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Title:
The role of tumor microenvironment on cancer stem cell fate in solid tumors | Cell Communication and Signaling
Description:
In the last few decades, the role of cancer stem cells in initiating tumors, metastasis, invasion, and resistance to therapies has been recognized as a potential target for tumor therapy. Understanding the mechanisms by which CSCs contribute to cancer progression can help to provide novel therapeutic approaches against solid tumors. In this line, the effects of mechanical forces on CSCs such as epithelial-mesenchymal transition, cellular plasticity, etc., the metabolism pathways of CSCs, players of the tumor microenvironment, and their influence on the regulating of CSCs can lead to cancer progression. This review focused on some of these mechanisms of CSCs, paving the way for a better understanding of their regulatory mechanisms and developing platforms for targeted therapies. While progress has been made in research, more studies will be required in the future to explore more aspects of how CSCs contribute to cancer progression. Video Abstract
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Keywords {🔍}
pubmed, cells, cancer, article, scholar, google, cas, cscs, cell, stem, central, tumor, metabolism, breast, mitochondrial, glycolysis, expression, growth, metabolic, signaling, microenvironment, role, factor, res, metastasis, stemness, factors, invasion, acid, wang, tumors, resistance, therapy, tme, lung, glucose, activation, hypoxia, human, activity, stemlike, lactate, plasticity, regulation, glycolytic, production, liu, oncotarget, pathway, progression,
Topics {✒️}
wnt/beta-catenin-foxm1-twist signaling peroxisome proliferator-activated receptor-gamma peroxisome-proliferator activated receptor-gamma multi-drug-resistant murine colon anti-hepatoma-derived growth factor granulocyte–macrophage colony-stimulating factor tgf-beta1-induced protective mechanisms wnt/beta-catenin signaling pathways human colon-cancer-initiating cells mitogen-activated protein kinase myc/pgc-1α balance determines cxcr4/cxcl12 axis increases bone marrow-derived cells cxcr4/cxcl12 axis triggers article download pdf tumour-derived lactic acid tgf-beta1 signaling pathway connecting tgf-beta signaling myeloid-derived suppressor cells wnt-induced epithelial-mesenchymal wnt positive-signaling loop acetyl-coa carboxylase suppresses urokinase-type plasminogen activators glutamine analog l-don severe combined immune-deficient targeting epithelial-mesenchymal transition martinez-outschoorn ue /extracellular signal-regulated kinase tumor necrosis factor-alpha wnt/b-catenin activity e-cadherin-dependent manner pdgf-induced glioma cells cd44 receptor-mediated endocytosis fluid shear stress tumor-infiltrating immune cell lung cancer-initiating cells embden-meyerhoff/glycolytic pathway simultaneous high-speed proliferation tumor-shed vesicles depends prefer low-oxygen environments triple-negative breast cancer brain tumor-initiating cells mitochondrial substrate-level phosphorylation cell–cell adhesion mediated tissue-resident stem cells tgf-β induces expression neutrophil activating protein/interleukin-8 pgi-klf4 pathway regulates stearoyl-coa desaturase-1 6-phosphofructo-2-kinase/fructose-2
Questions {❓}
- Asymmetric division: a marker for cancer stem cells?
- Cancer metabolism: is glutamine sweeter than glucose?
- Innate or adaptive immunity?
- Stat3: linking inflammation to epithelial cancer - more than a “gut” feeling?
- Tackling the cancer stem cells - what challenges do they pose?
- The Warburg effect: how does it benefit cancer cells?
- Wnt meets Warburg: another piece in the puzzle?
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headline:The role of tumor microenvironment on cancer stem cell fate in solid tumors
description:In the last few decades, the role of cancer stem cells in initiating tumors, metastasis, invasion, and resistance to therapies has been recognized as a potential target for tumor therapy. Understanding the mechanisms by which CSCs contribute to cancer progression can help to provide novel therapeutic approaches against solid tumors. In this line, the effects of mechanical forces on CSCs such as epithelial-mesenchymal transition, cellular plasticity, etc., the metabolism pathways of CSCs, players of the tumor microenvironment, and their influence on the regulating of CSCs can lead to cancer progression. This review focused on some of these mechanisms of CSCs, paving the way for a better understanding of their regulatory mechanisms and developing platforms for targeted therapies. While progress has been made in research, more studies will be required in the future to explore more aspects of how CSCs contribute to cancer progression.
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Tumor microenvironment
Metabolism
Solid tumors
EMT
Cellular plasticity
Signaling pathways
Cell Biology
Protein-Ligand Interactions
Receptors
Cytokines and Growth Factors
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headline:The role of tumor microenvironment on cancer stem cell fate in solid tumors
description:In the last few decades, the role of cancer stem cells in initiating tumors, metastasis, invasion, and resistance to therapies has been recognized as a potential target for tumor therapy. Understanding the mechanisms by which CSCs contribute to cancer progression can help to provide novel therapeutic approaches against solid tumors. In this line, the effects of mechanical forces on CSCs such as epithelial-mesenchymal transition, cellular plasticity, etc., the metabolism pathways of CSCs, players of the tumor microenvironment, and their influence on the regulating of CSCs can lead to cancer progression. This review focused on some of these mechanisms of CSCs, paving the way for a better understanding of their regulatory mechanisms and developing platforms for targeted therapies. While progress has been made in research, more studies will be required in the future to explore more aspects of how CSCs contribute to cancer progression.
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Tumor microenvironment
Metabolism
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EMT
Cellular plasticity
Signaling pathways
Cell Biology
Protein-Ligand Interactions
Receptors
Cytokines and Growth Factors
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