We are analyzing https://link.springer.com/article/10.1007/s12026-014-8561-9.

Title:
Pathogenesis of adult-onset Still’s disease: new insights from the juvenile counterpart | Immunologic Research
Description:
Adult-onset Still’s disease (AOSD) is a rare inflammatory disease characterized by the classical triad of daily fever, arthritis, and typical salmon-colored rash. Recent accumulation of knowledge, mostly arising from hereditary autoinflammatory diseases and from the systemic-onset juvenile idiopathic arthritis (sJIA), has given raise to new hypotheses on the pathophysiology of AOSD. In this review, we first discuss on the continuum between AOSD and sJIA. Then, we summarize current hypotheses on the underlying pathogenesis: (1) an infectious hypothesis; (2) an autoinflammatory hypothesis; (3) a lymphohistiocytic hypothesis; and (4) a hyperferritinemic hypothesis. Finally, we present the recent data suggesting that patients with AOSD fall into two distinct subgroups with different courses, one with prominent systemic features and one with chronic arthritis.
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Keywords {🔍}

pubmed, google, scholar, article, cas, disease, arthritis, stills, juvenile, idiopathic, adultonset, patients, central, rheumatol, systemic, rheum, adult, onset, syndrome, clin, activation, autoinflammatory, dis, immunol, macrophage, jamilloux, chen, pathogenesis, clinical, gene, rev, ann, lee, kim, interleukin, yvan, systemiconset, treatment, cell, res, research, gerfaudvalentin, association, role, cytokine, profiles, henry, cells, natural, killer,

Topics {✒️}

hemophagocytic lymphohistiocytosis targeting interleukin-1β perforin-mediated target-cell death month download article/chapter mathieu gerfaud-valentin reactive haemophagocytic syndrome secondary hemophagocytic syndrome author information authors alexandre belot iron-independent protein kinase macrophage-colony stimulating factor tnf-alpha-producing macrophages mhc-encoded lmp7 gene typical salmon-colored rash liver biopsy illustrating hôpital femme-mère-enfant hereditary autoinflammatory diseases monogenic autoinflammatory diseases juvenile idiopathic arthritis ifn-gamma-producing lymphocytes circulating cd4 + cd25high regulatory author correspondence anti-interleukin-1 treatment distinguishes il-18/il-18bp gerfaud-valentin serum cytokine profiles full article pdf autoinflammatory diseases plasma il-6 levels line disease-modifying therapy il-1 gene family phd research project proinflammatory cytokine profiles distinct cytokine profiles related subjects check access instant access nlrp3 inflammasome gene expression profiling myeloid-related proteins 8 privacy choices/manage cookies cell death dis autoinflammatory syndromes goldbach-mansky park d pascal sève yvan jamilloux acknowledges nk cell function autoinflammatory disease reloaded ogilvie em

Questions {❓}

Ferritin in adult-onset still’s disease: just a useful innocent bystander?
How should we approach classification of autoinflammatory diseases?
Is Still’s disease an autoinflammatory syndrome?
Still’s disease and the mitochondrion: the other face of an old friend?
Targeting interleukin-1β in CAPS (cryopyrin-associated periodic) syndromes: what did we learn?

Schema {🗺️}

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         headline:Pathogenesis of adult-onset Still’s disease: new insights from the juvenile counterpart
         description: Adult-onset Still’s disease (AOSD) is a rare inflammatory disease characterized by the classical triad of daily fever, arthritis, and typical salmon-colored rash. Recent accumulation of knowledge, mostly arising from hereditary autoinflammatory diseases and from the systemic-onset juvenile idiopathic arthritis (sJIA), has given raise to new hypotheses on the pathophysiology of AOSD. In this review, we first discuss on the continuum between AOSD and sJIA. Then, we summarize current hypotheses on the underlying pathogenesis: (1) an infectious hypothesis; (2) an autoinflammatory hypothesis; (3) a lymphohistiocytic hypothesis; and (4) a hyperferritinemic hypothesis. Finally, we present the recent data suggesting that patients with AOSD fall into two distinct subgroups with different courses, one with prominent systemic features and one with chronic arthritis.
         datePublished:2014-11-12T00:00:00Z
         dateModified:2014-11-12T00:00:00Z
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            Systemic-onset juvenile idiopathic arthritis
            Autoinflammatory diseases
            Reactive hemophagocytic lymphohistiocytosis
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            Ferritin
            Immunology
            Allergology
            Medicine/Public Health
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      headline:Pathogenesis of adult-onset Still’s disease: new insights from the juvenile counterpart
      description: Adult-onset Still’s disease (AOSD) is a rare inflammatory disease characterized by the classical triad of daily fever, arthritis, and typical salmon-colored rash. Recent accumulation of knowledge, mostly arising from hereditary autoinflammatory diseases and from the systemic-onset juvenile idiopathic arthritis (sJIA), has given raise to new hypotheses on the pathophysiology of AOSD. In this review, we first discuss on the continuum between AOSD and sJIA. Then, we summarize current hypotheses on the underlying pathogenesis: (1) an infectious hypothesis; (2) an autoinflammatory hypothesis; (3) a lymphohistiocytic hypothesis; and (4) a hyperferritinemic hypothesis. Finally, we present the recent data suggesting that patients with AOSD fall into two distinct subgroups with different courses, one with prominent systemic features and one with chronic arthritis.
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      dateModified:2014-11-12T00:00:00Z
      pageStart:53
      pageEnd:62
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         Adult-onset Still’s disease
         Systemic-onset juvenile idiopathic arthritis
         Autoinflammatory diseases
         Reactive hemophagocytic lymphohistiocytosis
         IL-1β
         IL-18
         Ferritin
         Immunology
         Allergology
         Medicine/Public Health
         general
         Internal Medicine
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               type:PostalAddress
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      affiliation:
            name:University of Lausanne
            address:
               name:Department of Biochemistry, University of Lausanne, Epalinges, Switzerland
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      name:Alexandre Belot
      affiliation:
            name:University Claude Bernard-Lyon 1
            address:
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            name:Hôpital Femme-Mère-Enfant
            address:
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            address:
               name:International Research Center on Infectiology (CIRI), Inserm U1111, CNRS UMR5308-ENS de Lyon, Lyon, France
               type:PostalAddress
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      affiliation:
            name:Hopital de la Croix-Rousse
            address:
               name:Department of Internal Medicine, Hopital de la Croix-Rousse, Lyon, France
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            type:Organization
            name:University Claude Bernard-Lyon 1
            address:
               name:University Claude Bernard-Lyon 1, Lyon, France
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      name:Department of Internal Medicine, Hopital de la Croix-Rousse, Lyon, France
      name:University Claude Bernard-Lyon 1, Lyon, France
      name:Department of Biochemistry, University of Lausanne, Epalinges, Switzerland
      name:International Research Center on Infectiology (CIRI), Inserm U1111, CNRS UMR5308-ENS de Lyon, Lyon, France
      name:Department of Internal Medicine, Hopital de la Croix-Rousse, Lyon, France
      name:University Claude Bernard-Lyon 1, Lyon, France
      name:Department of Biochemistry, University of Lausanne, Epalinges, Switzerland
      name:University Claude Bernard-Lyon 1, Lyon, France
      name:Department of Paediatric Nephrology, Rheumatology, and Dermatology, Hôpital Femme-Mère-Enfant, Bron, France
      name:University Claude Bernard-Lyon 1, Lyon, France
      name:International Research Center on Infectiology (CIRI), Inserm U1111, CNRS UMR5308-ENS de Lyon, Lyon, France
      name:Department of Internal Medicine, Hopital de la Croix-Rousse, Lyon, France
      name:University Claude Bernard-Lyon 1, Lyon, France
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