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Title[redir]:
Tissue-specific and convergent metabolic transformation of cancer correlates with metastatic potential and patient survival - PMC
Description:
Cancer cells undergo a multifaceted rewiring of cellular metabolism to support their biosynthetic needs. Although the major determinants of this metabolic transformation have been elucidated, their broad biological implications and clinical ...
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Keywords {π}
cancer, metabolic, expression, normal, data, genes, gene, supplementary, pathways, mitochondrial, patients, survival, fig, cancers, tissues, metastatic, cell, samples, tissue, doi, google, scholar, pubmed, pmc, analysis, article, types, metabolism, pathway, cells, compared, free, downregulated, oxphos, low, study, upregulated, high, tissuespecific, correlation, ncommssxlsx, xlsx, downregulation, metastasis, enriched, lines, differential, line, obtained, primary,
Topics {βοΈ}
final gene-level information [google scholar] hu pmc beta search ataris gene-level score9 cross-platform data set context-specific genetic dependencies accession number gse39004/gse37751 tumor-induced gene expression parallel genome-scale loss tissue-specific metabolic signatures tissue-specific metabolic functions benjamini-hochberg adjusted p tissue-specific metabolic rewiring cancer-causing genes undergo final correlation p-values tissue-independent metabolic signatures promiscuity-corrected t-values benjamini-hochberg correction method normal tissue-specific functions normal-tissue-specific functions tissue-specific metabolic reprogramming additional information tissue-independent metabolic clustering similar metabolic signatures supplementary information files recent pan-cancer analysis tissue-dependent metabolic pathways internal circle shows license information pmcid adjusted p-values lower genome-wide data large-scale information supplementary materials included skin cutaneous melanoma linking differential expression rnaseq raw counts showing heterogeneous distribution manually curated genetic reactivation suppresses mitochondrial dysfunction triggered gene set analysis found significantly altered independent data set copy number alterations differential gene expression pie charts represent top predicted functions benjamini-hochberg method idh1 mediates lipogenesis οΏ½hallmark_epithelial_mesenchymal_transition' gene set
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