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  2. Matching Content Categories
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We began analyzing https://link.springer.com/article/10.1007/s10552-014-0361-y, but it redirected us to https://link.springer.com/article/10.1007/s10552-014-0361-y. The analysis below is for the second page.

Title[redir]:
Genetic variation in vitamin D-related genes and risk of colorectal cancer in African Americans | Cancer Causes & Control
Description:
Disparities in both colorectal cancer (CRC) incidence and survival impact African Americans (AAs) more than other US ethnic groups. Because vitamin D is thought to protect against CRC and AAs have lower serum vitamin D levels, genetic variants that modulate the levels of active hormone in the tissues could explain some of the cancer health disparity. Consequently, we hypothesized that genetic variants in vitamin D-related genes are associated with CRC risk. To test this hypothesis, we studied 39 potentially functional single-nucleotide polymorphisms (SNPs) in eight genes (CYP2R1, CYP3A4, CYP24A1, CYP27A1, CYP27B1, GC, DHCR7, and VDR) in 961 AA CRC cases and 838 healthy AA controls from Chicago and North Carolina. We tested whether SNPs are associated with CRC incidence using logistic regression models to calculate p values, odds ratios, and 95 % confidence intervals. In the logistic regression, we used a log-additive genetic model and used age, gender, and percent West African ancestry, which we estimated with the program STRUCTURE, as covariates in the models. A nominally significant association was detected between CRC and the SNP rs12794714 in the vitamin D 25-hydroxylase gene CYP2R1 (p = 0.019), a SNP that has previously been associated with serum vitamin D levels. Two SNPs, rs16847024 in the GC gene and rs6022990 in the CYP24A1 gene, were nominally associated with left-sided CRC (p = 0.015 and p = 0.018, respectively). Our results strongly suggest that genetic variation in vitamin D-related genes could affect CRC susceptibility in AAs.

Matching Content Categories {📚}

  • Education
  • Health & Fitness
  • Science

Content Management System {📝}

What CMS is doi.org built with?

Custom-built

No common CMS systems were detected on Doi.org, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of doi.org audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


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How Does Doi.org Make Money? {💸}

The income method remains a mystery to us.

The purpose of some websites isn't monetary gain; they're meant to inform, educate, or foster collaboration. Everyone has unique reasons for building websites. This could be an example. Doi.org might be earning cash quietly, but we haven't detected the monetization method.

Keywords {🔍}

vitamin, cancer, pubmed, google, scholar, article, crc, cas, study, levels, colorectal, colon, risk, snps, ohd, serum, genetic, genes, cases, central, table, association, cypa, analysis, drelated, snp, african, aas, groups, data, americans, age, polymorphisms, associations, health, controls, hydroxyvitamin, cccc, allele, lcrc, protein, ncccs, chicago, values, significant, gene, studies, university, rcrc, epidemiol,

Topics {✒️}

article download pdf population-based case–control study megalin-receptor-mediated endocytosis medicare-eligible beneficiaries obtained genome-wide association study log-additive genetic model nonsteroidal anti-inflammatory drugs vitamin d-related genes vitamin d-related polymorphisms nested case–control study gene group-specific component sided chi-square test left-sided colorectal cancer american cancer society left-sided colon cancer vitamin d-binding protein end results–medicare data permuting case–control status vitamin d-related snps multiple testing gene-wide chicago medical center single-nucleotide polymorphisms single nucleotide polymorphisms crc health disparities privacy choices/manage cookies inflammatory bowel disease cancer-related deaths article pibiri r-crc development compared postmenopausal breast cancer asymptomatic average-risk individuals european american men full access health professionals follow receptor gene expression gene-wide basis medical records ascertained eastern north carolina north carolina division cancer health disparity rectal–sigmoid cancers west african ancestry left-sided colonic central hypothesis human genetics 25-hydroxyvitamin d-24-hydroxylase case–control study individual ancestry estimates individual study groups larger study groups

Questions {❓}

  • Garland CF, Garland FC (1980) Do sunlight and vitamin D reduce the likelihood of colon cancer?
  • Lagergren J, Ye W, Ekbom A (2001) Intestinal cancer after cholecystectomy: is bile involved in carcinogenesis?
  • Meguid RA, Slidell MB, Wolfgang CL, Chang DC, Ahuja N (2008) Is there a difference in survival between right-versus left-sided colon cancers?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Genetic variation in vitamin D-related genes and risk of colorectal cancer in African Americans
         description:Disparities in both colorectal cancer (CRC) incidence and survival impact African Americans (AAs) more than other US ethnic groups. Because vitamin D is thought to protect against CRC and AAs have lower serum vitamin D levels, genetic variants that modulate the levels of active hormone in the tissues could explain some of the cancer health disparity. Consequently, we hypothesized that genetic variants in vitamin D-related genes are associated with CRC risk. To test this hypothesis, we studied 39 potentially functional single-nucleotide polymorphisms (SNPs) in eight genes (CYP2R1, CYP3A4, CYP24A1, CYP27A1, CYP27B1, GC, DHCR7, and VDR) in 961 AA CRC cases and 838 healthy AA controls from Chicago and North Carolina. We tested whether SNPs are associated with CRC incidence using logistic regression models to calculate p values, odds ratios, and 95 % confidence intervals. In the logistic regression, we used a log-additive genetic model and used age, gender, and percent West African ancestry, which we estimated with the program STRUCTURE, as covariates in the models. A nominally significant association was detected between CRC and the SNP rs12794714 in the vitamin D 25-hydroxylase gene CYP2R1 (p = 0.019), a SNP that has previously been associated with serum vitamin D levels. Two SNPs, rs16847024 in the GC gene and rs6022990 in the CYP24A1 gene, were nominally associated with left-sided CRC (p = 0.015 and p = 0.018, respectively). Our results strongly suggest that genetic variation in vitamin D-related genes could affect CRC susceptibility in AAs.
         datePublished:2014-02-23T00:00:00Z
         dateModified:2014-02-23T00:00:00Z
         pageStart:561
         pageEnd:570
         sameAs:https://doi.org/10.1007/s10552-014-0361-y
         keywords:
            Vitamin D
            Colorectal cancer
            Genetic risk factors
            Cancer health disparities
            African American population
            Cancer Research
            Biomedicine
            general
            Oncology
            Public Health
            Epidemiology
            Hematology
         image:
         isPartOf:
            name:Cancer Causes & Control
            issn:
               1573-7225
               0957-5243
            volumeNumber:25
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer International Publishing
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
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               name:Fabio Pibiri
               affiliation:
                     name:University of Illinois at Chicago
                     address:
                        name:Department of Pediatrics and the Institute of Human Genetics, University of Illinois at Chicago, Chicago, USA
                        type:PostalAddress
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               affiliation:
                     name:University of Illinois at Chicago
                     address:
                        name:Department of Medicine and the Institute of Human Genetics, University of Illinois at Chicago, Chicago, USA
                        type:PostalAddress
                     type:Organization
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               name:Robert S. Sandler
               affiliation:
                     name:University of North Carolina
                     address:
                        name:Division of Gastroenterology and Hepatology, Department of Medicine, University of North Carolina, Chapel Hill, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Temitope O. Keku
               affiliation:
                     name:University of North Carolina
                     address:
                        name:Division of Gastroenterology and Hepatology, Department of Medicine, University of North Carolina, Chapel Hill, USA
                        type:PostalAddress
                     type:Organization
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               name:Sonia S. Kupfer
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                     name:University of Chicago Medicine
                     address:
                        name:Department of Medicine, Section of Gastroenterology, Hepatology and Nutrition, University of Chicago Medicine, Chicago, USA
                        type:PostalAddress
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                     address:
                        name:Department of Medicine and the Institute of Human Genetics, University of Illinois at Chicago, Chicago, USA
                        type:PostalAddress
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               affiliation:
                     name:University of Illinois at Chicago
                     address:
                        name:Department of Medicine and the Institute of Human Genetics, University of Illinois at Chicago, Chicago, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Nathan A. Ellis
               affiliation:
                     name:University of Illinois at Chicago
                     address:
                        name:Department of Pediatrics and the Institute of Human Genetics, University of Illinois at Chicago, Chicago, USA
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:1
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Genetic variation in vitamin D-related genes and risk of colorectal cancer in African Americans
      description:Disparities in both colorectal cancer (CRC) incidence and survival impact African Americans (AAs) more than other US ethnic groups. Because vitamin D is thought to protect against CRC and AAs have lower serum vitamin D levels, genetic variants that modulate the levels of active hormone in the tissues could explain some of the cancer health disparity. Consequently, we hypothesized that genetic variants in vitamin D-related genes are associated with CRC risk. To test this hypothesis, we studied 39 potentially functional single-nucleotide polymorphisms (SNPs) in eight genes (CYP2R1, CYP3A4, CYP24A1, CYP27A1, CYP27B1, GC, DHCR7, and VDR) in 961 AA CRC cases and 838 healthy AA controls from Chicago and North Carolina. We tested whether SNPs are associated with CRC incidence using logistic regression models to calculate p values, odds ratios, and 95 % confidence intervals. In the logistic regression, we used a log-additive genetic model and used age, gender, and percent West African ancestry, which we estimated with the program STRUCTURE, as covariates in the models. A nominally significant association was detected between CRC and the SNP rs12794714 in the vitamin D 25-hydroxylase gene CYP2R1 (p = 0.019), a SNP that has previously been associated with serum vitamin D levels. Two SNPs, rs16847024 in the GC gene and rs6022990 in the CYP24A1 gene, were nominally associated with left-sided CRC (p = 0.015 and p = 0.018, respectively). Our results strongly suggest that genetic variation in vitamin D-related genes could affect CRC susceptibility in AAs.
      datePublished:2014-02-23T00:00:00Z
      dateModified:2014-02-23T00:00:00Z
      pageStart:561
      pageEnd:570
      sameAs:https://doi.org/10.1007/s10552-014-0361-y
      keywords:
         Vitamin D
         Colorectal cancer
         Genetic risk factors
         Cancer health disparities
         African American population
         Cancer Research
         Biomedicine
         general
         Oncology
         Public Health
         Epidemiology
         Hematology
      image:
      isPartOf:
         name:Cancer Causes & Control
         issn:
            1573-7225
            0957-5243
         volumeNumber:25
         type:
            Periodical
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      publisher:
         name:Springer International Publishing
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Fabio Pibiri
            affiliation:
                  name:University of Illinois at Chicago
                  address:
                     name:Department of Pediatrics and the Institute of Human Genetics, University of Illinois at Chicago, Chicago, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Rick A. Kittles
            affiliation:
                  name:University of Illinois at Chicago
                  address:
                     name:Department of Medicine and the Institute of Human Genetics, University of Illinois at Chicago, Chicago, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Robert S. Sandler
            affiliation:
                  name:University of North Carolina
                  address:
                     name:Division of Gastroenterology and Hepatology, Department of Medicine, University of North Carolina, Chapel Hill, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Temitope O. Keku
            affiliation:
                  name:University of North Carolina
                  address:
                     name:Division of Gastroenterology and Hepatology, Department of Medicine, University of North Carolina, Chapel Hill, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Sonia S. Kupfer
            affiliation:
                  name:University of Chicago Medicine
                  address:
                     name:Department of Medicine, Section of Gastroenterology, Hepatology and Nutrition, University of Chicago Medicine, Chicago, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Rosa M. Xicola
            affiliation:
                  name:University of Illinois at Chicago
                  address:
                     name:Department of Medicine and the Institute of Human Genetics, University of Illinois at Chicago, Chicago, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Xavier Llor
            affiliation:
                  name:University of Illinois at Chicago
                  address:
                     name:Department of Medicine and the Institute of Human Genetics, University of Illinois at Chicago, Chicago, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Nathan A. Ellis
            affiliation:
                  name:University of Illinois at Chicago
                  address:
                     name:Department of Pediatrics and the Institute of Human Genetics, University of Illinois at Chicago, Chicago, USA
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      name:Springer International Publishing
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      name:University of Illinois at Chicago
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         name:Department of Pediatrics and the Institute of Human Genetics, University of Illinois at Chicago, Chicago, USA
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         name:Department of Medicine and the Institute of Human Genetics, University of Illinois at Chicago, Chicago, USA
         type:PostalAddress
      name:University of North Carolina
      address:
         name:Division of Gastroenterology and Hepatology, Department of Medicine, University of North Carolina, Chapel Hill, USA
         type:PostalAddress
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      address:
         name:Division of Gastroenterology and Hepatology, Department of Medicine, University of North Carolina, Chapel Hill, USA
         type:PostalAddress
      name:University of Chicago Medicine
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         name:Department of Medicine, Section of Gastroenterology, Hepatology and Nutrition, University of Chicago Medicine, Chicago, USA
         type:PostalAddress
      name:University of Illinois at Chicago
      address:
         name:Department of Medicine and the Institute of Human Genetics, University of Illinois at Chicago, Chicago, USA
         type:PostalAddress
      name:University of Illinois at Chicago
      address:
         name:Department of Medicine and the Institute of Human Genetics, University of Illinois at Chicago, Chicago, USA
         type:PostalAddress
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      name:Fabio Pibiri
      affiliation:
            name:University of Illinois at Chicago
            address:
               name:Department of Pediatrics and the Institute of Human Genetics, University of Illinois at Chicago, Chicago, USA
               type:PostalAddress
            type:Organization
      name:Rick A. Kittles
      affiliation:
            name:University of Illinois at Chicago
            address:
               name:Department of Medicine and the Institute of Human Genetics, University of Illinois at Chicago, Chicago, USA
               type:PostalAddress
            type:Organization
      name:Robert S. Sandler
      affiliation:
            name:University of North Carolina
            address:
               name:Division of Gastroenterology and Hepatology, Department of Medicine, University of North Carolina, Chapel Hill, USA
               type:PostalAddress
            type:Organization
      name:Temitope O. Keku
      affiliation:
            name:University of North Carolina
            address:
               name:Division of Gastroenterology and Hepatology, Department of Medicine, University of North Carolina, Chapel Hill, USA
               type:PostalAddress
            type:Organization
      name:Sonia S. Kupfer
      affiliation:
            name:University of Chicago Medicine
            address:
               name:Department of Medicine, Section of Gastroenterology, Hepatology and Nutrition, University of Chicago Medicine, Chicago, USA
               type:PostalAddress
            type:Organization
      name:Rosa M. Xicola
      affiliation:
            name:University of Illinois at Chicago
            address:
               name:Department of Medicine and the Institute of Human Genetics, University of Illinois at Chicago, Chicago, USA
               type:PostalAddress
            type:Organization
      name:Xavier Llor
      affiliation:
            name:University of Illinois at Chicago
            address:
               name:Department of Medicine and the Institute of Human Genetics, University of Illinois at Chicago, Chicago, USA
               type:PostalAddress
            type:Organization
      name:Nathan A. Ellis
      affiliation:
            name:University of Illinois at Chicago
            address:
               name:Department of Pediatrics and the Institute of Human Genetics, University of Illinois at Chicago, Chicago, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Department of Pediatrics and the Institute of Human Genetics, University of Illinois at Chicago, Chicago, USA
      name:Department of Medicine and the Institute of Human Genetics, University of Illinois at Chicago, Chicago, USA
      name:Division of Gastroenterology and Hepatology, Department of Medicine, University of North Carolina, Chapel Hill, USA
      name:Division of Gastroenterology and Hepatology, Department of Medicine, University of North Carolina, Chapel Hill, USA
      name:Department of Medicine, Section of Gastroenterology, Hepatology and Nutrition, University of Chicago Medicine, Chicago, USA
      name:Department of Medicine and the Institute of Human Genetics, University of Illinois at Chicago, Chicago, USA
      name:Department of Medicine and the Institute of Human Genetics, University of Illinois at Chicago, Chicago, USA
      name:Department of Pediatrics and the Institute of Human Genetics, University of Illinois at Chicago, Chicago, USA

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