
NCBI . NLM . NIH . GOV {
}
Title[redir]:
Clonal evolution in tyrosine kinase inhibitor-resistance: lessons from in vitro-models - PMC
Description:
Resistance in anti-cancer treatment is a result of clonal evolution and clonal selection. In chronic myeloid leukemia (CML), the hematopoietic neoplasm is predominantly caused by the formation of the BCR::ABL1 kinase. Evidently, treatment with ...
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Keywords {π}
doi, resistance, cells, cell, imatinib, ptpn, pubmed, google, scholar, variants, tki, mutations, figure, leukemia, chr, tkiresistant, highimr, cancer, pmc, lines, article, nras, data, chronic, myeloid, pdgfrb, ptyrcys, nilotinib, sublines, number, free, cml, supplementary, tkisensitive, patients, pglnlys, expression, pglugln, mutation, therapy, variant, resistant, cosv, performed, fold, activity, analyzed, compared, lowimr, kinase,
Topics {βοΈ}
platelet-derived growth factor restored ras-map-kinase signaling pmc beta search bcr-abl1-induced hematologic neoplasia philadelphia-chromosome-positive leukaemia ras-map-kinase signaling intercept/tbs blocking solution ph chromosome-positive leukemia pselect-puromycin-mcs vector abl1-induced hematologic neoplasms nilotinib-resistant subline n-r2 primer-specific annealing temperatures protein-protein interaction network selecting puromycin-resistant cells tyrosine kinase inhibitor-resistance highim-r1 lowim-r4 lown-r2 twelve tki-resistant sublines tki-resistant sublines pointed genome-wide expression datasets nilotinib-resistant sublines derived tki-sensitive cells pointing kit-induced myeloproliferative diseases genome-wide expression analyses pathogenic kinase-domain mutation tki-sensitive k-562 cells tki-resistant cell lines n-terminal src homology molecular-defined clonal evolution random-primed cdna library imatinib-resistant sublines showing data availability statement tki-resistant cell line tki-resistant sublines compared sh-sy5y neuroblastoma cells context-dependent protein function uncovering disease-disease relationships imatinib-resistant cell lines tki-relapsed cml patients positive philadelphia chromosome microrna-212/abcg2-axis contributes long-term drug exposure circumvent imatinib-induced bcr abl1 affect tki-response low tki-resistant cells tyrosine kinase inhibitor noonan syndrome-causing genes epigenetic modulator dna negative control-transfected cells protein-protein-interaction chronic myelogenous leukemia
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