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• A retrospective study of patients with adult-onset Still’s disease: is pericarditis a possible predictor for biological disease-modifying anti-rheumatic drugs need?

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         headline:Adult-onset Still’s disease: an Italian multicentre retrospective observational study of manifestations and treatments in 245 patients
         description:Adult-onset Still’s disease (AOSD) is a systemic inflammatory condition of unknown aetiology characterized by typical episodes of spiking fever, evanescent rash, arthralgia, leukocytosis and hyperferritinemia. Given the lack of data in Italian series, we promote a multicentric data collection to characterize the clinical phenotype of Italian patients with AOSD. Data from 245 subjects diagnosed with AOSD were collected by 15 centres between March and May 2013. The diagnosis was made following Yamaguchi’s criteria. Data regarding clinical manifestations, laboratory features, disease course and treatments were reported and compared with those presented in other published series of different ethnicity. The most frequent features were the following: arthritis (93 %), pyrexia (92.6 %), leukocytosis (89 %), negative ANA (90.4 %) and neutrophilia (82 %). As compared to other North American, North European, Middle Eastern and Far Eastern cohorts, Italian data show differences in clinical and laboratory findings. Regarding the treatments, in 21.9 % of cases, corticosteroids and traditional DMARDs have not been able to control the disease while biologics have been shown to be effective in 48 to 58 patients. This retrospective work summarizes the largest Italian multicentre series of AOSD patients and presents clinical and laboratory features that appear to be influenced by the ethnicity of the affected subjects.
         datePublished:2016-05-20T00:00:00Z
         dateModified:2016-05-20T00:00:00Z
         pageStart:1683
         pageEnd:1689
         sameAs:https://doi.org/10.1007/s10067-016-3308-8
         keywords:
            Adult-onset Still’s disease
            Biologic drugs
            Clinical presentation
            Laboratory findings
            Retrospective study
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      headline:Adult-onset Still’s disease: an Italian multicentre retrospective observational study of manifestations and treatments in 245 patients
      description:Adult-onset Still’s disease (AOSD) is a systemic inflammatory condition of unknown aetiology characterized by typical episodes of spiking fever, evanescent rash, arthralgia, leukocytosis and hyperferritinemia. Given the lack of data in Italian series, we promote a multicentric data collection to characterize the clinical phenotype of Italian patients with AOSD. Data from 245 subjects diagnosed with AOSD were collected by 15 centres between March and May 2013. The diagnosis was made following Yamaguchi’s criteria. Data regarding clinical manifestations, laboratory features, disease course and treatments were reported and compared with those presented in other published series of different ethnicity. The most frequent features were the following: arthritis (93 %), pyrexia (92.6 %), leukocytosis (89 %), negative ANA (90.4 %) and neutrophilia (82 %). As compared to other North American, North European, Middle Eastern and Far Eastern cohorts, Italian data show differences in clinical and laboratory findings. Regarding the treatments, in 21.9 % of cases, corticosteroids and traditional DMARDs have not been able to control the disease while biologics have been shown to be effective in 48 to 58 patients. This retrospective work summarizes the largest Italian multicentre series of AOSD patients and presents clinical and laboratory features that appear to be influenced by the ethnicity of the affected subjects.
      datePublished:2016-05-20T00:00:00Z
      dateModified:2016-05-20T00:00:00Z
      pageStart:1683
      pageEnd:1689
      sameAs:https://doi.org/10.1007/s10067-016-3308-8
      keywords:
         Adult-onset Still’s disease
         Biologic drugs
         Clinical presentation
         Laboratory findings
         Retrospective study
         Rheumatology
      image:
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         name:Clinical Rheumatology
         issn:
            1434-9949
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         name:Springer London
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            name:Paolo Sfriso
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            name:Roberta Priori
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            name:Silvia Rossi
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            name:Carlo Maurizio Montecucco
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      name:Rheumatology Section, Department of Clinical and Experimental Internal Medicine, Second University of Napoli, Naples, Italy
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