We are analyzing https://link.springer.com/article/10.1007/s10552-014-0361-y.

Title:
Genetic variation in vitamin D-related genes and risk of colorectal cancer in African Americans | Cancer Causes & Control
Description:
Disparities in both colorectal cancer (CRC) incidence and survival impact African Americans (AAs) more than other US ethnic groups. Because vitamin D is thought to protect against CRC and AAs have lower serum vitamin D levels, genetic variants that modulate the levels of active hormone in the tissues could explain some of the cancer health disparity. Consequently, we hypothesized that genetic variants in vitamin D-related genes are associated with CRC risk. To test this hypothesis, we studied 39 potentially functional single-nucleotide polymorphisms (SNPs) in eight genes (CYP2R1, CYP3A4, CYP24A1, CYP27A1, CYP27B1, GC, DHCR7, and VDR) in 961 AA CRC cases and 838 healthy AA controls from Chicago and North Carolina. We tested whether SNPs are associated with CRC incidence using logistic regression models to calculate p values, odds ratios, and 95 % confidence intervals. In the logistic regression, we used a log-additive genetic model and used age, gender, and percent West African ancestry, which we estimated with the program STRUCTURE, as covariates in the models. A nominally significant association was detected between CRC and the SNP rs12794714 in the vitamin D 25-hydroxylase gene CYP2R1 (p = 0.019), a SNP that has previously been associated with serum vitamin D levels. Two SNPs, rs16847024 in the GC gene and rs6022990 in the CYP24A1 gene, were nominally associated with left-sided CRC (p = 0.015 and p = 0.018, respectively). Our results strongly suggest that genetic variation in vitamin D-related genes could affect CRC susceptibility in AAs.
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Keywords {🔍}

vitamin, cancer, pubmed, google, scholar, article, crc, cas, study, levels, colorectal, colon, risk, snps, ohd, serum, genetic, genes, cases, central, table, association, cypa, analysis, drelated, snp, african, aas, groups, data, americans, age, polymorphisms, associations, health, controls, hydroxyvitamin, cccc, allele, lcrc, protein, ncccs, chicago, values, significant, gene, studies, university, rcrc, epidemiol,

Topics {✒️}

article download pdf population-based case–control study megalin-receptor-mediated endocytosis medicare-eligible beneficiaries obtained genome-wide association study log-additive genetic model nonsteroidal anti-inflammatory drugs vitamin d-related genes vitamin d-related polymorphisms nested case–control study gene group-specific component sided chi-square test left-sided colorectal cancer american cancer society left-sided colon cancer vitamin d-binding protein end results–medicare data permuting case–control status vitamin d-related snps multiple testing gene-wide chicago medical center single-nucleotide polymorphisms single nucleotide polymorphisms crc health disparities privacy choices/manage cookies inflammatory bowel disease cancer-related deaths article pibiri r-crc development compared postmenopausal breast cancer asymptomatic average-risk individuals european american men full access health professionals follow receptor gene expression gene-wide basis medical records ascertained eastern north carolina north carolina division cancer health disparity rectal–sigmoid cancers west african ancestry left-sided colonic central hypothesis human genetics 25-hydroxyvitamin d-24-hydroxylase case–control study individual ancestry estimates individual study groups larger study groups

Questions {❓}

Garland CF, Garland FC (1980) Do sunlight and vitamin D reduce the likelihood of colon cancer?
Lagergren J, Ye W, Ekbom A (2001) Intestinal cancer after cholecystectomy: is bile involved in carcinogenesis?
Meguid RA, Slidell MB, Wolfgang CL, Chang DC, Ahuja N (2008) Is there a difference in survival between right-versus left-sided colon cancers?

Schema {🗺️}

WebPage:
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         headline:Genetic variation in vitamin D-related genes and risk of colorectal cancer in African Americans
         description:Disparities in both colorectal cancer (CRC) incidence and survival impact African Americans (AAs) more than other US ethnic groups. Because vitamin D is thought to protect against CRC and AAs have lower serum vitamin D levels, genetic variants that modulate the levels of active hormone in the tissues could explain some of the cancer health disparity. Consequently, we hypothesized that genetic variants in vitamin D-related genes are associated with CRC risk. To test this hypothesis, we studied 39 potentially functional single-nucleotide polymorphisms (SNPs) in eight genes (CYP2R1, CYP3A4, CYP24A1, CYP27A1, CYP27B1, GC, DHCR7, and VDR) in 961 AA CRC cases and 838 healthy AA controls from Chicago and North Carolina. We tested whether SNPs are associated with CRC incidence using logistic regression models to calculate p values, odds ratios, and 95 % confidence intervals. In the logistic regression, we used a log-additive genetic model and used age, gender, and percent West African ancestry, which we estimated with the program STRUCTURE, as covariates in the models. A nominally significant association was detected between CRC and the SNP rs12794714 in the vitamin D 25-hydroxylase gene CYP2R1 (p = 0.019), a SNP that has previously been associated with serum vitamin D levels. Two SNPs, rs16847024 in the GC gene and rs6022990 in the CYP24A1 gene, were nominally associated with left-sided CRC (p = 0.015 and p = 0.018, respectively). Our results strongly suggest that genetic variation in vitamin D-related genes could affect CRC susceptibility in AAs.
         datePublished:2014-02-23T00:00:00Z
         dateModified:2014-02-23T00:00:00Z
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            Colorectal cancer
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            Cancer health disparities
            African American population
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            Epidemiology
            Hematology
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      headline:Genetic variation in vitamin D-related genes and risk of colorectal cancer in African Americans
      description:Disparities in both colorectal cancer (CRC) incidence and survival impact African Americans (AAs) more than other US ethnic groups. Because vitamin D is thought to protect against CRC and AAs have lower serum vitamin D levels, genetic variants that modulate the levels of active hormone in the tissues could explain some of the cancer health disparity. Consequently, we hypothesized that genetic variants in vitamin D-related genes are associated with CRC risk. To test this hypothesis, we studied 39 potentially functional single-nucleotide polymorphisms (SNPs) in eight genes (CYP2R1, CYP3A4, CYP24A1, CYP27A1, CYP27B1, GC, DHCR7, and VDR) in 961 AA CRC cases and 838 healthy AA controls from Chicago and North Carolina. We tested whether SNPs are associated with CRC incidence using logistic regression models to calculate p values, odds ratios, and 95 % confidence intervals. In the logistic regression, we used a log-additive genetic model and used age, gender, and percent West African ancestry, which we estimated with the program STRUCTURE, as covariates in the models. A nominally significant association was detected between CRC and the SNP rs12794714 in the vitamin D 25-hydroxylase gene CYP2R1 (p = 0.019), a SNP that has previously been associated with serum vitamin D levels. Two SNPs, rs16847024 in the GC gene and rs6022990 in the CYP24A1 gene, were nominally associated with left-sided CRC (p = 0.015 and p = 0.018, respectively). Our results strongly suggest that genetic variation in vitamin D-related genes could affect CRC susceptibility in AAs.
      datePublished:2014-02-23T00:00:00Z
      dateModified:2014-02-23T00:00:00Z
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         Vitamin D
         Colorectal cancer
         Genetic risk factors
         Cancer health disparities
         African American population
         Cancer Research
         Biomedicine
         general
         Oncology
         Public Health
         Epidemiology
         Hematology
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            address:
               name:Division of Gastroenterology and Hepatology, Department of Medicine, University of North Carolina, Chapel Hill, USA
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            name:University of Chicago Medicine
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               type:PostalAddress
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            name:University of Illinois at Chicago
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      name:Department of Medicine, Section of Gastroenterology, Hepatology and Nutrition, University of Chicago Medicine, Chicago, USA
      name:Department of Medicine and the Institute of Human Genetics, University of Illinois at Chicago, Chicago, USA
      name:Department of Medicine and the Institute of Human Genetics, University of Illinois at Chicago, Chicago, USA
      name:Department of Pediatrics and the Institute of Human Genetics, University of Illinois at Chicago, Chicago, USA

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