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We are analyzing https://www.nature.com/articles/s41580-018-0007-0.

Title:
Contextual determinants of TGFβ action in development, immunity and cancer | Nature Reviews Molecular Cell Biology
Description:
Few cell signals match the impact of the transforming growth factor-β (TGFβ) family in metazoan biology. TGFβ cytokines regulate cell fate decisions during development, tissue homeostasis and regeneration, and are major players in tumorigenesis, fibrotic disorders, immune malfunctions and various congenital diseases. The effects of the TGFβ family are mediated by a combinatorial set of ligands and receptors and by a common set of receptor-activated mothers against decapentaplegic homologue (SMAD) transcription factors, yet the effects can differ dramatically depending on the cell type and the conditions. Recent progress has illuminated a model of TGFβ action in which SMADs bind genome-wide in partnership with lineage-determining transcription factors and additionally integrate inputs from other pathways and the chromatin to trigger specific cellular responses. These new insights clarify the operating logic of the TGFβ pathway in physiology and disease. Transforming growth factor-β (TGFβ) family cytokines are important regulators of cell fate with pleiotropic roles in development, tissue homeostasis, regeneration and tumorigenesis. Recent studies revealed that this context dependency relies on the convergence between TGFβ signals and other contextual inputs, whereby transcription factors downstream of these pathways collaboratively act to regulate gene expression.
Website Age:
30 years and 10 months (reg. 1994-08-11).

Matching Content Categories {📚}

  • Education
  • Science
  • Telecommunications

Content Management System {📝}

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Custom-built

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🌠 Phenomenal Traffic: 5M - 10M visitors per month


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Reseller Advertisers (38)
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How Much Does Nature.com Make? {💰}


Display Ads {🎯}

$63,100 per month
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Keywords {🔍}

pubmed, article, google, scholar, cas, cell, central, tgfbeta, smad, signaling, cancer, cells, nature, biol, growth, development, transcription, dev, transforming, bmp, mol, massagué, nat, factor, differentiation, pathways, rev, transcriptional, tgfβ, factors, genes, family, smads, stem, access, signalling, sci, human, activation, receptor, tumor, metastasis, epithelial, type, regulation, tumour, protein, biology, regulate, signal,

Topics {✒️}

permissions reprints nature portfolio journals privacy policy transforming growth factor-β nature portfolio editing transforming growth factor-beta advertising tgf-beta-induced foxp3 inhibits phosphoinositide 3-kinase-akt-mammalian target quantitative index tgfbeta-induced epithelial-mesenchymal transition china authors tgf-beta-induced transcriptional activation social media radiation-induced lung injury signal-dependent transcription factors t-box transcription factors author correspondence cyclin-dependent kinases regulate sequence-specific transcription activators tgf-beta induced transdifferentiation lineage-determining transcription factors cyclin-dependent kinase inhibitor context-dependent bmp-2 antagonist tgf-beta gene responses protein-binding zinc fingers tgf-beta promotes heterogeneity noncanonical octamer-binding site tgf-beta-driven program surface-bound tgf-beta including researching data lysine-methylated histone tails tgf-beta-mediated regulation limit tgf-beta signaling tgf-beta-stimulated cooperation histone post-translational modifications regulates bmp-dependent dendritogenesis tgf-beta signal transduction tgf-beta-smad pathway transcription factor foxp3 tgf-beta family signaling tgf-beta receptor activity mediator establish super-enhancers peripheral cd4 + cd25- naive epithelial-mesenchymal cell transformation tgf-beta access lineage-defining super-enhancers tgf-beta tumor suppression promoting tumour growth

Questions {❓}

  • Epithelial-mesenchymal transition (EMT) and metastasis: yes, no, maybe?

Schema {🗺️}

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      description:Few cell signals match the impact of the transforming growth factor-β (TGFβ) family in metazoan biology. TGFβ cytokines regulate cell fate decisions during development, tissue homeostasis and regeneration, and are major players in tumorigenesis, fibrotic disorders, immune malfunctions and various congenital diseases. The effects of the TGFβ family are mediated by a combinatorial set of ligands and receptors and by a common set of receptor-activated mothers against decapentaplegic homologue (SMAD) transcription factors, yet the effects can differ dramatically depending on the cell type and the conditions. Recent progress has illuminated a model of TGFβ action in which SMADs bind genome-wide in partnership with lineage-determining transcription factors and additionally integrate inputs from other pathways and the chromatin to trigger specific cellular responses. These new insights clarify the operating logic of the TGFβ pathway in physiology and disease. Transforming growth factor-β (TGFβ) family cytokines are important regulators of cell fate with pleiotropic roles in development, tissue homeostasis, regeneration and tumorigenesis. Recent studies revealed that this context dependency relies on the convergence between TGFβ signals and other contextual inputs, whereby transcription factors downstream of these pathways collaboratively act to regulate gene expression.
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