell biol amp-activated protein kinase anti-igf-ir therapy research & therapy integrin-linked kinase contributes 2-phenylquinolin-7-yl-derived imidazo[1 nature biotechnol fasting-induced hormone fgf21 nature rev cancer research nature genet igf-ii influencing stability laboratory research rapamycin-dependent translation initiation plasma c-peptide concentration serum c-peptide level p38 kinase-dependent mechanism anthracene-induced mammary carcinoma estrogen-dependent breast cancer igf-1r-dependent mechanism pi3k/akt pathway activation growth factor-binding protein-3 nature 377 nature 454 nature 452 nature 443 nature 306 nature 310 nature 284 nature 313 nature humanized monoclonal antibody plasma c-peptide levels growth factor-binding proteins
Questions {❓}
- Are findings from studies of obesity and prostate cancer really in conflict?
- Cancer and aging: more puzzles, more promises?
- Inhaled insulin's last gasp?
- LKB1: a sweet side to Peutz-Jeghers syndrome?
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Insulin and insulin-like growth factors (IGFs) are well-known as key regulators of energy metabolism and growth and have important roles in neoplasia. This Review documents the various methods are being used to investigate novel cancer prevention and treatment strategies related to insulin and IGF signalling. Insulin and insulin-like growth factors (IGFs) are well known as key regulators of energy metabolism and growth. There is now considerable evidence that these hormones and the signal transduction networks they regulate have important roles in neoplasia. Epidermiological, clinical and laboratory research methods are being used to investigate novel cancer prevention and treatment strategies related to insulin and IGF signalling. Pharmacological strategies under study include the use of novel receptor-specific antibodies, receptor kinase inhibitors and AMP-activated protein kinase activators such as metformin. There is evidence that insulin and IGF signalling may also be relevant to dietary and lifestyle factors that influence cancer risk and cancer prognosis. Recent results are encouraging and have justified the expansion of many translational research programmes.
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