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🌠 Phenomenal Traffic: 5M - 10M visitors per month


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Keywords {🔍}

doi, google, scholar, pubmed, human, genome, aneuploidy, aging, brain, chromosome, cin, variations, cells, ontogeny, pmc, yurov, vorsanova, genomic, diseases, ontogenetic, sgv, iourov, article, development, prenatal, chromosomal, free, instability, somatic, cell, gin, mosaicism, studies, variation, rates, tissues, early, stages, gincin, normal, mol, cytogenet, disease, natural, due, abnormal, chromosomes, data, res, nlm,

Topics {✒️}

pmc beta search low-level chromosomal mosaicism low-level mosaic aneuploidy low-level chromosomal aneuploidy random tissue-specific distribution publisher site pdf human cleavage-stage embryos altered genome exhibits gin'n'cin hypothesis full karyotype analysis concluding remarks exhibit increased rates philip morris usa license information pmcid tissue-specific chromosomal mosaicism single-cell genomic [google scholar] 4 [google scholar] 53 molecular cytogenetic studies demonstrated gene mutations �average cell concept” single-cell biology demonstrates genomic variations induce chromosome missegregation average cell genome” previous ontogenetic periods aneuploid cell lines acquired genomic instability programmed cell death molecular cytogenetic technologies demonstrates high rates single cell analysis transfected human cells somatic gene mutation abnormal mitotic behavior somatic genome variations united states government voinova-ulas viu voinova-ulas vy mediates cerebellar degeneration post-mitotic neurons changing current assessing somatic genomic variations aging-related alterations ontogenetic genome variations mediate developmental regulatory accelerated senescent phenotypes normal ontogenetic variations autistic spectrum disorders van den berg

Questions {❓}

• Brain Aneuploidy + ?
• Cell division in the CNS: protective response or lethal event in post-mitotic neurons?
• Down syndrome(trisomy 21) Blood lymphocytes (other tissues are rarely analyzed) 100% (?
• NA Aneuploidy/structural abnormalities + ?
• Somatic genome variations interact with environment, genome and epigenome in the determination of the phenotype: a paradigm shift in genomics?
• What can progeroid syndromes tell us about human aging?

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