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  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Doi.org Make Money
  6. Keywords
  7. Topics
  8. Questions
  9. Schema
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We began analyzing https://link.springer.com/article/10.1007/s12031-024-02227-1, but it redirected us to https://link.springer.com/article/10.1007/s12031-024-02227-1. The analysis below is for the second page.

Title[redir]:
Aneuploidy is Linked to Neurological Phenotypes Through Oxidative Stress | Journal of Molecular Neuroscience
Description:
Aneuploidy, having an aberrant genome, is gaining increasing attention in neurodegenerative diseases. It gives rise to proteotoxic stress as well as a stereotypical oxidative shift which makes these cells sensitive to internal and environmental stresses. A growing body of research from numerous laboratories suggests that many neurodegenerative disorders, especially Alzheimer’s disease and frontotemporal dementia, are characterised by neuronal aneuploidy and the ensuing apoptosis, which may contribute to neuronal loss. Using Drosophila as a model, we investigated the effect of induced aneuploidy in GABAergic neurons. We found an increased proportion of aneuploidy due to Mad2 depletion in the third-instar larval brain and increased cell death. Depletion of Mad2 in GABAergic neurons also gave a defective climbing and seizure phenotype. Feeding animals an antioxidant rescued the climbing and seizure phenotype. These findings suggest that increased aneuploidy leads to higher oxidative stress in GABAergic neurons which causes cell death, climbing defects, and seizure phenotype. Antioxidant feeding represents a potential therapy to reduce the aneuploidy-driven neurological phenotype.

Matching Content Categories {📚}

  • Education
  • Science
  • Health & Fitness

Content Management System {📝}

What CMS is doi.org built with?

Custom-built

No common CMS systems were detected on Doi.org, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of doi.org audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
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How Does Doi.org Make Money? {💸}

The income method remains a mystery to us.

Websites don't always need to be profitable; some serve as platforms for education or personal expression. Websites can serve multiple purposes. And this might be one of them. Doi.org might be earning cash quietly, but we haven't detected the monetization method.

Keywords {🔍}

pubmed, aneuploidy, article, google, scholar, cas, cell, brain, central, disease, neurons, drosophila, neurological, climbing, stress, alzheimers, mad, death, increased, control, cells, neuronal, flies, phenotype, oxidative, phenotypes, defects, diseases, depletion, neurodegenerative, gabaergic, seizure, aneuploid, feeding, iourov, yurov, chromosome, adult, disorders, fig, neurogenesis, model, wildtype, mol, analysis, shaukat, chromosomal, repeat, larval, dna,

Topics {✒️}

central nervous system low-level post-zygotic aneuploidy article download pdf dino-lite digital microscope genome-damaged cells safeguards dosage-compensated aneuploids relative unaffected aged-matched controls writing—original draft preparation mad2-depleted larval brains ki67 phospho-protein expression gov/pubmed/9176387 migliore bang-sensitive behavioural assays elevated beta-secretase expression hypoxia-induced cell death clarify genetic-environmental interactions mad2-depleted larval brain gad1-gal4 driver visualised mad2-depleted flies compared bang-sensitivity behavioural assay wild-type larval brain n-acetylcysteine amide chromosome mis-segregation instar larval brains privacy choices/manage cookies free radical formation remain post-mitotic amyloid beta peptide normal climbing ability polyalanine repeat sequence 100 µg/ml naca feeding aneuploidy-driven neurological phenotype age-related neurodegenerative diseases age-related metabolic disorders gabaergic neuron increased spalding kl yurov yb instar larval brain induce neuronal aneuploidy pre-existing neurons stem cell biology article islam wild-type control flies related subjects garcia-verdugo jm medical research institute naca feeding showed climbing defects compared 500 ml measuring cylinder increased oxidative stress spindle assembly checkpoint

Questions {❓}

  • Arendt T, Stieler J, Ueberham U (2017) Is sporadic Alzheimer’s disease a developmental disorder?
  • Neuronal hyperexcitability in Alzheimer’s disease: what are the drivers behind this aberrant phenotype?
  • Vincent I, Rosado M, Davies P (1996) Mitotic mechanisms in Alzheimer’s disease?

Schema {🗺️}

WebPage:
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         headline:Aneuploidy is Linked to Neurological Phenotypes Through Oxidative Stress
         description:Aneuploidy, having an aberrant genome, is gaining increasing attention in neurodegenerative diseases. It gives rise to proteotoxic stress as well as a stereotypical oxidative shift which makes these cells sensitive to internal and environmental stresses. A growing body of research from numerous laboratories suggests that many neurodegenerative disorders, especially Alzheimer’s disease and frontotemporal dementia, are characterised by neuronal aneuploidy and the ensuing apoptosis, which may contribute to neuronal loss. Using Drosophila as a model, we investigated the effect of induced aneuploidy in GABAergic neurons. We found an increased proportion of aneuploidy due to Mad2 depletion in the third-instar larval brain and increased cell death. Depletion of Mad2 in GABAergic neurons also gave a defective climbing and seizure phenotype. Feeding animals an antioxidant rescued the climbing and seizure phenotype. These findings suggest that increased aneuploidy leads to higher oxidative stress in GABAergic neurons which causes cell death, climbing defects, and seizure phenotype. Antioxidant feeding represents a potential therapy to reduce the aneuploidy-driven neurological phenotype.
         datePublished:2024-05-02T00:00:00Z
         dateModified:2024-05-02T00:00:00Z
         pageStart:1
         pageEnd:11
         license:http://creativecommons.org/licenses/by/4.0/
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            Aneuploidy
            GABAergic neuron
            Oxidative stress
            Neurological phenotypes
            Neurosciences
            Neurochemistry
            Cell Biology
            Proteomics
            Neurology
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      headline:Aneuploidy is Linked to Neurological Phenotypes Through Oxidative Stress
      description:Aneuploidy, having an aberrant genome, is gaining increasing attention in neurodegenerative diseases. It gives rise to proteotoxic stress as well as a stereotypical oxidative shift which makes these cells sensitive to internal and environmental stresses. A growing body of research from numerous laboratories suggests that many neurodegenerative disorders, especially Alzheimer’s disease and frontotemporal dementia, are characterised by neuronal aneuploidy and the ensuing apoptosis, which may contribute to neuronal loss. Using Drosophila as a model, we investigated the effect of induced aneuploidy in GABAergic neurons. We found an increased proportion of aneuploidy due to Mad2 depletion in the third-instar larval brain and increased cell death. Depletion of Mad2 in GABAergic neurons also gave a defective climbing and seizure phenotype. Feeding animals an antioxidant rescued the climbing and seizure phenotype. These findings suggest that increased aneuploidy leads to higher oxidative stress in GABAergic neurons which causes cell death, climbing defects, and seizure phenotype. Antioxidant feeding represents a potential therapy to reduce the aneuploidy-driven neurological phenotype.
      datePublished:2024-05-02T00:00:00Z
      dateModified:2024-05-02T00:00:00Z
      pageStart:1
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      license:http://creativecommons.org/licenses/by/4.0/
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      keywords:
         Aneuploidy
         GABAergic neuron
         Oxidative stress
         Neurological phenotypes
         Neurosciences
         Neurochemistry
         Cell Biology
         Proteomics
         Neurology
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            name:Clinical and Health Sciences, University of South Australia
            address:
               name:Epilepsy Research Group, Australian Centre for Precision Health, Clinical and Health Sciences, University of South Australia, Adelaide, Australia
               type:PostalAddress
            type:Organization
      name:Leanne M. Dibbens
      affiliation:
            name:Clinical and Health Sciences, University of South Australia
            address:
               name:Epilepsy Research Group, Australian Centre for Precision Health, Clinical and Health Sciences, University of South Australia, Adelaide, Australia
               type:PostalAddress
            type:Organization
      name:Stephen L. Gregory
      affiliation:
            name:Flinders University
            address:
               name:Flinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, Australia
               type:PostalAddress
            type:Organization
      email:[email protected]
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      name:Flinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, Australia
      name:Epilepsy Research Group, Australian Centre for Precision Health, Clinical and Health Sciences, University of South Australia, Adelaide, Australia
      name:Epilepsy Research Group, Australian Centre for Precision Health, Clinical and Health Sciences, University of South Australia, Adelaide, Australia
      name:Epilepsy Research Group, Australian Centre for Precision Health, Clinical and Health Sciences, University of South Australia, Adelaide, Australia
      name:Epilepsy Research Group, Australian Centre for Precision Health, Clinical and Health Sciences, University of South Australia, Adelaide, Australia
      name:Epilepsy Research Group, Australian Centre for Precision Health, Clinical and Health Sciences, University of South Australia, Adelaide, Australia
      name:Flinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, Australia

External Links {🔗}(433)

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Libraries {📚}

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Mail Servers:

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CDN Services {📦}

  • Crossref

4.8s.