We are analyzing https://link.springer.com/article/10.1186/1755-8166-1-26.

Title:
Chromosomal mosaicism goes global | Molecular Cytogenetics
Description:
Intercellular differences of chromosomal content in the same individual are defined as chromosomal mosaicism (alias intercellular or somatic genomic variations or, in a number of publications, mosaic aneuploidy). It has long been suggested that this phenomenon poorly contributes both to intercellular (interindividual) diversity and to human disease. However, our views have recently become to change due to a series of communications demonstrated a higher incidence of chromosomal mosaicism in diseased individuals (major psychiatric disorders and autoimmune diseases) as well as depicted chromosomal mosaicism contribution to genetic diversity, the central nervous system development, and aging. The later has been produced by significant achievements in the field of molecular cytogenetics. Recently, Molecular Cytogenetics has published an article by Maj Hulten and colleagues that has provided evidences for chromosomal mosaicism to underlie formation of germline aneuploidy in human female gametes using trisomy 21 (Down syndrome) as a model. Since meiotic aneuploidy is suggested to be the leading genetic cause of human prenatal mortality and postnatal morbidity, these data together with previous findings define chromosomal mosaicism not as a casual finding during cytogenetic analyses but as a more significant biological phenomenon than previously recognized. Finally, the significance of chromosomal mosaicism can be drawn from the fact, that this phenomenon is involved in genetic diversity, normal and abnormal prenatal development, human diseases, aging, and meiotic aneuploidy, the intrinsic cause of which remains, as yet, unknown.
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Keywords {🔍}

mosaicism, chromosomal, article, human, pubmed, google, scholar, aneuploidy, chromosome, molecular, yurov, brain, cas, iourov, vorsanova, diseases, central, cytogenetic, somatic, prenatal, studies, tissues, cytogenetics, variations, liehr, genetic, interphase, aneuploidization, cytogenet, research, intercellular, development, aging, original, mol, normal, current, genome, figure, soloviev, authors, analysis, data, genomic, phenomenon, meiotic, published, mosaic, diversity, disease,

Topics {✒️}

made array-cgh-based techniques open-access article distributed allowing bar-coding painting age-/environment-dependant inhibition central nervous system cellular/tissular physiology requires article download pdf low-level mosaic aneuploidy low-level chromosomal aneuploidy array-cgh miss cases high-resolution surveys human tissue-specific pathology privacy choices/manage cookies low-level aneuploidy full size image chromosome mosaicism research uncovering low-level molecular cytogenetic techniques gene expression patterns somatic-germline aneuploidization pathway abnormal prenatal development powerful methodological basis philip morris usa authors’ original file unbalanced chromosome aberrations abnormal external genitalia specific cell population molecular cytogenetic technique molecular cytogenetic developments article iourov confined placental mosaicism multi-system diseases somatic genome variations somatic genome variation accompanies human development chromosomal mosaicism confines chromosomal mosaicism contribution european economic area give experimental support idea put forward strong experimental background severe developmental delays requires additional evaluations large heterochromatin regions post mortem brain technical problems encountered sperm aneuploidy rates main content log real biomedical meaning increasing chromosomal instability

Schema {🗺️}

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         headline:Chromosomal mosaicism goes global
         description:Intercellular differences of chromosomal content in the same individual are defined as chromosomal mosaicism (alias intercellular or somatic genomic variations or, in a number of publications, mosaic aneuploidy). It has long been suggested that this phenomenon poorly contributes both to intercellular (interindividual) diversity and to human disease. However, our views have recently become to change due to a series of communications demonstrated a higher incidence of chromosomal mosaicism in diseased individuals (major psychiatric disorders and autoimmune diseases) as well as depicted chromosomal mosaicism contribution to genetic diversity, the central nervous system development, and aging. The later has been produced by significant achievements in the field of molecular cytogenetics. Recently, Molecular Cytogenetics has published an article by Maj Hulten and colleagues that has provided evidences for chromosomal mosaicism to underlie formation of germline aneuploidy in human female gametes using trisomy 21 (Down syndrome) as a model. Since meiotic aneuploidy is suggested to be the leading genetic cause of human prenatal mortality and postnatal morbidity, these data together with previous findings define chromosomal mosaicism not as a casual finding during cytogenetic analyses but as a more significant biological phenomenon than previously recognized. Finally, the significance of chromosomal mosaicism can be drawn from the fact, that this phenomenon is involved in genetic diversity, normal and abnormal prenatal development, human diseases, aging, and meiotic aneuploidy, the intrinsic cause of which remains, as yet, unknown.
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      headline:Chromosomal mosaicism goes global
      description:Intercellular differences of chromosomal content in the same individual are defined as chromosomal mosaicism (alias intercellular or somatic genomic variations or, in a number of publications, mosaic aneuploidy). It has long been suggested that this phenomenon poorly contributes both to intercellular (interindividual) diversity and to human disease. However, our views have recently become to change due to a series of communications demonstrated a higher incidence of chromosomal mosaicism in diseased individuals (major psychiatric disorders and autoimmune diseases) as well as depicted chromosomal mosaicism contribution to genetic diversity, the central nervous system development, and aging. The later has been produced by significant achievements in the field of molecular cytogenetics. Recently, Molecular Cytogenetics has published an article by Maj Hulten and colleagues that has provided evidences for chromosomal mosaicism to underlie formation of germline aneuploidy in human female gametes using trisomy 21 (Down syndrome) as a model. Since meiotic aneuploidy is suggested to be the leading genetic cause of human prenatal mortality and postnatal morbidity, these data together with previous findings define chromosomal mosaicism not as a casual finding during cytogenetic analyses but as a more significant biological phenomenon than previously recognized. Finally, the significance of chromosomal mosaicism can be drawn from the fact, that this phenomenon is involved in genetic diversity, normal and abnormal prenatal development, human diseases, aging, and meiotic aneuploidy, the intrinsic cause of which remains, as yet, unknown.
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