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DOI . ORG {}

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Doi.org Make Money
  6. Keywords
  7. Topics
  8. Questions
  9. Schema
  10. Social Networks
  11. External Links
  12. Analytics And Tracking
  13. Libraries
  14. Hosting Providers
  15. CDN Services

We began analyzing https://www.nature.com/articles/ng.730, but it redirected us to https://www.nature.com/articles/ng.730. The analysis below is for the second page.

Title[redir]:
FOXA1 is a key determinant of estrogen receptor function and endocrine response | Nature Genetics
Description:
Jason Carroll and colleagues report that the forkhead protein FOXA1 is an important determinant of estrogen receptor binding and show that expression of FOXA1 in non–breast cancer cells is sufficient to confer estrogen receptor binding and response to endocrine treatment. Estrogen receptor-α (ER) is the key feature of most breast cancers and binding of ER to the genome correlates with expression of the Forkhead protein FOXA1 (also called HNF3α). Here we show that FOXA1 is a key determinant that can influence differential interactions between ER and chromatin. Almost all ER-chromatin interactions and gene expression changes depended on the presence of FOXA1 and FOXA1 influenced genome-wide chromatin accessibility. Furthermore, we found that CTCF was an upstream negative regulator of FOXA1-chromatin interactions. In estrogen-responsive breast cancer cells, the dependency on FOXA1 for tamoxifen-ER activity was absolute; in tamoxifen-resistant cells, ER binding was independent of ligand but depended on FOXA1. Expression of FOXA1 in non-breast cancer cells can alter ER binding and function. As such, FOXA1 is a major determinant of estrogen-ER activity and endocrine response in breast cancer cells.

Matching Content Categories {📚}

  • Education
  • Science
  • Telecommunications

Content Management System {📝}

What CMS is doi.org built with?

Custom-built

No common CMS systems were detected on Doi.org, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of doi.org audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 5,000,420 visitors per month in the current month.

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How Does Doi.org Make Money? {💸}

We can't figure out the monetization strategy.

Websites don't always need to be profitable; some serve as platforms for education or personal expression. Websites can serve multiple purposes. And this might be one of them. Doi.org might be making money, but it's not detectable how they're doing it.

Keywords {🔍}

article, google, scholar, cas, cancer, estrogen, breast, nature, foxa, receptor, cell, expression, chromatin, binding, cells, access, content, gene, carroll, res, cookies, analysis, genome, transcription, research, privacy, data, genetics, response, lines, nat, genes, regulation, mol, human, alpha, factor, function, information, key, determinant, hurtado, holmes, rossinnes, schmidt, interactions, accessibility, rev, dev, regulatory,

Topics {✒️}

nature portfolio permissions reprints privacy policy cancer research uk enhancer-driven lineage-specific transcription cambridge research institute advertising estrogen receptor-regulated transcription ccctc-binding factor confines nature 462 nature 406 nature social media endocrine-responsive breast cancer retinoic acid receptor-alpha p130–e2f4 complexes characteristic tamoxifen-resistant mcf-7 cells discover protein-dna interactions tamoxifen-dependent gene expression tissue-specific transcription author correspondence springerlink instant access estrogen receptor alpha permissions personal data breast cancer cells breast cancer cells chromatin accessibility profiling enhanced estrogen receptor data protection breast cancer–correlation tamoxifen-resistant cells human breast tumours breast tumor subtypes estrogen receptor function androgen receptor interacts breast cancer res estrogen-er activity estrogen receptors alpha hutchison whampoa limited gene expression profiling endogenous gene expression privacy foxa1-bound enhancers upstream negative regulator competing financial interests chromosome-wide mapping tamoxifen-er activity genome-wide analysis cell cycle progression

Questions {❓}

  • Estrogen receptor null mice: what have we learned and where will they lead us?

Schema {🗺️}

WebPage:
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         headline:FOXA1 is a key determinant of estrogen receptor function and endocrine response
         description:Jason Carroll and colleagues report that the forkhead protein FOXA1 is an important determinant of estrogen receptor binding and show that expression of FOXA1 in non–breast cancer cells is sufficient to confer estrogen receptor binding and response to endocrine treatment. Estrogen receptor-α (ER) is the key feature of most breast cancers and binding of ER to the genome correlates with expression of the Forkhead protein FOXA1 (also called HNF3α). Here we show that FOXA1 is a key determinant that can influence differential interactions between ER and chromatin. Almost all ER-chromatin interactions and gene expression changes depended on the presence of FOXA1 and FOXA1 influenced genome-wide chromatin accessibility. Furthermore, we found that CTCF was an upstream negative regulator of FOXA1-chromatin interactions. In estrogen-responsive breast cancer cells, the dependency on FOXA1 for tamoxifen-ER activity was absolute; in tamoxifen-resistant cells, ER binding was independent of ligand but depended on FOXA1. Expression of FOXA1 in non-breast cancer cells can alter ER binding and function. As such, FOXA1 is a major determinant of estrogen-ER activity and endocrine response in breast cancer cells.
         datePublished:2010-12-12T00:00:00Z
         dateModified:2010-12-12T00:00:00Z
         pageStart:27
         pageEnd:33
         sameAs:https://doi.org/10.1038/ng.730
         keywords:
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            Cancer genetics
            Endocrinology
            Biomedicine
            general
            Human Genetics
            Cancer Research
            Agriculture
            Gene Function
            Animal Genetics and Genomics
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      headline:FOXA1 is a key determinant of estrogen receptor function and endocrine response
      description:Jason Carroll and colleagues report that the forkhead protein FOXA1 is an important determinant of estrogen receptor binding and show that expression of FOXA1 in non–breast cancer cells is sufficient to confer estrogen receptor binding and response to endocrine treatment. Estrogen receptor-α (ER) is the key feature of most breast cancers and binding of ER to the genome correlates with expression of the Forkhead protein FOXA1 (also called HNF3α). Here we show that FOXA1 is a key determinant that can influence differential interactions between ER and chromatin. Almost all ER-chromatin interactions and gene expression changes depended on the presence of FOXA1 and FOXA1 influenced genome-wide chromatin accessibility. Furthermore, we found that CTCF was an upstream negative regulator of FOXA1-chromatin interactions. In estrogen-responsive breast cancer cells, the dependency on FOXA1 for tamoxifen-ER activity was absolute; in tamoxifen-resistant cells, ER binding was independent of ligand but depended on FOXA1. Expression of FOXA1 in non-breast cancer cells can alter ER binding and function. As such, FOXA1 is a major determinant of estrogen-ER activity and endocrine response in breast cancer cells.
      datePublished:2010-12-12T00:00:00Z
      dateModified:2010-12-12T00:00:00Z
      pageStart:27
      pageEnd:33
      sameAs:https://doi.org/10.1038/ng.730
      keywords:
         Breast cancer
         Cancer genetics
         Endocrinology
         Biomedicine
         general
         Human Genetics
         Cancer Research
         Agriculture
         Gene Function
         Animal Genetics and Genomics
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               type:PostalAddress
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      affiliation:
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            address:
               name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK
               type:PostalAddress
            type:Organization
      name:Dominic Schmidt
      affiliation:
            name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre
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Social Networks {👍}(2)

External Links {🔗}(201)

Analytics and Tracking {📊}

  • Google Tag Manager

Libraries {📚}

  • Prism.js
  • Zoom.js

Emails and Hosting {✉️}

Mail Servers:

  • mx.zoho.eu
  • mx2.zoho.eu
  • mx3.zoho.eu

Name Servers:

  • josh.ns.cloudflare.com
  • zita.ns.cloudflare.com

CDN Services {📦}

  • Crossref

4.87s.