
NATURE . COM {
}
Title:
FOXA1 is a key determinant of estrogen receptor function and endocrine response | Nature Genetics
Description:
Jason Carroll and colleagues report that the forkhead protein FOXA1 is an important determinant of estrogen receptor binding and show that expression of FOXA1 in non–breast cancer cells is sufficient to confer estrogen receptor binding and response to endocrine treatment. Estrogen receptor-α (ER) is the key feature of most breast cancers and binding of ER to the genome correlates with expression of the Forkhead protein FOXA1 (also called HNF3α). Here we show that FOXA1 is a key determinant that can influence differential interactions between ER and chromatin. Almost all ER-chromatin interactions and gene expression changes depended on the presence of FOXA1 and FOXA1 influenced genome-wide chromatin accessibility. Furthermore, we found that CTCF was an upstream negative regulator of FOXA1-chromatin interactions. In estrogen-responsive breast cancer cells, the dependency on FOXA1 for tamoxifen-ER activity was absolute; in tamoxifen-resistant cells, ER binding was independent of ligand but depended on FOXA1. Expression of FOXA1 in non-breast cancer cells can alter ER binding and function. As such, FOXA1 is a major determinant of estrogen-ER activity and endocrine response in breast cancer cells.
Website Age:
30 years and 10 months (reg. 1994-08-11).
Matching Content Categories {📚}
- Education
- Science
- Telecommunications
Content Management System {📝}
What CMS is nature.com built with?
Custom-built
No common CMS systems were detected on Nature.com, and no known web development framework was identified.
Traffic Estimate {📈}
What is the average monthly size of nature.com audience?
🌠 Phenomenal Traffic: 5M - 10M visitors per month
Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.
check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush
How Does Nature.com Make Money? {💸}
Display Ads {🎯}
The website utilizes display ads within its content to generate revenue. Check the next section for further revenue estimates.
Ads are managed by yourbow.com. Particular relationships are as follows:
Direct Advertisers (10)
google.com, pmc.com, doceree.com, yourbow.com, audienciad.com, onlinemediasolutions.com, advibe.media, aps.amazon.com, getmediamx.com, onomagic.comReseller Advertisers (38)
conversantmedia.com, rubiconproject.com, pubmatic.com, appnexus.com, openx.com, smartadserver.com, lijit.com, sharethrough.com, video.unrulymedia.com, google.com, yahoo.com, triplelift.com, onetag.com, sonobi.com, contextweb.com, 33across.com, indexexchange.com, media.net, themediagrid.com, adform.com, richaudience.com, sovrn.com, improvedigital.com, freewheel.tv, smaato.com, yieldmo.com, amxrtb.com, adyoulike.com, adpone.com, criteo.com, smilewanted.com, 152media.info, e-planning.net, smartyads.com, loopme.com, opera.com, mediafuse.com, betweendigital.comHow Much Does Nature.com Make? {💰}
Display Ads {🎯}
$63,100 per month
Our analysis indicates Nature.com generates between $42,042 and $115,616 monthly online from display ads.
Keywords {🔍}
article, google, scholar, cas, cancer, estrogen, breast, nature, foxa, receptor, cell, expression, chromatin, binding, cells, access, content, gene, carroll, res, cookies, analysis, genome, transcription, research, privacy, data, genetics, response, lines, nat, genes, regulation, mol, human, alpha, factor, function, information, key, determinant, hurtado, holmes, rossinnes, schmidt, interactions, accessibility, rev, dev, regulatory,
Topics {✒️}
nature portfolio permissions reprints privacy policy cancer research uk enhancer-driven lineage-specific transcription cambridge research institute advertising estrogen receptor-regulated transcription ccctc-binding factor confines nature 462 nature 406 nature social media endocrine-responsive breast cancer retinoic acid receptor-alpha p130–e2f4 complexes characteristic tamoxifen-resistant mcf-7 cells discover protein-dna interactions tamoxifen-dependent gene expression tissue-specific transcription author correspondence springerlink instant access estrogen receptor alpha permissions personal data breast cancer cells breast cancer cells chromatin accessibility profiling enhanced estrogen receptor data protection breast cancer–correlation tamoxifen-resistant cells human breast tumours breast tumor subtypes estrogen receptor function androgen receptor interacts breast cancer res estrogen-er activity estrogen receptors alpha hutchison whampoa limited gene expression profiling endogenous gene expression privacy foxa1-bound enhancers upstream negative regulator competing financial interests chromosome-wide mapping tamoxifen-er activity genome-wide analysis cell cycle progression
Questions {❓}
- Estrogen receptor null mice: what have we learned and where will they lead us?
Schema {🗺️}
WebPage:
mainEntity:
headline:FOXA1 is a key determinant of estrogen receptor function and endocrine response
description:Jason Carroll and colleagues report that the forkhead protein FOXA1 is an important determinant of estrogen receptor binding and show that expression of FOXA1 in nonâbreast cancer cells is sufficient to confer estrogen receptor binding and response to endocrine treatment. Estrogen receptor-α (ER) is the key feature of most breast cancers and binding of ER to the genome correlates with expression of the Forkhead protein FOXA1 (also called HNF3α). Here we show that FOXA1 is a key determinant that can influence differential interactions between ER and chromatin. Almost all ER-chromatin interactions and gene expression changes depended on the presence of FOXA1 and FOXA1 influenced genome-wide chromatin accessibility. Furthermore, we found that CTCF was an upstream negative regulator of FOXA1-chromatin interactions. In estrogen-responsive breast cancer cells, the dependency on FOXA1 for tamoxifen-ER activity was absolute; in tamoxifen-resistant cells, ER binding was independent of ligand but depended on FOXA1. Expression of FOXA1 in non-breast cancer cells can alter ER binding and function. As such, FOXA1 is a major determinant of estrogen-ER activity and endocrine response in breast cancer cells.
datePublished:2010-12-12T00:00:00Z
dateModified:2010-12-12T00:00:00Z
pageStart:27
pageEnd:33
sameAs:https://doi.org/10.1038/ng.730
keywords:
Breast cancer
Cancer genetics
Endocrinology
Biomedicine
general
Human Genetics
Cancer Research
Agriculture
Gene Function
Animal Genetics and Genomics
image:
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fng.730/MediaObjects/41588_2011_Article_BFng730_Fig1_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fng.730/MediaObjects/41588_2011_Article_BFng730_Fig2_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fng.730/MediaObjects/41588_2011_Article_BFng730_Fig3_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fng.730/MediaObjects/41588_2011_Article_BFng730_Fig4_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fng.730/MediaObjects/41588_2011_Article_BFng730_Fig5_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fng.730/MediaObjects/41588_2011_Article_BFng730_Fig6_HTML.jpg
isPartOf:
name:Nature Genetics
issn:
1546-1718
1061-4036
volumeNumber:43
type:
Periodical
PublicationVolume
publisher:
name:Nature Publishing Group US
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
type:Organization
author:
name:Antoni Hurtado
affiliation:
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre
address:
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK
type:PostalAddress
type:Organization
type:Person
name:Kelly A Holmes
affiliation:
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre
address:
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK
type:PostalAddress
type:Organization
type:Person
name:Caryn S Ross-Innes
affiliation:
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre
address:
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK
type:PostalAddress
type:Organization
type:Person
name:Dominic Schmidt
affiliation:
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre
address:
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK
type:PostalAddress
type:Organization
type:Person
name:Jason S Carroll
affiliation:
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre
address:
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK
type:PostalAddress
type:Organization
email:[email protected]
type:Person
isAccessibleForFree:
hasPart:
isAccessibleForFree:
cssSelector:.main-content
type:WebPageElement
type:ScholarlyArticle
context:https://schema.org
ScholarlyArticle:
headline:FOXA1 is a key determinant of estrogen receptor function and endocrine response
description:Jason Carroll and colleagues report that the forkhead protein FOXA1 is an important determinant of estrogen receptor binding and show that expression of FOXA1 in nonâbreast cancer cells is sufficient to confer estrogen receptor binding and response to endocrine treatment. Estrogen receptor-α (ER) is the key feature of most breast cancers and binding of ER to the genome correlates with expression of the Forkhead protein FOXA1 (also called HNF3α). Here we show that FOXA1 is a key determinant that can influence differential interactions between ER and chromatin. Almost all ER-chromatin interactions and gene expression changes depended on the presence of FOXA1 and FOXA1 influenced genome-wide chromatin accessibility. Furthermore, we found that CTCF was an upstream negative regulator of FOXA1-chromatin interactions. In estrogen-responsive breast cancer cells, the dependency on FOXA1 for tamoxifen-ER activity was absolute; in tamoxifen-resistant cells, ER binding was independent of ligand but depended on FOXA1. Expression of FOXA1 in non-breast cancer cells can alter ER binding and function. As such, FOXA1 is a major determinant of estrogen-ER activity and endocrine response in breast cancer cells.
datePublished:2010-12-12T00:00:00Z
dateModified:2010-12-12T00:00:00Z
pageStart:27
pageEnd:33
sameAs:https://doi.org/10.1038/ng.730
keywords:
Breast cancer
Cancer genetics
Endocrinology
Biomedicine
general
Human Genetics
Cancer Research
Agriculture
Gene Function
Animal Genetics and Genomics
image:
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fng.730/MediaObjects/41588_2011_Article_BFng730_Fig1_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fng.730/MediaObjects/41588_2011_Article_BFng730_Fig2_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fng.730/MediaObjects/41588_2011_Article_BFng730_Fig3_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fng.730/MediaObjects/41588_2011_Article_BFng730_Fig4_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fng.730/MediaObjects/41588_2011_Article_BFng730_Fig5_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fng.730/MediaObjects/41588_2011_Article_BFng730_Fig6_HTML.jpg
isPartOf:
name:Nature Genetics
issn:
1546-1718
1061-4036
volumeNumber:43
type:
Periodical
PublicationVolume
publisher:
name:Nature Publishing Group US
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
type:Organization
author:
name:Antoni Hurtado
affiliation:
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre
address:
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK
type:PostalAddress
type:Organization
type:Person
name:Kelly A Holmes
affiliation:
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre
address:
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK
type:PostalAddress
type:Organization
type:Person
name:Caryn S Ross-Innes
affiliation:
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre
address:
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK
type:PostalAddress
type:Organization
type:Person
name:Dominic Schmidt
affiliation:
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre
address:
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK
type:PostalAddress
type:Organization
type:Person
name:Jason S Carroll
affiliation:
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre
address:
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK
type:PostalAddress
type:Organization
email:[email protected]
type:Person
isAccessibleForFree:
hasPart:
isAccessibleForFree:
cssSelector:.main-content
type:WebPageElement
["Periodical","PublicationVolume"]:
name:Nature Genetics
issn:
1546-1718
1061-4036
volumeNumber:43
Organization:
name:Nature Publishing Group US
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre
address:
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK
type:PostalAddress
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre
address:
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK
type:PostalAddress
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre
address:
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK
type:PostalAddress
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre
address:
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK
type:PostalAddress
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre
address:
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK
type:PostalAddress
ImageObject:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
name:Antoni Hurtado
affiliation:
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre
address:
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK
type:PostalAddress
type:Organization
name:Kelly A Holmes
affiliation:
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre
address:
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK
type:PostalAddress
type:Organization
name:Caryn S Ross-Innes
affiliation:
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre
address:
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK
type:PostalAddress
type:Organization
name:Dominic Schmidt
affiliation:
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre
address:
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK
type:PostalAddress
type:Organization
name:Jason S Carroll
affiliation:
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre
address:
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK
type:PostalAddress
type:Organization
email:[email protected]
PostalAddress:
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK
WebPageElement:
isAccessibleForFree:
cssSelector:.main-content
External Links {🔗}(104)
- What's the monthly income of https://link.springer.com/article/10.1038/ng.730?utm_source=nature&utm_medium=referral&utm_campaign=buyArticle?
- What is the monthly revenue of https://doi.org/10.1038%2Fnrc721?
- http://scholar.google.com/scholar_lookup?&title=Endocrine-responsive%20breast%20cancer%20and%20strategies%20for%20combating%20resistance&journal=Nat.%20Rev.%20Cancer&doi=10.1038%2Fnrc721&volume=2&pages=101-112&publication_year=2002&author=Ali%2CS&author=Coombes%2CRC's financial summary
- What's the financial outcome of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=11171938?
- What is the earnings of http://scholar.google.com/scholar_lookup?&title=Cellular%20and%20molecular%20pharmacology%20of%20antiestrogen%20action%20and%20resistance&journal=Pharmacol.%20Rev.&volume=53&pages=25-71&publication_year=2001&author=Clarke%2CR&author=Leonessa%2CF&author=Welch%2CJN&author=Skaar%2CTC?
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=10652267 income
- Learn about the earnings of http://scholar.google.com/scholar_lookup?&title=The%20coregulator%20exchange%20in%20transcriptional%20functions%20of%20nuclear%20receptors&journal=Genes%20Dev.&volume=14&pages=121-141&publication_year=2000&author=Glass%2CCK&author=Rosenfeld%2CMG
- How much profit does https://doi.org/10.1210%2Fme.2007-0546 generate?
- How much cash flow does http://scholar.google.com/scholar_lookup?&title=Nuclear%20receptor%20location%20analyses%20in%20mammalian%20genomes%3A%20from%20gene%20regulation%20to%20regulatory%20networks&journal=Mol.%20Endocrinol.&doi=10.1210%2Fme.2007-0546&volume=22&pages=1999-2011&publication_year=2008&author=Deblois%2CG&author=Giguere%2CV have monthly?
- What's the financial gain of https://doi.org/10.1038%2Fnature08497?
- http://scholar.google.com/scholar_lookup?&title=An%20oestrogen-receptor-alpha-bound%20human%20chromatin%20interactome&journal=Nature&doi=10.1038%2Fnature08497&volume=462&pages=58-64&publication_year=2009&author=Fullwood%2CMJ income
- What's the financial gain of https://doi.org/10.1038%2Fng1901?
- How much does http://scholar.google.com/scholar_lookup?&title=Genome-wide%20analysis%20of%20estrogen%20receptor%20binding%20sites&journal=Nat.%20Genet.&doi=10.1038%2Fng1901&volume=38&pages=1289-1297&publication_year=2006&author=Carroll%2CJS pull in?
- What are the earnings of https://doi.org/10.1371%2Fjournal.pgen.0030087?
- How much profit does http://scholar.google.com/scholar_lookup?&title=Whole-genome%20cartography%20of%20estrogen%20receptor%20alpha%20binding%20sites&journal=PLoS%20Genet.&doi=10.1371%2Fjournal.pgen.0030087&volume=3&publication_year=2007&author=Lin%2CCY make?
- https://doi.org/10.1038%2Femboj.2009.88 income
- How much profit does http://scholar.google.com/scholar_lookup?&title=ChIP-Seq%20of%20ERalpha%20and%20RNA%20polymerase%20II%20defines%20genes%20differentially%20responding%20to%20ligands&journal=EMBO%20J.&doi=10.1038%2Femboj.2009.88&volume=28&pages=1418-1428&publication_year=2009&author=Welboren%2CWJ make?
- What's the financial gain of https://doi.org/10.1073%2Fpnas.0505575102?
- How much income does http://scholar.google.com/scholar_lookup?&title=Location%20analysis%20of%20estrogen%20receptor%20alpha%20target%20promoters%20reveals%20that%20FOXA1%20defines%20a%20domain%20of%20the%20estrogen%20response&journal=Proc.%20Natl.%20Acad.%20Sci.%20USA&doi=10.1073%2Fpnas.0505575102&volume=102&pages=11651-11656&publication_year=2005&author=Lagani%C3%A8re%2CJ have?
- Profit of https://doi.org/10.1016%2Fj.cell.2005.05.008
- How much money does http://scholar.google.com/scholar_lookup?&title=Chromosome-wide%20mapping%20of%20estrogen%20receptor%20binding%20reveals%20long-range%20regulation%20requiring%20the%20forkhead%20protein%20FoxA1&journal=Cell&doi=10.1016%2Fj.cell.2005.05.008&volume=122&pages=33-43&publication_year=2005&author=Carroll%2CJS make?
- How profitable is https://doi.org/10.1016%2Fj.cell.2008.01.018?
- Earnings of http://scholar.google.com/scholar_lookup?&title=FoxA1%20translates%20epigenetic%20signatures%20into%20enhancer-driven%20lineage-specific%20transcription&journal=Cell&doi=10.1016%2Fj.cell.2008.01.018&volume=132&pages=958-970&publication_year=2008&author=Lupien%2CM
- What is the monthly revenue of https://doi.org/10.1093%2Femboj%2F17.1.244?
- Monthly income for http://scholar.google.com/scholar_lookup?&title=Binding%20of%20the%20winged-helix%20transcription%20factor%20HNF3%20to%20a%20linker%20histone%20site%20on%20the%20nucleosome&journal=EMBO%20J.&doi=10.1093%2Femboj%2F17.1.244&volume=17&pages=244-254&publication_year=1998&author=Cirillo%2CLA
- How much revenue does https://doi.org/10.1016%2FS1097-2765%2802%2900459-8 bring in?
- How much money does http://scholar.google.com/scholar_lookup?&title=Opening%20of%20compacted%20chromatin%20by%20early%20developmental%20transcription%20factors%20HNF3%20%28FoxA%29%20and%20GATA-4&journal=Mol.%20Cell&doi=10.1016%2FS1097-2765%2802%2900459-8&volume=9&pages=279-289&publication_year=2002&author=Cirillo%2CLA generate?
- What's the financial gain of https://doi.org/10.1158%2F1078-0432.CCR-07-0122?
- How much profit does http://scholar.google.com/scholar_lookup?&title=FOXA1%20expression%20in%20breast%20cancer%E2%80%93correlation%20with%20luminal%20subtype%20A%20and%20survival&journal=Clin.%20Cancer%20Res.&doi=10.1158%2F1078-0432.CCR-07-0122&volume=13&pages=4415-4421&publication_year=2007&author=Badve%2CS make?
- https://doi.org/10.1038%2F35021093's financial summary
- How much does http://scholar.google.com/scholar_lookup?&title=Molecular%20portraits%20of%20human%20breast%20tumours&journal=Nature&doi=10.1038%2F35021093&volume=406&pages=747-752&publication_year=2000&author=Perou%2CCM net monthly?
- How much does https://doi.org/10.1073%2Fpnas.0932692100 rake in every month?
- Explore the financials of http://scholar.google.com/scholar_lookup?&title=Repeated%20observation%20of%20breast%20tumor%20subtypes%20in%20independent%20gene%20expression%20data%20sets&journal=Proc.%20Natl.%20Acad.%20Sci.%20USA&doi=10.1073%2Fpnas.0932692100&volume=100&pages=8418-8423&publication_year=2003&author=Sorlie%2CT
- How much profit does https://doi.org/10.1023%2FB%3ABREA.0000014042.54925.cc make?
- How much revenue does http://scholar.google.com/scholar_lookup?&title=Relevance%20of%20breast%20cancer%20cell%20lines%20as%20models%20for%20breast%20tumours%3A%20an%20update&journal=Breast%20Cancer%20Res.%20Treat.&doi=10.1023%2FB%3ABREA.0000014042.54925.cc&volume=83&pages=249-289&publication_year=2004&author=Lacroix%2CM&author=Leclercq%2CG produce monthly?
- How profitable is https://link.springer.com/doi/10.1186/gb-2008-9-9-r137?
- What's the profit of http://scholar.google.com/scholar_lookup?&title=Model-based%20analysis%20of%20ChIP-seq%20%28MACS%29&journal=Genome%20Biol.&doi=10.1186%2Fgb-2008-9-9-r137&volume=9&publication_year=2008&author=Zhang%2CY?
- Find out how much https://doi.org/10.1101%2Fgad.552910 earns monthly
- Profit of http://scholar.google.com/scholar_lookup?&title=Cooperative%20interaction%20between%20retinoic%20acid%20receptor-alpha%20and%20estrogen%20receptor%20in%20breast%20cancer&journal=Genes%20Dev.&doi=10.1101%2Fgad.552910&volume=24&pages=171-182&publication_year=2010&author=Ross-Innes%2CCS
- Financial intake of https://doi.org/10.1038%2Fnrd1031
- Find out how much http://scholar.google.com/scholar_lookup?&title=Tamoxifen%3A%20a%20most%20unlikely%20pioneering%20medicine&journal=Nat.%20Rev.%20Drug%20Discov.&doi=10.1038%2Fnrd1031&volume=2&pages=205-213&publication_year=2003&author=Jordan%2CVC earns monthly
- How much does https://doi.org/10.1016%2FS0092-8674%2800%2900188-4 pull in monthly?
- What's the income generated by http://scholar.google.com/scholar_lookup?&title=Cofactor%20dynamics%20and%20sufficiency%20in%20estrogen%20receptor-regulated%20transcription&journal=Cell&doi=10.1016%2FS0092-8674%2800%2900188-4&volume=103&pages=843-852&publication_year=2000&author=Shang%2CY&author=Hu%2CX&author=DiRenzo%2CJ&author=Lazar%2CMA&author=Brown%2CM each month?
- What's the financial gain of https://doi.org/10.1158%2F0008-5472.CAN-03-3326?
- Learn about the earnings of http://scholar.google.com/scholar_lookup?&title=Selective%20estrogen%20receptor%20modulators%3A%20discrimination%20of%20agonistic%20versus%20antagonistic%20activities%20by%20gene%20expression%20profiling%20in%20breast%20cancer%20cells&journal=Cancer%20Res.&doi=10.1158%2F0008-5472.CAN-03-3326&volume=64&pages=1522-1533&publication_year=2004&author=Frasor%2CJ
- What are the total earnings of https://doi.org/10.1210%2Fen.2002-220620?
- How much profit does http://scholar.google.com/scholar_lookup?&title=Elevated%20levels%20of%20epidermal%20growth%20factor%20receptor%2Fc-erbB2%20heterodimers%20mediate%20an%20autocrine%20growth%20regulatory%20pathway%20in%20tamoxifen-resistant%20MCF-7%20cells&journal=Endocrinology&doi=10.1210%2Fen.2002-220620&volume=144&pages=1032-1044&publication_year=2003&author=Knowlden%2CJM make?
- What is the monthly revenue of https://doi.org/10.1002%2Fjcb.10633?
- How much revenue does http://scholar.google.com/scholar_lookup?&title=Estrogen%20receptor%20isoform-specific%20regulation%20of%20endogenous%20gene%20expression%20in%20human%20osteoblastic%20cell%20lines%20expressing%20either%20ERalpha%20or%20ERbeta&journal=J.%20Cell.%20Biochem.&doi=10.1002%2Fjcb.10633&volume=90&pages=315-326&publication_year=2003&author=Monroe%2CDG generate?
- What's https://doi.org/10.1210%2Fme.2008-0100's gross income?
- What's the financial gain of http://scholar.google.com/scholar_lookup?&title=Unique%20ERalpha%20cistromes%20control%20cell%20type-specific%20gene%20regulation&journal=Mol.%20Endocrinol.&doi=10.1210%2Fme.2008-0100&volume=22&pages=2393-2406&publication_year=2008&author=Krum%2CSA?
- Learn about the earnings of https://doi.org/10.1210%2Fme.2004-0381
- How much income is http://scholar.google.com/scholar_lookup?&title=Estrogen%20receptor%20alpha%20and%20beta%20heterodimers%20exert%20unique%20effects%20on%20estrogen-%20and%20tamoxifen-dependent%20gene%20expression%20in%20human%20U2OS%20osteosarcoma%20cells&journal=Mol.%20Endocrinol.&doi=10.1210%2Fme.2004-0381&volume=19&pages=1555-1568&publication_year=2005&author=Monroe%2CDG earning monthly?
- What's the profit of https://doi.org/10.1101%2Fgad.1446006?
- How much profit does http://scholar.google.com/scholar_lookup?&title=A%20cell-type-specific%20transcriptional%20network%20required%20for%20estrogen%20regulation%20of%20cyclin%20D1%20and%20cell%20cycle%20progression%20in%20breast%20cancer&journal=Genes%20Dev.&doi=10.1101%2Fgad.1446006&volume=20&pages=2513-2526&publication_year=2006&author=Eeckhoute%2CJ&author=Carroll%2CJS&author=Geistlinger%2CTR&author=Torres-Arzayus%2CMI&author=Brown%2CM generate?
- Check the income stats for https://doi.org/10.1101%2Fgr.5533506
- How much cash flow does http://scholar.google.com/scholar_lookup?&title=FAIRE%20%28formaldehyde-assisted%20isolation%20of%20regulatory%20elements%29%20isolates%20active%20regulatory%20elements%20from%20human%20chromatin&journal=Genome%20Res.&doi=10.1101%2Fgr.5533506&volume=17&pages=877-885&publication_year=2007&author=Giresi%2CPG&author=Kim%2CJ&author=McDaniell%2CRM&author=Iyer%2CVR&author=Lieb%2CJD have monthly?
- What's the profit of https://doi.org/10.1101%2Fgr.084582.108?
- How much does http://scholar.google.com/scholar_lookup?&title=Cell-type%20selective%20chromatin%20remodeling%20defines%20the%20active%20subset%20of%20FOXA1-bound%20enhancers&journal=Genome%20Res.&doi=10.1101%2Fgr.084582.108&volume=19&pages=372-380&publication_year=2009&author=Eeckhoute%2CJ generate monthly?
- Financial intake of https://doi.org/10.1101%2Fgr.100479.109
- What's the revenue for http://scholar.google.com/scholar_lookup?&title=A%20CTCF-independent%20role%20for%20cohesin%20in%20tissue-specific%20transcription&journal=Genome%20Res.&doi=10.1101%2Fgr.100479.109&volume=20&pages=578-588&publication_year=2010&author=Schmidt%2CD?
- How much income is https://doi.org/10.1158%2F0008-5472.CAN-08-2632 earning monthly?
- What's the profit of http://scholar.google.com/scholar_lookup?&title=CCCTC-binding%20factor%20confines%20the%20distal%20action%20of%20estrogen%20receptor&journal=Cancer%20Res.&doi=10.1158%2F0008-5472.CAN-08-2632&volume=68&pages=9041-9049&publication_year=2008&author=Chan%2CCS&author=Song%2CJS?
- What are the earnings of https://doi.org/10.1074%2Fjbc.M110.149658?
- How much does http://scholar.google.com/scholar_lookup?&title=CCCTC-binding%20factor%20acts%20upstream%20of%20FOXA1%20and%20demarcates%20the%20genomic%20response%20to%20estrogen&journal=J.%20Biol.%20Chem.&doi=10.1074%2Fjbc.M110.149658&volume=285&pages=28604-28613&publication_year=2010&author=Zhang%2CY gross monthly?
- Revenue of https://doi.org/10.1210%2Fme.2009-0252
- What's http://scholar.google.com/scholar_lookup?&title=Genome-wide%20dynamics%20of%20chromatin%20binding%20of%20estrogen%20receptors%20alpha%20and%20beta%3A%20mutual%20restriction%20and%20competitive%20site%20selection&journal=Mol.%20Endocrinol.&doi=10.1210%2Fme.2009-0252&volume=24&pages=47-59&publication_year=2010&author=Charn%2CTH's gross income?
- Financial intake of https://doi.org/10.1074%2Fjbc.M305226200
- How much income is http://scholar.google.com/scholar_lookup?&title=Enhanced%20estrogen%20receptor%20%28ER%29%20alpha%2C%20ERBB2%2C%20and%20MAPK%20signal%20transduction%20pathways%20operate%20during%20the%20adaptation%20of%20MCF-7%20cells%20to%20long%20term%20estrogen%20deprivation&journal=J.%20Biol.%20Chem.&doi=10.1074%2Fjbc.M305226200&volume=278&pages=30458-30468&publication_year=2003&author=Martin%2CLA earning monthly?
- How much revenue does https://doi.org/10.1210%2Fedrv.20.3.0370 bring in?
- How much does http://scholar.google.com/scholar_lookup?&title=Estrogen%20receptor%20null%20mice%3A%20what%20have%20we%20learned%20and%20where%20will%20they%20lead%20us%3F&journal=Endocr.%20Rev.&doi=10.1210%2Fedrv.20.3.0370&volume=20&pages=358-417&publication_year=1999&author=Couse%2CJF&author=Korach%2CKS gross monthly?
- What is the earnings of https://doi.org/10.1101%2Fgad.399506?
- Discover the revenue of http://scholar.google.com/scholar_lookup?&title=CTCF%20mediates%20long-range%20chromatin%20looping%20and%20local%20histone%20modification%20in%20the%20beta-globin%20locus&journal=Genes%20Dev.&doi=10.1101%2Fgad.399506&volume=20&pages=2349-2354&publication_year=2006&author=Splinter%2CE
- How much cash flow does https://doi.org/10.1016%2Fj.ccr.2006.10.008 have monthly?
- How much does http://scholar.google.com/scholar_lookup?&title=A%20collection%20of%20breast%20cancer%20cell%20lines%20for%20the%20study%20of%20functionally%20distinct%20cancer%20subtypes&journal=Cancer%20Cell&doi=10.1016%2Fj.ccr.2006.10.008&volume=10&pages=515-527&publication_year=2006&author=Neve%2CRM gross monthly?
- Explore the financials of https://doi.org/10.1016%2Fj.ymeth.2009.03.001
- What's the revenue for http://scholar.google.com/scholar_lookup?&title=ChIP-seq%3A%20Using%20high-throughput%20sequencing%20to%20discover%20protein-DNA%20interactions&journal=Methods&doi=10.1016%2Fj.ymeth.2009.03.001&volume=48&pages=240-248&publication_year=2009&author=Schmidt%2CD?
- Monthly income for https://doi.org/10.1074%2Fjbc.M004424200
- How much revenue does http://scholar.google.com/scholar_lookup?&title=A%20pure%20estrogen%20antagonist%20inhibits%20cyclin%20E-Cdk2%20activity%20in%20MCF-7%20breast%20cancer%20cells%20and%20induces%20accumulation%20of%20p130%E2%80%93E2F4%20complexes%20characteristic%20of%20quiescence&journal=J.%20Biol.%20Chem.&doi=10.1074%2Fjbc.M004424200&volume=275&pages=38221-38229&publication_year=2000&author=Carroll%2CJS&author=Prall%2COW&author=Musgrove%2CEA&author=Sutherland%2CRL bring in?
- Find out how much https://doi.org/10.1016%2Fj.cell.2006.05.052 earns monthly
- What's the monthly money flow for http://scholar.google.com/scholar_lookup?&title=A%20novel%20role%20for%20high-mobility%20group%20a%20proteins%20in%20cellular%20senescence%20and%20heterochromatin%20formation&journal=Cell&doi=10.1016%2Fj.cell.2006.05.052&volume=126&pages=503-514&publication_year=2006&author=Narita%2CM?
- What's the monthly income of https://citation-needed.springer.com/v2/references/10.1038/ng.730?format=refman&flavour=references?
- Revenue of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Antoni%20Hurtado
- How much income is https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Antoni%20Hurtado%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en earning monthly?
- Revenue of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Kelly%20A%20Holmes
- What is the monthly revenue of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Kelly%20A%20Holmes%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
- How much money does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Caryn%20S%20Ross-Innes generate?
- Find out how much https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Caryn%20S%20Ross-Innes%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en earns monthly
- How much does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Dominic%20Schmidt pull in monthly?
- Find out how much https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Dominic%20Schmidt%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en earns monthly
- How much income does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Jason%20S%20Carroll have?
- How much does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Jason%20S%20Carroll%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en pull in?
- What's the revenue for https://static-content.springer.com/esm/art%3A10.1038%2Fng.730/MediaObjects/41588_2011_BFng730_MOESM16_ESM.pdf?
- What are the total earnings of https://s100.copyright.com/AppDispatchServlet?title=FOXA1%20is%20a%20key%20determinant%20of%20estrogen%20receptor%20function%20and%20endocrine%20response&author=Antoni%20Hurtado%20et%20al&contentID=10.1038%2Fng.730©right=Springer%20Nature%20America%2C%20Inc.&publication=1061-4036&publicationDate=2010-12-12&publisherName=SpringerNature&orderBeanReset=true?
- How much revenue does https://citation-needed.springer.com/v2/references/10.1038/ng.730?format=refman&flavour=citation generate?
- How much cash flow does https://doi.org/10.1186/s13059-023-03161-y have monthly?
- https://doi.org/10.1038/s41398-024-02783-5 income
- https://doi.org/10.1038/s41594-023-01181-7's financial summary
- How much does https://doi.org/10.1186/s12610-023-00199-7 rake in every month?
- What is the earnings of https://doi.org/10.1186/s12885-023-11421-0?
- What's the financial outcome of https://www.protocols.io/?
- Get to know what's the income of https://www.natureindex.com/
- What's the financial gain of http://www.naturechina.com?
- Get to know https://www.natureasia.com/ja-jp's earnings
Analytics and Tracking {📊}
- Google Tag Manager
Libraries {📚}
- Prism.js
- Zoom.js
Emails and Hosting {✉️}
Mail Servers:
- mxa-002c5801.gslb.pphosted.com
- mxb-002c5801.gslb.pphosted.com
Name Servers:
- pdns1.ultradns.net
- pdns2.ultradns.net
- pdns3.ultradns.org
- pdns4.ultradns.org
- pdns5.ultradns.info
- pdns6.ultradns.co.uk
CDN Services {📦}
- Crossref