Here's how DOI.ORG makes money* and how much!

*Please read our disclaimer before using our estimates.
Loading...

DOI . ORG {}

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Doi.org Make Money
  6. Keywords
  7. Topics
  8. Questions
  9. Schema
  10. External Links
  11. Analytics And Tracking
  12. Libraries
  13. Hosting Providers
  14. CDN Services

We began analyzing https://link.springer.com/article/10.1007/s00439-025-02745-x, but it redirected us to https://link.springer.com/article/10.1007/s00439-025-02745-x. The analysis below is for the second page.

Title[redir]:
Advancing chronic myeloid leukemia research with next-generation sequencing: potential benefits, limitations, and future clinical integration | Human Genetics
Description:
Next-generation sequencing (NGS) has emerged as a powerful tool for advancing research in chronic myeloid leukemia (CML) by providing a deeper understanding of its genetic complexity. Beyond detecting the hallmark BCR::ABL1 fusion gene, NGS has enabled the identification of additional mutations associated with disease progression, therapy resistance, and clonal evolution. NGS also facilitates the detection of rare BCR::ABL1 fusion variants and cryptic rearrangements, offering a more refined genetic characterization of the disease. Additionally, it enhances the study of minimal residual disease (MRD) and evolving resistance patterns, which are crucial for developing targeted therapeutic strategies. However, challenges such as data interpretation, standardization, and cost constraints continue to limit the widespread application of NGS in routine research and clinical settings. This review explores the contributions of NGS to CML research, highlighting its role in uncovering novel genetic alterations, tracking clonal evolution, and identifying potential therapeutic targets. As sequencing technologies evolve, NGS is expected to further shape the future of CML research, providing critical insights that may ultimately refine disease management strategies.

Matching Content Categories {πŸ“š}

  • Education
  • Science
  • Health & Fitness

Content Management System {πŸ“}

What CMS is doi.org built with?

Custom-built

No common CMS systems were detected on Doi.org, and no known web development framework was identified.

Traffic Estimate {πŸ“ˆ}

What is the average monthly size of doi.org audience?

πŸ™οΈ Massive Traffic: 50M - 100M visitors per month


Based on our best estimate, this website will receive around 98,426,998 visitors per month in the current month.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Doi.org Make Money? {πŸ’Έ}

We're unsure if the website is profiting.

Not all websites are made for profit; some exist to inform or educate users. Or any other reason why people make websites. And this might be the case. Doi.org might be cashing in, but we can't detect the method they're using.

Keywords {πŸ”}

article, google, scholar, pubmed, leukemia, myeloid, chronic, cas, central, sequencing, nextgeneration, bcrabl, patients, mutations, kinase, cancer, clinical, disease, cml, blood, analysis, ngs, residual, res, detection, httpsdoiorgs, research, data, molecular, medicine, httpsdoiorgblood, treatment, tyrosine, clin, review, resistance, domain, leuk, wang, med, oncology, kim, oncol, gene, minimal, mutation, cell, digital, pcr, genomic,

Topics {βœ’οΈ}

/trupcr-bcr-abl1-transcript-screening-kit bcr-abl35ins insertion/truncation mutant pradana zaky romadhon machine learning-based meta-ensemble ai-driven multi-omics integration month download article/chapter bcr-abl1 fusion transcript bcr-abl1 transcript type multi-omics data unlocks hifi long-read genomes genotype-environment-phenotype relationships ai-driven drug discovery long-read rna sequencing tyrosine kinase inhibitor-resistance bcr-abl fusion transcripts multi-scale predictive modeling prospective multi-institutional study real-time quantitative pcr real-time molecular classification genomically-based risk assessment integrated long-read epigenetic full-length transcriptome sequencing bcr-abl1 positive leukemias neoantigen-based cancer vaccines bone marrow stem/progenitors full article pdf ngs-based screening related subjects abl1 transcript type de novi la acute lymphoblastic leukemia ai-driven precision medicine chronic myeloid leukemia chronic myeloid leukemia philadelphia chromosome variants tyrosine kinase inhibitors franke g tki-resistant mutations privacy choices/manage cookies abl1 fusion gene abl kinase inhibition digital-droplet-pcr droplet digital pcr digital droplet pcr springer international publishing advancing research bcr–abl1 mutations dna-based methods comprehensive genomic profiling springer nature singapore

Questions {❓}

  • Luskin MR, Murakami MA, Manalis SR, Weinstock DM (2018) Targeting minimal residual disease: a path to cure?

Schema {πŸ—ΊοΈ}

WebPage:
      mainEntity:
         headline:Advancing chronic myeloid leukemia research with next-generation sequencing: potential benefits, limitations, and future clinical integration
         description:Next-generation sequencing (NGS) has emerged as a powerful tool for advancing research in chronic myeloid leukemia (CML) by providing a deeper understanding of its genetic complexity. Beyond detecting the hallmark BCR::ABL1 fusion gene, NGS has enabled the identification of additional mutations associated with disease progression, therapy resistance, and clonal evolution. NGS also facilitates the detection of rare BCR::ABL1 fusion variants and cryptic rearrangements, offering a more refined genetic characterization of the disease. Additionally, it enhances the study of minimal residual disease (MRD) and evolving resistance patterns, which are crucial for developing targeted therapeutic strategies. However, challenges such as data interpretation, standardization, and cost constraints continue to limit the widespread application of NGS in routine research and clinical settings. This review explores the contributions of NGS to CML research, highlighting its role in uncovering novel genetic alterations, tracking clonal evolution, and identifying potential therapeutic targets. As sequencing technologies evolve, NGS is expected to further shape the future of CML research, providing critical insights that may ultimately refine disease management strategies.
         datePublished:2025-04-21T00:00:00Z
         dateModified:2025-04-21T00:00:00Z
         pageStart:481
         pageEnd:503
         sameAs:https://doi.org/10.1007/s00439-025-02745-x
         keywords:
            Human Genetics
            Molecular Medicine
            Gene Function
            Metabolic Diseases
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00439-025-02745-x/MediaObjects/439_2025_2745_Fig1_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00439-025-02745-x/MediaObjects/439_2025_2745_Fig2_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00439-025-02745-x/MediaObjects/439_2025_2745_Fig3_HTML.png
         isPartOf:
            name:Human Genetics
            issn:
               1432-1203
               0340-6717
            volumeNumber:144
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer Berlin Heidelberg
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Henry Sutanto
               affiliation:
                     name:Universitas Airlangga
                     address:
                        name:Internal Medicine Study Program, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia
                        type:PostalAddress
                     type:Organization
                     name:Dr. Soetomo General Academic Hospital
                     address:
                        name:Department of Internal Medicine, Dr. Soetomo General Academic Hospital, Surabaya, Indonesia
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:Laras Pratiwi
               affiliation:
                     name:Universitas Airlangga
                     address:
                        name:Internal Medicine Study Program, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia
                        type:PostalAddress
                     type:Organization
                     name:Dr. Soetomo General Academic Hospital
                     address:
                        name:Department of Internal Medicine, Dr. Soetomo General Academic Hospital, Surabaya, Indonesia
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Pradana Zaky Romadhon
               affiliation:
                     name:Universitas Airlangga
                     address:
                        name:Division of Hematology and Medical Oncology, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia
                        type:PostalAddress
                     type:Organization
                     name:Universitas Airlangga Hospital
                     address:
                        name:Department of Internal Medicine, Universitas Airlangga Hospital, Surabaya, Indonesia
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Siprianus Ugroseno Yudho Bintoro
               affiliation:
                     name:Universitas Airlangga
                     address:
                        name:Internal Medicine Study Program, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia
                        type:PostalAddress
                     type:Organization
                     name:Dr. Soetomo General Academic Hospital
                     address:
                        name:Department of Internal Medicine, Dr. Soetomo General Academic Hospital, Surabaya, Indonesia
                        type:PostalAddress
                     type:Organization
                     name:Universitas Airlangga
                     address:
                        name:Division of Hematology and Medical Oncology, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Advancing chronic myeloid leukemia research with next-generation sequencing: potential benefits, limitations, and future clinical integration
      description:Next-generation sequencing (NGS) has emerged as a powerful tool for advancing research in chronic myeloid leukemia (CML) by providing a deeper understanding of its genetic complexity. Beyond detecting the hallmark BCR::ABL1 fusion gene, NGS has enabled the identification of additional mutations associated with disease progression, therapy resistance, and clonal evolution. NGS also facilitates the detection of rare BCR::ABL1 fusion variants and cryptic rearrangements, offering a more refined genetic characterization of the disease. Additionally, it enhances the study of minimal residual disease (MRD) and evolving resistance patterns, which are crucial for developing targeted therapeutic strategies. However, challenges such as data interpretation, standardization, and cost constraints continue to limit the widespread application of NGS in routine research and clinical settings. This review explores the contributions of NGS to CML research, highlighting its role in uncovering novel genetic alterations, tracking clonal evolution, and identifying potential therapeutic targets. As sequencing technologies evolve, NGS is expected to further shape the future of CML research, providing critical insights that may ultimately refine disease management strategies.
      datePublished:2025-04-21T00:00:00Z
      dateModified:2025-04-21T00:00:00Z
      pageStart:481
      pageEnd:503
      sameAs:https://doi.org/10.1007/s00439-025-02745-x
      keywords:
         Human Genetics
         Molecular Medicine
         Gene Function
         Metabolic Diseases
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00439-025-02745-x/MediaObjects/439_2025_2745_Fig1_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00439-025-02745-x/MediaObjects/439_2025_2745_Fig2_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00439-025-02745-x/MediaObjects/439_2025_2745_Fig3_HTML.png
      isPartOf:
         name:Human Genetics
         issn:
            1432-1203
            0340-6717
         volumeNumber:144
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer Berlin Heidelberg
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Henry Sutanto
            affiliation:
                  name:Universitas Airlangga
                  address:
                     name:Internal Medicine Study Program, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia
                     type:PostalAddress
                  type:Organization
                  name:Dr. Soetomo General Academic Hospital
                  address:
                     name:Department of Internal Medicine, Dr. Soetomo General Academic Hospital, Surabaya, Indonesia
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Laras Pratiwi
            affiliation:
                  name:Universitas Airlangga
                  address:
                     name:Internal Medicine Study Program, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia
                     type:PostalAddress
                  type:Organization
                  name:Dr. Soetomo General Academic Hospital
                  address:
                     name:Department of Internal Medicine, Dr. Soetomo General Academic Hospital, Surabaya, Indonesia
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Pradana Zaky Romadhon
            affiliation:
                  name:Universitas Airlangga
                  address:
                     name:Division of Hematology and Medical Oncology, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia
                     type:PostalAddress
                  type:Organization
                  name:Universitas Airlangga Hospital
                  address:
                     name:Department of Internal Medicine, Universitas Airlangga Hospital, Surabaya, Indonesia
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Siprianus Ugroseno Yudho Bintoro
            affiliation:
                  name:Universitas Airlangga
                  address:
                     name:Internal Medicine Study Program, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia
                     type:PostalAddress
                  type:Organization
                  name:Dr. Soetomo General Academic Hospital
                  address:
                     name:Department of Internal Medicine, Dr. Soetomo General Academic Hospital, Surabaya, Indonesia
                     type:PostalAddress
                  type:Organization
                  name:Universitas Airlangga
                  address:
                     name:Division of Hematology and Medical Oncology, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Human Genetics
      issn:
         1432-1203
         0340-6717
      volumeNumber:144
Organization:
      name:Springer Berlin Heidelberg
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Universitas Airlangga
      address:
         name:Internal Medicine Study Program, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia
         type:PostalAddress
      name:Dr. Soetomo General Academic Hospital
      address:
         name:Department of Internal Medicine, Dr. Soetomo General Academic Hospital, Surabaya, Indonesia
         type:PostalAddress
      name:Universitas Airlangga
      address:
         name:Internal Medicine Study Program, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia
         type:PostalAddress
      name:Dr. Soetomo General Academic Hospital
      address:
         name:Department of Internal Medicine, Dr. Soetomo General Academic Hospital, Surabaya, Indonesia
         type:PostalAddress
      name:Universitas Airlangga
      address:
         name:Division of Hematology and Medical Oncology, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia
         type:PostalAddress
      name:Universitas Airlangga Hospital
      address:
         name:Department of Internal Medicine, Universitas Airlangga Hospital, Surabaya, Indonesia
         type:PostalAddress
      name:Universitas Airlangga
      address:
         name:Internal Medicine Study Program, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia
         type:PostalAddress
      name:Dr. Soetomo General Academic Hospital
      address:
         name:Department of Internal Medicine, Dr. Soetomo General Academic Hospital, Surabaya, Indonesia
         type:PostalAddress
      name:Universitas Airlangga
      address:
         name:Division of Hematology and Medical Oncology, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Henry Sutanto
      affiliation:
            name:Universitas Airlangga
            address:
               name:Internal Medicine Study Program, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia
               type:PostalAddress
            type:Organization
            name:Dr. Soetomo General Academic Hospital
            address:
               name:Department of Internal Medicine, Dr. Soetomo General Academic Hospital, Surabaya, Indonesia
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Laras Pratiwi
      affiliation:
            name:Universitas Airlangga
            address:
               name:Internal Medicine Study Program, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia
               type:PostalAddress
            type:Organization
            name:Dr. Soetomo General Academic Hospital
            address:
               name:Department of Internal Medicine, Dr. Soetomo General Academic Hospital, Surabaya, Indonesia
               type:PostalAddress
            type:Organization
      name:Pradana Zaky Romadhon
      affiliation:
            name:Universitas Airlangga
            address:
               name:Division of Hematology and Medical Oncology, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia
               type:PostalAddress
            type:Organization
            name:Universitas Airlangga Hospital
            address:
               name:Department of Internal Medicine, Universitas Airlangga Hospital, Surabaya, Indonesia
               type:PostalAddress
            type:Organization
      name:Siprianus Ugroseno Yudho Bintoro
      affiliation:
            name:Universitas Airlangga
            address:
               name:Internal Medicine Study Program, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia
               type:PostalAddress
            type:Organization
            name:Dr. Soetomo General Academic Hospital
            address:
               name:Department of Internal Medicine, Dr. Soetomo General Academic Hospital, Surabaya, Indonesia
               type:PostalAddress
            type:Organization
            name:Universitas Airlangga
            address:
               name:Division of Hematology and Medical Oncology, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Internal Medicine Study Program, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia
      name:Department of Internal Medicine, Dr. Soetomo General Academic Hospital, Surabaya, Indonesia
      name:Internal Medicine Study Program, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia
      name:Department of Internal Medicine, Dr. Soetomo General Academic Hospital, Surabaya, Indonesia
      name:Division of Hematology and Medical Oncology, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia
      name:Department of Internal Medicine, Universitas Airlangga Hospital, Surabaya, Indonesia
      name:Internal Medicine Study Program, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia
      name:Department of Internal Medicine, Dr. Soetomo General Academic Hospital, Surabaya, Indonesia
      name:Division of Hematology and Medical Oncology, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {πŸ”—}(389)

Analytics and Tracking {πŸ“Š}

  • Google Tag Manager

Libraries {πŸ“š}

  • Clipboard.js
  • Prism.js

Emails and Hosting {βœ‰οΈ}

Mail Servers:

  • mx.zoho.eu
  • mx2.zoho.eu
  • mx3.zoho.eu

Name Servers:

  • josh.ns.cloudflare.com
  • zita.ns.cloudflare.com

CDN Services {πŸ“¦}

  • Crossref

5.42s.