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We are analyzing https://www.nature.com/articles/s41589-021-00805-7.

Title:
RNA structure probing uncovers RNA structure-dependent biological functions | Nature Chemical Biology
Description:
RNA molecules fold into complex structures that enable their diverse functions in cells. Recent revolutionary innovations in transcriptome-wide RNA structural probing of living cells have ushered in a new era in understanding RNA functions. Here, we summarize the latest technological advances for probing RNA secondary structures and discuss striking discoveries that have linked RNA regulation and biological processes through interrogation of RNA structures. In particular, we highlight how different long noncoding RNAs form into distinct secondary structures that determine their modes of interactions with protein partners to realize their unique functions. These dynamic structures mediate RNA regulatory functions through altering interactions with proteins and other RNAs. We also outline current methodological hurdles and speculate about future directions for development of the next generation of RNA structure-probing technologies of higher sensitivity and resolution, which could then be applied in increasingly physiologically relevant studies. This Review summarizes the recent technical advances in probing RNA secondary structures and discusses their connection with RNA regulatory functions in various biological processes and future directions in RNA structure-probing methods.
Website Age:
30 years and 10 months (reg. 1994-08-11).

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Keywords {🔍}

pubmed, article, cas, google, scholar, rna, central, cell, structure, nature, nat, secondary, biol, mol, rnas, interactions, structures, probing, functions, noncoding, reveals, vivo, long, rev, biology, structural, genomewide, chen, regulatory, access, molecular, mrna, lncrna, science, china, analysis, wang, res, function, content, data, liu, cells, cellular, profiling, transcriptome, functional, cookies, chemical, regulation,

Topics {✒️}

permissions reprints nature portfolio journals frontier research center privacy policy nature portfolio xi-wen wang qiangfeng cliff zhang advertising social media positive-strand rna viruses rna structure-probing technologies higher-order organization principles ling-ling chen intermolecular rna–rna interactions human rna–rna interactions transcriptome-wide structure probing rna–rna spatial interactions zinc-finger transcription factor noncoding rna revolution-trashing data protection mapping rna–rna interactome high-resolution shape probing antisense coolair mediates rna-directed chromosome conformation chu-xiao liu accurate genome-wide profiling super-resolution microscopy analysis polyq-driven phase separation peer review rna–protein interactions article wang dynamic rna structurome nature+ nature 467 nature 505 nature 519 nature 582 nature 521 nature 546 nature 518 nature probing rna structure shanghai key laboratory paper developed shape-map permissions higher-order organization vivo genome-wide profiling force probing rna early zebrafish embryogenesis rna–protein interaction

Questions {❓}

  • NF90 isoforms, a new family of cellular proteins involved in viral replication?
  • RNA regulation: a new genetics?

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