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Title[redir]:
Mosaic Brain Aneuploidy in Mental Illnesses: An Association of Low-level Post-zygotic Aneuploidy with Schizophrenia and Comorbid Psychiatric Disorders - PMC
Description:
Postzygotic chromosomal variation in neuronal cells is hypothesized to make a substantial contribution to the etiology and pathogenesis of neuropsychiatric disorders. However, the role of somatic genome instability and mosaic genome variations in ...
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Keywords {π}
doi, aneuploidy, brain, pubmed, google, scholar, scz, mosaic, chromosomes, cells, chromosome, pmc, lowlevel, article, sex, free, human, somatic, disorders, frequency, controls, yurov, vorsanova, iourov, control, chromosomal, genome, patients, normal, mental, schizophrenia, tissues, fish, mosaicism, samples, autism, cases, involving, genetic, variation, cell, table, median, number, instability, chromosomespecific, autosomes, genet, comorbid, burden,
Topics {βοΈ}
springer-f7009ee5-7eb3-38c7-95d0-13bca7e0740d low-level post-zygotic aneuploidy large-scale chromosome alterations mosaic low-level aneuploidy low-level mosaic aneuploidy / science/article/pii/s0149763415001360 low-level chromosomal aneuploidy low-level somatic aneuploidy monitoring chromosome-specific aneuploidy site-specific dna probes methanol/acetic acid mixture true low-level aneuploidy sex chromosome-specific aneuploidy gene copy-number alterations sex chromosome-specific probes single-cell sequencing estimates low-level somatic mosaicism pmc beta search autosome/sex chromosome aneuploidy brain-specific chromosome variation chromosome mosaic deletion/duplication low-level autosomal org/plosgenetics/article org/plosone/ article low-level spontaneous post-mortem brain tissues single-cell sequencing studies clarify genetic-environmental interactions chromosome-enumeration dna probes postnatal human germ-line org/content/316/5823/445 [abstract 20] chromosome gain/loss frequency springer science+business media genes negatively affecting low-level aneuploidy genome sequencing reveals [google scholar] 42 [google scholar] 43 [google scholar] 74 lowβlevel mosaicism low-level mosaicism somatic chromosomal mutations involving sex chromosomes chromosome-specific aneuploidy single cell resolution org/doi/abs/10 nervous system disorders dna probes specific single-cell sequencing brain somatic mutations
Questions {β}
- Brain somatic mutations: the dark matter of psychiatric genetics?
- LINE-1 retrotransposons: Mediators of somatic variation in neuronal genomes?
- Mosaike im Gehirn des Menschen: Diagnostische relevanz in der zukunft?
- Com/ science/article/pii/S0149763415001360?
- Edu/ viewdoc/download?
- Org/plosgenetics/article?
- Org/plosone/ article?
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