We are analyzing https://link.springer.com/article/10.1186/bcr1642.

Title:
Vitamin D pathway gene polymorphisms, diet, and risk of postmenopausal breast cancer: a nested case-control study | Breast Cancer Research
Description:
Introduction Vitamin D receptor (VDR) polymorphisms have been inconsistently associated with breast cancer risk. Whether risk is influenced by polymorphisms in other vitamin D metabolism genes and whether calcium or vitamin D intake modifies risk by genotype have not been evaluated. Methods We conducted a nested case-control study within the Cancer Prevention Study II Nutrition Cohort of associations between breast cancer and four VDR single-nucleotide polymorphisms (SNPs), Bsm1,Apa1,Taq1, and Fok1, a poly(A) microsatellite, and associated haplotypes (baTL and BAtS). We also examined one SNP in the 24-hydroxylase gene (CYP24A1) and two in the vitamin D-binding protein (group-specific component [GC]) gene. Participants completed a questionnaire on diet and medical history at baseline in 1992. This study includes 500 postmenopausal breast cancer cases and 500 controls matched by age, race/ethnicity, and date of blood collection. Results Incident breast cancer was not associated with any genotype examined. However, women with the Bsm1 bb SNP who consumed greater than the median intake of total calcium (≥902 mg/day) had lower odds of breast cancer compared to women with the Bb or BB genotype and less than the median calcium intake (odds ratio 0.61, 95% confidence interval 0.38 to 0.96; p interaction = 0.01). Similar interactions were observed for Taq1 (T allele) and the poly(A) (LL) repeat. Conclusion We found no overall association between selected vitamin D pathway genes and postmenopausal breast cancer risk. However, certain VDR gene polymorphisms were associated with lower risk in women consuming high levels of calcium, suggesting that dietary factors may modify associations by VDR genotype.
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Keywords {🔍}

cancer, breast, vitamin, risk, vdr, article, google, scholar, calcium, pubmed, gene, polymorphisms, study, genotype, cas, postmenopausal, women, receptor, snps, intake, dietary, association, diet, cypa, studies, cases, total, examined, interactions, prevention, haplotypes, table, research, cohort, associations, protein, lower, observed, ohd, pathway, fok, polya, snp, dbinding, questionnaire, bsm, median, factors, control, res,

Topics {✒️}

american cancer society article download pdf nuclear transcription-regulating factor expectation-maximization algorithm implemented ii nutrition cohort nested case-control study female sprague-dawley rats bertone-johnson er haplotype-specific relative risks gov/fnic/foodcomp/data/ bone mineral homeostasis group-specific component protein postmenopausal breast cancer vitamin d-binding protein breast tissue-specific synthesis cancer prevention study group-specific component [gc] cps ii cohort breast cancer risk influence autocrine/paracrine vitamin influence tissue-specific vitamin breast cancer survivors sporadic breast cancer influence cancer risk postmenopausal female control full access metastatic breast cancer calcium intake lower privacy choices/manage cookies vdr single-nucleotide polymorphisms breast cancer cases reported increased risk article number r9 malignant breast tissue total calcium intake national cancer institute cancer cell lines large prospective cohort group-specific component breast cancer compared conditional logistic regression intake modifies risk bone miner res total energy intake calcium intake higher case-control study melanoma skin cancer considered statistically significant postmenopausal women enrolled vitamin d-binding

Schema {🗺️}

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         headline:Vitamin D pathway gene polymorphisms, diet, and risk of postmenopausal breast cancer: a nested case-control study
         description:Vitamin D receptor (VDR) polymorphisms have been inconsistently associated with breast cancer risk. Whether risk is influenced by polymorphisms in other vitamin D metabolism genes and whether calcium or vitamin D intake modifies risk by genotype have not been evaluated. We conducted a nested case-control study within the Cancer Prevention Study II Nutrition Cohort of associations between breast cancer and four VDR single-nucleotide polymorphisms (SNPs), Bsm1,Apa1,Taq1, and Fok1, a poly(A) microsatellite, and associated haplotypes (baTL and BAtS). We also examined one SNP in the 24-hydroxylase gene (CYP24A1) and two in the vitamin D-binding protein (group-specific component [GC]) gene. Participants completed a questionnaire on diet and medical history at baseline in 1992. This study includes 500 postmenopausal breast cancer cases and 500 controls matched by age, race/ethnicity, and date of blood collection. Incident breast cancer was not associated with any genotype examined. However, women with the Bsm1 bb SNP who consumed greater than the median intake of total calcium (≥902 mg/day) had lower odds of breast cancer compared to women with the Bb or BB genotype and less than the median calcium intake (odds ratio 0.61, 95% confidence interval 0.38 to 0.96; p interaction = 0.01). Similar interactions were observed for Taq1 (T allele) and the poly(A) (LL) repeat. We found no overall association between selected vitamin D pathway genes and postmenopausal breast cancer risk. However, certain VDR gene polymorphisms were associated with lower risk in women consuming high levels of calcium, suggesting that dietary factors may modify associations by VDR genotype.
         datePublished:2007-01-23T00:00:00Z
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      headline:Vitamin D pathway gene polymorphisms, diet, and risk of postmenopausal breast cancer: a nested case-control study
      description:Vitamin D receptor (VDR) polymorphisms have been inconsistently associated with breast cancer risk. Whether risk is influenced by polymorphisms in other vitamin D metabolism genes and whether calcium or vitamin D intake modifies risk by genotype have not been evaluated. We conducted a nested case-control study within the Cancer Prevention Study II Nutrition Cohort of associations between breast cancer and four VDR single-nucleotide polymorphisms (SNPs), Bsm1,Apa1,Taq1, and Fok1, a poly(A) microsatellite, and associated haplotypes (baTL and BAtS). We also examined one SNP in the 24-hydroxylase gene (CYP24A1) and two in the vitamin D-binding protein (group-specific component [GC]) gene. Participants completed a questionnaire on diet and medical history at baseline in 1992. This study includes 500 postmenopausal breast cancer cases and 500 controls matched by age, race/ethnicity, and date of blood collection. Incident breast cancer was not associated with any genotype examined. However, women with the Bsm1 bb SNP who consumed greater than the median intake of total calcium (≥902 mg/day) had lower odds of breast cancer compared to women with the Bb or BB genotype and less than the median calcium intake (odds ratio 0.61, 95% confidence interval 0.38 to 0.96; p interaction = 0.01). Similar interactions were observed for Taq1 (T allele) and the poly(A) (LL) repeat. We found no overall association between selected vitamin D pathway genes and postmenopausal breast cancer risk. However, certain VDR gene polymorphisms were associated with lower risk in women consuming high levels of calcium, suggesting that dietary factors may modify associations by VDR genotype.
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         Postmenopausal Breast Cancer
         Postmenopausal Breast Cancer Risk
         Lower Breast Cancer Risk
         Total Calcium Intake
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         Oncology
         Surgical Oncology
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