
NCBI . NLM . NIH . GOV {
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Title[redir]:
The aromatase inhibitor letrozole and inhibitors of insulin-like growth factor I receptor synergistically induce apoptosis in in vitro models of estrogen-dependent breast cancer - PMC
Description:
Endocrine-dependent, estrogen receptor positive breast cancer cells proliferate in response to estrogens, synthesized by the cytochrome p450 aromatase enzyme. Letrozole is a potent nonsteroidal aromatase inhibitor that is registered for the ...
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Keywords {🔍}
cells, cancer, letrozole, doi, breast, aew, pubmed, google, scholar, growth, igfir, cell, combination, receptor, signaling, mcfaro, proliferation, factor, inhibition, insulinlike, synergistic, presence, estrogen, figure, tdaro, nmoll, res, aromatase, lane, levels, mcf, treated, concentrations, treatment, hours, values, data, study, estrogendependent, agent, cycle, igfi, table, inhibitor, vitro, steroiddeprived, versus, response, combined, tamoxifen,
Topics {✒️}
igf-ir/pi3k/pkb/akt pathway lowering phospho-pkb/akt levels selective small-molecular-weight inhibitors igf-i-dependent survival assay igf-i-dependent proliferation assays dr carlos garcia-echeverria circumventing long-term deprivation phospho-pkb/akt levels decreased steroid-deprived mcf7/aro cells blocking igf-ir auto-phosphorylation igf-ir-dependent survival pathways estrogen-dependent igf-ir signaling mediating estradiol-dependent proliferation/survival long-term estrogen deprivation poly [adp-ribose] polymerase chou-talalay derived equations trans-subunit auto-phosphorylation fluoresence-activated cell sorting fluorescence-activated cell sorting igf-ir antibody decreases pmc beta search igf-ir antibody proved estrogen-dependent breast cancers estrogen-dependent cancer setting mitogen-activated protein kinase estrogen-dependent breast cancer results estrogen-dependent proliferation growth factor-defined medium early-stage breast cancer pi3k/pkb/akt signaling steroid-deprived mcf7/aro growth factor-mediated signaling mediating estrogen-dependent proliferation aromatase-driven breast cancer igf-ir-mediated signaling competing interests er-positive tumor cells selective igf-ir inhibitor inhibits igf-ir signaling license information pmcid inhibit igf-ir signalling er-positive cells led dose-effect fit curves inhibiting androstenedione-dependent proliferation dose-dependent inhibitory effect previously endocrine-insensitive tumor estrogen-induced proliferative response t47d/aro cells accumulated induce s-phase entry anti-phospho-p44/42 mapk
Questions {❓}
- Combination therapy with aromatase inhibitors: the next era of breast cancer treatment?
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