We are analyzing https://link.springer.com/article/10.1007/s00726-006-0477-9.

Title:
Effects of amino acid-derived luminal metabolites on the colonic epithelium and physiopathological consequences | Amino Acids
Description:
Depending on the amount of alimentary proteins, between 6 and 18 g nitrogenous material per day enter the large intestine lumen through the ileocaecal junction. This material is used as substrates by the flora resulting eventually in the presence of a complex mixture of metabolites including ammonia, hydrogen sulfide, short and branched-chain fatty acids, amines; phenolic, indolic and N-nitroso compounds. The beneficial versus deleterious effects of these compounds on the colonic epithelium depend on parameters such as their luminal concentrations, the duration of the colonic stasis, the detoxication capacity of epithelial cells in response to increase of metabolite concentrations, the cellular metabolic utilization of these metabolites as well as their effects on colonocyte intermediary and oxidative metabolism. Furthermore, the effects of metabolites on electrolyte movements through the colonic epithelium must as well be taken into consideration for such an evaluation. The situation is further complicated by the fact that other non-nitrogenous compounds are believed to interfere with these various phenomenons. Finally, the pathological consequences of the presence of excessive concentrations of these compounds are related to the short- and, most important, long-term effects of these compounds on the rapid colonic epithelium renewing and homeostasis.
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Keywords {🔍}

google, scholar, cas, pubmed, colon, cancer, colonic, nutr, human, physiol, colitis, gut, acids, nitric, metabolism, oxide, amino, rat, biochem, protein, cell, clin, effects, ammonia, fatty, intestinal, ulcerative, article, acid, cells, effect, sci, large, dietary, luminal, sulfide, polyamines, rats, intestine, production, cummings, activity, res, bowel, disease, shortchain, epithelial, diet, humans, bacteria,

Topics {✒️}

dc%2bd3c%2fjtfkqta%3d%3d 10 �-nitro-n-nitrosoguanidine-induced colon carcinogenesis campbell-thomson id weiner prasad ja smith thevenod cp smith neale jh cummings vikulina jd klein zimber wj visek inoue sd jackson acyl-coa dehydrogenase level hughes jh cummings denis-pouxviel jc murat short-chain fatty acids month download article/chapter satishchandram sm boyle short-chain fatty acid nurnberg cc metges dc%2bd2mxotfeju7o%3d 10 dyak1m7kslciug%3d%3d 10 dyak28xltfyqug%3d%3d 10 dyal1c7isvelug%3d%3d 10 dyaf1cxksl2gsw%3d%3d 10 chacko jh cummings hennig kj petzke balsitis bjr whittle branched-chain fatty acids singh mas chapman hay gr gibson greenwood aj thomson chu mh montrose disease raven press bonnen mr clausen high-performance liquid chromatography allison gr gibson pignatelli jr pollock escherichia coli k-12 göthert gj molderings cherbut jp galmiche prospective cohort study roediger wj babidge millard wew roediger tomita sm bugnasco zhao jw hawes whitemore ah wu-williams darcy-vrillon mt morel soya-bean-milk protein ascherio wc willett colorectal high-grade adenomas jorgensen pb mortensen noordgaard pb mortensen

Questions {❓}

KR Silvester JH Cummings (1995) Does digestibility of meat protein help explain large bowel cancer risk?
MC Pitcher JM Pitcher (1996) Hydrogen sulfide: a bacterial toxin in ulcerative colitis?
SA Bingham B Pignatelli JR Pollock A Ellul C Malaveille G Gross S Runswick JH Cummings IK O’Neill (1996) Does increased endogenous formation of N-nitroso compounds in the human colon explain the association between red meat and colon cancer?
WEW Roediger (1980) The colonic epithelium in ulcerative colitis: an energy-deficiency disease?

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         headline:Effects of amino acid-derived luminal metabolites on the colonic epithelium and physiopathological consequences
         description:Depending on the amount of alimentary proteins, between 6 and 18 g nitrogenous material per day enter the large intestine lumen through the ileocaecal junction. This material is used as substrates by the flora resulting eventually in the presence of a complex mixture of metabolites including ammonia, hydrogen sulfide, short and branched-chain fatty acids, amines; phenolic, indolic and N-nitroso compounds. The beneficial versus deleterious effects of these compounds on the colonic epithelium depend on parameters such as their luminal concentrations, the duration of the colonic stasis, the detoxication capacity of epithelial cells in response to increase of metabolite concentrations, the cellular metabolic utilization of these metabolites as well as their effects on colonocyte intermediary and oxidative metabolism. Furthermore, the effects of metabolites on electrolyte movements through the colonic epithelium must as well be taken into consideration for such an evaluation. The situation is further complicated by the fact that other non-nitrogenous compounds are believed to interfere with these various phenomenons. Finally, the pathological consequences of the presence of excessive concentrations of these compounds are related to the short- and, most important, long-term effects of these compounds on the rapid colonic epithelium renewing and homeostasis.
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      headline:Effects of amino acid-derived luminal metabolites on the colonic epithelium and physiopathological consequences
      description:Depending on the amount of alimentary proteins, between 6 and 18 g nitrogenous material per day enter the large intestine lumen through the ileocaecal junction. This material is used as substrates by the flora resulting eventually in the presence of a complex mixture of metabolites including ammonia, hydrogen sulfide, short and branched-chain fatty acids, amines; phenolic, indolic and N-nitroso compounds. The beneficial versus deleterious effects of these compounds on the colonic epithelium depend on parameters such as their luminal concentrations, the duration of the colonic stasis, the detoxication capacity of epithelial cells in response to increase of metabolite concentrations, the cellular metabolic utilization of these metabolites as well as their effects on colonocyte intermediary and oxidative metabolism. Furthermore, the effects of metabolites on electrolyte movements through the colonic epithelium must as well be taken into consideration for such an evaluation. The situation is further complicated by the fact that other non-nitrogenous compounds are believed to interfere with these various phenomenons. Finally, the pathological consequences of the presence of excessive concentrations of these compounds are related to the short- and, most important, long-term effects of these compounds on the rapid colonic epithelium renewing and homeostasis.
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         general
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