We are analyzing https://link.springer.com/article/10.1007/s10620-011-1926-1.

Title:
Circulating Vitamin D and Colorectal Adenoma in Asymptomatic Average-Risk Individuals Who Underwent First Screening Colonoscopy: A Case–Control Study | Digestive Diseases and Sciences
Description:
A higher circulating vitamin D level is inversely associated with the risk of colorectal cancer, but the association with adenoma risk is less clear. We examined the association between the circulating 25-hydroxyvitamin D3 [25(OH)D3] concentration and colorectal adenoma in asymptomatic average-risk participants undergoing initial screening colonoscopy. The study subjects were comprised of 143 cases of colorectal adenomas and 143 age- and gender-matched controls with normal colonoscopy among the 586 asymptomatic average-risk subjects (median age, 58 years; range, 50–73 years) who underwent first screening colonoscopy and measurement of the serum 25(OH)D3 between December 2009 and April 2010, consistent with winter months of the region. The mean concentration of serum 25(OH)D3 in the adenoma and control groups was 20.0 ± 11.0 ng/ml and 25.0 ± 20.0 ng/ml, respectively (P = 0.009). Using multivariate analysis, higher levels of 25(OH)D3 were associated with a statistically significant decreased risk of colorectal adenoma after multivariable adjustment (highest vs. lowest quartile OR 0.38, 95% CI 0.18–0.80, P trend = 0.012). The inverse association of circulating 25(OH)D3 with colorectal adenoma was stronger among the patients with proximal adenoma than that among the patients without proximal adenoma (highest vs. lowest quartile OR 0.29, 95% CI 0.13–0.66, P trend = 0.001). The present study suggests that high levels of circulating vitamin D are associated with a decreased risk of colorectal adenoma, and especially adenoma located in the proximal colon.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Education
Health & Fitness
Cryptocurrency

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We can't see how the site brings in money.

Earning money isn't the goal of every website; some are designed to offer support or promote social causes. People have different reasons for creating websites. This might be one such reason. Link.springer.com might be plotting its profit, but the way they're doing it isn't detectable yet.

Keywords {🔍}

google, scholar, pubmed, article, vitamin, colorectal, cancer, cas, adenoma, risk, calcium, epidemiol, hydroxyvitamin, circulating, study, biomarkers, prev, colonoscopy, colon, adenomas, access, garland, asymptomatic, sung, association, ohd, serum, nutr, privacy, cookies, content, averagerisk, casecontrol, hong, kim, normal, prevention, giovannucci, konkuk, university, medicine, publish, search, screening, choe, subjects, levels, decreased, patients, open,

Topics {✒️}

month download article/chapter mina hur & yeo-min yun article digestive diseases pooled case–control study nonsteroidal anti-inflammatory drug hyung seok park & chan 25-hydroxyvitamin d-1alpha-hydroxylase e3n-epic prospective study population-based prospective cohorts french case–control study asymptomatic average-risk individuals 25-hydroxyvitamin d3–1{alpha}-hydroxylase advanced colonic neoplasia boutron-ruault mc jeong hwan kim full article pdf case–control study yeo-min yun privacy choices/manage cookies dis colon rectum article hong malignant human colon malignant colon tissue related subjects hee-won moon present study suggests average-risk screenees 40 gorham ed natl cancer inst european economic area sun-young lee gender-matched controls konkuk university school conditions privacy policy dong choon seol study subjects won hyeok choe colon cancer decreased adenoma recurrence check access instant access screening colonoscopy distal colorectal adenoma accepting optional cookies article log ann intern med colorectal adenoma recurrence quantitative meta analysis colorectal adenoma risk author information authors

Questions {❓}

Calcium, vitamin D, and risk for colorectal adenoma: dependency on vitamin D receptor Bsmi polymorphism and nonsteroidal anti-inflammatory drug use?
Do sunlight and vitamin D reduce the likelihood of colon cancer?
Epidemiology of vitamin D and colorectal cancer: casual or causal link?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Circulating Vitamin D and Colorectal Adenoma in Asymptomatic Average-Risk Individuals Who Underwent First Screening Colonoscopy: A Case–Control Study
         description:A higher circulating vitamin D level is inversely associated with the risk of colorectal cancer, but the association with adenoma risk is less clear. We examined the association between the circulating 25-hydroxyvitamin D3 [25(OH)D3] concentration and colorectal adenoma in asymptomatic average-risk participants undergoing initial screening colonoscopy. The study subjects were comprised of 143 cases of colorectal adenomas and 143 age- and gender-matched controls with normal colonoscopy among the 586 asymptomatic average-risk subjects (median age, 58 years; range, 50–73 years) who underwent first screening colonoscopy and measurement of the serum 25(OH)D3 between December 2009 and April 2010, consistent with winter months of the region. The mean concentration of serum 25(OH)D3 in the adenoma and control groups was 20.0 ± 11.0 ng/ml and 25.0 ± 20.0 ng/ml, respectively (P = 0.009). Using multivariate analysis, higher levels of 25(OH)D3 were associated with a statistically significant decreased risk of colorectal adenoma after multivariable adjustment (highest vs. lowest quartile OR 0.38, 95% CI 0.18–0.80, P trend = 0.012). The inverse association of circulating 25(OH)D3 with colorectal adenoma was stronger among the patients with proximal adenoma than that among the patients without proximal adenoma (highest vs. lowest quartile OR 0.29, 95% CI 0.13–0.66, P trend = 0.001). The present study suggests that high levels of circulating vitamin D are associated with a decreased risk of colorectal adenoma, and especially adenoma located in the proximal colon.
         datePublished:2011-10-08T00:00:00Z
         dateModified:2011-10-08T00:00:00Z
         pageStart:753
         pageEnd:763
         sameAs:https://doi.org/10.1007/s10620-011-1926-1
         keywords:
            Colorectal adenoma
            Vitamin D
            25-hydroxyvitamin D3
            Colonoscopy
            Case–control study
            Gastroenterology
            Hepatology
            Oncology
            Transplant Surgery
            Biochemistry
            general
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10620-011-1926-1/MediaObjects/10620_2011_1926_Fig1_HTML.gif
         isPartOf:
            name:Digestive Diseases and Sciences
            issn:
               1573-2568
               0163-2116
            volumeNumber:57
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer US
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Sung Noh Hong
               affiliation:
                     name:Konkuk University School of Medicine
                     address:
                        name:Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea
                        type:PostalAddress
                     type:Organization
                     name:Konkuk University School of Medicine
                     address:
                        name:Medical Immunology Center, Institute of Biomedical Science and Technology, Konkuk University School of Medicine, Seoul, Korea
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Jeong Hwan Kim
               affiliation:
                     name:Konkuk University School of Medicine
                     address:
                        name:Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea
                        type:PostalAddress
                     type:Organization
                     name:Konkuk University School of Medicine
                     address:
                        name:Medical Immunology Center, Institute of Biomedical Science and Technology, Konkuk University School of Medicine, Seoul, Korea
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Won Hyeok Choe
               affiliation:
                     name:Konkuk University School of Medicine
                     address:
                        name:Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Sun-Young Lee
               affiliation:
                     name:Konkuk University School of Medicine
                     address:
                        name:Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Dong Choon Seol
               affiliation:
                     name:Konkuk University School of Medicine
                     address:
                        name:Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Hee-Won Moon
               affiliation:
                     name:Konkuk University School of Medicine
                     address:
                        name:Department of Laboratory Medicine, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Mina Hur
               affiliation:
                     name:Konkuk University School of Medicine
                     address:
                        name:Department of Laboratory Medicine, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Yeo-Min Yun
               affiliation:
                     name:Konkuk University School of Medicine
                     address:
                        name:Department of Laboratory Medicine, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea
                        type:PostalAddress
                     type:Organization
               type:Person
               name:In Kyung Sung
               affiliation:
                     name:Konkuk University School of Medicine
                     address:
                        name:Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:Hyung Seok Park
               affiliation:
                     name:Konkuk University School of Medicine
                     address:
                        name:Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Chan Sup Shim
               affiliation:
                     name:Konkuk University School of Medicine
                     address:
                        name:Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea
                        type:PostalAddress
                     type:Organization
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Circulating Vitamin D and Colorectal Adenoma in Asymptomatic Average-Risk Individuals Who Underwent First Screening Colonoscopy: A Case–Control Study
      description:A higher circulating vitamin D level is inversely associated with the risk of colorectal cancer, but the association with adenoma risk is less clear. We examined the association between the circulating 25-hydroxyvitamin D3 [25(OH)D3] concentration and colorectal adenoma in asymptomatic average-risk participants undergoing initial screening colonoscopy. The study subjects were comprised of 143 cases of colorectal adenomas and 143 age- and gender-matched controls with normal colonoscopy among the 586 asymptomatic average-risk subjects (median age, 58 years; range, 50–73 years) who underwent first screening colonoscopy and measurement of the serum 25(OH)D3 between December 2009 and April 2010, consistent with winter months of the region. The mean concentration of serum 25(OH)D3 in the adenoma and control groups was 20.0 ± 11.0 ng/ml and 25.0 ± 20.0 ng/ml, respectively (P = 0.009). Using multivariate analysis, higher levels of 25(OH)D3 were associated with a statistically significant decreased risk of colorectal adenoma after multivariable adjustment (highest vs. lowest quartile OR 0.38, 95% CI 0.18–0.80, P trend = 0.012). The inverse association of circulating 25(OH)D3 with colorectal adenoma was stronger among the patients with proximal adenoma than that among the patients without proximal adenoma (highest vs. lowest quartile OR 0.29, 95% CI 0.13–0.66, P trend = 0.001). The present study suggests that high levels of circulating vitamin D are associated with a decreased risk of colorectal adenoma, and especially adenoma located in the proximal colon.
      datePublished:2011-10-08T00:00:00Z
      dateModified:2011-10-08T00:00:00Z
      pageStart:753
      pageEnd:763
      sameAs:https://doi.org/10.1007/s10620-011-1926-1
      keywords:
         Colorectal adenoma
         Vitamin D
         25-hydroxyvitamin D3
         Colonoscopy
         Case–control study
         Gastroenterology
         Hepatology
         Oncology
         Transplant Surgery
         Biochemistry
         general
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10620-011-1926-1/MediaObjects/10620_2011_1926_Fig1_HTML.gif
      isPartOf:
         name:Digestive Diseases and Sciences
         issn:
            1573-2568
            0163-2116
         volumeNumber:57
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer US
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Sung Noh Hong
            affiliation:
                  name:Konkuk University School of Medicine
                  address:
                     name:Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea
                     type:PostalAddress
                  type:Organization
                  name:Konkuk University School of Medicine
                  address:
                     name:Medical Immunology Center, Institute of Biomedical Science and Technology, Konkuk University School of Medicine, Seoul, Korea
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Jeong Hwan Kim
            affiliation:
                  name:Konkuk University School of Medicine
                  address:
                     name:Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea
                     type:PostalAddress
                  type:Organization
                  name:Konkuk University School of Medicine
                  address:
                     name:Medical Immunology Center, Institute of Biomedical Science and Technology, Konkuk University School of Medicine, Seoul, Korea
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Won Hyeok Choe
            affiliation:
                  name:Konkuk University School of Medicine
                  address:
                     name:Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Sun-Young Lee
            affiliation:
                  name:Konkuk University School of Medicine
                  address:
                     name:Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Dong Choon Seol
            affiliation:
                  name:Konkuk University School of Medicine
                  address:
                     name:Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Hee-Won Moon
            affiliation:
                  name:Konkuk University School of Medicine
                  address:
                     name:Department of Laboratory Medicine, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Mina Hur
            affiliation:
                  name:Konkuk University School of Medicine
                  address:
                     name:Department of Laboratory Medicine, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Yeo-Min Yun
            affiliation:
                  name:Konkuk University School of Medicine
                  address:
                     name:Department of Laboratory Medicine, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea
                     type:PostalAddress
                  type:Organization
            type:Person
            name:In Kyung Sung
            affiliation:
                  name:Konkuk University School of Medicine
                  address:
                     name:Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Hyung Seok Park
            affiliation:
                  name:Konkuk University School of Medicine
                  address:
                     name:Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Chan Sup Shim
            affiliation:
                  name:Konkuk University School of Medicine
                  address:
                     name:Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea
                     type:PostalAddress
                  type:Organization
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Digestive Diseases and Sciences
      issn:
         1573-2568
         0163-2116
      volumeNumber:57
Organization:
      name:Springer US
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Konkuk University School of Medicine
      address:
         name:Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea
         type:PostalAddress
      name:Konkuk University School of Medicine
      address:
         name:Medical Immunology Center, Institute of Biomedical Science and Technology, Konkuk University School of Medicine, Seoul, Korea
         type:PostalAddress
      name:Konkuk University School of Medicine
      address:
         name:Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea
         type:PostalAddress
      name:Konkuk University School of Medicine
      address:
         name:Medical Immunology Center, Institute of Biomedical Science and Technology, Konkuk University School of Medicine, Seoul, Korea
         type:PostalAddress
      name:Konkuk University School of Medicine
      address:
         name:Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea
         type:PostalAddress
      name:Konkuk University School of Medicine
      address:
         name:Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea
         type:PostalAddress
      name:Konkuk University School of Medicine
      address:
         name:Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea
         type:PostalAddress
      name:Konkuk University School of Medicine
      address:
         name:Department of Laboratory Medicine, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea
         type:PostalAddress
      name:Konkuk University School of Medicine
      address:
         name:Department of Laboratory Medicine, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea
         type:PostalAddress
      name:Konkuk University School of Medicine
      address:
         name:Department of Laboratory Medicine, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea
         type:PostalAddress
      name:Konkuk University School of Medicine
      address:
         name:Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea
         type:PostalAddress
      name:Konkuk University School of Medicine
      address:
         name:Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea
         type:PostalAddress
      name:Konkuk University School of Medicine
      address:
         name:Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Sung Noh Hong
      affiliation:
            name:Konkuk University School of Medicine
            address:
               name:Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea
               type:PostalAddress
            type:Organization
            name:Konkuk University School of Medicine
            address:
               name:Medical Immunology Center, Institute of Biomedical Science and Technology, Konkuk University School of Medicine, Seoul, Korea
               type:PostalAddress
            type:Organization
      name:Jeong Hwan Kim
      affiliation:
            name:Konkuk University School of Medicine
            address:
               name:Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea
               type:PostalAddress
            type:Organization
            name:Konkuk University School of Medicine
            address:
               name:Medical Immunology Center, Institute of Biomedical Science and Technology, Konkuk University School of Medicine, Seoul, Korea
               type:PostalAddress
            type:Organization
      name:Won Hyeok Choe
      affiliation:
            name:Konkuk University School of Medicine
            address:
               name:Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea
               type:PostalAddress
            type:Organization
      name:Sun-Young Lee
      affiliation:
            name:Konkuk University School of Medicine
            address:
               name:Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea
               type:PostalAddress
            type:Organization
      name:Dong Choon Seol
      affiliation:
            name:Konkuk University School of Medicine
            address:
               name:Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea
               type:PostalAddress
            type:Organization
      name:Hee-Won Moon
      affiliation:
            name:Konkuk University School of Medicine
            address:
               name:Department of Laboratory Medicine, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea
               type:PostalAddress
            type:Organization
      name:Mina Hur
      affiliation:
            name:Konkuk University School of Medicine
            address:
               name:Department of Laboratory Medicine, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea
               type:PostalAddress
            type:Organization
      name:Yeo-Min Yun
      affiliation:
            name:Konkuk University School of Medicine
            address:
               name:Department of Laboratory Medicine, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea
               type:PostalAddress
            type:Organization
      name:In Kyung Sung
      affiliation:
            name:Konkuk University School of Medicine
            address:
               name:Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Hyung Seok Park
      affiliation:
            name:Konkuk University School of Medicine
            address:
               name:Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea
               type:PostalAddress
            type:Organization
      name:Chan Sup Shim
      affiliation:
            name:Konkuk University School of Medicine
            address:
               name:Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea
      name:Medical Immunology Center, Institute of Biomedical Science and Technology, Konkuk University School of Medicine, Seoul, Korea
      name:Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea
      name:Medical Immunology Center, Institute of Biomedical Science and Technology, Konkuk University School of Medicine, Seoul, Korea
      name:Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea
      name:Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea
      name:Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea
      name:Department of Laboratory Medicine, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea
      name:Department of Laboratory Medicine, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea
      name:Department of Laboratory Medicine, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea
      name:Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea
      name:Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea
      name:Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(156)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

4.75s.

LINK . SPRINGER . COM {}