We are analyzing https://link.springer.com/article/10.1007/s10753-012-9484-z.

Title:
Short-Chain Fatty Acids Suppress Lipopolysaccharide-Induced Production of Nitric Oxide and Proinflammatory Cytokines Through Inhibition of NF-κB Pathway in RAW264.7 Cells | Inflammation
Description:
Short-chain fatty acids (SCFAs) produced by the colonic bacterial fermentation of dietary fiber contribute a significant proportion of daily energy requirement. Furthermore, these compounds are modulators of macrophage function and potential targets for the development of new drugs. The aims of this study were to evaluate the effects of three types of SCFAs (sodium acetate (NaAc), sodium propionate (NaP), and sodium butyrate (NaB)) on the production of NO and inducible nitric oxide synthase (iNOS) and proinflammatory and antiinflammatory cytokines (tumor necrosis factor-α (TNF-α) and interleukin (IL-1, IL-6, and IL-10)) and to observe the effect of NaAc on inhibiting lipopolysaccharide (LPS)-induced NF-κB activation in LPS-stimulated RAW264.7 cells. The results show that three types of SCFAs (acetate, propionate, and butyrate) reduced the production of proinflammatory factors, including TNF-α, IL-1β, IL-6, and NO, and inhibited the vitality of iNOS. Meanwhile, SCFAs enhanced the production of antiinflammatory cytokine IL-10 in lower concentrations (1–1,200 μmol/L). Like NaB, NaAC inhibited LPS-induced NF-κB activation. These results may hold promise on the role that SCFAs have on the prevention and treatment of various inflammatory conditions.
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Keywords {🔍}

article, google, scholar, cas, pubmed, fatty, acids, journal, shortchain, nitric, liu, short, chain, production, oxide, proinflammatory, cytokines, inflammatory, research, cells, scfas, effects, butyrate, access, function, colonic, macrophage, antiinflammatory, effect, hebei, privacy, cookies, content, nfκb, raw, sodium, activation, clinical, health, nutrition, sciences, publish, search, inflammation, yuxin, acetate, propionate, synthase, open, acid,

Topics {✒️}

short-chain-fatty acid irrigation induced nf-κb activation short-chain fatty acids month download article/chapter tumor necrosis factor-α capillary gas–liquid chromatography protein-coupled receptors gpr41 ifn-[gamma]-stimulated raw 264 apolipoprotein e-deficient mice nf-κb pathway dietary fiber contribute inflammatory response induced article inflammation aims full article pdf privacy choices/manage cookies lps-stimulated raw264 proinflammatory factors antiinflammatory cytokine il-10 matrix metalloproteinase secretion human large intestine pro-inflammatory cytokines kun xie human colonic mucosa key project anti-inflammatory properties anti-inflammatory effects european economic area daily energy requirement including tnf-α histone acetylation modification histone deacetylase inhibitor porcine fetal fibroblasts erk signaling pathways regulating prostaglandin e2 excellent technical assistance bacterial population dynamics innate immune response anti-inflammatory cytokines inflammatory bowel disease conditions privacy policy inhibiting lipopolysaccharide accepting optional cookies check access instant access article liu main content log affiliations laboratory review article article log colonic bacterial fermentation

Questions {❓}

Butyrate and other short-chain fatty acids as modulators of immunity: What relevance for health?

Schema {🗺️}

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      description:Short-chain fatty acids (SCFAs) produced by the colonic bacterial fermentation of dietary fiber contribute a significant proportion of daily energy requirement. Furthermore, these compounds are modulators of macrophage function and potential targets for the development of new drugs. The aims of this study were to evaluate the effects of three types of SCFAs (sodium acetate (NaAc), sodium propionate (NaP), and sodium butyrate (NaB)) on the production of NO and inducible nitric oxide synthase (iNOS) and proinflammatory and antiinflammatory cytokines (tumor necrosis factor-α (TNF-α) and interleukin (IL-1, IL-6, and IL-10)) and to observe the effect of NaAc on inhibiting lipopolysaccharide (LPS)-induced NF-κB activation in LPS-stimulated RAW264.7 cells. The results show that three types of SCFAs (acetate, propionate, and butyrate) reduced the production of proinflammatory factors, including TNF-α, IL-1β, IL-6, and NO, and inhibited the vitality of iNOS. Meanwhile, SCFAs enhanced the production of antiinflammatory cytokine IL-10 in lower concentrations (1–1,200 μmol/L). Like NaB, NaAC inhibited LPS-induced NF-κB activation. These results may hold promise on the role that SCFAs have on the prevention and treatment of various inflammatory conditions.
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