We are analyzing https://link.springer.com/article/10.1186/s12935-021-02264-5.

Title:
Roles of ferroptosis in urologic malignancies | Cancer Cell International
Description:
Ferroptosis, an iron-dependent form of non-apoptotic cell death, is believed to strongly contribute to the pathogenesis of multiple cancers. Recently, the positive association between ferroptosis and urologic malignancies has drawn considerable attention, while a comprehensive review focused on this issue is absent. Based on this review, ferroptosis has been implicated in the development and therapeutic responses of prostate cancer, kidney cancer, and bladder cancer. Mechanistically, a large number of biomolecules and tumor-associated signaling pathways, including DECR1, PANX2, HSPB1, ACOT8, SUV39H1, NCOA4, PI3K-AKT-mTOR signaling, VHL/HIF-2α pathway, and Hippo/TAZ signaling pathway, have been reported to regulate ferroptosis in urologic cancers. Ferroptosis inducers, such as erastin, ART, CPNPs, and quinazolinyl-arylurea derivatives, exert potential therapeutic effects per se and/or enhance the anticancer response of other anticancer drugs in urologic oncology. A better understanding of ferroptosis may provide a promising way to treat therapy-resistant urologic cancers.
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Keywords {🔍}

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Topics {✒️}

voltage-dependent anion channel pi3k/akt/mtor pathway-mediated ferroptosis pi3k/akt/mtor pathway promotes vhl/hif-2α pathway-related ferroptosis pi3k/akt/mtor pathway inhibits pi3k/akt/mtor pathway participated mir-378a-3p regulate ferroptosis p-p38-mediated gpx4/xct lactate-mediated ampk-scd1 activity multi-drug-resistant gc cells p62-keap1-nrf2 pathway protects pi3k/akt/mtor pathway pi3k-akt-mtor pathway pi3k-akt-mtor signaling pi3k/akt/mtor signaling pi3k/akt signaling pathway acyl-coa thioesterase superfamily pi3k-akt-mtorc1 pathway fatty acyl-coa ester article download pdf mri-guided photothermal therapy hippo/taz signaling pathway stem cell biology emp1-nox4 signal axis p38delta/pmapkapk2/phsp27 pathway reactive oxygen species /r-induced renal injury genotype-selective antitumor agents vhl/hif-2α pathway oxidative iron-dependent form small heat-shock protein suv39h1/dnmt3a-dependent methylation small-cell lung cancer therapy-induced lipid remodeling therapy-induced lipid uptake cancer-acquired drug resistance sunitinib-resistant rcc cells anti-cell death effects vhl von hippel-lindau diverse drug-resistance mechanisms ferroptosis-related gene signature pi3k/akt pathway [46] ferroptosis-related urological cancers acyl-coa thioesterase 8 cystine transporter slc7a11/xct phosphorylation-sensitive intermolecular interactions ferroptosis-inducing agents erastin central nervous system androgen-repressed survival factor cell death-based approaches

Questions {❓}

The emerging role of ferroptosis in non-cancer liver diseases: hype or increasing hope?

Schema {🗺️}

WebPage:
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         headline:Roles of ferroptosis in urologic malignancies
         description:Ferroptosis, an iron-dependent form of non-apoptotic cell death, is believed to strongly contribute to the pathogenesis of multiple cancers. Recently, the positive association between ferroptosis and urologic malignancies has drawn considerable attention, while a comprehensive review focused on this issue is absent. Based on this review, ferroptosis has been implicated in the development and therapeutic responses of prostate cancer, kidney cancer, and bladder cancer. Mechanistically, a large number of biomolecules and tumor-associated signaling pathways, including DECR1, PANX2, HSPB1, ACOT8, SUV39H1, NCOA4, PI3K-AKT-mTOR signaling, VHL/HIF-2α pathway, and Hippo/TAZ signaling pathway, have been reported to regulate ferroptosis in urologic cancers. Ferroptosis inducers, such as erastin, ART, CPNPs, and quinazolinyl-arylurea derivatives, exert potential therapeutic effects per se and/or enhance the anticancer response of other anticancer drugs in urologic oncology. A better understanding of ferroptosis may provide a promising way to treat therapy-resistant urologic cancers.
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      headline:Roles of ferroptosis in urologic malignancies
      description:Ferroptosis, an iron-dependent form of non-apoptotic cell death, is believed to strongly contribute to the pathogenesis of multiple cancers. Recently, the positive association between ferroptosis and urologic malignancies has drawn considerable attention, while a comprehensive review focused on this issue is absent. Based on this review, ferroptosis has been implicated in the development and therapeutic responses of prostate cancer, kidney cancer, and bladder cancer. Mechanistically, a large number of biomolecules and tumor-associated signaling pathways, including DECR1, PANX2, HSPB1, ACOT8, SUV39H1, NCOA4, PI3K-AKT-mTOR signaling, VHL/HIF-2α pathway, and Hippo/TAZ signaling pathway, have been reported to regulate ferroptosis in urologic cancers. Ferroptosis inducers, such as erastin, ART, CPNPs, and quinazolinyl-arylurea derivatives, exert potential therapeutic effects per se and/or enhance the anticancer response of other anticancer drugs in urologic oncology. A better understanding of ferroptosis may provide a promising way to treat therapy-resistant urologic cancers.
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         Regulated cell death
         Urologic oncology
         Mechanism
         Therapy
         Cancer Research
         Cell Biology
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      name:Department of Urology, First Affiliated Hospital of Gannan Medical University, Ganzhou, China
      name:Department of Urology, Taizhou Central Hospital (Taizhou University Hospital), Taizhou, China
      name:Department of Urology, Taizhou Central Hospital (Taizhou University Hospital), Taizhou, China

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