
NCBI . NLM . NIH . GOV {
}
Title[redir]:
mTOR Inhibition Induces Upstream Receptor Tyrosine Kinase Signaling and Activates Akt - PMC
Description:
Stimulation of the insulin and insulin-like growth factor I (IGF-I) receptor activates the phosphoinositide-3-kinase/Akt/mTOR pathway causing pleiotropic cellular effects including an mTOR-dependent loss in insulin receptor substrate-1 expression ...
Matching Content Categories {๐}
- Science
- Education
- Health & Fitness
Content Management System {๐}
What CMS is ncbi.nlm.nih.gov built with?
Custom-built
No common CMS systems were detected on Ncbi.nlm.nih.gov, and no known web development framework was identified.
Traffic Estimate {๐}
What is the average monthly size of ncbi.nlm.nih.gov audience?
๐ Phenomenal Traffic: 5M - 10M visitors per month
Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.
check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush
How Does Ncbi.nlm.nih.gov Make Money? {๐ธ}
We find it hard to spot revenue streams.
Earning money isn't the goal of every website; some are designed to offer support or promote social causes. People have different reasons for creating websites. This might be one such reason. Ncbi.nlm.nih.gov might be plotting its profit, but the way they're doing it isn't detectable yet.
Keywords {๐}
rapamycin, akt, cells, doi, inhibition, cell, mtor, signaling, cancer, tumor, igfi, activation, activity, phosphorylation, kinase, igfir, pubmed, google, scholar, induction, mcf, treatment, nmoll, irs, pakt, levels, effects, fig, receptor, treated, insulin, nvpaew, pathway, inhibitors, patients, lines, hours, growth, rad, feedback, tumors, mdamb, increased, pmc, antitumor, rapamycininduced, human, line, total, induces,
Topics {โ๏ธ}
myr-akt-driven transgenic models increased igf-ir/irs-1/pi3k signaling igf-i-dependent akt activation pi3k/akt/mtor signaling leads phosphoinositide-3-kinase/akt kinase nih grant po1-ca094060 peroxidase-labeled polymer conjugated tris-hcl buffer [dakocytomation baseline time pointโprior frap/raft/tor component induces rictor-mtor activity akt s473 kinase/pdk2 p70/s6k mediates phosphorylation goat anti-rabbit method detect antigen-antibody reaction pmc beta search mda-mb-468 cell lines mtor/s6k-dependent loss mtor-dependent s6k phosphorylation igf-ir-dependent manner small-molecule nvp-aew541 nvp-aew541 shows selectivity augmenting igf-ir signaling methods cell lines gsk3ฮฑ/ฮฒ phosphorylation occurred total p70/s6k levels p-gsk3ฮฑ/ฮฒ antibody s21/9 gsk3ฮฑ/ฮฒ phosphorylation rapamycin-induced akt activation rapamycin-induced akt phosphorylation rapamycin-induced foxo phosphorylation mda-mb-468 cells reveals mtor-dependent feedback inhibition igf-ir inhibitors enhance pi3k/akt signaling due cancer cell lines small-molecule inhibitor insulin receptor substrate-1 cell-cycle subcompartments induces irs-1 expression kinase activity leads induces akt phosphorylation mtor-dependent negative regulation publisher site pdf rhabdomyosarcoma line rh30 methods cell biol tumor cell lines upstream signaling molecules igf-ir inhibition enhanced advanced solid tumors
Questions {โ}
- Will mTOR inhibitors make it as cancer drugs?
Social Networks {๐}(6)
External Links {๐}(66)
- How much revenue does https://doi.org/10.1158/0008-5472.CAN-05-2925 bring in?
- Explore the financials of https://doi.org/10.1038/nrc839
- What are the total earnings of https://scholar.google.com/scholar_lookup?journal=Nat%20Rev%20Cancer&title=The%20phosphatidylinositol%203-kinase%20AKT%20pathway%20in%20human%20cancer&author=I%20Vivanco&author=CL%20Sawyers&volume=2&publication_year=2002&pages=489-501&pmid=12094235&doi=10.1038/nrc839&?
- Discover the revenue of https://doi.org/10.1038/nrc1362
- How much does https://scholar.google.com/scholar_lookup?journal=Nat%20Rev%20Cancer&title=The%20TOR%20pathway:%20a%20target%20for%20cancer%20therapy&author=MA%20Bjornsti&author=PJ%20Houghton&volume=4&publication_year=2004&pages=335-48&pmid=15122205&doi=10.1038/nrc1362& net monthly?
- How much does https://doi.org/10.1016/s0962-8924(02)00042-9 rake in every month?
- How much does https://scholar.google.com/scholar_lookup?journal=Trends%20Cell%20Biol&title=Insulin/IGF%20and%20target%20of%20rapamycin%20signaling:%20a%20TOR%20de%20force%20in%20growth%20control&author=S%20Oldham&author=E%20Hafen&volume=13&publication_year=2003&pages=79-85&pmid=12559758&doi=10.1016/s0962-8924(02)00042-9& bring in each month?
- What's https://doi.org/10.1210/mend.14.6.0446's gross income?
- What's the financial intake of https://scholar.google.com/scholar_lookup?journal=Mol%20Endocrinol&title=A%20rapamycin-sensitive%20pathway%20down-regulates%20insulin%20signaling%20via%20phosphorylation%20and%20proteasomal%20degradation%20of%20insulin%20receptor%20substrate-1&author=T%20Haruta&author=T%20Uno&author=J%20Kawahara&volume=14&publication_year=2000&pages=783-94&pmid=10847581&doi=10.1210/mend.14.6.0446&?
- How much does https://doi.org/10.2337/diabetes.50.1.24 earn?
- https://scholar.google.com/scholar_lookup?journal=Diabetes&title=Serine/threonine%20phosphorylation%20of%20IRS-1%20triggers%20its%20degradation:%20possible%20regulation%20by%20tyrosine%20phosphorylation&author=TM%20Pederson&author=DL%20Kramer&author=CM%20Rondinone&volume=50&publication_year=2001&pages=24-31&pmid=11147790&doi=10.2337/diabetes.50.1.24& income
- How much revenue does https://doi.org/10.2337/diabetes.48.7.1359 produce monthly?
- What is the earnings of https://scholar.google.com/scholar_lookup?journal=Diabetes&title=Insulin-induced%20insulin%20receptor%20substrate-1%20degradation%20is%20mediated%20by%20the%20proteasome%20degradation%20pathway&author=XJ%20Sun&author=JL%20Goldberg&author=LY%20Qiao&author=JJ%20Mitchell&volume=48&publication_year=1999&pages=1359-64&pmid=10389839&doi=10.2337/diabetes.48.7.1359&?
- https://doi.org/10.1016/j.cub.2004.08.026's financial summary
- How much revenue does https://scholar.google.com/scholar_lookup?journal=Curr%20Biol&title=Inappropriate%20activation%20of%20the%20TSC/Rheb/mTOR/S6K%20cassette%20induces%20IRS1/2%20depletion,%20insulin%20resistance,%20and%20cell%20survival%20deficiencies&author=OJ%20Shah&author=Z%20Wang&author=T%20Hunter&volume=14&publication_year=2004&pages=1650-6&pmid=15380067&doi=10.1016/j.cub.2004.08.026& bring in?
- How much revenue does https://doi.org/10.1038/nature02866 bring in?
- Discover the revenue of https://scholar.google.com/scholar_lookup?journal=Nature&title=Absence%20of%20S6K1%20protects%20against%20age-%20and%20diet-induced%20obesity%20while%20enhancing%20insulin%20sensitivity&author=SH%20Um&author=F%20Frigerio&author=M%20Watanabe&volume=431&publication_year=2004&pages=200-5&pmid=15306821&doi=10.1038/nature02866&
- Explore the financials of https://doi.org/10.1007/978-3-642-80481-6_8
- What's https://scholar.google.com/scholar_lookup?journal=Curr%20Top%20Microbiol%20Immunol&title=The%20IRS-signaling%20system:%20a%20network%20of%20docking%20proteins%20that%20mediate%20insulin%20and%20cytokine%20action&author=MF%20White&author=L%20Yenush&volume=228&publication_year=1998&pages=179-208&pmid=9401207&doi=10.1007/978-3-642-80481-6_8&'s gross income?
- Get to know https://doi.org/10.1126/science.1073096's earnings
- How much does https://scholar.google.com/scholar_lookup?journal=Science&title=Cancer.%20Addiction%20to%20oncogenes%E2%80%94the%20Achilles%20heal%20of%20cancer&author=IB%20Weinstein&volume=297&publication_year=2002&pages=63-4&pmid=12098689&doi=10.1126/science.1073096& earn?
- How much does https://doi.org/10.1073/pnas.191379498 rake in every month?
- Get to know https://scholar.google.com/scholar_lookup?journal=Proc%20Natl%20Acad%20Sci%20U%20S%20A&title=Linking%20molecular%20therapeutics%20to%20molecular%20diagnostics:%20inhibition%20of%20the%20FRAP/RAFT/TOR%20component%20of%20the%20PI3K%20pathway%20preferentially%20blocks%20PTEN%20mutant%20cells%20in%20vitro%20and%20in%20vivo&author=GB%20Mills&author=Y%20Lu&author=EC%20Kohn&volume=98&publication_year=2001&pages=10031-3&pmid=11526226&doi=10.1073/pnas.191379498&'s earnings
- How much cash flow does https://doi.org/10.1016/0046-8177(95)90060-8 have monthly?
- https://scholar.google.com/scholar_lookup?journal=Hum%20Pathol&title=A%20new%20immunohistochemical%20antibody%20for%20the%20assessment%20of%20estrogen%20receptor%20status%20on%20routine%20formalin-fixed%20tissue%20samples&author=H%20Goulding&author=S%20Pinder&author=P%20Cannon&volume=26&publication_year=1995&pages=291-4&pmid=7890280&doi=10.1016/0046-8177(95)90060-8&'s total income per month
- How profitable is https://doi.org/10.1016/s0091-679x(08)61730-6?
- Income figures for https://scholar.google.com/scholar_lookup?journal=Methods%20Cell%20Biol&title=Light%20scatter%20of%20isolated%20cell%20nuclei%20as%20a%20parameter%20discriminating%20the%20cell-cycle%20subcompartments&author=W%20Giaretti&author=M%20Nusse&volume=41&publication_year=1994&pages=389-400&pmid=7861971&doi=10.1016/s0091-679x(08)61730-6&
- https://doi.org/10.4161/cbt.3.8.994's revenue stream
- Check the income stats for https://scholar.google.com/scholar_lookup?journal=Cancer%20Biol%20Ther&title=The%20PIK3CA%20gene%20is%20mutated%20with%20high%20frequency%20in%20human%20breast%20cancers&author=KE%20Bachman&author=P%20Argani&author=Y%20Samuels&volume=3&publication_year=2004&pages=772-5&pmid=15254419&doi=10.4161/cbt.3.8.994&
- What's the financial gain of https://doi.org/10.1158/0008-5472.CAN-05-0917?
- How much income is https://scholar.google.com/scholar_lookup?journal=Cancer%20Res&title=Activation%20of%20Akt%20and%20eIF4E%20survival%20pathways%20by%20rapamycin-mediated%20mammalian%20target%20of%20rapamycin%20inhibition&author=SY%20Sun&author=LM%20Rosenberg&author=X%20Wang&volume=65&publication_year=2005&pages=7052-8&pmid=16103051&doi=10.1158/0008-5472.CAN-05-0917& earning monthly?
- How much does https://doi.org/10.1073/pnas.171076798 rake in every month?
- How much does https://scholar.google.com/scholar_lookup?journal=Proc%20Natl%20Acad%20Sci%20U%20S%20A&title=Enhanced%20sensitivity%20of%20PTEN-deficient%20tumors%20to%20inhibition%20of%20FRAP/mTOR&author=MS%20Neshat&author=IK%20Mellinghoff&author=C%20Tran&volume=98&publication_year=2001&pages=10314-9&pmid=11504908&doi=10.1073/pnas.171076798& gross monthly?
- What's the financial gain of https://doi.org/10.1038/nm1052?
- How much cash flow does https://scholar.google.com/scholar_lookup?journal=Nat%20Med&title=mTOR%20inhibition%20reverses%20Akt-dependent%20prostate%20intraepithelial%20neoplasia%20through%20regulation%20of%20apoptotic%20and%20HIF-1-dependent%20pathways&author=PK%20Majumder&author=PG%20Febbo&author=R%20Bikoff&volume=10&publication_year=2004&pages=594-601&pmid=15156201&doi=10.1038/nm1052& have monthly?
- How much does https://doi.org/10.1158/0008-5472.can-3554-2 earn?
- How much does https://scholar.google.com/scholar_lookup?journal=Cancer%20Res&title=Antitumor%20efficacy%20of%20intermittent%20treatment%20schedules%20with%20the%20rapamycin%20derivative%20RAD001%20correlates%20with%20prolonged%20inactivation%20of%20ribosomal%20protein%20S6%20kinase%201%20in%20peripheral%20blood%20mononuclear%20cells&author=A%20Boulay&author=S%20Zumstein-Mecker&author=C%20Stephan&volume=64&publication_year=2004&pages=252-61&pmid=14729632&doi=10.1158/0008-5472.can-3554-2& net monthly?
- Discover the revenue of https://doi.org/10.1016/s1535-6108(04)00051-0
- Check the income stats for https://scholar.google.com/scholar_lookup?journal=Cancer%20Cell&title=In%20vivo%20antitumor%20activity%20of%20NVP-AEW541-A%20novel,%20potent,%20and%20selective%20inhibitor%20of%20the%20IGF-IR%20kinase&author=C%20Garcia-Echeverria&author=MA%20Pearson&author=A%20Marti&volume=5&publication_year=2004&pages=231-9&pmid=15050915&doi=10.1016/s1535-6108(04)00051-0&
- Get to know https://scholar.google.com/scholar_lookup?journal=Cancer%20Res&title=A%20fully%20human%20monoclonal%20antibody%20to%20the%20insulin-like%20growth%20factor%20I%20receptor%20blocks%20ligand-dependent%20signaling%20and%20inhibits%20human%20tumor%20growth%20in%20vivo&author=D%20Burtrum&author=Z%20Zhu&author=D%20Lu&volume=63&publication_year=2003&pages=8912-21&pmid=14695208&'s earnings
- https://doi.org/10.1016/s1535-6108(03)00275-7 income
- What's the financial gain of https://scholar.google.com/scholar_lookup?journal=Cancer%20Cell&title=Will%20mTOR%20inhibitors%20make%20it%20as%20cancer%20drugs?&author=CL%20Sawyers&volume=4&publication_year=2003&pages=343-8&pmid=14667501&doi=10.1016/s1535-6108(03)00275-7&?
- What are the earnings of https://doi.org/10.1074/jbc.M211398200?
- Get to know https://scholar.google.com/scholar_lookup?journal=J%20Biol%20Chem&title=Type%201%20insulin-like%20growth%20factor%20receptor%20(IGF-IR)%20signaling%20inhibits%20apoptosis%20signal-regulating%20kinase%201%20(ASK1)&author=V%20Galvan&author=A%20Logvinova&author=S%20Sperandio&author=H%20Ichijo&author=DE%20Bredesen&volume=278&publication_year=2003&pages=13325-32&pmid=12556535&doi=10.1074/jbc.M211398200&'s earnings
- What's the monthly income of https://doi.org/10.1083/jcb.200403069?
- Learn how profitable https://scholar.google.com/scholar_lookup?journal=J%20Cell%20Biol&title=The%20TSC1-2%20tumor%20suppressor%20controls%20insulin-PI3K%20signaling%20via%20regulation%20of%20IRS%20proteins&author=LS%20Harrington&author=GM%20Findlay&author=A%20Gray&volume=166&publication_year=2004&pages=213-23&pmid=15249583&doi=10.1083/jcb.200403069& is on a monthly basis
- How much money does https://doi.org/10.1083/jcb.200408161 make?
- How much does https://scholar.google.com/scholar_lookup?journal=J%20Cell%20Biol&title=Balancing%20Akt%20with%20S6K:%20implications%20for%20both%20metabolic%20diseases%20and%20tumorigenesis&author=BD%20Manning&volume=167&publication_year=2004&pages=399-403&pmid=15533996&doi=10.1083/jcb.200408161& earn?
- How much revenue does https://doi.org/10.1016/j.cub.2004.06.054 bring in?
- Monthly income for https://scholar.google.com/scholar_lookup?journal=Curr%20Biol&title=Rictor,%20a%20novel%20binding%20partner%20of%20mTOR,%20defines%20a%20rapamycin-insensitive%20and%20raptor-independent%20pathway%20that%20regulates%20the%20cytoskeleton&author=DD%20Sarbassov&author=SM%20Ali&author=DH%20Kim&volume=14&publication_year=2004&pages=1296-302&pmid=15268862&doi=10.1016/j.cub.2004.06.054&
- Discover the revenue of https://doi.org/10.1074/jbc.M508361200
- How much does https://scholar.google.com/scholar_lookup?journal=J%20Biol%20Chem&title=mTOR/RICTOR%20is%20the%20Ser473%20kinase%20for%20Akt/PKB%20in%203T3-L1%20adipocytes&author=RC%20Hresko&author=M%20Mueckler&volume=280&publication_year=2005&pages=40406-16&pmid=16221682&doi=10.1074/jbc.M508361200& pull in monthly?
- How profitable is https://doi.org/10.1126/science.1106148?
- How much profit does https://scholar.google.com/scholar_lookup?journal=Science&title=Phosphorylation%20and%20regulation%20of%20Akt/PKB%20by%20the%20rictor-mTOR%20complex&author=DD%20Sarbassov&author=DA%20Guertin&author=SM%20Ali&author=DM%20Sabatini&volume=307&publication_year=2005&pages=1098-101&pmid=15718470&doi=10.1126/science.1106148& make?
- See how much https://github.com/ncbi makes per month
- What is the earnings of https://www.google.com/maps/place/8600+Rockville+Pike,+Bethesda,+MD+20894/%4038.9959508, -77.101021,17z/data%3D!3m1!4b1!4m5!3m4!1s0x89b7c95e25765ddb%3A0x19156f88b27635b8!8m2!3d38.9959508! 4d-77.0988323?
- What's the profit of https://www.nlm.nih.gov/web_policies.html?
- Revenue of https://www.nih.gov/institutes-nih/nih-office-director/office-communications-public-liaison/freedom-information-act-office
- See how much https://www.hhs.gov/vulnerability-disclosure-policy/index.html makes per month
- How much does https://support.nlm.nih.gov/?pagename=cloudpmc-viewer%3Apmc%3Aarticle%3Amanuscript pull in?
- How much does https://www.nlm.nih.gov/accessibility.html earn?
- Explore the financials of https://www.nlm.nih.gov/careers/careers.html
- How much does https://www.nlm.nih.gov/ earn?
- Income figures for https://www.nih.gov/
- How much cash flow does https://www.hhs.gov/ have monthly?
- How much does https://www.usa.gov/ generate monthly?
Analytics and Tracking {๐}
- Google Analytics
- Google Analytics 4
- Google Tag Manager
Libraries {๐}
- Foundation
- jQuery
- jQuery module (jquery-3.6.0)
- Zoom.js
Emails and Hosting {โ๏ธ}
Mail Servers:
- nihcesxway.hub.nih.gov
- nihcesxway2.hub.nih.gov
- nihcesxway3.hub.nih.gov
- nihcesxway4.hub.nih.gov
- nihcesxway5.hub.nih.gov
Name Servers:
- dns1-ncbi.ncbi.nlm.nih.gov
- dns2-ncbi.ncbi.nlm.nih.gov
- lhcns1.nlm.nih.gov
- lhcns2.nlm.nih.gov
CDN Services {๐ฆ}
- Ncbi