We are analyzing https://link.springer.com/article/10.1186/s13059-020-02022-2.

Title:
RNA structural dynamics regulate early embryogenesis through controlling transcriptome fate and function | Genome Biology
Description:
Background Vertebrate early embryogenesis is initially directed by a set of maternal RNAs and proteins, yet the mechanisms controlling this program remain largely unknown. Recent transcriptome-wide studies on RNA structure have revealed its pervasive and crucial roles in RNA processing and functions, but whether and how RNA structure regulates the fate of the maternal transcriptome have yet to be determined. Results Here we establish the global map of four nucleotide-based mRNA structures by icSHAPE during zebrafish early embryogenesis. Strikingly, we observe that RNA structurally variable regions are enriched in the 3′ UTR and contain cis-regulatory elements important for maternal-to-zygotic transition (MZT). We find that the RNA-binding protein Elavl1a stabilizes maternal mRNAs by binding to the cis-elements. Conversely, RNA structure formation suppresses Elavl1a’s binding leading to the decay of its maternal targets. Conclusions Our study finds that RNA structurally variable regions are enriched in mRNA 3′ UTRs and contain cis-regulatory elements during zebrafish early embryogenesis. We reveal that Elavl1a regulates maternal RNA stability in an RNA structure-dependent fashion. Overall, our findings reveal a broad and fundamental role of RNA structure-based regulation in vertebrate early embryogenesis.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Education
Books & Literature
Science

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 7,626,432 visitors per month in the current month.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

The income method remains a mystery to us.

Websites don't always need to be profitable; some serve as platforms for education or personal expression. Websites can serve multiple purposes. And this might be one of them. Link.springer.com might be cashing in, but we can't detect the method they're using.

Keywords {🔍}

rna, elavla, binding, pubmed, fig, hpf, additional, article, file, zebrafish, regions, cas, maternal, variable, google, scholar, structurally, structural, mrna, sites, structure, icshape, early, test, zhang, genes, central, motif, analysis, embryogenesis, cell, utr, embryos, gene, protein, transcripts, reactivity, sequence, buffer, stability, performed, yang, values, transcriptome, set, vivo, significance, control, data, calculated,

Topics {✒️}

008/attachment/51bc4461-fc31-4e4d-9b6d-c0db20a7e62b/mmc3 007/attachment/ed673aa9-bc87-4a4e-94b9-64fbaa1a6f61/mmc3 ap-conjugated anti-dig antibody large-scale structure-based regulome large-scale structure-based regulomes anti-β-actin antibody streptavidin-conjugated magnetic beads cis-regulatory elements important regulating pre-mrna splicing sequence-specific rna-binding protein curved anterior-posterior axis structure-based cis-elements cy3-labeled dna primer flag-elavl1a mrna-injected embryos rna structure-dependent fashion including reverse-transcription national key research yun-gui yang smarter smrna-seq kit rabbit anti-flag-hrp elavl1a-mediated mrna stability article download pdf cn/gsa/browse/cra001139 yong-liang zhao bind single-stranded rna rna structure-based regulation biotin-labeled rna probes cross-mating heterozygous mutants gov/geo/query/acc rna-guided cas9 nuclease nucleotide-based rna structure guide rna-protein interactions biotin-labeled rna oligonucleotides including p1-wild-type rna-binding protein hur /μl t4 rna ligase tsinghua-peking joint center bind single-strand rna designed p1 wild-type pcs2-flag-elavl1a plasmids large-scale regulome structure-based genetic regulation bind single-stranded rnas individual-nucleotide resolution crosslinking anti-flag antibody structure-based regulomes rna 5-methylcytosine facilitates nucleotide-based mrna structures mo-mismatched binding site mo-mismatch binding site

Questions {❓}

Schema {🗺️}

WebPage:
      mainEntity:
         headline:RNA structural dynamics regulate early embryogenesis through controlling transcriptome fate and function
         description:Vertebrate early embryogenesis is initially directed by a set of maternal RNAs and proteins, yet the mechanisms controlling this program remain largely unknown. Recent transcriptome-wide studies on RNA structure have revealed its pervasive and crucial roles in RNA processing and functions, but whether and how RNA structure regulates the fate of the maternal transcriptome have yet to be determined. Here we establish the global map of four nucleotide-based mRNA structures by icSHAPE during zebrafish early embryogenesis. Strikingly, we observe that RNA structurally variable regions are enriched in the 3′ UTR and contain cis-regulatory elements important for maternal-to-zygotic transition (MZT). We find that the RNA-binding protein Elavl1a stabilizes maternal mRNAs by binding to the cis-elements. Conversely, RNA structure formation suppresses Elavl1a’s binding leading to the decay of its maternal targets. Our study finds that RNA structurally variable regions are enriched in mRNA 3′ UTRs and contain cis-regulatory elements during zebrafish early embryogenesis. We reveal that Elavl1a regulates maternal RNA stability in an RNA structure-dependent fashion. Overall, our findings reveal a broad and fundamental role of RNA structure-based regulation in vertebrate early embryogenesis.
         datePublished:2020-05-18T00:00:00Z
         dateModified:2020-05-18T00:00:00Z
         pageStart:1
         pageEnd:27
         license:http://creativecommons.org/publicdomain/zero/1.0/
         sameAs:https://doi.org/10.1186/s13059-020-02022-2
         keywords:
            RNA structure
            Zebrafish early embryogenesis
            Structure-based regulome
            Elavl1a
            Animal Genetics and Genomics
            Human Genetics
            Plant Genetics and Genomics
            Microbial Genetics and Genomics
            Bioinformatics
            Evolutionary Biology
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs13059-020-02022-2/MediaObjects/13059_2020_2022_Fig1_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs13059-020-02022-2/MediaObjects/13059_2020_2022_Fig2_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs13059-020-02022-2/MediaObjects/13059_2020_2022_Fig3_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs13059-020-02022-2/MediaObjects/13059_2020_2022_Fig4_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs13059-020-02022-2/MediaObjects/13059_2020_2022_Fig5_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs13059-020-02022-2/MediaObjects/13059_2020_2022_Fig6_HTML.png
         isPartOf:
            name:Genome Biology
            issn:
               1474-760X
            volumeNumber:21
            type:
               Periodical
               PublicationVolume
         publisher:
            name:BioMed Central
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Boyang Shi
               affiliation:
                     name:Beijing Institute of Genomics, Chinese Academy of Sciences
                     address:
                        name:CAS Key Laboratory of Genomic and Precision Medicine, Collaborative Innovation Center of Genetics and Development, College of Future Technology, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China
                        type:PostalAddress
                     type:Organization
                     name:University of Chinese Academy of Sciences
                     address:
                        name:University of Chinese Academy of Sciences, Beijing, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Jinsong Zhang
               affiliation:
                     name:Tsinghua University
                     address:
                        name:MOE Key Laboratory of Bioinformatics, Center for Synthetic and Systems Biology, Beijing Advanced Innovation Center for Structural Biology, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Jian Heng
               affiliation:
                     name:University of Chinese Academy of Sciences
                     address:
                        name:University of Chinese Academy of Sciences, Beijing, China
                        type:PostalAddress
                     type:Organization
                     name:Institute of Zoology, Chinese Academy of Sciences
                     address:
                        name:State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Jing Gong
               affiliation:
                     name:Tsinghua University
                     address:
                        name:MOE Key Laboratory of Bioinformatics, Center for Synthetic and Systems Biology, Beijing Advanced Innovation Center for Structural Biology, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Ting Zhang
               affiliation:
                     name:Beijing Institute of Genomics, Chinese Academy of Sciences
                     address:
                        name:CAS Key Laboratory of Genomic and Precision Medicine, Collaborative Innovation Center of Genetics and Development, College of Future Technology, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China
                        type:PostalAddress
                     type:Organization
                     name:University of Chinese Academy of Sciences
                     address:
                        name:University of Chinese Academy of Sciences, Beijing, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Pan Li
               affiliation:
                     name:Tsinghua University
                     address:
                        name:MOE Key Laboratory of Bioinformatics, Center for Synthetic and Systems Biology, Beijing Advanced Innovation Center for Structural Biology, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Bao-Fa Sun
               affiliation:
                     name:Beijing Institute of Genomics, Chinese Academy of Sciences
                     address:
                        name:CAS Key Laboratory of Genomic and Precision Medicine, Collaborative Innovation Center of Genetics and Development, College of Future Technology, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China
                        type:PostalAddress
                     type:Organization
                     name:Institute of Stem Cell and Regeneration, Chinese Academy of Sciences
                     address:
                        name:Institute of Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Ying Yang
               affiliation:
                     name:Beijing Institute of Genomics, Chinese Academy of Sciences
                     address:
                        name:CAS Key Laboratory of Genomic and Precision Medicine, Collaborative Innovation Center of Genetics and Development, College of Future Technology, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China
                        type:PostalAddress
                     type:Organization
                     name:Institute of Stem Cell and Regeneration, Chinese Academy of Sciences
                     address:
                        name:Institute of Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Ning Zhang
               affiliation:
                     name:State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences
                     address:
                        name:State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Yong-Liang Zhao
               affiliation:
                     name:Beijing Institute of Genomics, Chinese Academy of Sciences
                     address:
                        name:CAS Key Laboratory of Genomic and Precision Medicine, Collaborative Innovation Center of Genetics and Development, College of Future Technology, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China
                        type:PostalAddress
                     type:Organization
                     name:University of Chinese Academy of Sciences
                     address:
                        name:University of Chinese Academy of Sciences, Beijing, China
                        type:PostalAddress
                     type:Organization
                     name:Institute of Stem Cell and Regeneration, Chinese Academy of Sciences
                     address:
                        name:Institute of Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Hai-Lin Wang
               affiliation:
                     name:University of Chinese Academy of Sciences
                     address:
                        name:University of Chinese Academy of Sciences, Beijing, China
                        type:PostalAddress
                     type:Organization
                     name:State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences
                     address:
                        name:State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Feng Liu
               affiliation:
                     name:University of Chinese Academy of Sciences
                     address:
                        name:University of Chinese Academy of Sciences, Beijing, China
                        type:PostalAddress
                     type:Organization
                     name:Institute of Zoology, Chinese Academy of Sciences
                     address:
                        name:State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:Qiangfeng Cliff Zhang
               affiliation:
                     name:Tsinghua University
                     address:
                        name:MOE Key Laboratory of Bioinformatics, Center for Synthetic and Systems Biology, Beijing Advanced Innovation Center for Structural Biology, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, China
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:Yun-Gui Yang
               affiliation:
                     name:Beijing Institute of Genomics, Chinese Academy of Sciences
                     address:
                        name:CAS Key Laboratory of Genomic and Precision Medicine, Collaborative Innovation Center of Genetics and Development, College of Future Technology, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China
                        type:PostalAddress
                     type:Organization
                     name:University of Chinese Academy of Sciences
                     address:
                        name:University of Chinese Academy of Sciences, Beijing, China
                        type:PostalAddress
                     type:Organization
                     name:Institute of Stem Cell and Regeneration, Chinese Academy of Sciences
                     address:
                        name:Institute of Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:1
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:RNA structural dynamics regulate early embryogenesis through controlling transcriptome fate and function
      description:Vertebrate early embryogenesis is initially directed by a set of maternal RNAs and proteins, yet the mechanisms controlling this program remain largely unknown. Recent transcriptome-wide studies on RNA structure have revealed its pervasive and crucial roles in RNA processing and functions, but whether and how RNA structure regulates the fate of the maternal transcriptome have yet to be determined. Here we establish the global map of four nucleotide-based mRNA structures by icSHAPE during zebrafish early embryogenesis. Strikingly, we observe that RNA structurally variable regions are enriched in the 3′ UTR and contain cis-regulatory elements important for maternal-to-zygotic transition (MZT). We find that the RNA-binding protein Elavl1a stabilizes maternal mRNAs by binding to the cis-elements. Conversely, RNA structure formation suppresses Elavl1a’s binding leading to the decay of its maternal targets. Our study finds that RNA structurally variable regions are enriched in mRNA 3′ UTRs and contain cis-regulatory elements during zebrafish early embryogenesis. We reveal that Elavl1a regulates maternal RNA stability in an RNA structure-dependent fashion. Overall, our findings reveal a broad and fundamental role of RNA structure-based regulation in vertebrate early embryogenesis.
      datePublished:2020-05-18T00:00:00Z
      dateModified:2020-05-18T00:00:00Z
      pageStart:1
      pageEnd:27
      license:http://creativecommons.org/publicdomain/zero/1.0/
      sameAs:https://doi.org/10.1186/s13059-020-02022-2
      keywords:
         RNA structure
         Zebrafish early embryogenesis
         Structure-based regulome
         Elavl1a
         Animal Genetics and Genomics
         Human Genetics
         Plant Genetics and Genomics
         Microbial Genetics and Genomics
         Bioinformatics
         Evolutionary Biology
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs13059-020-02022-2/MediaObjects/13059_2020_2022_Fig1_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs13059-020-02022-2/MediaObjects/13059_2020_2022_Fig2_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs13059-020-02022-2/MediaObjects/13059_2020_2022_Fig3_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs13059-020-02022-2/MediaObjects/13059_2020_2022_Fig4_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs13059-020-02022-2/MediaObjects/13059_2020_2022_Fig5_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs13059-020-02022-2/MediaObjects/13059_2020_2022_Fig6_HTML.png
      isPartOf:
         name:Genome Biology
         issn:
            1474-760X
         volumeNumber:21
         type:
            Periodical
            PublicationVolume
      publisher:
         name:BioMed Central
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Boyang Shi
            affiliation:
                  name:Beijing Institute of Genomics, Chinese Academy of Sciences
                  address:
                     name:CAS Key Laboratory of Genomic and Precision Medicine, Collaborative Innovation Center of Genetics and Development, College of Future Technology, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China
                     type:PostalAddress
                  type:Organization
                  name:University of Chinese Academy of Sciences
                  address:
                     name:University of Chinese Academy of Sciences, Beijing, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Jinsong Zhang
            affiliation:
                  name:Tsinghua University
                  address:
                     name:MOE Key Laboratory of Bioinformatics, Center for Synthetic and Systems Biology, Beijing Advanced Innovation Center for Structural Biology, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Jian Heng
            affiliation:
                  name:University of Chinese Academy of Sciences
                  address:
                     name:University of Chinese Academy of Sciences, Beijing, China
                     type:PostalAddress
                  type:Organization
                  name:Institute of Zoology, Chinese Academy of Sciences
                  address:
                     name:State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Jing Gong
            affiliation:
                  name:Tsinghua University
                  address:
                     name:MOE Key Laboratory of Bioinformatics, Center for Synthetic and Systems Biology, Beijing Advanced Innovation Center for Structural Biology, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Ting Zhang
            affiliation:
                  name:Beijing Institute of Genomics, Chinese Academy of Sciences
                  address:
                     name:CAS Key Laboratory of Genomic and Precision Medicine, Collaborative Innovation Center of Genetics and Development, College of Future Technology, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China
                     type:PostalAddress
                  type:Organization
                  name:University of Chinese Academy of Sciences
                  address:
                     name:University of Chinese Academy of Sciences, Beijing, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Pan Li
            affiliation:
                  name:Tsinghua University
                  address:
                     name:MOE Key Laboratory of Bioinformatics, Center for Synthetic and Systems Biology, Beijing Advanced Innovation Center for Structural Biology, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Bao-Fa Sun
            affiliation:
                  name:Beijing Institute of Genomics, Chinese Academy of Sciences
                  address:
                     name:CAS Key Laboratory of Genomic and Precision Medicine, Collaborative Innovation Center of Genetics and Development, College of Future Technology, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China
                     type:PostalAddress
                  type:Organization
                  name:Institute of Stem Cell and Regeneration, Chinese Academy of Sciences
                  address:
                     name:Institute of Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Ying Yang
            affiliation:
                  name:Beijing Institute of Genomics, Chinese Academy of Sciences
                  address:
                     name:CAS Key Laboratory of Genomic and Precision Medicine, Collaborative Innovation Center of Genetics and Development, College of Future Technology, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China
                     type:PostalAddress
                  type:Organization
                  name:Institute of Stem Cell and Regeneration, Chinese Academy of Sciences
                  address:
                     name:Institute of Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Ning Zhang
            affiliation:
                  name:State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences
                  address:
                     name:State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Yong-Liang Zhao
            affiliation:
                  name:Beijing Institute of Genomics, Chinese Academy of Sciences
                  address:
                     name:CAS Key Laboratory of Genomic and Precision Medicine, Collaborative Innovation Center of Genetics and Development, College of Future Technology, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China
                     type:PostalAddress
                  type:Organization
                  name:University of Chinese Academy of Sciences
                  address:
                     name:University of Chinese Academy of Sciences, Beijing, China
                     type:PostalAddress
                  type:Organization
                  name:Institute of Stem Cell and Regeneration, Chinese Academy of Sciences
                  address:
                     name:Institute of Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Hai-Lin Wang
            affiliation:
                  name:University of Chinese Academy of Sciences
                  address:
                     name:University of Chinese Academy of Sciences, Beijing, China
                     type:PostalAddress
                  type:Organization
                  name:State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences
                  address:
                     name:State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Feng Liu
            affiliation:
                  name:University of Chinese Academy of Sciences
                  address:
                     name:University of Chinese Academy of Sciences, Beijing, China
                     type:PostalAddress
                  type:Organization
                  name:Institute of Zoology, Chinese Academy of Sciences
                  address:
                     name:State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Qiangfeng Cliff Zhang
            affiliation:
                  name:Tsinghua University
                  address:
                     name:MOE Key Laboratory of Bioinformatics, Center for Synthetic and Systems Biology, Beijing Advanced Innovation Center for Structural Biology, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, China
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Yun-Gui Yang
            affiliation:
                  name:Beijing Institute of Genomics, Chinese Academy of Sciences
                  address:
                     name:CAS Key Laboratory of Genomic and Precision Medicine, Collaborative Innovation Center of Genetics and Development, College of Future Technology, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China
                     type:PostalAddress
                  type:Organization
                  name:University of Chinese Academy of Sciences
                  address:
                     name:University of Chinese Academy of Sciences, Beijing, China
                     type:PostalAddress
                  type:Organization
                  name:Institute of Stem Cell and Regeneration, Chinese Academy of Sciences
                  address:
                     name:Institute of Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:1
["Periodical","PublicationVolume"]:
      name:Genome Biology
      issn:
         1474-760X
      volumeNumber:21
Organization:
      name:BioMed Central
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Beijing Institute of Genomics, Chinese Academy of Sciences
      address:
         name:CAS Key Laboratory of Genomic and Precision Medicine, Collaborative Innovation Center of Genetics and Development, College of Future Technology, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China
         type:PostalAddress
      name:University of Chinese Academy of Sciences
      address:
         name:University of Chinese Academy of Sciences, Beijing, China
         type:PostalAddress
      name:Tsinghua University
      address:
         name:MOE Key Laboratory of Bioinformatics, Center for Synthetic and Systems Biology, Beijing Advanced Innovation Center for Structural Biology, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, China
         type:PostalAddress
      name:University of Chinese Academy of Sciences
      address:
         name:University of Chinese Academy of Sciences, Beijing, China
         type:PostalAddress
      name:Institute of Zoology, Chinese Academy of Sciences
      address:
         name:State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
         type:PostalAddress
      name:Tsinghua University
      address:
         name:MOE Key Laboratory of Bioinformatics, Center for Synthetic and Systems Biology, Beijing Advanced Innovation Center for Structural Biology, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, China
         type:PostalAddress
      name:Beijing Institute of Genomics, Chinese Academy of Sciences
      address:
         name:CAS Key Laboratory of Genomic and Precision Medicine, Collaborative Innovation Center of Genetics and Development, College of Future Technology, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China
         type:PostalAddress
      name:University of Chinese Academy of Sciences
      address:
         name:University of Chinese Academy of Sciences, Beijing, China
         type:PostalAddress
      name:Tsinghua University
      address:
         name:MOE Key Laboratory of Bioinformatics, Center for Synthetic and Systems Biology, Beijing Advanced Innovation Center for Structural Biology, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, China
         type:PostalAddress
      name:Beijing Institute of Genomics, Chinese Academy of Sciences
      address:
         name:CAS Key Laboratory of Genomic and Precision Medicine, Collaborative Innovation Center of Genetics and Development, College of Future Technology, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China
         type:PostalAddress
      name:Institute of Stem Cell and Regeneration, Chinese Academy of Sciences
      address:
         name:Institute of Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China
         type:PostalAddress
      name:Beijing Institute of Genomics, Chinese Academy of Sciences
      address:
         name:CAS Key Laboratory of Genomic and Precision Medicine, Collaborative Innovation Center of Genetics and Development, College of Future Technology, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China
         type:PostalAddress
      name:Institute of Stem Cell and Regeneration, Chinese Academy of Sciences
      address:
         name:Institute of Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China
         type:PostalAddress
      name:State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences
      address:
         name:State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China
         type:PostalAddress
      name:Beijing Institute of Genomics, Chinese Academy of Sciences
      address:
         name:CAS Key Laboratory of Genomic and Precision Medicine, Collaborative Innovation Center of Genetics and Development, College of Future Technology, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China
         type:PostalAddress
      name:University of Chinese Academy of Sciences
      address:
         name:University of Chinese Academy of Sciences, Beijing, China
         type:PostalAddress
      name:Institute of Stem Cell and Regeneration, Chinese Academy of Sciences
      address:
         name:Institute of Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China
         type:PostalAddress
      name:University of Chinese Academy of Sciences
      address:
         name:University of Chinese Academy of Sciences, Beijing, China
         type:PostalAddress
      name:State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences
      address:
         name:State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China
         type:PostalAddress
      name:University of Chinese Academy of Sciences
      address:
         name:University of Chinese Academy of Sciences, Beijing, China
         type:PostalAddress
      name:Institute of Zoology, Chinese Academy of Sciences
      address:
         name:State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
         type:PostalAddress
      name:Tsinghua University
      address:
         name:MOE Key Laboratory of Bioinformatics, Center for Synthetic and Systems Biology, Beijing Advanced Innovation Center for Structural Biology, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, China
         type:PostalAddress
      name:Beijing Institute of Genomics, Chinese Academy of Sciences
      address:
         name:CAS Key Laboratory of Genomic and Precision Medicine, Collaborative Innovation Center of Genetics and Development, College of Future Technology, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China
         type:PostalAddress
      name:University of Chinese Academy of Sciences
      address:
         name:University of Chinese Academy of Sciences, Beijing, China
         type:PostalAddress
      name:Institute of Stem Cell and Regeneration, Chinese Academy of Sciences
      address:
         name:Institute of Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Boyang Shi
      affiliation:
            name:Beijing Institute of Genomics, Chinese Academy of Sciences
            address:
               name:CAS Key Laboratory of Genomic and Precision Medicine, Collaborative Innovation Center of Genetics and Development, College of Future Technology, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China
               type:PostalAddress
            type:Organization
            name:University of Chinese Academy of Sciences
            address:
               name:University of Chinese Academy of Sciences, Beijing, China
               type:PostalAddress
            type:Organization
      name:Jinsong Zhang
      affiliation:
            name:Tsinghua University
            address:
               name:MOE Key Laboratory of Bioinformatics, Center for Synthetic and Systems Biology, Beijing Advanced Innovation Center for Structural Biology, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, China
               type:PostalAddress
            type:Organization
      name:Jian Heng
      affiliation:
            name:University of Chinese Academy of Sciences
            address:
               name:University of Chinese Academy of Sciences, Beijing, China
               type:PostalAddress
            type:Organization
            name:Institute of Zoology, Chinese Academy of Sciences
            address:
               name:State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
               type:PostalAddress
            type:Organization
      name:Jing Gong
      affiliation:
            name:Tsinghua University
            address:
               name:MOE Key Laboratory of Bioinformatics, Center for Synthetic and Systems Biology, Beijing Advanced Innovation Center for Structural Biology, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, China
               type:PostalAddress
            type:Organization
      name:Ting Zhang
      affiliation:
            name:Beijing Institute of Genomics, Chinese Academy of Sciences
            address:
               name:CAS Key Laboratory of Genomic and Precision Medicine, Collaborative Innovation Center of Genetics and Development, College of Future Technology, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China
               type:PostalAddress
            type:Organization
            name:University of Chinese Academy of Sciences
            address:
               name:University of Chinese Academy of Sciences, Beijing, China
               type:PostalAddress
            type:Organization
      name:Pan Li
      affiliation:
            name:Tsinghua University
            address:
               name:MOE Key Laboratory of Bioinformatics, Center for Synthetic and Systems Biology, Beijing Advanced Innovation Center for Structural Biology, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, China
               type:PostalAddress
            type:Organization
      name:Bao-Fa Sun
      affiliation:
            name:Beijing Institute of Genomics, Chinese Academy of Sciences
            address:
               name:CAS Key Laboratory of Genomic and Precision Medicine, Collaborative Innovation Center of Genetics and Development, College of Future Technology, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China
               type:PostalAddress
            type:Organization
            name:Institute of Stem Cell and Regeneration, Chinese Academy of Sciences
            address:
               name:Institute of Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China
               type:PostalAddress
            type:Organization
      name:Ying Yang
      affiliation:
            name:Beijing Institute of Genomics, Chinese Academy of Sciences
            address:
               name:CAS Key Laboratory of Genomic and Precision Medicine, Collaborative Innovation Center of Genetics and Development, College of Future Technology, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China
               type:PostalAddress
            type:Organization
            name:Institute of Stem Cell and Regeneration, Chinese Academy of Sciences
            address:
               name:Institute of Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China
               type:PostalAddress
            type:Organization
      name:Ning Zhang
      affiliation:
            name:State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences
            address:
               name:State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China
               type:PostalAddress
            type:Organization
      name:Yong-Liang Zhao
      affiliation:
            name:Beijing Institute of Genomics, Chinese Academy of Sciences
            address:
               name:CAS Key Laboratory of Genomic and Precision Medicine, Collaborative Innovation Center of Genetics and Development, College of Future Technology, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China
               type:PostalAddress
            type:Organization
            name:University of Chinese Academy of Sciences
            address:
               name:University of Chinese Academy of Sciences, Beijing, China
               type:PostalAddress
            type:Organization
            name:Institute of Stem Cell and Regeneration, Chinese Academy of Sciences
            address:
               name:Institute of Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China
               type:PostalAddress
            type:Organization
      name:Hai-Lin Wang
      affiliation:
            name:University of Chinese Academy of Sciences
            address:
               name:University of Chinese Academy of Sciences, Beijing, China
               type:PostalAddress
            type:Organization
            name:State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences
            address:
               name:State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China
               type:PostalAddress
            type:Organization
      name:Feng Liu
      affiliation:
            name:University of Chinese Academy of Sciences
            address:
               name:University of Chinese Academy of Sciences, Beijing, China
               type:PostalAddress
            type:Organization
            name:Institute of Zoology, Chinese Academy of Sciences
            address:
               name:State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Qiangfeng Cliff Zhang
      affiliation:
            name:Tsinghua University
            address:
               name:MOE Key Laboratory of Bioinformatics, Center for Synthetic and Systems Biology, Beijing Advanced Innovation Center for Structural Biology, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, China
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Yun-Gui Yang
      affiliation:
            name:Beijing Institute of Genomics, Chinese Academy of Sciences
            address:
               name:CAS Key Laboratory of Genomic and Precision Medicine, Collaborative Innovation Center of Genetics and Development, College of Future Technology, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China
               type:PostalAddress
            type:Organization
            name:University of Chinese Academy of Sciences
            address:
               name:University of Chinese Academy of Sciences, Beijing, China
               type:PostalAddress
            type:Organization
            name:Institute of Stem Cell and Regeneration, Chinese Academy of Sciences
            address:
               name:Institute of Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:CAS Key Laboratory of Genomic and Precision Medicine, Collaborative Innovation Center of Genetics and Development, College of Future Technology, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China
      name:University of Chinese Academy of Sciences, Beijing, China
      name:MOE Key Laboratory of Bioinformatics, Center for Synthetic and Systems Biology, Beijing Advanced Innovation Center for Structural Biology, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, China
      name:University of Chinese Academy of Sciences, Beijing, China
      name:State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
      name:MOE Key Laboratory of Bioinformatics, Center for Synthetic and Systems Biology, Beijing Advanced Innovation Center for Structural Biology, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, China
      name:CAS Key Laboratory of Genomic and Precision Medicine, Collaborative Innovation Center of Genetics and Development, College of Future Technology, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China
      name:University of Chinese Academy of Sciences, Beijing, China
      name:MOE Key Laboratory of Bioinformatics, Center for Synthetic and Systems Biology, Beijing Advanced Innovation Center for Structural Biology, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, China
      name:CAS Key Laboratory of Genomic and Precision Medicine, Collaborative Innovation Center of Genetics and Development, College of Future Technology, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China
      name:Institute of Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China
      name:CAS Key Laboratory of Genomic and Precision Medicine, Collaborative Innovation Center of Genetics and Development, College of Future Technology, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China
      name:Institute of Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China
      name:State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China
      name:CAS Key Laboratory of Genomic and Precision Medicine, Collaborative Innovation Center of Genetics and Development, College of Future Technology, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China
      name:University of Chinese Academy of Sciences, Beijing, China
      name:Institute of Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China
      name:University of Chinese Academy of Sciences, Beijing, China
      name:State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China
      name:University of Chinese Academy of Sciences, Beijing, China
      name:State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
      name:MOE Key Laboratory of Bioinformatics, Center for Synthetic and Systems Biology, Beijing Advanced Innovation Center for Structural Biology, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, China
      name:CAS Key Laboratory of Genomic and Precision Medicine, Collaborative Innovation Center of Genetics and Development, College of Future Technology, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China
      name:University of Chinese Academy of Sciences, Beijing, China
      name:Institute of Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China

External Links {🔗}(309)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

5.92s.

LINK . SPRINGER . COM {}