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Title[redir]:
Frequency of ALK and GD2 Expression in Neuroblastoma: Fetal and Pediatric Pathology: Vol 38 , No 4 - Get Access
Description:
Peripheral neuroblastic tumors are the most common extracranial solid tumors in childhood. They originate from embryonal neural crest cells. The mean age of diagnosis is 18 months and the frequency...
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Keywords {🔍}
taylor, francis, access, article, log, online, alk, group, page, search, medicine, pathology, university, journals, register, cart, pediatric, issue, turkey, cerrahpaşacerrahpaşa, faculty, istanbul, differentiation, pdf, content, add, read, articles, research, statistically, tumor, stage, immunostaining, open, login, browse, eprints, features, fetal, volume, frequency, expression, journal, citations, date, neuroblastoma, hospital, urology, clinic, reprints,
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downloaded article pdf journals medicine fetal downloaded article pdfs francis group limited period gaziosmanpaşa taksim education immunohistochemical staining patterns favorable/unfavorable histology statistically significant correlation statistically significantly higher journals books receive personalised research access rights institution access advanced search fetal peripheral neuroblastic tumors favorable/unfavorable features differentiated group pediatric pathology list article https published online cart search issue 4 frequency research hospital date register register log read gd2 immunostaining alk immunostaining issues volume 38 pediatric surgery pediatric hematooncology institution log shibboleth log gd2 expression gd2 immunopositivity taylor scheduled work pathology unit urology clinic 1 ganglioneuroma cases immunohistochemically stained shared devices purchases made printed usd 68 printed usd 928 contact newsroom email sign england & wales sw1p 1wg
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articleSection:Articles
name:Frequency of ALK and GD2 Expression in Neuroblastoma
headline:Frequency of ALK and GD2 Expression in Neuroblastoma
abstract:Background: The aim of this study was to elucidate the significance of immunohistochemical staining patterns of ALK and GD2 in peripheral neuroblastic tumors with different stages and favorable/unfavorable features. Materials and methods: 32 neuroblastomas, 7 ganglioneuroblastomas, and 1 ganglioneuroma cases were immunohistochemically stained with ALK and GD2, and the expressions were graded and correlated with differentiation, size, and favorable/unfavorable histology. Results: There was no statistically significant correlation between ALK immunopositivity and tumor differentiation or stage. Although there was no statistically significant correlation between GD2 immunopositivity and stage, the intensity and prevalence of GD2 immunostaining were statistically significantly higher in the well differentiated group and in tumors which were smaller than 10 cm. Conclusion: GD2 immunostaining levels correlated with tumor differentiation and size. ALK immunostaining was not related to tumor differentiation or stage.
description:Background: The aim of this study was to elucidate the significance of immunohistochemical staining patterns of ALK and GD2 in peripheral neuroblastic tumors with different stages and favorable/unfavorable features. Materials and methods: 32 neuroblastomas, 7 ganglioneuroblastomas, and 1 ganglioneuroma cases were immunohistochemically stained with ALK and GD2, and the expressions were graded and correlated with differentiation, size, and favorable/unfavorable histology. Results: There was no statistically significant correlation between ALK immunopositivity and tumor differentiation or stage. Although there was no statistically significant correlation between GD2 immunopositivity and stage, the intensity and prevalence of GD2 immunostaining were statistically significantly higher in the well differentiated group and in tumors which were smaller than 10 cm. Conclusion: GD2 immunostaining levels correlated with tumor differentiation and size. ALK immunostaining was not related to tumor differentiation or stage.
author:
type:Person
name:Nil Comunoglu
type:Person
name:Oktay Ãzman
type:Person
name:Tiraje Celkan
type:Person
name:Åenol Emre
type:Person
name:Åebnem Batur
type:Person
name:Zeynep Aygün
keywords:Neuroblastoma, ALK, GD2, immunohistochemistry
pageStart:326
pageEnd:334
datePublished:2019-04-07
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