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Keywords {🔍}

doi, smad, pubmed, google, scholar, tgfβ, signaling, cell, ectotifγ, pmc, monoubiquitylation, ubiquitylation, article, free, regulation, activity, ubiquitin, rsmad, ligase, protein, usp, degradation, cells, rsmads, signal, smads, dna, target, embryos, bmp, proteins, mol, deubiquitylation, polyubiquitylation, role, phosphorylation, transcription, complexes, biol, receptor, facets, mono, fat, complex, studies, ligases, genetic, mouse, famuspx, nodal,

Topics {✒️}

inhibit betaftz-f1-dependent transcription c-terminal phd–bromo domain tgf–β-induced smads compete tgf–β-smad signal transduction tgf–β stimulation sets ecto/tif1–γ mutant phenotypes domain-enables ecto/tif1–γ e3 ligase ecto/tif1–γ phd finger-bromodomain activates endogenous r-smad/smad4 complexes activated r-smad-smad4 complex smad4-independent tgf–β pathway primary tgf–β ligand larval neuro-muscular junctions pmc beta search phenocopy tgf–β mα wnt/gsk3-β regulates ecto/tif1–γ acts fused/smurf complex controls positive r-smad cofactor tgf-β family ligands regulates tgf–β signaling tgf–β signal concentrations tgf–β signal transduction tgf-β signal transduction receptor tyrosine kinase/ras terminate tgf–β signaling tgf–β morphogen signal experiments ecto/tif1–γ ecto/tif1–γ serves krab-zinc finger proteins tgf–β family signaling total r-smad degradation tgf–β pathways ability ectodermin/tif1-γ patterns tgf-β/bmp-dependent k63-linked polyubiquitylation acts regulate tgf–β signaling foxo-smad synexpression group inhibits r-smad binding phd–bromo domain interaction tgf–β-dependent patterning phospho-r-smad binding tgf–β stimulation protecting tgf–β receptors kap1/tif1-β/trim28 tgf–β ligand concentration ectodermin/tif1-γ/trim33 ectodermin/tif1–γ/trim33 sno-ski family proteins

Questions {❓}

• The finding that Ecto/Tif1–γ is regulated by chromatin opens new questions about how Smads themselves interact with chromatin such as: what are the histone modifications promoted by Smads and what are the epigenetic contexts in which Ecto/Tif1–γ regulation of Smads is permitted or prohibited?
• This model begs the question - why are Smads engaged in these cycles?
• What is the molecular nature of the nuclear mechanism that continuously dissociates Smad complexes?

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• What's https://www.hhs.gov/vulnerability-disclosure-policy/index.html's gross income?
• What's the monthly income of https://support.nlm.nih.gov/?pagename=cloudpmc-viewer%3Apmc%3Aarticle%3Amanuscript?
• How much does https://www.nlm.nih.gov/accessibility.html generate monthly?
• What's the revenue for https://www.nlm.nih.gov/careers/careers.html?
• See how much https://www.nlm.nih.gov/ makes per month
• What's the financial outcome of https://www.nih.gov/?
• What are the earnings of https://www.hhs.gov/?
• What is the monthly revenue of https://www.usa.gov/?

Analytics and Tracking {📊}

• Google Analytics
• Google Analytics 4
• Google Tag Manager

Libraries {📚}

• jQuery
• jQuery module (jquery-3.6.0)

Emails and Hosting {✉️}

Mail Servers:

• nihcesxway.hub.nih.gov
• nihcesxway2.hub.nih.gov
• nihcesxway3.hub.nih.gov
• nihcesxway4.hub.nih.gov
• nihcesxway5.hub.nih.gov

Name Servers:

• dns1-ncbi.ncbi.nlm.nih.gov
• dns2-ncbi.ncbi.nlm.nih.gov
• lhcns1.nlm.nih.gov
• lhcns2.nlm.nih.gov

CDN Services {📦}

• Ncbi