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DOI . ORG {}

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Doi.org Make Money
  6. Keywords
  7. Topics
  8. Questions
  9. Schema
  10. External Links
  11. Analytics And Tracking
  12. Libraries
  13. Hosting Providers
  14. CDN Services

We began analyzing https://link.springer.com/article/10.1007/s40265-018-0956-9, but it redirected us to https://link.springer.com/article/10.1007/s40265-018-0956-9. The analysis below is for the second page.

Title[redir]:
Adult-Onset Still’s Disease: Molecular Pathophysiology and Therapeutic Advances | Drugs
Description:
Adult-onset Still’s disease (AOSD) is a rare inflammatory disorder of unknown etiology generally characterized by persistent high spiking fever, evanescent rash, and polyarthritis. The pathogenesis of AOSD is only partially known. The pivotal role of macrophage cell activation, which leads to T-helper 1 (Th1) cell cytokine activation, is now well-established in AOSD. Moreover, pro-inflammatory cytokines such as interleukin (IL)-1, -6, and -18 seem to play a key role in this disorder, giving rise to the development of new targeted therapies. For years, treatment of AOSD has been largely empirical, using nonsteroidal anti-inflammatory drugs, corticosteroids, and disease-modifying antirheumatic drugs. Patients with steroid- and methotrexate-refractory AOSD can now benefit from efficient and well-tolerated biologic agents such as IL-1, IL-6, and tumor necrosis factor-α antagonists.

Matching Content Categories {📚}

  • Health & Fitness
  • Science
  • Education

Content Management System {📝}

What CMS is doi.org built with?

Custom-built

No common CMS systems were detected on Doi.org, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of doi.org audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

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How Does Doi.org Make Money? {💸}

We find it hard to spot revenue streams.

Many websites are intended to earn money, but some serve to share ideas or build connections. Websites exist for all kinds of purposes. This might be one of them. Doi.org could be getting rich in stealth mode, or the way it's monetizing isn't detectable.

Keywords {🔍}

pubmed, disease, google, scholar, article, stills, cas, adultonset, rheumatol, adult, arthritis, patients, rheum, central, treatment, clin, chen, onset, refractory, interleukin, clinical, syndrome, systemic, ann, dis, juvenile, study, idiopathic, exp, efficacy, tocilizumab, med, case, sfriso, macrophage, activation, cytokine, res, lin, hsieh, anakinra, drugs, aosd, pathogenesis, therapy, rev, oxford, lee, response, van,

Topics {✒️}

month download article/chapter sara bindoli & paola galozzi macrophage-colony stimulating factor anti-cd20 monoclonal antibody nonsteroidal anti-inflammatory drugs steroidal anti-inflammatory drugs ifn-gamma-producing lymphocytes autologous stem-cell transplantation tnf-alpha-producing macrophages anti-il1 drug anakinra macrophage activation syndrome disease-modifying antirheumatic drugs article drugs aims full article pdf conventional treatment-refractory adult-onset van rossum ma line disease-modifying therapy il-1r inhibitor anakinra anti-interleukin-1 treatment distinguishes gerfaud-valentin privacy choices/manage cookies autoinflammatory disease reloaded anti-tnf-alpha active systemic features nlrp3 inflammasome van der veen high serum level liver biopsy illustrating open label treatment pro-inflammatory cytokines van damme-lombaerts long-acting inhibitor reduced perforin expression article sfriso anti-tnf switching connect tissue res hemophagocytic syndrome anti-interleukin-1 agents nold-petry ca european economic area 5ème édition paris nationwide epidemiological survey toxoplasma gondii infection intercellular adhesion molecule-1 serum cx3cl1 level sampalis js arthritis res ther arthritis care res rare inflammatory disorder tolerated biologic agents

Questions {❓}

  • Is anti-TNF switching in refractory Still’s disease safe and effective?
  • Targeting interleukin-1 b in CAPS (cryopyrin-associated periodic) syndromes: what did we learn?

Schema {🗺️}

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         headline:Adult-Onset Still’s Disease: Molecular Pathophysiology and Therapeutic Advances
         description:Adult-onset Still’s disease (AOSD) is a rare inflammatory disorder of unknown etiology generally characterized by persistent high spiking fever, evanescent rash, and polyarthritis. The pathogenesis of AOSD is only partially known. The pivotal role of macrophage cell activation, which leads to T-helper 1 (Th1) cell cytokine activation, is now well-established in AOSD. Moreover, pro-inflammatory cytokines such as interleukin (IL)-1, -6, and -18 seem to play a key role in this disorder, giving rise to the development of new targeted therapies. For years, treatment of AOSD has been largely empirical, using nonsteroidal anti-inflammatory drugs, corticosteroids, and disease-modifying antirheumatic drugs. Patients with steroid- and methotrexate-refractory AOSD can now benefit from efficient and well-tolerated biologic agents such as IL-1, IL-6, and tumor necrosis factor-α antagonists.
         datePublished:2018-08-01T00:00:00Z
         dateModified:2018-08-01T00:00:00Z
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      headline:Adult-Onset Still’s Disease: Molecular Pathophysiology and Therapeutic Advances
      description:Adult-onset Still’s disease (AOSD) is a rare inflammatory disorder of unknown etiology generally characterized by persistent high spiking fever, evanescent rash, and polyarthritis. The pathogenesis of AOSD is only partially known. The pivotal role of macrophage cell activation, which leads to T-helper 1 (Th1) cell cytokine activation, is now well-established in AOSD. Moreover, pro-inflammatory cytokines such as interleukin (IL)-1, -6, and -18 seem to play a key role in this disorder, giving rise to the development of new targeted therapies. For years, treatment of AOSD has been largely empirical, using nonsteroidal anti-inflammatory drugs, corticosteroids, and disease-modifying antirheumatic drugs. Patients with steroid- and methotrexate-refractory AOSD can now benefit from efficient and well-tolerated biologic agents such as IL-1, IL-6, and tumor necrosis factor-α antagonists.
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External Links {🔗}(345)

Analytics and Tracking {📊}

  • Google Tag Manager

Libraries {📚}

  • Clipboard.js
  • Prism.js

Emails and Hosting {✉️}

Mail Servers:

  • mx.zoho.eu
  • mx2.zoho.eu
  • mx3.zoho.eu

Name Servers:

  • josh.ns.cloudflare.com
  • zita.ns.cloudflare.com

CDN Services {📦}

  • Crossref

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