
NATURE . COM {
}
Title:
FOXA1 is a key determinant of estrogen receptor function and endocrine response | Nature Genetics
Description:
Jason Carroll and colleagues report that the forkhead protein FOXA1 is an important determinant of estrogen receptor binding and show that expression of FOXA1 in non–breast cancer cells is sufficient to confer estrogen receptor binding and response to endocrine treatment. Estrogen receptor-α (ER) is the key feature of most breast cancers and binding of ER to the genome correlates with expression of the Forkhead protein FOXA1 (also called HNF3α). Here we show that FOXA1 is a key determinant that can influence differential interactions between ER and chromatin. Almost all ER-chromatin interactions and gene expression changes depended on the presence of FOXA1 and FOXA1 influenced genome-wide chromatin accessibility. Furthermore, we found that CTCF was an upstream negative regulator of FOXA1-chromatin interactions. In estrogen-responsive breast cancer cells, the dependency on FOXA1 for tamoxifen-ER activity was absolute; in tamoxifen-resistant cells, ER binding was independent of ligand but depended on FOXA1. Expression of FOXA1 in non-breast cancer cells can alter ER binding and function. As such, FOXA1 is a major determinant of estrogen-ER activity and endocrine response in breast cancer cells.
Website Age:
30 years and 10 months (reg. 1994-08-11).
Matching Content Categories {📚}
- Education
- Science
- Telecommunications
Content Management System {📝}
What CMS is nature.com built with?
Custom-built
No common CMS systems were detected on Nature.com, and no known web development framework was identified.
Traffic Estimate {📈}
What is the average monthly size of nature.com audience?
🌆 Monumental Traffic: 20M - 50M visitors per month
Based on our best estimate, this website will receive around 42,797,153 visitors per month in the current month.
check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush
How Does Nature.com Make Money? {💸}
Display Ads {🎯}
The website utilizes display ads within its content to generate revenue. Check the next section for further revenue estimates.
Ads are managed by yourbow.com. Particular relationships are as follows:
Direct Advertisers (10)
google.com, pmc.com, doceree.com, yourbow.com, audienciad.com, onlinemediasolutions.com, advibe.media, aps.amazon.com, getmediamx.com, onomagic.comReseller Advertisers (38)
conversantmedia.com, rubiconproject.com, pubmatic.com, appnexus.com, openx.com, smartadserver.com, lijit.com, sharethrough.com, video.unrulymedia.com, google.com, yahoo.com, triplelift.com, onetag.com, sonobi.com, contextweb.com, 33across.com, indexexchange.com, media.net, themediagrid.com, adform.com, richaudience.com, sovrn.com, improvedigital.com, freewheel.tv, smaato.com, yieldmo.com, amxrtb.com, adyoulike.com, adpone.com, criteo.com, smilewanted.com, 152media.info, e-planning.net, smartyads.com, loopme.com, opera.com, mediafuse.com, betweendigital.comHow Much Does Nature.com Make? {💰}
Display Ads {🎯}
$539,300 per month
Our calculations suggest that Nature.com earns between $359,538 and $988,730 monthly online from display advertisements.
Keywords {🔍}
article, google, scholar, cas, cancer, estrogen, breast, nature, foxa, receptor, cell, expression, chromatin, binding, cells, access, content, gene, carroll, res, cookies, analysis, genome, transcription, research, privacy, data, genetics, response, lines, nat, genes, regulation, mol, human, alpha, factor, function, information, key, determinant, hurtado, holmes, rossinnes, schmidt, interactions, accessibility, rev, dev, regulatory,
Topics {✒️}
nature portfolio permissions reprints privacy policy cancer research uk enhancer-driven lineage-specific transcription cambridge research institute advertising estrogen receptor-regulated transcription ccctc-binding factor confines nature 462 nature 406 nature social media endocrine-responsive breast cancer retinoic acid receptor-alpha p130–e2f4 complexes characteristic tamoxifen-resistant mcf-7 cells discover protein-dna interactions tamoxifen-dependent gene expression tissue-specific transcription author correspondence springerlink instant access estrogen receptor alpha permissions personal data breast cancer cells breast cancer cells chromatin accessibility profiling enhanced estrogen receptor data protection breast cancer–correlation tamoxifen-resistant cells human breast tumours breast tumor subtypes estrogen receptor function androgen receptor interacts breast cancer res estrogen-er activity estrogen receptors alpha hutchison whampoa limited gene expression profiling endogenous gene expression privacy foxa1-bound enhancers upstream negative regulator competing financial interests chromosome-wide mapping tamoxifen-er activity genome-wide analysis cell cycle progression
Questions {❓}
- Estrogen receptor null mice: what have we learned and where will they lead us?
Schema {🗺️}
WebPage:
mainEntity:
headline:FOXA1 is a key determinant of estrogen receptor function and endocrine response
description:Jason Carroll and colleagues report that the forkhead protein FOXA1 is an important determinant of estrogen receptor binding and show that expression of FOXA1 in nonâbreast cancer cells is sufficient to confer estrogen receptor binding and response to endocrine treatment. Estrogen receptor-α (ER) is the key feature of most breast cancers and binding of ER to the genome correlates with expression of the Forkhead protein FOXA1 (also called HNF3α). Here we show that FOXA1 is a key determinant that can influence differential interactions between ER and chromatin. Almost all ER-chromatin interactions and gene expression changes depended on the presence of FOXA1 and FOXA1 influenced genome-wide chromatin accessibility. Furthermore, we found that CTCF was an upstream negative regulator of FOXA1-chromatin interactions. In estrogen-responsive breast cancer cells, the dependency on FOXA1 for tamoxifen-ER activity was absolute; in tamoxifen-resistant cells, ER binding was independent of ligand but depended on FOXA1. Expression of FOXA1 in non-breast cancer cells can alter ER binding and function. As such, FOXA1 is a major determinant of estrogen-ER activity and endocrine response in breast cancer cells.
datePublished:2010-12-12T00:00:00Z
dateModified:2010-12-12T00:00:00Z
pageStart:27
pageEnd:33
sameAs:https://doi.org/10.1038/ng.730
keywords:
Breast cancer
Cancer genetics
Endocrinology
Biomedicine
general
Human Genetics
Cancer Research
Agriculture
Gene Function
Animal Genetics and Genomics
image:
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fng.730/MediaObjects/41588_2011_Article_BFng730_Fig1_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fng.730/MediaObjects/41588_2011_Article_BFng730_Fig2_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fng.730/MediaObjects/41588_2011_Article_BFng730_Fig3_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fng.730/MediaObjects/41588_2011_Article_BFng730_Fig4_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fng.730/MediaObjects/41588_2011_Article_BFng730_Fig5_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fng.730/MediaObjects/41588_2011_Article_BFng730_Fig6_HTML.jpg
isPartOf:
name:Nature Genetics
issn:
1546-1718
1061-4036
volumeNumber:43
type:
Periodical
PublicationVolume
publisher:
name:Nature Publishing Group US
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
type:Organization
author:
name:Antoni Hurtado
affiliation:
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre
address:
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK
type:PostalAddress
type:Organization
type:Person
name:Kelly A Holmes
affiliation:
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre
address:
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK
type:PostalAddress
type:Organization
type:Person
name:Caryn S Ross-Innes
affiliation:
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre
address:
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK
type:PostalAddress
type:Organization
type:Person
name:Dominic Schmidt
affiliation:
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre
address:
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK
type:PostalAddress
type:Organization
type:Person
name:Jason S Carroll
affiliation:
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre
address:
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK
type:PostalAddress
type:Organization
email:[email protected]
type:Person
isAccessibleForFree:
hasPart:
isAccessibleForFree:
cssSelector:.main-content
type:WebPageElement
type:ScholarlyArticle
context:https://schema.org
ScholarlyArticle:
headline:FOXA1 is a key determinant of estrogen receptor function and endocrine response
description:Jason Carroll and colleagues report that the forkhead protein FOXA1 is an important determinant of estrogen receptor binding and show that expression of FOXA1 in nonâbreast cancer cells is sufficient to confer estrogen receptor binding and response to endocrine treatment. Estrogen receptor-α (ER) is the key feature of most breast cancers and binding of ER to the genome correlates with expression of the Forkhead protein FOXA1 (also called HNF3α). Here we show that FOXA1 is a key determinant that can influence differential interactions between ER and chromatin. Almost all ER-chromatin interactions and gene expression changes depended on the presence of FOXA1 and FOXA1 influenced genome-wide chromatin accessibility. Furthermore, we found that CTCF was an upstream negative regulator of FOXA1-chromatin interactions. In estrogen-responsive breast cancer cells, the dependency on FOXA1 for tamoxifen-ER activity was absolute; in tamoxifen-resistant cells, ER binding was independent of ligand but depended on FOXA1. Expression of FOXA1 in non-breast cancer cells can alter ER binding and function. As such, FOXA1 is a major determinant of estrogen-ER activity and endocrine response in breast cancer cells.
datePublished:2010-12-12T00:00:00Z
dateModified:2010-12-12T00:00:00Z
pageStart:27
pageEnd:33
sameAs:https://doi.org/10.1038/ng.730
keywords:
Breast cancer
Cancer genetics
Endocrinology
Biomedicine
general
Human Genetics
Cancer Research
Agriculture
Gene Function
Animal Genetics and Genomics
image:
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fng.730/MediaObjects/41588_2011_Article_BFng730_Fig1_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fng.730/MediaObjects/41588_2011_Article_BFng730_Fig2_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fng.730/MediaObjects/41588_2011_Article_BFng730_Fig3_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fng.730/MediaObjects/41588_2011_Article_BFng730_Fig4_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fng.730/MediaObjects/41588_2011_Article_BFng730_Fig5_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fng.730/MediaObjects/41588_2011_Article_BFng730_Fig6_HTML.jpg
isPartOf:
name:Nature Genetics
issn:
1546-1718
1061-4036
volumeNumber:43
type:
Periodical
PublicationVolume
publisher:
name:Nature Publishing Group US
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
type:Organization
author:
name:Antoni Hurtado
affiliation:
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre
address:
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK
type:PostalAddress
type:Organization
type:Person
name:Kelly A Holmes
affiliation:
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre
address:
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK
type:PostalAddress
type:Organization
type:Person
name:Caryn S Ross-Innes
affiliation:
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre
address:
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK
type:PostalAddress
type:Organization
type:Person
name:Dominic Schmidt
affiliation:
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre
address:
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK
type:PostalAddress
type:Organization
type:Person
name:Jason S Carroll
affiliation:
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre
address:
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK
type:PostalAddress
type:Organization
email:[email protected]
type:Person
isAccessibleForFree:
hasPart:
isAccessibleForFree:
cssSelector:.main-content
type:WebPageElement
["Periodical","PublicationVolume"]:
name:Nature Genetics
issn:
1546-1718
1061-4036
volumeNumber:43
Organization:
name:Nature Publishing Group US
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre
address:
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK
type:PostalAddress
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre
address:
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK
type:PostalAddress
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre
address:
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK
type:PostalAddress
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre
address:
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK
type:PostalAddress
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre
address:
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK
type:PostalAddress
ImageObject:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
name:Antoni Hurtado
affiliation:
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre
address:
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK
type:PostalAddress
type:Organization
name:Kelly A Holmes
affiliation:
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre
address:
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK
type:PostalAddress
type:Organization
name:Caryn S Ross-Innes
affiliation:
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre
address:
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK
type:PostalAddress
type:Organization
name:Dominic Schmidt
affiliation:
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre
address:
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK
type:PostalAddress
type:Organization
name:Jason S Carroll
affiliation:
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre
address:
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK
type:PostalAddress
type:Organization
email:[email protected]
PostalAddress:
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK
name:Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK
WebPageElement:
isAccessibleForFree:
cssSelector:.main-content
External Links {🔗}(104)
- What's the financial intake of https://link.springer.com/article/10.1038/ng.730?utm_source=nature&utm_medium=referral&utm_campaign=buyArticle?
- What's the income generated by https://doi.org/10.1038%2Fnrc721 each month?
- What's the revenue for http://scholar.google.com/scholar_lookup?&title=Endocrine-responsive%20breast%20cancer%20and%20strategies%20for%20combating%20resistance&journal=Nat.%20Rev.%20Cancer&doi=10.1038%2Fnrc721&volume=2&pages=101-112&publication_year=2002&author=Ali%2CS&author=Coombes%2CRC?
- Revenue of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=11171938
- http://scholar.google.com/scholar_lookup?&title=Cellular%20and%20molecular%20pharmacology%20of%20antiestrogen%20action%20and%20resistance&journal=Pharmacol.%20Rev.&volume=53&pages=25-71&publication_year=2001&author=Clarke%2CR&author=Leonessa%2CF&author=Welch%2CJN&author=Skaar%2CTC's total income per month
- How much does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=10652267 rake in every month?
- What's the financial gain of http://scholar.google.com/scholar_lookup?&title=The%20coregulator%20exchange%20in%20transcriptional%20functions%20of%20nuclear%20receptors&journal=Genes%20Dev.&volume=14&pages=121-141&publication_year=2000&author=Glass%2CCK&author=Rosenfeld%2CMG?
- What is the earnings of https://doi.org/10.1210%2Fme.2007-0546?
- Get to know http://scholar.google.com/scholar_lookup?&title=Nuclear%20receptor%20location%20analyses%20in%20mammalian%20genomes%3A%20from%20gene%20regulation%20to%20regulatory%20networks&journal=Mol.%20Endocrinol.&doi=10.1210%2Fme.2007-0546&volume=22&pages=1999-2011&publication_year=2008&author=Deblois%2CG&author=Giguere%2CV's earnings
- What's the income of https://doi.org/10.1038%2Fnature08497?
- Check the income stats for http://scholar.google.com/scholar_lookup?&title=An%20oestrogen-receptor-alpha-bound%20human%20chromatin%20interactome&journal=Nature&doi=10.1038%2Fnature08497&volume=462&pages=58-64&publication_year=2009&author=Fullwood%2CMJ
- How much does https://doi.org/10.1038%2Fng1901 pull in?
- Learn about the earnings of http://scholar.google.com/scholar_lookup?&title=Genome-wide%20analysis%20of%20estrogen%20receptor%20binding%20sites&journal=Nat.%20Genet.&doi=10.1038%2Fng1901&volume=38&pages=1289-1297&publication_year=2006&author=Carroll%2CJS
- What are the total earnings of https://doi.org/10.1371%2Fjournal.pgen.0030087?
- How much money does http://scholar.google.com/scholar_lookup?&title=Whole-genome%20cartography%20of%20estrogen%20receptor%20alpha%20binding%20sites&journal=PLoS%20Genet.&doi=10.1371%2Fjournal.pgen.0030087&volume=3&publication_year=2007&author=Lin%2CCY generate?
- How much does https://doi.org/10.1038%2Femboj.2009.88 pull in monthly?
- Monthly income for http://scholar.google.com/scholar_lookup?&title=ChIP-Seq%20of%20ERalpha%20and%20RNA%20polymerase%20II%20defines%20genes%20differentially%20responding%20to%20ligands&journal=EMBO%20J.&doi=10.1038%2Femboj.2009.88&volume=28&pages=1418-1428&publication_year=2009&author=Welboren%2CWJ
- How much revenue does https://doi.org/10.1073%2Fpnas.0505575102 produce monthly?
- Discover the revenue of http://scholar.google.com/scholar_lookup?&title=Location%20analysis%20of%20estrogen%20receptor%20alpha%20target%20promoters%20reveals%20that%20FOXA1%20defines%20a%20domain%20of%20the%20estrogen%20response&journal=Proc.%20Natl.%20Acad.%20Sci.%20USA&doi=10.1073%2Fpnas.0505575102&volume=102&pages=11651-11656&publication_year=2005&author=Lagani%C3%A8re%2CJ
- What are the total earnings of https://doi.org/10.1016%2Fj.cell.2005.05.008?
- How much money does http://scholar.google.com/scholar_lookup?&title=Chromosome-wide%20mapping%20of%20estrogen%20receptor%20binding%20reveals%20long-range%20regulation%20requiring%20the%20forkhead%20protein%20FoxA1&journal=Cell&doi=10.1016%2Fj.cell.2005.05.008&volume=122&pages=33-43&publication_year=2005&author=Carroll%2CJS generate?
- How much does https://doi.org/10.1016%2Fj.cell.2008.01.018 pull in?
- How much revenue does http://scholar.google.com/scholar_lookup?&title=FoxA1%20translates%20epigenetic%20signatures%20into%20enhancer-driven%20lineage-specific%20transcription&journal=Cell&doi=10.1016%2Fj.cell.2008.01.018&volume=132&pages=958-970&publication_year=2008&author=Lupien%2CM generate?
- How much income does https://doi.org/10.1093%2Femboj%2F17.1.244 have?
- What are the earnings of http://scholar.google.com/scholar_lookup?&title=Binding%20of%20the%20winged-helix%20transcription%20factor%20HNF3%20to%20a%20linker%20histone%20site%20on%20the%20nucleosome&journal=EMBO%20J.&doi=10.1093%2Femboj%2F17.1.244&volume=17&pages=244-254&publication_year=1998&author=Cirillo%2CLA?
- What's the financial outcome of https://doi.org/10.1016%2FS1097-2765%2802%2900459-8?
- How much money does http://scholar.google.com/scholar_lookup?&title=Opening%20of%20compacted%20chromatin%20by%20early%20developmental%20transcription%20factors%20HNF3%20%28FoxA%29%20and%20GATA-4&journal=Mol.%20Cell&doi=10.1016%2FS1097-2765%2802%2900459-8&volume=9&pages=279-289&publication_year=2002&author=Cirillo%2CLA generate?
- Learn about the earnings of https://doi.org/10.1158%2F1078-0432.CCR-07-0122
- How much revenue does http://scholar.google.com/scholar_lookup?&title=FOXA1%20expression%20in%20breast%20cancer%E2%80%93correlation%20with%20luminal%20subtype%20A%20and%20survival&journal=Clin.%20Cancer%20Res.&doi=10.1158%2F1078-0432.CCR-07-0122&volume=13&pages=4415-4421&publication_year=2007&author=Badve%2CS produce monthly?
- What's the financial gain of https://doi.org/10.1038%2F35021093?
- Explore the financials of http://scholar.google.com/scholar_lookup?&title=Molecular%20portraits%20of%20human%20breast%20tumours&journal=Nature&doi=10.1038%2F35021093&volume=406&pages=747-752&publication_year=2000&author=Perou%2CCM
- Find out how much https://doi.org/10.1073%2Fpnas.0932692100 earns monthly
- What's the financial outcome of http://scholar.google.com/scholar_lookup?&title=Repeated%20observation%20of%20breast%20tumor%20subtypes%20in%20independent%20gene%20expression%20data%20sets&journal=Proc.%20Natl.%20Acad.%20Sci.%20USA&doi=10.1073%2Fpnas.0932692100&volume=100&pages=8418-8423&publication_year=2003&author=Sorlie%2CT?
- Check the income stats for https://doi.org/10.1023%2FB%3ABREA.0000014042.54925.cc
- How much does http://scholar.google.com/scholar_lookup?&title=Relevance%20of%20breast%20cancer%20cell%20lines%20as%20models%20for%20breast%20tumours%3A%20an%20update&journal=Breast%20Cancer%20Res.%20Treat.&doi=10.1023%2FB%3ABREA.0000014042.54925.cc&volume=83&pages=249-289&publication_year=2004&author=Lacroix%2CM&author=Leclercq%2CG gross monthly?
- How much does https://link.springer.com/doi/10.1186/gb-2008-9-9-r137 net monthly?
- How much revenue does http://scholar.google.com/scholar_lookup?&title=Model-based%20analysis%20of%20ChIP-seq%20%28MACS%29&journal=Genome%20Biol.&doi=10.1186%2Fgb-2008-9-9-r137&volume=9&publication_year=2008&author=Zhang%2CY produce monthly?
- Discover the revenue of https://doi.org/10.1101%2Fgad.552910
- How much income does http://scholar.google.com/scholar_lookup?&title=Cooperative%20interaction%20between%20retinoic%20acid%20receptor-alpha%20and%20estrogen%20receptor%20in%20breast%20cancer&journal=Genes%20Dev.&doi=10.1101%2Fgad.552910&volume=24&pages=171-182&publication_year=2010&author=Ross-Innes%2CCS have?
- Discover the revenue of https://doi.org/10.1038%2Fnrd1031
- How much does http://scholar.google.com/scholar_lookup?&title=Tamoxifen%3A%20a%20most%20unlikely%20pioneering%20medicine&journal=Nat.%20Rev.%20Drug%20Discov.&doi=10.1038%2Fnrd1031&volume=2&pages=205-213&publication_year=2003&author=Jordan%2CVC bring in each month?
- How much income does https://doi.org/10.1016%2FS0092-8674%2800%2900188-4 have?
- Discover the revenue of http://scholar.google.com/scholar_lookup?&title=Cofactor%20dynamics%20and%20sufficiency%20in%20estrogen%20receptor-regulated%20transcription&journal=Cell&doi=10.1016%2FS0092-8674%2800%2900188-4&volume=103&pages=843-852&publication_year=2000&author=Shang%2CY&author=Hu%2CX&author=DiRenzo%2CJ&author=Lazar%2CMA&author=Brown%2CM
- What's the monthly income of https://doi.org/10.1158%2F0008-5472.CAN-03-3326?
- How much profit does http://scholar.google.com/scholar_lookup?&title=Selective%20estrogen%20receptor%20modulators%3A%20discrimination%20of%20agonistic%20versus%20antagonistic%20activities%20by%20gene%20expression%20profiling%20in%20breast%20cancer%20cells&journal=Cancer%20Res.&doi=10.1158%2F0008-5472.CAN-03-3326&volume=64&pages=1522-1533&publication_year=2004&author=Frasor%2CJ generate?
- Check the income stats for https://doi.org/10.1210%2Fen.2002-220620
- What's http://scholar.google.com/scholar_lookup?&title=Elevated%20levels%20of%20epidermal%20growth%20factor%20receptor%2Fc-erbB2%20heterodimers%20mediate%20an%20autocrine%20growth%20regulatory%20pathway%20in%20tamoxifen-resistant%20MCF-7%20cells&journal=Endocrinology&doi=10.1210%2Fen.2002-220620&volume=144&pages=1032-1044&publication_year=2003&author=Knowlden%2CJM's gross income?
- https://doi.org/10.1002%2Fjcb.10633 income
- What's the profit of http://scholar.google.com/scholar_lookup?&title=Estrogen%20receptor%20isoform-specific%20regulation%20of%20endogenous%20gene%20expression%20in%20human%20osteoblastic%20cell%20lines%20expressing%20either%20ERalpha%20or%20ERbeta&journal=J.%20Cell.%20Biochem.&doi=10.1002%2Fjcb.10633&volume=90&pages=315-326&publication_year=2003&author=Monroe%2CDG?
- Monthly income for https://doi.org/10.1210%2Fme.2008-0100
- Profit of http://scholar.google.com/scholar_lookup?&title=Unique%20ERalpha%20cistromes%20control%20cell%20type-specific%20gene%20regulation&journal=Mol.%20Endocrinol.&doi=10.1210%2Fme.2008-0100&volume=22&pages=2393-2406&publication_year=2008&author=Krum%2CSA
- https://doi.org/10.1210%2Fme.2004-0381's financial summary
- How much income is http://scholar.google.com/scholar_lookup?&title=Estrogen%20receptor%20alpha%20and%20beta%20heterodimers%20exert%20unique%20effects%20on%20estrogen-%20and%20tamoxifen-dependent%20gene%20expression%20in%20human%20U2OS%20osteosarcoma%20cells&journal=Mol.%20Endocrinol.&doi=10.1210%2Fme.2004-0381&volume=19&pages=1555-1568&publication_year=2005&author=Monroe%2CDG earning monthly?
- What's the revenue for https://doi.org/10.1101%2Fgad.1446006?
- What's http://scholar.google.com/scholar_lookup?&title=A%20cell-type-specific%20transcriptional%20network%20required%20for%20estrogen%20regulation%20of%20cyclin%20D1%20and%20cell%20cycle%20progression%20in%20breast%20cancer&journal=Genes%20Dev.&doi=10.1101%2Fgad.1446006&volume=20&pages=2513-2526&publication_year=2006&author=Eeckhoute%2CJ&author=Carroll%2CJS&author=Geistlinger%2CTR&author=Torres-Arzayus%2CMI&author=Brown%2CM's gross income?
- What is the monthly revenue of https://doi.org/10.1101%2Fgr.5533506?
- How much does http://scholar.google.com/scholar_lookup?&title=FAIRE%20%28formaldehyde-assisted%20isolation%20of%20regulatory%20elements%29%20isolates%20active%20regulatory%20elements%20from%20human%20chromatin&journal=Genome%20Res.&doi=10.1101%2Fgr.5533506&volume=17&pages=877-885&publication_year=2007&author=Giresi%2CPG&author=Kim%2CJ&author=McDaniell%2CRM&author=Iyer%2CVR&author=Lieb%2CJD gross monthly?
- What's the total monthly financial gain of https://doi.org/10.1101%2Fgr.084582.108?
- Explore the financials of http://scholar.google.com/scholar_lookup?&title=Cell-type%20selective%20chromatin%20remodeling%20defines%20the%20active%20subset%20of%20FOXA1-bound%20enhancers&journal=Genome%20Res.&doi=10.1101%2Fgr.084582.108&volume=19&pages=372-380&publication_year=2009&author=Eeckhoute%2CJ
- How much does https://doi.org/10.1101%2Fgr.100479.109 earn?
- What's the monthly money flow for http://scholar.google.com/scholar_lookup?&title=A%20CTCF-independent%20role%20for%20cohesin%20in%20tissue-specific%20transcription&journal=Genome%20Res.&doi=10.1101%2Fgr.100479.109&volume=20&pages=578-588&publication_year=2010&author=Schmidt%2CD?
- Revenue of https://doi.org/10.1158%2F0008-5472.CAN-08-2632
- How much money does http://scholar.google.com/scholar_lookup?&title=CCCTC-binding%20factor%20confines%20the%20distal%20action%20of%20estrogen%20receptor&journal=Cancer%20Res.&doi=10.1158%2F0008-5472.CAN-08-2632&volume=68&pages=9041-9049&publication_year=2008&author=Chan%2CCS&author=Song%2CJS make?
- How much profit is https://doi.org/10.1074%2Fjbc.M110.149658 making per month?
- What's the financial gain of http://scholar.google.com/scholar_lookup?&title=CCCTC-binding%20factor%20acts%20upstream%20of%20FOXA1%20and%20demarcates%20the%20genomic%20response%20to%20estrogen&journal=J.%20Biol.%20Chem.&doi=10.1074%2Fjbc.M110.149658&volume=285&pages=28604-28613&publication_year=2010&author=Zhang%2CY?
- What's the profit of https://doi.org/10.1210%2Fme.2009-0252?
- How much income is http://scholar.google.com/scholar_lookup?&title=Genome-wide%20dynamics%20of%20chromatin%20binding%20of%20estrogen%20receptors%20alpha%20and%20beta%3A%20mutual%20restriction%20and%20competitive%20site%20selection&journal=Mol.%20Endocrinol.&doi=10.1210%2Fme.2009-0252&volume=24&pages=47-59&publication_year=2010&author=Charn%2CTH earning monthly?
- What's the income of https://doi.org/10.1074%2Fjbc.M305226200?
- http://scholar.google.com/scholar_lookup?&title=Enhanced%20estrogen%20receptor%20%28ER%29%20alpha%2C%20ERBB2%2C%20and%20MAPK%20signal%20transduction%20pathways%20operate%20during%20the%20adaptation%20of%20MCF-7%20cells%20to%20long%20term%20estrogen%20deprivation&journal=J.%20Biol.%20Chem.&doi=10.1074%2Fjbc.M305226200&volume=278&pages=30458-30468&publication_year=2003&author=Martin%2CLA's financial summary
- Discover the revenue of https://doi.org/10.1210%2Fedrv.20.3.0370
- How much revenue does http://scholar.google.com/scholar_lookup?&title=Estrogen%20receptor%20null%20mice%3A%20what%20have%20we%20learned%20and%20where%20will%20they%20lead%20us%3F&journal=Endocr.%20Rev.&doi=10.1210%2Fedrv.20.3.0370&volume=20&pages=358-417&publication_year=1999&author=Couse%2CJF&author=Korach%2CKS produce monthly?
- How much does https://doi.org/10.1101%2Fgad.399506 pull in?
- What's the financial intake of http://scholar.google.com/scholar_lookup?&title=CTCF%20mediates%20long-range%20chromatin%20looping%20and%20local%20histone%20modification%20in%20the%20beta-globin%20locus&journal=Genes%20Dev.&doi=10.1101%2Fgad.399506&volume=20&pages=2349-2354&publication_year=2006&author=Splinter%2CE?
- Discover the revenue of https://doi.org/10.1016%2Fj.ccr.2006.10.008
- What's the financial outcome of http://scholar.google.com/scholar_lookup?&title=A%20collection%20of%20breast%20cancer%20cell%20lines%20for%20the%20study%20of%20functionally%20distinct%20cancer%20subtypes&journal=Cancer%20Cell&doi=10.1016%2Fj.ccr.2006.10.008&volume=10&pages=515-527&publication_year=2006&author=Neve%2CRM?
- What's the revenue for https://doi.org/10.1016%2Fj.ymeth.2009.03.001?
- What's the income generated by http://scholar.google.com/scholar_lookup?&title=ChIP-seq%3A%20Using%20high-throughput%20sequencing%20to%20discover%20protein-DNA%20interactions&journal=Methods&doi=10.1016%2Fj.ymeth.2009.03.001&volume=48&pages=240-248&publication_year=2009&author=Schmidt%2CD each month?
- How much income is https://doi.org/10.1074%2Fjbc.M004424200 earning monthly?
- Revenue of http://scholar.google.com/scholar_lookup?&title=A%20pure%20estrogen%20antagonist%20inhibits%20cyclin%20E-Cdk2%20activity%20in%20MCF-7%20breast%20cancer%20cells%20and%20induces%20accumulation%20of%20p130%E2%80%93E2F4%20complexes%20characteristic%20of%20quiescence&journal=J.%20Biol.%20Chem.&doi=10.1074%2Fjbc.M004424200&volume=275&pages=38221-38229&publication_year=2000&author=Carroll%2CJS&author=Prall%2COW&author=Musgrove%2CEA&author=Sutherland%2CRL
- What's the revenue for https://doi.org/10.1016%2Fj.cell.2006.05.052?
- How much does http://scholar.google.com/scholar_lookup?&title=A%20novel%20role%20for%20high-mobility%20group%20a%20proteins%20in%20cellular%20senescence%20and%20heterochromatin%20formation&journal=Cell&doi=10.1016%2Fj.cell.2006.05.052&volume=126&pages=503-514&publication_year=2006&author=Narita%2CM rake in every month?
- Learn about the earnings of https://citation-needed.springer.com/v2/references/10.1038/ng.730?format=refman&flavour=references
- What's the income of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Antoni%20Hurtado?
- How much does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Antoni%20Hurtado%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en pull in?
- How much does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Kelly%20A%20Holmes make?
- How much does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Kelly%20A%20Holmes%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en rake in every month?
- How much does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Caryn%20S%20Ross-Innes earn?
- What are the earnings of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Caryn%20S%20Ross-Innes%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
- Profit of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Dominic%20Schmidt
- How much does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Dominic%20Schmidt%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en earn?
- How much income does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Jason%20S%20Carroll have?
- How much does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Jason%20S%20Carroll%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en generate monthly?
- How much does https://static-content.springer.com/esm/art%3A10.1038%2Fng.730/MediaObjects/41588_2011_BFng730_MOESM16_ESM.pdf rake in every month?
- https://s100.copyright.com/AppDispatchServlet?title=FOXA1%20is%20a%20key%20determinant%20of%20estrogen%20receptor%20function%20and%20endocrine%20response&author=Antoni%20Hurtado%20et%20al&contentID=10.1038%2Fng.730©right=Springer%20Nature%20America%2C%20Inc.&publication=1061-4036&publicationDate=2010-12-12&publisherName=SpringerNature&orderBeanReset=true's revenue stream
- https://citation-needed.springer.com/v2/references/10.1038/ng.730?format=refman&flavour=citation's revenue stream
- How much money does https://doi.org/10.1186/s13059-023-03161-y make?
- What's the income of https://doi.org/10.1038/s41398-024-02783-5?
- Explore the financials of https://doi.org/10.1038/s41594-023-01181-7
- Get to know https://doi.org/10.1186/s12610-023-00199-7's earnings
- How much cash flow does https://doi.org/10.1186/s12885-023-11421-0 have monthly?
- Check the income stats for https://www.protocols.io/
- What's the financial gain of https://www.natureindex.com/?
- How much does http://www.naturechina.com generate monthly?
- How much does https://www.natureasia.com/ja-jp net monthly?
Analytics and Tracking {📊}
- Google Tag Manager
Libraries {📚}
- Prism.js
- Zoom.js
Emails and Hosting {✉️}
Mail Servers:
- mxa-002c5801.gslb.pphosted.com
- mxb-002c5801.gslb.pphosted.com
Name Servers:
- pdns1.ultradns.net
- pdns2.ultradns.net
- pdns3.ultradns.org
- pdns4.ultradns.org
- pdns5.ultradns.info
- pdns6.ultradns.co.uk
CDN Services {📦}
- Crossref