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article, google, scholar, cas, pubmed, microbiota, bifidobacterium, probiotics, gut, lipid, diabetes, tmc, effect, probiotic, profile, wang, effects, lactobacillus, metabolic, health, intestinal, subjects, intervention, cholesterol, type, consumption, microbiol, httpsdoiorgs, kumar, china, research, bifidum, plasma, access, study, disease, central, sci, biotechnol, yogurt, privacy, cookies, content, patients, controlled, nutrition, van, zhang, nutr, food,

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filename=yyxx201606007&dbname=cjfq2016 saito filename=spyk201109061&dbname=cjfq2011 ren filename=sspj201701010&dbname=cjfq2017 zanotti filename=spyk201407031&dbname=cjfq2014 odamaki diet-induced leptin-resistant mice month download article/chapter org/core/journals/british-journal streptozotocin-induced diabetic rats high-density lipoprotein cholesterol net/kcms/detail/detail gut-brain neural circuits low-density lipoprotein cholesterol net/grid2008/dbpub/detail /retrieve/pii/s0966-842x inhibit fat cells ameliorate intestinal microflora microbiome census data full article pdf antimicrobial proteins aims feng ll randomized controlled trials lactobacillus plantarum intake journalcode=kgmi20 everard privacy choices/manage cookies nicholson jk plasma lipid profiles west china school bifidobacterium bifidum tmc3115 de rezende cm bifidobacterium bifidum prl2010 inflammatory bowel disease org/plosone/article randomised controlled trials bifidobacterium lactis lb-1 de vos wm human gut microbiota hebei yiran biotechnology young healthy women firmicutes correlated negatively de souza rg cholesterol-lowering activity bifidobacterium longum bb536 article wang nutrition/article/effects /retrieve/pii/s0939-4753 /retrieve/pii/s0022-0302 /retrieve/pii/s1075-9964 /retrieve/pii/s0092-8674 health service center european economic area

Questions {❓}

• 1071872?
• 1361092?
• Org/plosone/article?

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         headline:Bifidobacterium bifidum TMC3115 Can Characteristically Influence Glucose and Lipid Profile and Intestinal Microbiota in the Middle-Aged and Elderly
         description:Bifidobacterium bifidum TMC3115 strain (TMC3115) was orally administrated to 47 subjects with mild hyperglycaemia and dyslipidaemia aged 45 to 75 years for 3 weeks. Blood samples were collected before and after intervention for profiling plasma total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol and triglyceride concentrations, as well as fasting blood glucose. Before and 3 and 4 weeks after intervention, the faecal samples were collected to analyse faecal microbiota using the sequencing of 16S rRNA genes with a next-generation sequencer. TMC3115 significantly decreased plasma TC and LDL-C levels of the tested subjects after intervention (P < 0.05). The frequencies of defaecation and faecal odour after the intervention and 1 week later were significantly better than at pre-intervention, respectively. TMC3115 administration increased Firmicutes, Bacteroides and Actinobacteria and decreases in Proteobacteria and Fusobacteria. There were significant increases in the proportions of Dorea and Lachnospira after the intervention (P < 0.05). TMC3115 also increased the level of Firmicutes and decreased that of Bacteroidetes 1 week after the intervention (P < 0.05). Serum triglycerides correlated negatively with the proportions of Bacteroidetes (R = − 0.21, P = 0.047) and Bacteroides (R = − 0.23, P = 0.029), while the relative abundance of Dialister of Firmicutes correlated negatively and significantly with the serum LDL-C (R = − 0.24, P = 0.022) and TC levels (R = − 0.22, P = 0.030). These results indicate that TMC3115 might exhibit beneficial effects on the serum cholesterol metabolism of subjects with dyslipidaemia through modulation of their intestinal microbiota. Trial registration: ChiCTR-OOC-16010271
         datePublished:2018-07-05T00:00:00Z
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            Hyperglycaemia
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            Microbiology
            Applied Microbiology
            Chemistry/Food Science
            general
            Protein Science
            Nutrition
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      headline:Bifidobacterium bifidum TMC3115 Can Characteristically Influence Glucose and Lipid Profile and Intestinal Microbiota in the Middle-Aged and Elderly
      description:Bifidobacterium bifidum TMC3115 strain (TMC3115) was orally administrated to 47 subjects with mild hyperglycaemia and dyslipidaemia aged 45 to 75 years for 3 weeks. Blood samples were collected before and after intervention for profiling plasma total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol and triglyceride concentrations, as well as fasting blood glucose. Before and 3 and 4 weeks after intervention, the faecal samples were collected to analyse faecal microbiota using the sequencing of 16S rRNA genes with a next-generation sequencer. TMC3115 significantly decreased plasma TC and LDL-C levels of the tested subjects after intervention (P < 0.05). The frequencies of defaecation and faecal odour after the intervention and 1 week later were significantly better than at pre-intervention, respectively. TMC3115 administration increased Firmicutes, Bacteroides and Actinobacteria and decreases in Proteobacteria and Fusobacteria. There were significant increases in the proportions of Dorea and Lachnospira after the intervention (P < 0.05). TMC3115 also increased the level of Firmicutes and decreased that of Bacteroidetes 1 week after the intervention (P < 0.05). Serum triglycerides correlated negatively with the proportions of Bacteroidetes (R = − 0.21, P = 0.047) and Bacteroides (R = − 0.23, P = 0.029), while the relative abundance of Dialister of Firmicutes correlated negatively and significantly with the serum LDL-C (R = − 0.24, P = 0.022) and TC levels (R = − 0.22, P = 0.030). These results indicate that TMC3115 might exhibit beneficial effects on the serum cholesterol metabolism of subjects with dyslipidaemia through modulation of their intestinal microbiota. Trial registration: ChiCTR-OOC-16010271
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         Probiotic supplementation
         Intestinal microflora
         Hyperglycaemia
         Dyslipidaemia
         Microbiology
         Applied Microbiology
         Chemistry/Food Science
         general
         Protein Science
         Nutrition
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      name:The Health Service Center of Huayang Community, Chengdu, People’s Republic of China
      name:West China School of Public Health and Healthy Food Evaluation Research Center, Sichuan University, Chengdu, People’s Republic of China
      name:West China School of Public Health and Healthy Food Evaluation Research Center, Sichuan University, Chengdu, People’s Republic of China
      name:Hebei Inatural Biotech Co. Ltd., Shijiazhuang, People’s Republic of China
      name:Hebei Inatural Biotech Co. Ltd., Shijiazhuang, People’s Republic of China
      name:ReGenera R&D International for Aging Intervention and San Babila Clinic, Milan, Italy
      name:West China School of Public Health and Healthy Food Evaluation Research Center, Sichuan University, Chengdu, People’s Republic of China
      name:Department of Nutrition, Food Safety and Toxicology, West China School of Public Health, Sichuan University, Chengdu, People’s Republic of China
      name:West China School of Public Health and Healthy Food Evaluation Research Center, Sichuan University, Chengdu, People’s Republic of China
      name:Department of Nutrition, Food Safety and Toxicology, West China School of Public Health, Sichuan University, Chengdu, People’s Republic of China
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