We are analyzing https://link.springer.com/article/10.1007/bf01540341.

Title:
GLP-1 (glucagon-like peptide 1) and truncated GLP-1, fragments of human proglucagon, inhibit gastric acid secretion in humans | Digestive Diseases and Sciences
Description:
Glucagon-like peptide 1 amide (GLP-1 amide), a predicted product of the glucagon gene (proglucagon 72-107-amide), and truncated GLP-1 (proglucagon 78-107-amide), recently isolated from porcine small intestine, were infused in doses of 100 and 400 ng/kg/hr and 12.5 and 50 ng/kg/hr, respectively, into eight volunteers to study pharmacokinetics and effects on pentagastrin- stimulated gastric acid secretion (plateau stimulation with pentagastrin at D 50:100ng/kg/hr). The concentration of GLP-1 in plasma increased from 64±12 to 189±23 and 631±76 pmol/liter, respectively. The concentration of truncated GLP increased from approximately 7 pmol/liter to 28±3 pmol/liter during the high rate of infusion. A similar increase was seen in response to a mixed meal in eight normal volunteers. The metabolic clearance rate (MCR) of GLP-1 was 2.2±0.3 and 2.6±0.3 ml/kg/min, respectively, and the half- life in plasma was 17±2 min. The MCR of truncated GLP-1 was 13±2.8 ml/kg/min and the half- life 11.4±2.1 min. GLP-1 reduced the pentagastrin- stimulated acid secretion 16±9% during the low-rate infusion and 23±12% during the high rate (P<0.05). Truncated GLP-1 caused a 36±3% inhibition during the high infusion rate. Thus truncated GLP-1, a naturally occurring peptide, is a potent inhibitor of acid secretion in man and more so than GLP-1.
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Keywords {🔍}

glp, google, scholar, pubmed, peptide, article, glucagonlike, holst, truncated, acid, secretion, ørskov, gastric, christiansen, glucagon, privacy, cookies, content, proglucagon, schjoldager, mortensen, amide, gene, rate, man, access, clin, information, publish, research, search, effects, pentagastrin, products, nature, diabetologia, insulin, data, log, journal, human, ngkghr, pharmacokinetics, plasma, pmolliter, high, infusion, discover, pancreas, gut,

Topics {✒️}

month download article/chapter c-terminal amide formation related subjects article digestive diseases privacy choices/manage cookies full article pdf gastric acid secretion c-terminal sequence naturally occurring peptide european economic area scope submit manuscript porcine small intestine 400 ng/kg/hr 50 ng/kg/hr 100ng/kg/hr pig small intestine sensitive precise radioimmunoassay practical nonparametric statistics emerging beneficial effects prolonged pentagastrin stimulation conditions privacy policy metabolic clearance rate free hormone moieties insulin-releasing hormone endogenous glp-1 production perfused rat pancreas accepting optional cookies 3 ml/kg/min 8 ml/kg/min low-rate infusion serum insulin relying approximately 7 pmol/liter truncated glp-1 caused high infusion rate journal finder publish truncated glp increased acid secretion check access instant access gastric acid predicted products holst jj human preproglucagon gene pharmacokinetics access article log insulin secretion peptide 1 amide article schjoldager insulin release privacy policy

Questions {❓}

Ghiglione M, Uttenthal LO, George SK, Bloom SR: How glugagon-like is glucagon-like-peptide 1?
Holst JJ, Olsen J, Lund T: Are the enteroglucagons encoded by the glucagon gene?

Schema {🗺️}

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         headline:GLP-1 (glucagon-like peptide 1) and truncated GLP-1, fragments of human proglucagon, inhibit gastric acid secretion in humans
         description: Glucagon-like peptide 1 amide (GLP-1 amide), a predicted product of the glucagon gene (proglucagon 72-107-amide), and truncated GLP-1 (proglucagon 78-107-amide), recently isolated from porcine small intestine, were infused in doses of 100 and 400 ng/kg/hr and 12.5 and 50 ng/kg/hr, respectively, into eight volunteers to study pharmacokinetics and effects on pentagastrin- stimulated gastric acid secretion (plateau stimulation with pentagastrin at D 50:100ng/kg/hr). The concentration of GLP-1 in plasma increased from 64±12 to 189±23 and 631±76 pmol/liter, respectively. The concentration of truncated GLP increased from approximately 7 pmol/liter to 28±3 pmol/liter during the high rate of infusion. A similar increase was seen in response to a mixed meal in eight normal volunteers. The metabolic clearance rate (MCR) of GLP-1 was 2.2±0.3 and 2.6±0.3 ml/kg/min, respectively, and the half- life in plasma was 17±2 min. The MCR of truncated GLP-1 was 13±2.8 ml/kg/min and the half- life 11.4±2.1 min. GLP-1 reduced the pentagastrin- stimulated acid secretion 16±9% during the low-rate infusion and 23±12% during the high rate (P<0.05). Truncated GLP-1 caused a 36±3% inhibition during the high infusion rate. Thus truncated GLP-1, a naturally occurring peptide, is a potent inhibitor of acid secretion in man and more so than GLP-1.
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      headline:GLP-1 (glucagon-like peptide 1) and truncated GLP-1, fragments of human proglucagon, inhibit gastric acid secretion in humans
      description: Glucagon-like peptide 1 amide (GLP-1 amide), a predicted product of the glucagon gene (proglucagon 72-107-amide), and truncated GLP-1 (proglucagon 78-107-amide), recently isolated from porcine small intestine, were infused in doses of 100 and 400 ng/kg/hr and 12.5 and 50 ng/kg/hr, respectively, into eight volunteers to study pharmacokinetics and effects on pentagastrin- stimulated gastric acid secretion (plateau stimulation with pentagastrin at D 50:100ng/kg/hr). The concentration of GLP-1 in plasma increased from 64±12 to 189±23 and 631±76 pmol/liter, respectively. The concentration of truncated GLP increased from approximately 7 pmol/liter to 28±3 pmol/liter during the high rate of infusion. A similar increase was seen in response to a mixed meal in eight normal volunteers. The metabolic clearance rate (MCR) of GLP-1 was 2.2±0.3 and 2.6±0.3 ml/kg/min, respectively, and the half- life in plasma was 17±2 min. The MCR of truncated GLP-1 was 13±2.8 ml/kg/min and the half- life 11.4±2.1 min. GLP-1 reduced the pentagastrin- stimulated acid secretion 16±9% during the low-rate infusion and 23±12% during the high rate (P<0.05). Truncated GLP-1 caused a 36±3% inhibition during the high infusion rate. Thus truncated GLP-1, a naturally occurring peptide, is a potent inhibitor of acid secretion in man and more so than GLP-1.
      datePublished:
      dateModified:
      pageStart:703
      pageEnd:708
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      keywords:
         enteroglucagon
         enterogastrone
         proglucagon-processing, metabolism, pharmacokinetics
         Gastroenterology
         Hepatology
         Oncology
         Transplant Surgery
         Biochemistry
         general
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