
PMC . NCBI . NLM . NIH . GOV {
}
Title:
Variant rs8400 enhances ALKBH5 expression through disrupting miR-186 binding and promotes neuroblastoma progression - PMC
Description:
AlkB homolog 5 (ALKBH5) has been proven to be closely related to tumors. However, the role and molecular mechanism of ALKBH5 in neuroblastomas have rarely been reported. The potential functional single-nucleotide polymorphisms (SNPs) in ALKBH5 were ...
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Keywords {🔍}
alkbh, neuroblastoma, doi, expression, cells, cell, figure, pubmed, google, scholar, pmc, free, genes, article, gene, allele, spp, cancer, showed, analysis, control, compared, significantly, rna, lines, knockdown, mrna, results, mirp, risk, proliferation, study, increased, target, snps, effect, open, susceptibility, tab, binding, tumor, snp, patients, assay, genetic, modification, adjusted, progression, effects, luciferase,
Topics {✒️}
activating atm-chk2-p53/cdc25c signalling al n6-methyladenosine-dependent regulation reverse transcription kit m6a-ythdf2-dependent manner anti-rabbit secondary antibody inhibiting ly6/plaur domain n6-methyladenosine eraser alkbh5 ikkε/tbk1/irf3 pathway crispr-cas9 genome editing pmc beta search hrp-conjugated anti-mouse mir-186-3p-alkbh5-spp1 axis crispr-cas9 technology prior al high-dose rapid stable ko-alkbh5 sk-n m6a-guided epigenetic inhibition high-throughput rna sequencing making mir-186-3p unable mettl3-eif3h enhances translation fit chi-square test paraffin-embedded tissue sections generate single-end reads inhibiting interferon-alpha production anti-gd2 antibody response methylated rna immunoprecipitation genome-wide association studies glucose metabolism-related genes online genotype-tissue expression allele-overexpressing cell lines mir-186-3p negatively regulates centre case-control study lmo1 super-enhancer polymorphism al mettl14 suppresses mammalian rna demethylase rna-seq data showed center case-control study mir-186-3p level inhibited final microrna-target complex childhood cancer-related deaths alkbh5-mediated m6a-demethylation m6a modification-related genes rna demethylase alkbh5 mir-186-alkbh5-spp1 axis rs8400 a-overexpressing cells minimum free energy allele-overexpressing cells formed cell proliferation program reducing yap expression critical m6a demethylase key m6a demethylase
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