We are analyzing https://link.springer.com/chapter/10.1007/978-981-13-7342-8_4.

Title:
RNA N 6-Methyladenosine Modification in Normal and Malignant Hematopoiesis | SpringerLink
Description:
As the most abundant internal modification in eukaryotic messenger RNAs (mRNAs), N 6-methyladenosine (m6A) modification has been shown recently to posttranscriptionally regulate expression of thousands of messenger RNA (mRNA) transcripts in each mammalian cell type...
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Keywords {🔍}

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Topics {✒️}

m6a individual-nucleotide-resolution cross-linking mrna-binding factor rbm15/spenito month download article/chapter a-dependent translation control mettl3/mettl14/wtap complex n6-methyladenosine-dependent regulation regulated protein-rna interactome post-transcriptional gene regulation huilin huang & jianjun chen human hnrnp a2/b1 rna n6-methyladenosine methyltransferase mettl3-mettl14 complex rna n6-methyladenosine modification functional c-myb gene sierra-ramirez ja modulates haematopoietic stem ythdf3 facilitates translation regulate mrna homeostasis progenitor cell specification machinery component wtap/fl device instant download adult hematopoietic progenitors privacy choices/manage cookies posttranscriptionally regulate expression hematopoietic stem cells acute myeloid leukemia hsu pj methyladenosine binding protein mammalian rna demethylase regulates mammalian spermatogenesis rna n6-methyladenosine editor information editors beckman research institute methyladenosine methyltransferase complex embryonic stem cells acute megakaryoblastic leukemia leukemia stem cells dna damage response single nucleotide polymorphisms messenger rna stability m6a methyltransferase complex ythdf2 reveals mechanism methyladenosine rna demethylase hematopoietic stem cell fto-dependent demethylation dna methylation patterns tet-mediated formation roundtree ia single-stranded dna internal n6-methyladenosine

Questions {❓}

Plaks V, Kong N, Werb Z (2015) The cancer stem cell niche: how essential is the niche in regulating stemness of tumor cells?

Schema {🗺️}

ScholarlyArticle:
      headline:RNA N 6-Methyladenosine Modification in Normal and Malignant Hematopoiesis
      pageEnd:93
      pageStart:75
      image:https://media.springernature.com/w153/springer-static/cover/book/978-981-13-7342-8.jpg
      genre:
         Biomedical and Life Sciences
         Biomedical and Life Sciences (R0)
      isPartOf:
         name:Leukemia Stem Cells in Hematologic Malignancies
         isbn:
            978-981-13-7342-8
            978-981-13-7341-1
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      publisher:
         name:Springer Singapore
         logo:
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            type:ImageObject
         type:Organization
      author:
            name:Hengyou Weng
            affiliation:
                  name:Beckman Research Institute of City of Hope
                  address:
                     name:Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, USA
                     type:PostalAddress
                  type:Organization
                  name:Beckman Research Institute of City of Hope
                  address:
                     name:The Gehr Family Center for Leukemia Research, Beckman Research Institute of City of Hope, Monrovia, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Huilin Huang
            affiliation:
                  name:Beckman Research Institute of City of Hope
                  address:
                     name:Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, USA
                     type:PostalAddress
                  type:Organization
                  name:Beckman Research Institute of City of Hope
                  address:
                     name:The Gehr Family Center for Leukemia Research, Beckman Research Institute of City of Hope, Monrovia, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Jianjun Chen
            affiliation:
                  name:Beckman Research Institute of City of Hope
                  address:
                     name:Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, USA
                     type:PostalAddress
                  type:Organization
                  name:Beckman Research Institute of City of Hope
                  address:
                     name:The Gehr Family Center for Leukemia Research, Beckman Research Institute of City of Hope, Monrovia, USA
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      keywords:m6A demethylases, m6A modification, Normal hematopoiesis, AML
      description:As the most abundant internal modification in eukaryotic messenger RNAs (mRNAs), N 6-methyladenosine (m6A) modification has been shown recently to posttranscriptionally regulate expression of thousands of messenger RNA (mRNA) transcripts in each mammalian cell type in a dynamic and reversible manner. This epigenetic mark is deposited by the m6A methyltransferase complex (i.e., the METTL3/METTL14/WTAP complex and other cofactor proteins) and erased by m6A demethylases such as FTO and ALKBH5. Specific recognition of these m6A-modified mRNAs by m6A-binding proteins (i.e., m6A readers) determines the fate of target mRNAs through affecting splicing, nuclear export, RNA stability, and/or translation. During the past few years, m6A modification has been demonstrated to play a critical role in many major normal bioprocesses including self-renewal and differentiation of embryonic stem cells and hematopoietic stem cells, tissue development, circadian rhythm, heat shock or DNA damage response, and sex determination. Thus, it is not surprising that dysregulation of the m6A machinery is also closely associated with pathogenesis and drug response of both solid tumors and hematologic malignancies. In this chapter, we summarize and discuss recent findings regarding the biological functions and underlying mechanisms of m6A modification and the associated machinery in normal hematopoiesis and the initiation, progression, and drug response of acute myeloid leukemia (AML), a major subtype of leukemia usually associated with unfavorable prognosis.
      datePublished:2019
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Book:
      name:Leukemia Stem Cells in Hematologic Malignancies
      isbn:
         978-981-13-7342-8
         978-981-13-7341-1
Organization:
      name:Springer Singapore
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Beckman Research Institute of City of Hope
      address:
         name:Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, USA
         type:PostalAddress
      name:Beckman Research Institute of City of Hope
      address:
         name:The Gehr Family Center for Leukemia Research, Beckman Research Institute of City of Hope, Monrovia, USA
         type:PostalAddress
      name:Beckman Research Institute of City of Hope
      address:
         name:Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, USA
         type:PostalAddress
      name:Beckman Research Institute of City of Hope
      address:
         name:The Gehr Family Center for Leukemia Research, Beckman Research Institute of City of Hope, Monrovia, USA
         type:PostalAddress
      name:Beckman Research Institute of City of Hope
      address:
         name:Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, USA
         type:PostalAddress
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      address:
         name:The Gehr Family Center for Leukemia Research, Beckman Research Institute of City of Hope, Monrovia, USA
         type:PostalAddress
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Person:
      name:Hengyou Weng
      affiliation:
            name:Beckman Research Institute of City of Hope
            address:
               name:Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, USA
               type:PostalAddress
            type:Organization
            name:Beckman Research Institute of City of Hope
            address:
               name:The Gehr Family Center for Leukemia Research, Beckman Research Institute of City of Hope, Monrovia, USA
               type:PostalAddress
            type:Organization
      name:Huilin Huang
      affiliation:
            name:Beckman Research Institute of City of Hope
            address:
               name:Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, USA
               type:PostalAddress
            type:Organization
            name:Beckman Research Institute of City of Hope
            address:
               name:The Gehr Family Center for Leukemia Research, Beckman Research Institute of City of Hope, Monrovia, USA
               type:PostalAddress
            type:Organization
      name:Jianjun Chen
      affiliation:
            name:Beckman Research Institute of City of Hope
            address:
               name:Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, USA
               type:PostalAddress
            type:Organization
            name:Beckman Research Institute of City of Hope
            address:
               name:The Gehr Family Center for Leukemia Research, Beckman Research Institute of City of Hope, Monrovia, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, USA
      name:The Gehr Family Center for Leukemia Research, Beckman Research Institute of City of Hope, Monrovia, USA
      name:Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, USA
      name:The Gehr Family Center for Leukemia Research, Beckman Research Institute of City of Hope, Monrovia, USA
      name:Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, USA
      name:The Gehr Family Center for Leukemia Research, Beckman Research Institute of City of Hope, Monrovia, USA
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