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We began analyzing https://www.nature.com/articles/nrendo.2015.128, but it redirected us to https://www.nature.com/articles/nrendo.2015.128. The analysis below is for the second page.

Title[redir]:
Short-chain fatty acids in control of body weight and insulin sensitivity | Nature Reviews Endocrinology
Description:
Short-chain fatty acids (SCFA) are produced by the gut microbiota from indigestible food stuffs, and might have beneficial effects on metabolism and insulin sensitivity. Here, Canfora and colleagues discuss how SCFA can modulate energy homeostasis and metabolism in adipose tissue, muscle and the liver. The authors also discuss whether SCFA might be used to modulate glucose homeostasis in humans. The connection between the gut microbiota and the aetiology of obesity and cardiometabolic disorders is increasingly being recognized by clinicians. Our gut microbiota might affect the cardiometabolic phenotype by fermenting indigestible dietary components and thereby producing short-chain fatty acids (SCFA). These SCFA are not only of importance in gut health and as signalling molecules, but might also enter the systemic circulation and directly affect metabolism or the function of peripheral tissues. In this Review, we discuss the effects of three SCFA (acetate, propionate and butyrate) on energy homeostasis and metabolism, as well as how these SCFA can beneficially modulate adipose tissue, skeletal muscle and liver tissue function. As a result, these SCFA contribute to improved glucose homeostasis and insulin sensitivity. Furthermore, we also summarize the increasing evidence for a potential role of SCFA as metabolic targets to prevent and counteract obesity and its associated disorders in glucose metabolism and insulin resistance. However, most data are derived from animal and in vitro studies, and consequently the importance of SCFA and differential SCFA availability in human energy and substrate metabolism remains to be fully established. Well-controlled human intervention studies investigating the role of SCFA on cardiometabolic health are, therefore, eagerly awaited.

Matching Content Categories {📚}

  • Health & Fitness
  • Education
  • Science

Content Management System {📝}

What CMS is doi.org built with?

Custom-built

No common CMS systems were detected on Doi.org, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of doi.org audience?

🏙️ Massive Traffic: 50M - 100M visitors per month


Based on our best estimate, this website will receive around 80,479,999 visitors per month in the current month.

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How Does Doi.org Make Money? {💸}

We find it hard to spot revenue streams.

While profit motivates many websites, others exist to inspire, entertain, or provide valuable resources. Websites have a variety of goals. And this might be one of them. Doi.org might be cashing in, but we can't detect the method they're using.

Keywords {🔍}

pubmed, google, scholar, article, cas, fatty, gut, acids, central, shortchain, nutr, acid, metabolism, human, nature, tissue, adipose, obesity, microbiota, clin, diabetes, scfa, acetate, insulin, regulation, propionate, colonic, receptor, chain, gpr, short, metabolic, effects, peptide, lipid, intestinal, dietary, role, production, glucose, sci, physiol, cell, colon, res, fermentation, health, energy, appetite, butyrate,

Topics {✒️}

nature portfolio permissions reprints privacy policy short-chain fatty-acid binding author information authors advertising short-chain fatty acids precompetitive research translational research amp-activated protein kinase high-fat diet-induced obesity long-chain fatty acids social media g-protein-coupled receptor ffar2 high-fat diet-fed mice portal nature 444 nature 457 nature 504 nature sustained day-long manner author correspondence g-protein-coupled receptor tumour necrosis factor-alpha trans-galactooligosaccharides reduces markers gut-brain neural circuits protein-coupled receptor gpr41 acetic acid upregulates high-fat diet omega-3 fatty acids central homeostatic mechanism glucose-dependent insulinotropic peptide acetic acid activates inulin-type fructans metabolite-sensing receptors gpr43 fatty acid synthesis springerlink instant access protein-coupled receptors gpr41 nitric oxide–dependent mechanism transport l-lactate diet-induced resistance dietary protein supplements 3t3-l1 adipocytes hepatic glucose production microbial metabolites produced table 2 rights anorexic hormone production protein-coupled receptor 41 protein-coupled receptor 43 protein-coupled receptor

Questions {❓}

  • Short chain fatty acids exchange: Is the cirrhotic, dysfunctional liver still able to clear them?

Schema {🗺️}

WebPage:
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         headline:Short-chain fatty acids in control of body weight and insulin sensitivity
         description: Short-chain fatty acids (SCFA) are produced by the gut microbiota from indigestible food stuffs, and might have beneficial effects on metabolism and insulin sensitivity. Here, Canfora and colleagues discuss how SCFA can modulate energy homeostasis and metabolism in adipose tissue, muscle and the liver. The authors also discuss whether SCFA might be used to modulate glucose homeostasis in humans. The connection between the gut microbiota and the aetiology of obesity and cardiometabolic disorders is increasingly being recognized by clinicians. Our gut microbiota might affect the cardiometabolic phenotype by fermenting indigestible dietary components and thereby producing short-chain fatty acids (SCFA). These SCFA are not only of importance in gut health and as signalling molecules, but might also enter the systemic circulation and directly affect metabolism or the function of peripheral tissues. In this Review, we discuss the effects of three SCFA (acetate, propionate and butyrate) on energy homeostasis and metabolism, as well as how these SCFA can beneficially modulate adipose tissue, skeletal muscle and liver tissue function. As a result, these SCFA contribute to improved glucose homeostasis and insulin sensitivity. Furthermore, we also summarize the increasing evidence for a potential role of SCFA as metabolic targets to prevent and counteract obesity and its associated disorders in glucose metabolism and insulin resistance. However, most data are derived from animal and in vitro studies, and consequently the importance of SCFA and differential SCFA availability in human energy and substrate metabolism remains to be fully established. Well-controlled human intervention studies investigating the role of SCFA on cardiometabolic health are, therefore, eagerly awaited.
         datePublished:2015-08-11T00:00:00Z
         dateModified:2015-08-11T00:00:00Z
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      description: Short-chain fatty acids (SCFA) are produced by the gut microbiota from indigestible food stuffs, and might have beneficial effects on metabolism and insulin sensitivity. Here, Canfora and colleagues discuss how SCFA can modulate energy homeostasis and metabolism in adipose tissue, muscle and the liver. The authors also discuss whether SCFA might be used to modulate glucose homeostasis in humans. The connection between the gut microbiota and the aetiology of obesity and cardiometabolic disorders is increasingly being recognized by clinicians. Our gut microbiota might affect the cardiometabolic phenotype by fermenting indigestible dietary components and thereby producing short-chain fatty acids (SCFA). These SCFA are not only of importance in gut health and as signalling molecules, but might also enter the systemic circulation and directly affect metabolism or the function of peripheral tissues. In this Review, we discuss the effects of three SCFA (acetate, propionate and butyrate) on energy homeostasis and metabolism, as well as how these SCFA can beneficially modulate adipose tissue, skeletal muscle and liver tissue function. As a result, these SCFA contribute to improved glucose homeostasis and insulin sensitivity. Furthermore, we also summarize the increasing evidence for a potential role of SCFA as metabolic targets to prevent and counteract obesity and its associated disorders in glucose metabolism and insulin resistance. However, most data are derived from animal and in vitro studies, and consequently the importance of SCFA and differential SCFA availability in human energy and substrate metabolism remains to be fully established. Well-controlled human intervention studies investigating the role of SCFA on cardiometabolic health are, therefore, eagerly awaited.
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         Nutritional supplements
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         Type 2 diabetes
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         general
         Endocrinology
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External Links {🔗}(841)

Analytics and Tracking {📊}

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