We are analyzing https://link.springer.com/article/10.1186/s13073-016-0296-x.

Title:
Microbial metabolism of dietary components to bioactive metabolites: opportunities for new therapeutic interventions | Genome Medicine
Description:
Mass spectrometry- and nuclear magnetic resonance-based metabolomic studies comparing diseased versus healthy individuals have shown that microbial metabolites are often the compounds most markedly altered in the disease state. Recent studies suggest that several of these metabolites that derive from microbial transformation of dietary components have significant effects on physiological processes such as gut and immune homeostasis, energy metabolism, vascular function, and neurological behavior. Here, we review several of the most intriguing diet-dependent metabolites that may impact host physiology and may therefore be appropriate targets for therapeutic interventions, such as short-chain fatty acids, trimethylamine N-oxide, tryptophan and tyrosine derivatives, and oxidized fatty acids. Such interventions will require modulating either bacterial species or the bacterial biosynthetic enzymes required to produce these metabolites, so we briefly describe the current understanding of the bacterial and enzymatic pathways involved in their biosynthesis and summarize their molecular mechanisms of action. We then discuss in more detail the impact of these metabolites on health and disease, and review current strategies to modulate levels of these metabolites to promote human health. We also suggest future studies that are needed to realize the full therapeutic potential of targeting the gut microbiota.
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Keywords {🔍}

pubmed, google, scholar, article, cas, gut, central, microbial, metabolites, microbiota, disease, butyrate, acid, effects, levels, studies, dietary, fatty, human, intestinal, cancer, mice, tmao, cell, scfas, acids, production, cells, sulfate, bacteria, host, metabolic, indole, receptor, inflammation, potential, obesity, bacterial, inhibition, res, function, conjugated, activation, health, linoleic, metabolite, formation, colorectal, colonic, sci,

Topics {✒️}

include myosin-cross-reactive antigen cyclooxygenase-related linoleate 10s-dioxygenase short-chain fatty acids nuclear magnetic resonance protein-bound uremic toxins gastric inhibitory polypeptide butyrate-dependent tumor-suppressive effect short-chain dehydrogenase/oxidoreductase high-fat diet-induced obesity microbiota-host metabolic interactions quantifying diet-induced metabolic g-protein-coupled receptor 43 g-protein-coupled receptor ischemia-induced neuronal damage conjugate linolenic acids nf-κb pathway improved antioxidant/detoxifying defences udp-glucuronosyltransferase enzyme activities antibiotic-induced gut dysbiosis gpr40–mek–erk pathway [176] gpr40-mek-erk pathway increases th17-cell activity butyrate-mediated histone acetylation 10-hydroxy-cis-12-octadecenoic acid diet-dependent metabolic pathways metabolite-sensing receptor gpr43 satiety factor n-acylphosphatidylethanolamine article download pdf inoculating germ-free mice germ-free mice demonstrates intriguing diet-dependent metabolites high-fiber cereal supplement apolipoprotein e-deficient mice ppar-γ-dependent mechanism metabolite-sensing receptors gpr43 epithelial barrier function host metabotype-microbiome associations metabolic profiling reveals choline trimethylamine-lyase expands gastric bypass surgery tang wh unusual rieske-type oxygenase lactic acid bacteria gut microbiota-brain communication protein-coupled receptors gpr41 host-microbial meta-metabolome o'keefe jh left-sided ulcerative colitis tight junction proteins complex cross-feeding

Questions {❓}

Does butyrate protect from colorectal cancer?

Schema {🗺️}

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         headline:Microbial metabolism of dietary components to bioactive metabolites: opportunities for new therapeutic interventions
         description:Mass spectrometry- and nuclear magnetic resonance-based metabolomic studies comparing diseased versus healthy individuals have shown that microbial metabolites are often the compounds most markedly altered in the disease state. Recent studies suggest that several of these metabolites that derive from microbial transformation of dietary components have significant effects on physiological processes such as gut and immune homeostasis, energy metabolism, vascular function, and neurological behavior. Here, we review several of the most intriguing diet-dependent metabolites that may impact host physiology and may therefore be appropriate targets for therapeutic interventions, such as short-chain fatty acids, trimethylamine N-oxide, tryptophan and tyrosine derivatives, and oxidized fatty acids. Such interventions will require modulating either bacterial species or the bacterial biosynthetic enzymes required to produce these metabolites, so we briefly describe the current understanding of the bacterial and enzymatic pathways involved in their biosynthesis and summarize their molecular mechanisms of action. We then discuss in more detail the impact of these metabolites on health and disease, and review current strategies to modulate levels of these metabolites to promote human health. We also suggest future studies that are needed to realize the full therapeutic potential of targeting the gut microbiota.
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      headline:Microbial metabolism of dietary components to bioactive metabolites: opportunities for new therapeutic interventions
      description:Mass spectrometry- and nuclear magnetic resonance-based metabolomic studies comparing diseased versus healthy individuals have shown that microbial metabolites are often the compounds most markedly altered in the disease state. Recent studies suggest that several of these metabolites that derive from microbial transformation of dietary components have significant effects on physiological processes such as gut and immune homeostasis, energy metabolism, vascular function, and neurological behavior. Here, we review several of the most intriguing diet-dependent metabolites that may impact host physiology and may therefore be appropriate targets for therapeutic interventions, such as short-chain fatty acids, trimethylamine N-oxide, tryptophan and tyrosine derivatives, and oxidized fatty acids. Such interventions will require modulating either bacterial species or the bacterial biosynthetic enzymes required to produce these metabolites, so we briefly describe the current understanding of the bacterial and enzymatic pathways involved in their biosynthesis and summarize their molecular mechanisms of action. We then discuss in more detail the impact of these metabolites on health and disease, and review current strategies to modulate levels of these metabolites to promote human health. We also suggest future studies that are needed to realize the full therapeutic potential of targeting the gut microbiota.
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         Conjugate Linoleic Acid
         HDAC Inhibition
         Gastric Inhibitory Polypeptide
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         Metabolomics
         Bioinformatics
         Medicine/Public Health
         general
         Cancer Research
         Systems Biology
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