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We began analyzing https://www.nature.com/articles/s41564-020-00831-6, but it redirected us to https://www.nature.com/articles/s41564-020-00831-6. The analysis below is for the second page.

Title[redir]:
Bifidobacterium bifidum strains synergize with immune checkpoint inhibitors to reduce tumour burden in mice | Nature Microbiology
Description:
The gut microbiome can influence the development of tumours and the efficacy of cancer therapeutics1–5; however, the multi-omics characteristics of antitumour bacterial strains have not been fully elucidated. In this study, we integrated metagenomics, genomics and transcriptomics of bacteria, and analyses of mouse intestinal transcriptome and serum metabolome data to reveal an additional mechanism by which bacteria determine the efficacy of cancer therapeutics. In gut microbiome analyses of 96 samples from patients with non-small-cell lung cancer, Bifidobacterium bifidum was abundant in patients responsive to therapy. However, when we treated syngeneic mouse tumours with commercial strains of B. bifidum to establish relevance for potential therapeutic uses, only specific B. bifidum strains reduced tumour burden synergistically with PD-1 blockade or oxaliplatin treatment by eliciting an antitumour host immune response. In mice, these strains induced tuning of the immunological background by potentiating the production of interferon-γ, probably through the enhanced biosynthesis of immune-stimulating molecules and metabolites. An analysis of gut microbiomes of patients with non-small-cell lung cancer reveals an association between Bifidobacterium bifidum abundance and response to cancer therapy. In murine models of syngeneic tumours, administration of commercial B. bifidum strains synergizes with immune checkpoint blockade to reduce tumour burden, but the therapeutic potential of B. bifidum is affected by strain-level variation.

Matching Content Categories {📚}

  • Education
  • Science
  • Careers

Content Management System {📝}

What CMS is doi.org built with?

Custom-built

No common CMS systems were detected on Doi.org, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of doi.org audience?

🏙️ Massive Traffic: 50M - 100M visitors per month


Based on our best estimate, this website will receive around 96,105,781 visitors per month in the current month.

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How Does Doi.org Make Money? {💸}

The income method remains a mystery to us.

The purpose of some websites isn't monetary gain; they're meant to inform, educate, or foster collaboration. Everyone has unique reasons for building websites. This could be an example. Doi.org might have a hidden revenue stream, but it's not something we can detect.

Keywords {🔍}

pubmed, data, article, google, scholar, cas, antipd, central, nature, kim, source, oxp, bifk, cancer, korea, mice, versus, bifidum, science, analysis, lee, tumor, strains, show, gut, microbiome, calculated, cells, fig, means, sem, mouse, university, seoul, cell, research, extended, immune, access, genome, bioinformatics, bifidobacterium, park, development, patients, treated, statistical, supported, funded, comparison,

Topics {✒️}

nature portfolio journals permissions reprints nature portfolio privacy policy advertising deep-sequencing-based transcriptome data small-cell lung cancer social media middle-aged national research foundation gist research institute tumor necrosis factor-alpha facilitates anti-pd-l1 efficacy vitro t-cell assays tools high-throughput sequence data high-throughput sequencing reads high-resolution sample inference joon-suk park nature+ nature 535 nature 548 nature 377 nature mice se-hoon lee tumour necrosis factor kyoung wan yoon trigger anti-tumor immunity gwang bin lee hong sook kim se-hoon lee sided unpaired mann-whitney source data fig sung-yup cho 16s rrna sequences ifn-γ pathway genes permissions rna-seq data research hyun-suk yang springerlink instant access enriched gene ontology samsung medical center strains induced tuning single-cell sequencing metabolomics source data linear discriminant analysis principal component analysis syngeneic tumour model ewha womans university

Schema {🗺️}

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         headline:Bifidobacterium bifidum strains synergize with immune checkpoint inhibitors to reduce tumour burden in mice
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         datePublished:2021-01-11T00:00:00Z
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      headline:Bifidobacterium bifidum strains synergize with immune checkpoint inhibitors to reduce tumour burden in mice
      description:The gut microbiome can influence the development of tumours and the efficacy of cancer therapeutics1–5; however, the multi-omics characteristics of antitumour bacterial strains have not been fully elucidated. In this study, we integrated metagenomics, genomics and transcriptomics of bacteria, and analyses of mouse intestinal transcriptome and serum metabolome data to reveal an additional mechanism by which bacteria determine the efficacy of cancer therapeutics. In gut microbiome analyses of 96 samples from patients with non-small-cell lung cancer, Bifidobacterium bifidum was abundant in patients responsive to therapy. However, when we treated syngeneic mouse tumours with commercial strains of B. bifidum to establish relevance for potential therapeutic uses, only specific B. bifidum strains reduced tumour burden synergistically with PD-1 blockade or oxaliplatin treatment by eliciting an antitumour host immune response. In mice, these strains induced tuning of the immunological background by potentiating the production of interferon-γ, probably through the enhanced biosynthesis of immune-stimulating molecules and metabolites. An analysis of gut microbiomes of patients with non-small-cell lung cancer reveals an association between Bifidobacterium bifidum abundance and response to cancer therapy. In murine models of syngeneic tumours, administration of commercial B. bifidum strains synergizes with immune checkpoint blockade to reduce tumour burden, but the therapeutic potential of B. bifidum is affected by strain-level variation.
      datePublished:2021-01-11T00:00:00Z
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         Metagenomics
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         Medical Microbiology
         Parasitology
         Infectious Diseases
         Virology
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      name:Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology (GIST), Gwangju, Korea
      name:Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology (GIST), Gwangju, Korea
      name:Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology (GIST), Gwangju, Korea
      name:Department of Chemistry, Yonsei University, Seoul, Korea
      name:Genome and Company, Gyeonggi-do, Korea
      name:Genome and Company, Gyeonggi-do, Korea
      name:Division of Hematology–Oncology, Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
      name:Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology (GIST), Gwangju, Korea
      name:Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology (GIST), Gwangju, Korea
      name:Department of Biotechnology, Hoseo University, Asan, Korea
      name:Department of Biotechnology, Hoseo University, Asan, Korea
      name:Laboratory Animal Center, Daegu-Gyeongbuk Medical Innovation Foundation (DGMIF), Daegu, Korea
      name:Korea Basic Science Institute, Seoul Center, Seoul, Korea
      name:Department of Chemistry, Yonsei University, Seoul, Korea
      name:Korea Basic Science Institute, Seoul Center, Seoul, Korea
      name:The Jackson Laboratory for Genomic Medicine, Farmington, USA
      name:Department of Public Health Sciences, Seoul National University, Seoul, Korea
      name:Laboratory Animal Center, Daegu-Gyeongbuk Medical Innovation Foundation (DGMIF), Daegu, Korea
      name:The Jackson Laboratory for Genomic Medicine, Farmington, USA
      name:The Jackson Laboratory for Genomic Medicine, Farmington, USA
      name:Department of Life Science, Ewha Womans University, Seoul, Korea
      name:The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China
      name:Genome and Company, Gyeonggi-do, Korea
      name:Department of Biotechnology, Hoseo University, Asan, Korea
      name:Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology (GIST), Gwangju, Korea
      name:Genome and Company, Gyeonggi-do, Korea
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