
NATURE . COM {
}
Title:
FOXA1 is a key determinant of estrogen receptor function and endocrine response | Nature Genetics
Description:
Jason Carroll and colleagues report that the forkhead protein FOXA1 is an important determinant of estrogen receptor binding and show that expression of FOXA1 in non–breast cancer cells is sufficient to confer estrogen receptor binding and response to endocrine treatment. Estrogen receptor-α (ER) is the key feature of most breast cancers and binding of ER to the genome correlates with expression of the Forkhead protein FOXA1 (also called HNF3α). Here we show that FOXA1 is a key determinant that can influence differential interactions between ER and chromatin. Almost all ER-chromatin interactions and gene expression changes depended on the presence of FOXA1 and FOXA1 influenced genome-wide chromatin accessibility. Furthermore, we found that CTCF was an upstream negative regulator of FOXA1-chromatin interactions. In estrogen-responsive breast cancer cells, the dependency on FOXA1 for tamoxifen-ER activity was absolute; in tamoxifen-resistant cells, ER binding was independent of ligand but depended on FOXA1. Expression of FOXA1 in non-breast cancer cells can alter ER binding and function. As such, FOXA1 is a major determinant of estrogen-ER activity and endocrine response in breast cancer cells.
Website Age:
30 years and 10 months (reg. 1994-08-11).
Matching Content Categories {📚}
- Education
- Science
- Telecommunications
Content Management System {📝}
What CMS is nature.com built with?
Custom-built
No common CMS systems were detected on Nature.com, and no known web development framework was identified.
Traffic Estimate {📈}
What is the average monthly size of nature.com audience?
🌆 Monumental Traffic: 20M - 50M visitors per month
Based on our best estimate, this website will receive around 42,555,829 visitors per month in the current month.
check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush
How Does Nature.com Make Money? {💸}
Display Ads {🎯}
The website utilizes display ads within its content to generate revenue. Check the next section for further revenue estimates.
Ads are managed by yourbow.com. Particular relationships are as follows:
Direct Advertisers (10)
google.com, pmc.com, doceree.com, yourbow.com, audienciad.com, onlinemediasolutions.com, advibe.media, aps.amazon.com, getmediamx.com, onomagic.comReseller Advertisers (38)
conversantmedia.com, rubiconproject.com, pubmatic.com, appnexus.com, openx.com, smartadserver.com, lijit.com, sharethrough.com, video.unrulymedia.com, google.com, yahoo.com, triplelift.com, onetag.com, sonobi.com, contextweb.com, 33across.com, indexexchange.com, media.net, themediagrid.com, adform.com, richaudience.com, sovrn.com, improvedigital.com, freewheel.tv, smaato.com, yieldmo.com, amxrtb.com, adyoulike.com, adpone.com, criteo.com, smilewanted.com, 152media.info, e-planning.net, smartyads.com, loopme.com, opera.com, mediafuse.com, betweendigital.comHow Much Does Nature.com Make? {💰}
Display Ads {🎯}
$536,300 per month
Our calculations suggest that Nature.com earns between $357,511 and $983,155 monthly online from display advertisements.
Keywords {🔍}
article, google, scholar, cas, cancer, estrogen, breast, nature, foxa, receptor, cell, expression, chromatin, binding, cells, access, content, gene, carroll, res, cookies, analysis, genome, transcription, research, privacy, data, genetics, response, lines, nat, genes, regulation, mol, human, alpha, factor, function, information, key, determinant, hurtado, holmes, rossinnes, schmidt, interactions, accessibility, rev, dev, regulatory,
Topics {✒️}
nature portfolio permissions reprints privacy policy cancer research uk enhancer-driven lineage-specific transcription cambridge research institute advertising estrogen receptor-regulated transcription ccctc-binding factor confines nature 462 nature 406 nature social media endocrine-responsive breast cancer retinoic acid receptor-alpha p130–e2f4 complexes characteristic tamoxifen-resistant mcf-7 cells discover protein-dna interactions tamoxifen-dependent gene expression tissue-specific transcription author correspondence springerlink instant access estrogen receptor alpha permissions personal data breast cancer cells breast cancer cells chromatin accessibility profiling enhanced estrogen receptor data protection breast cancer–correlation tamoxifen-resistant cells human breast tumours breast tumor subtypes estrogen receptor function androgen receptor interacts breast cancer res estrogen-er activity estrogen receptors alpha hutchison whampoa limited gene expression profiling endogenous gene expression privacy foxa1-bound enhancers upstream negative regulator competing financial interests chromosome-wide mapping tamoxifen-er activity genome-wide analysis cell cycle progression
Questions {❓}
- Estrogen receptor null mice: what have we learned and where will they lead us?
Schema {🗺️}
WebPage:
mainEntity:
headline:FOXA1 is a key determinant of estrogen receptor function and endocrine response
description:Jason Carroll and colleagues report that the forkhead protein FOXA1 is an important determinant of estrogen receptor binding and show that expression of FOXA1 in nonâbreast cancer cells is sufficient to confer estrogen receptor binding and response to endocrine treatment. Estrogen receptor-α (ER) is the key feature of most breast cancers and binding of ER to the genome correlates with expression of the Forkhead protein FOXA1 (also called HNF3α). Here we show that FOXA1 is a key determinant that can influence differential interactions between ER and chromatin. Almost all ER-chromatin interactions and gene expression changes depended on the presence of FOXA1 and FOXA1 influenced genome-wide chromatin accessibility. Furthermore, we found that CTCF was an upstream negative regulator of FOXA1-chromatin interactions. In estrogen-responsive breast cancer cells, the dependency on FOXA1 for tamoxifen-ER activity was absolute; in tamoxifen-resistant cells, ER binding was independent of ligand but depended on FOXA1. Expression of FOXA1 in non-breast cancer cells can alter ER binding and function. As such, FOXA1 is a major determinant of estrogen-ER activity and endocrine response in breast cancer cells.
datePublished:2010-12-12T00:00:00Z
dateModified:2010-12-12T00:00:00Z
pageStart:27
pageEnd:33
sameAs:https://doi.org/10.1038/ng.730
keywords:
Breast cancer
Cancer genetics
Endocrinology
Biomedicine
general
Human Genetics
Cancer Research
Agriculture
Gene Function
Animal Genetics and Genomics
image:
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fng.730/MediaObjects/41588_2011_Article_BFng730_Fig1_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fng.730/MediaObjects/41588_2011_Article_BFng730_Fig2_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fng.730/MediaObjects/41588_2011_Article_BFng730_Fig3_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fng.730/MediaObjects/41588_2011_Article_BFng730_Fig4_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fng.730/MediaObjects/41588_2011_Article_BFng730_Fig5_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fng.730/MediaObjects/41588_2011_Article_BFng730_Fig6_HTML.jpg
isPartOf:
name:Nature Genetics
issn:
1546-1718
1061-4036
volumeNumber:43
type:
Periodical
PublicationVolume
publisher:
name:Nature Publishing Group US
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
type:Organization
author:
name:Antoni Hurtado
affiliation:
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre
address:
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK
type:PostalAddress
type:Organization
type:Person
name:Kelly A Holmes
affiliation:
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre
address:
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK
type:PostalAddress
type:Organization
type:Person
name:Caryn S Ross-Innes
affiliation:
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre
address:
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK
type:PostalAddress
type:Organization
type:Person
name:Dominic Schmidt
affiliation:
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre
address:
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK
type:PostalAddress
type:Organization
type:Person
name:Jason S Carroll
affiliation:
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre
address:
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK
type:PostalAddress
type:Organization
email:[email protected]
type:Person
isAccessibleForFree:
hasPart:
isAccessibleForFree:
cssSelector:.main-content
type:WebPageElement
type:ScholarlyArticle
context:https://schema.org
ScholarlyArticle:
headline:FOXA1 is a key determinant of estrogen receptor function and endocrine response
description:Jason Carroll and colleagues report that the forkhead protein FOXA1 is an important determinant of estrogen receptor binding and show that expression of FOXA1 in nonâbreast cancer cells is sufficient to confer estrogen receptor binding and response to endocrine treatment. Estrogen receptor-α (ER) is the key feature of most breast cancers and binding of ER to the genome correlates with expression of the Forkhead protein FOXA1 (also called HNF3α). Here we show that FOXA1 is a key determinant that can influence differential interactions between ER and chromatin. Almost all ER-chromatin interactions and gene expression changes depended on the presence of FOXA1 and FOXA1 influenced genome-wide chromatin accessibility. Furthermore, we found that CTCF was an upstream negative regulator of FOXA1-chromatin interactions. In estrogen-responsive breast cancer cells, the dependency on FOXA1 for tamoxifen-ER activity was absolute; in tamoxifen-resistant cells, ER binding was independent of ligand but depended on FOXA1. Expression of FOXA1 in non-breast cancer cells can alter ER binding and function. As such, FOXA1 is a major determinant of estrogen-ER activity and endocrine response in breast cancer cells.
datePublished:2010-12-12T00:00:00Z
dateModified:2010-12-12T00:00:00Z
pageStart:27
pageEnd:33
sameAs:https://doi.org/10.1038/ng.730
keywords:
Breast cancer
Cancer genetics
Endocrinology
Biomedicine
general
Human Genetics
Cancer Research
Agriculture
Gene Function
Animal Genetics and Genomics
image:
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fng.730/MediaObjects/41588_2011_Article_BFng730_Fig1_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fng.730/MediaObjects/41588_2011_Article_BFng730_Fig2_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fng.730/MediaObjects/41588_2011_Article_BFng730_Fig3_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fng.730/MediaObjects/41588_2011_Article_BFng730_Fig4_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fng.730/MediaObjects/41588_2011_Article_BFng730_Fig5_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fng.730/MediaObjects/41588_2011_Article_BFng730_Fig6_HTML.jpg
isPartOf:
name:Nature Genetics
issn:
1546-1718
1061-4036
volumeNumber:43
type:
Periodical
PublicationVolume
publisher:
name:Nature Publishing Group US
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
type:Organization
author:
name:Antoni Hurtado
affiliation:
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre
address:
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK
type:PostalAddress
type:Organization
type:Person
name:Kelly A Holmes
affiliation:
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre
address:
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK
type:PostalAddress
type:Organization
type:Person
name:Caryn S Ross-Innes
affiliation:
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre
address:
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK
type:PostalAddress
type:Organization
type:Person
name:Dominic Schmidt
affiliation:
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre
address:
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK
type:PostalAddress
type:Organization
type:Person
name:Jason S Carroll
affiliation:
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre
address:
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK
type:PostalAddress
type:Organization
email:[email protected]
type:Person
isAccessibleForFree:
hasPart:
isAccessibleForFree:
cssSelector:.main-content
type:WebPageElement
["Periodical","PublicationVolume"]:
name:Nature Genetics
issn:
1546-1718
1061-4036
volumeNumber:43
Organization:
name:Nature Publishing Group US
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre
address:
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK
type:PostalAddress
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre
address:
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK
type:PostalAddress
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre
address:
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK
type:PostalAddress
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre
address:
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK
type:PostalAddress
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre
address:
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK
type:PostalAddress
ImageObject:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
name:Antoni Hurtado
affiliation:
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre
address:
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK
type:PostalAddress
type:Organization
name:Kelly A Holmes
affiliation:
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre
address:
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK
type:PostalAddress
type:Organization
name:Caryn S Ross-Innes
affiliation:
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre
address:
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK
type:PostalAddress
type:Organization
name:Dominic Schmidt
affiliation:
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre
address:
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK
type:PostalAddress
type:Organization
name:Jason S Carroll
affiliation:
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre
address:
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK
type:PostalAddress
type:Organization
email:[email protected]
PostalAddress:
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK
WebPageElement:
isAccessibleForFree:
cssSelector:.main-content
External Links {🔗}(104)
- Monthly income for https://link.springer.com/article/10.1038/ng.730?utm_source=nature&utm_medium=referral&utm_campaign=buyArticle
- Find out how much https://doi.org/10.1038%2Fnrc721 earns monthly
- What's the profit of http://scholar.google.com/scholar_lookup?&title=Endocrine-responsive%20breast%20cancer%20and%20strategies%20for%20combating%20resistance&journal=Nat.%20Rev.%20Cancer&doi=10.1038%2Fnrc721&volume=2&pages=101-112&publication_year=2002&author=Ali%2CS&author=Coombes%2CRC?
- How much profit does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=11171938 make?
- What's the monthly money flow for http://scholar.google.com/scholar_lookup?&title=Cellular%20and%20molecular%20pharmacology%20of%20antiestrogen%20action%20and%20resistance&journal=Pharmacol.%20Rev.&volume=53&pages=25-71&publication_year=2001&author=Clarke%2CR&author=Leonessa%2CF&author=Welch%2CJN&author=Skaar%2CTC?
- How much does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=10652267 earn?
- How much revenue does http://scholar.google.com/scholar_lookup?&title=The%20coregulator%20exchange%20in%20transcriptional%20functions%20of%20nuclear%20receptors&journal=Genes%20Dev.&volume=14&pages=121-141&publication_year=2000&author=Glass%2CCK&author=Rosenfeld%2CMG generate?
- What's the financial intake of https://doi.org/10.1210%2Fme.2007-0546?
- What's the profit of http://scholar.google.com/scholar_lookup?&title=Nuclear%20receptor%20location%20analyses%20in%20mammalian%20genomes%3A%20from%20gene%20regulation%20to%20regulatory%20networks&journal=Mol.%20Endocrinol.&doi=10.1210%2Fme.2007-0546&volume=22&pages=1999-2011&publication_year=2008&author=Deblois%2CG&author=Giguere%2CV?
- What's the financial intake of https://doi.org/10.1038%2Fnature08497?
- What's the income generated by http://scholar.google.com/scholar_lookup?&title=An%20oestrogen-receptor-alpha-bound%20human%20chromatin%20interactome&journal=Nature&doi=10.1038%2Fnature08497&volume=462&pages=58-64&publication_year=2009&author=Fullwood%2CMJ each month?
- What's the monthly money flow for https://doi.org/10.1038%2Fng1901?
- Discover the revenue of http://scholar.google.com/scholar_lookup?&title=Genome-wide%20analysis%20of%20estrogen%20receptor%20binding%20sites&journal=Nat.%20Genet.&doi=10.1038%2Fng1901&volume=38&pages=1289-1297&publication_year=2006&author=Carroll%2CJS
- What are the total earnings of https://doi.org/10.1371%2Fjournal.pgen.0030087?
- Get to know what's the income of http://scholar.google.com/scholar_lookup?&title=Whole-genome%20cartography%20of%20estrogen%20receptor%20alpha%20binding%20sites&journal=PLoS%20Genet.&doi=10.1371%2Fjournal.pgen.0030087&volume=3&publication_year=2007&author=Lin%2CCY
- Income figures for https://doi.org/10.1038%2Femboj.2009.88
- What are the total earnings of http://scholar.google.com/scholar_lookup?&title=ChIP-Seq%20of%20ERalpha%20and%20RNA%20polymerase%20II%20defines%20genes%20differentially%20responding%20to%20ligands&journal=EMBO%20J.&doi=10.1038%2Femboj.2009.88&volume=28&pages=1418-1428&publication_year=2009&author=Welboren%2CWJ?
- Revenue of https://doi.org/10.1073%2Fpnas.0505575102
- What's the monthly income of http://scholar.google.com/scholar_lookup?&title=Location%20analysis%20of%20estrogen%20receptor%20alpha%20target%20promoters%20reveals%20that%20FOXA1%20defines%20a%20domain%20of%20the%20estrogen%20response&journal=Proc.%20Natl.%20Acad.%20Sci.%20USA&doi=10.1073%2Fpnas.0505575102&volume=102&pages=11651-11656&publication_year=2005&author=Lagani%C3%A8re%2CJ?
- What's the financial gain of https://doi.org/10.1016%2Fj.cell.2005.05.008?
- How much does http://scholar.google.com/scholar_lookup?&title=Chromosome-wide%20mapping%20of%20estrogen%20receptor%20binding%20reveals%20long-range%20regulation%20requiring%20the%20forkhead%20protein%20FoxA1&journal=Cell&doi=10.1016%2Fj.cell.2005.05.008&volume=122&pages=33-43&publication_year=2005&author=Carroll%2CJS rake in every month?
- How profitable is https://doi.org/10.1016%2Fj.cell.2008.01.018?
- See how much http://scholar.google.com/scholar_lookup?&title=FoxA1%20translates%20epigenetic%20signatures%20into%20enhancer-driven%20lineage-specific%20transcription&journal=Cell&doi=10.1016%2Fj.cell.2008.01.018&volume=132&pages=958-970&publication_year=2008&author=Lupien%2CM makes per month
- How much does https://doi.org/10.1093%2Femboj%2F17.1.244 gross monthly?
- What's the income generated by http://scholar.google.com/scholar_lookup?&title=Binding%20of%20the%20winged-helix%20transcription%20factor%20HNF3%20to%20a%20linker%20histone%20site%20on%20the%20nucleosome&journal=EMBO%20J.&doi=10.1093%2Femboj%2F17.1.244&volume=17&pages=244-254&publication_year=1998&author=Cirillo%2CLA each month?
- How much does https://doi.org/10.1016%2FS1097-2765%2802%2900459-8 make?
- What's http://scholar.google.com/scholar_lookup?&title=Opening%20of%20compacted%20chromatin%20by%20early%20developmental%20transcription%20factors%20HNF3%20%28FoxA%29%20and%20GATA-4&journal=Mol.%20Cell&doi=10.1016%2FS1097-2765%2802%2900459-8&volume=9&pages=279-289&publication_year=2002&author=Cirillo%2CLA's gross income?
- How much money does https://doi.org/10.1158%2F1078-0432.CCR-07-0122 make?
- What's the monthly money flow for http://scholar.google.com/scholar_lookup?&title=FOXA1%20expression%20in%20breast%20cancer%E2%80%93correlation%20with%20luminal%20subtype%20A%20and%20survival&journal=Clin.%20Cancer%20Res.&doi=10.1158%2F1078-0432.CCR-07-0122&volume=13&pages=4415-4421&publication_year=2007&author=Badve%2CS?
- What's the financial outcome of https://doi.org/10.1038%2F35021093?
- http://scholar.google.com/scholar_lookup?&title=Molecular%20portraits%20of%20human%20breast%20tumours&journal=Nature&doi=10.1038%2F35021093&volume=406&pages=747-752&publication_year=2000&author=Perou%2CCM's total income per month
- How much money does https://doi.org/10.1073%2Fpnas.0932692100 generate?
- http://scholar.google.com/scholar_lookup?&title=Repeated%20observation%20of%20breast%20tumor%20subtypes%20in%20independent%20gene%20expression%20data%20sets&journal=Proc.%20Natl.%20Acad.%20Sci.%20USA&doi=10.1073%2Fpnas.0932692100&volume=100&pages=8418-8423&publication_year=2003&author=Sorlie%2CT income
- How much does https://doi.org/10.1023%2FB%3ABREA.0000014042.54925.cc gross monthly?
- Monthly income for http://scholar.google.com/scholar_lookup?&title=Relevance%20of%20breast%20cancer%20cell%20lines%20as%20models%20for%20breast%20tumours%3A%20an%20update&journal=Breast%20Cancer%20Res.%20Treat.&doi=10.1023%2FB%3ABREA.0000014042.54925.cc&volume=83&pages=249-289&publication_year=2004&author=Lacroix%2CM&author=Leclercq%2CG
- How much profit does https://link.springer.com/doi/10.1186/gb-2008-9-9-r137 generate?
- What is the earnings of http://scholar.google.com/scholar_lookup?&title=Model-based%20analysis%20of%20ChIP-seq%20%28MACS%29&journal=Genome%20Biol.&doi=10.1186%2Fgb-2008-9-9-r137&volume=9&publication_year=2008&author=Zhang%2CY?
- How much does https://doi.org/10.1101%2Fgad.552910 earn?
- http://scholar.google.com/scholar_lookup?&title=Cooperative%20interaction%20between%20retinoic%20acid%20receptor-alpha%20and%20estrogen%20receptor%20in%20breast%20cancer&journal=Genes%20Dev.&doi=10.1101%2Fgad.552910&volume=24&pages=171-182&publication_year=2010&author=Ross-Innes%2CCS's financial summary
- How much does https://doi.org/10.1038%2Fnrd1031 pull in?
- What are the earnings of http://scholar.google.com/scholar_lookup?&title=Tamoxifen%3A%20a%20most%20unlikely%20pioneering%20medicine&journal=Nat.%20Rev.%20Drug%20Discov.&doi=10.1038%2Fnrd1031&volume=2&pages=205-213&publication_year=2003&author=Jordan%2CVC?
- How much cash flow does https://doi.org/10.1016%2FS0092-8674%2800%2900188-4 have monthly?
- http://scholar.google.com/scholar_lookup?&title=Cofactor%20dynamics%20and%20sufficiency%20in%20estrogen%20receptor-regulated%20transcription&journal=Cell&doi=10.1016%2FS0092-8674%2800%2900188-4&volume=103&pages=843-852&publication_year=2000&author=Shang%2CY&author=Hu%2CX&author=DiRenzo%2CJ&author=Lazar%2CMA&author=Brown%2CM's financial summary
- Earnings of https://doi.org/10.1158%2F0008-5472.CAN-03-3326
- How much revenue does http://scholar.google.com/scholar_lookup?&title=Selective%20estrogen%20receptor%20modulators%3A%20discrimination%20of%20agonistic%20versus%20antagonistic%20activities%20by%20gene%20expression%20profiling%20in%20breast%20cancer%20cells&journal=Cancer%20Res.&doi=10.1158%2F0008-5472.CAN-03-3326&volume=64&pages=1522-1533&publication_year=2004&author=Frasor%2CJ generate?
- How much does https://doi.org/10.1210%2Fen.2002-220620 pull in monthly?
- How much does http://scholar.google.com/scholar_lookup?&title=Elevated%20levels%20of%20epidermal%20growth%20factor%20receptor%2Fc-erbB2%20heterodimers%20mediate%20an%20autocrine%20growth%20regulatory%20pathway%20in%20tamoxifen-resistant%20MCF-7%20cells&journal=Endocrinology&doi=10.1210%2Fen.2002-220620&volume=144&pages=1032-1044&publication_year=2003&author=Knowlden%2CJM bring in each month?
- Profit of https://doi.org/10.1002%2Fjcb.10633
- Explore the financials of http://scholar.google.com/scholar_lookup?&title=Estrogen%20receptor%20isoform-specific%20regulation%20of%20endogenous%20gene%20expression%20in%20human%20osteoblastic%20cell%20lines%20expressing%20either%20ERalpha%20or%20ERbeta&journal=J.%20Cell.%20Biochem.&doi=10.1002%2Fjcb.10633&volume=90&pages=315-326&publication_year=2003&author=Monroe%2CDG
- How much cash flow does https://doi.org/10.1210%2Fme.2008-0100 have monthly?
- How much profit does http://scholar.google.com/scholar_lookup?&title=Unique%20ERalpha%20cistromes%20control%20cell%20type-specific%20gene%20regulation&journal=Mol.%20Endocrinol.&doi=10.1210%2Fme.2008-0100&volume=22&pages=2393-2406&publication_year=2008&author=Krum%2CSA generate?
- What's the monthly income of https://doi.org/10.1210%2Fme.2004-0381?
- What's the monthly money flow for http://scholar.google.com/scholar_lookup?&title=Estrogen%20receptor%20alpha%20and%20beta%20heterodimers%20exert%20unique%20effects%20on%20estrogen-%20and%20tamoxifen-dependent%20gene%20expression%20in%20human%20U2OS%20osteosarcoma%20cells&journal=Mol.%20Endocrinol.&doi=10.1210%2Fme.2004-0381&volume=19&pages=1555-1568&publication_year=2005&author=Monroe%2CDG?
- How much money does https://doi.org/10.1101%2Fgad.1446006 generate?
- Profit of http://scholar.google.com/scholar_lookup?&title=A%20cell-type-specific%20transcriptional%20network%20required%20for%20estrogen%20regulation%20of%20cyclin%20D1%20and%20cell%20cycle%20progression%20in%20breast%20cancer&journal=Genes%20Dev.&doi=10.1101%2Fgad.1446006&volume=20&pages=2513-2526&publication_year=2006&author=Eeckhoute%2CJ&author=Carroll%2CJS&author=Geistlinger%2CTR&author=Torres-Arzayus%2CMI&author=Brown%2CM
- https://doi.org/10.1101%2Fgr.5533506 income
- Monthly income for http://scholar.google.com/scholar_lookup?&title=FAIRE%20%28formaldehyde-assisted%20isolation%20of%20regulatory%20elements%29%20isolates%20active%20regulatory%20elements%20from%20human%20chromatin&journal=Genome%20Res.&doi=10.1101%2Fgr.5533506&volume=17&pages=877-885&publication_year=2007&author=Giresi%2CPG&author=Kim%2CJ&author=McDaniell%2CRM&author=Iyer%2CVR&author=Lieb%2CJD
- How much profit does https://doi.org/10.1101%2Fgr.084582.108 make?
- How much cash flow does http://scholar.google.com/scholar_lookup?&title=Cell-type%20selective%20chromatin%20remodeling%20defines%20the%20active%20subset%20of%20FOXA1-bound%20enhancers&journal=Genome%20Res.&doi=10.1101%2Fgr.084582.108&volume=19&pages=372-380&publication_year=2009&author=Eeckhoute%2CJ have monthly?
- What's the income of https://doi.org/10.1101%2Fgr.100479.109?
- How much does http://scholar.google.com/scholar_lookup?&title=A%20CTCF-independent%20role%20for%20cohesin%20in%20tissue-specific%20transcription&journal=Genome%20Res.&doi=10.1101%2Fgr.100479.109&volume=20&pages=578-588&publication_year=2010&author=Schmidt%2CD earn?
- What's the income generated by https://doi.org/10.1158%2F0008-5472.CAN-08-2632 each month?
- Get to know what's the income of http://scholar.google.com/scholar_lookup?&title=CCCTC-binding%20factor%20confines%20the%20distal%20action%20of%20estrogen%20receptor&journal=Cancer%20Res.&doi=10.1158%2F0008-5472.CAN-08-2632&volume=68&pages=9041-9049&publication_year=2008&author=Chan%2CCS&author=Song%2CJS
- https://doi.org/10.1074%2Fjbc.M110.149658 income
- Learn how profitable http://scholar.google.com/scholar_lookup?&title=CCCTC-binding%20factor%20acts%20upstream%20of%20FOXA1%20and%20demarcates%20the%20genomic%20response%20to%20estrogen&journal=J.%20Biol.%20Chem.&doi=10.1074%2Fjbc.M110.149658&volume=285&pages=28604-28613&publication_year=2010&author=Zhang%2CY is on a monthly basis
- https://doi.org/10.1210%2Fme.2009-0252 income
- What's the financial outcome of http://scholar.google.com/scholar_lookup?&title=Genome-wide%20dynamics%20of%20chromatin%20binding%20of%20estrogen%20receptors%20alpha%20and%20beta%3A%20mutual%20restriction%20and%20competitive%20site%20selection&journal=Mol.%20Endocrinol.&doi=10.1210%2Fme.2009-0252&volume=24&pages=47-59&publication_year=2010&author=Charn%2CTH?
- https://doi.org/10.1074%2Fjbc.M305226200's total income per month
- Financial intake of http://scholar.google.com/scholar_lookup?&title=Enhanced%20estrogen%20receptor%20%28ER%29%20alpha%2C%20ERBB2%2C%20and%20MAPK%20signal%20transduction%20pathways%20operate%20during%20the%20adaptation%20of%20MCF-7%20cells%20to%20long%20term%20estrogen%20deprivation&journal=J.%20Biol.%20Chem.&doi=10.1074%2Fjbc.M305226200&volume=278&pages=30458-30468&publication_year=2003&author=Martin%2CLA
- How much does https://doi.org/10.1210%2Fedrv.20.3.0370 rake in every month?
- Monthly income for http://scholar.google.com/scholar_lookup?&title=Estrogen%20receptor%20null%20mice%3A%20what%20have%20we%20learned%20and%20where%20will%20they%20lead%20us%3F&journal=Endocr.%20Rev.&doi=10.1210%2Fedrv.20.3.0370&volume=20&pages=358-417&publication_year=1999&author=Couse%2CJF&author=Korach%2CKS
- How much does https://doi.org/10.1101%2Fgad.399506 rake in every month?
- What's the income of http://scholar.google.com/scholar_lookup?&title=CTCF%20mediates%20long-range%20chromatin%20looping%20and%20local%20histone%20modification%20in%20the%20beta-globin%20locus&journal=Genes%20Dev.&doi=10.1101%2Fgad.399506&volume=20&pages=2349-2354&publication_year=2006&author=Splinter%2CE?
- What's the income generated by https://doi.org/10.1016%2Fj.ccr.2006.10.008 each month?
- How much profit is http://scholar.google.com/scholar_lookup?&title=A%20collection%20of%20breast%20cancer%20cell%20lines%20for%20the%20study%20of%20functionally%20distinct%20cancer%20subtypes&journal=Cancer%20Cell&doi=10.1016%2Fj.ccr.2006.10.008&volume=10&pages=515-527&publication_year=2006&author=Neve%2CRM making per month?
- Profit of https://doi.org/10.1016%2Fj.ymeth.2009.03.001
- How much revenue does http://scholar.google.com/scholar_lookup?&title=ChIP-seq%3A%20Using%20high-throughput%20sequencing%20to%20discover%20protein-DNA%20interactions&journal=Methods&doi=10.1016%2Fj.ymeth.2009.03.001&volume=48&pages=240-248&publication_year=2009&author=Schmidt%2CD produce monthly?
- How much does https://doi.org/10.1074%2Fjbc.M004424200 rake in every month?
- How much revenue does http://scholar.google.com/scholar_lookup?&title=A%20pure%20estrogen%20antagonist%20inhibits%20cyclin%20E-Cdk2%20activity%20in%20MCF-7%20breast%20cancer%20cells%20and%20induces%20accumulation%20of%20p130%E2%80%93E2F4%20complexes%20characteristic%20of%20quiescence&journal=J.%20Biol.%20Chem.&doi=10.1074%2Fjbc.M004424200&volume=275&pages=38221-38229&publication_year=2000&author=Carroll%2CJS&author=Prall%2COW&author=Musgrove%2CEA&author=Sutherland%2CRL produce monthly?
- How much does https://doi.org/10.1016%2Fj.cell.2006.05.052 earn?
- What's the financial intake of http://scholar.google.com/scholar_lookup?&title=A%20novel%20role%20for%20high-mobility%20group%20a%20proteins%20in%20cellular%20senescence%20and%20heterochromatin%20formation&journal=Cell&doi=10.1016%2Fj.cell.2006.05.052&volume=126&pages=503-514&publication_year=2006&author=Narita%2CM?
- Revenue of https://citation-needed.springer.com/v2/references/10.1038/ng.730?format=refman&flavour=references
- How much income is https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Antoni%20Hurtado earning monthly?
- What are the total earnings of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Antoni%20Hurtado%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
- Find out how much https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Kelly%20A%20Holmes earns monthly
- How much revenue does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Kelly%20A%20Holmes%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en bring in?
- What are the total earnings of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Caryn%20S%20Ross-Innes?
- How much money does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Caryn%20S%20Ross-Innes%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en generate?
- How much does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Dominic%20Schmidt bring in each month?
- How much does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Dominic%20Schmidt%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en generate monthly?
- What's the total monthly financial gain of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Jason%20S%20Carroll?
- How much profit does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Jason%20S%20Carroll%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en make?
- Income figures for https://static-content.springer.com/esm/art%3A10.1038%2Fng.730/MediaObjects/41588_2011_BFng730_MOESM16_ESM.pdf
- What's the revenue for https://s100.copyright.com/AppDispatchServlet?title=FOXA1%20is%20a%20key%20determinant%20of%20estrogen%20receptor%20function%20and%20endocrine%20response&author=Antoni%20Hurtado%20et%20al&contentID=10.1038%2Fng.730©right=Springer%20Nature%20America%2C%20Inc.&publication=1061-4036&publicationDate=2010-12-12&publisherName=SpringerNature&orderBeanReset=true?
- How much does https://citation-needed.springer.com/v2/references/10.1038/ng.730?format=refman&flavour=citation rake in every month?
- What's the financial intake of https://doi.org/10.1186/s13059-023-03161-y?
- How much revenue does https://doi.org/10.1038/s41398-024-02783-5 generate?
- What's the financial outcome of https://doi.org/10.1038/s41594-023-01181-7?
- How much revenue does https://doi.org/10.1186/s12610-023-00199-7 bring in?
- How much does https://doi.org/10.1186/s12885-023-11421-0 bring in each month?
- How much revenue does https://www.protocols.io/ generate?
- How much revenue does https://www.natureindex.com/ bring in?
- What are the total earnings of http://www.naturechina.com?
- How much does https://www.natureasia.com/ja-jp bring in each month?
Analytics and Tracking {📊}
- Google Tag Manager
Libraries {📚}
- Prism.js
- Zoom.js
Emails and Hosting {✉️}
Mail Servers:
- mxa-002c5801.gslb.pphosted.com
- mxb-002c5801.gslb.pphosted.com
Name Servers:
- pdns1.ultradns.net
- pdns2.ultradns.net
- pdns3.ultradns.org
- pdns4.ultradns.org
- pdns5.ultradns.info
- pdns6.ultradns.co.uk
CDN Services {📦}
- Crossref