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Keywords {🔍}

doi, yap, pubmed, google, scholar, hippo, pathway, cell, cells, pmc, article, free, signaling, stem, proliferation, mst, dev, development, protein, role, genes, tumor, liver, cancer, taz, drosophila, progenitor, kinase, expression, yaptaz, growth, activity, neural, lats, regeneration, tead, intestinal, biol, tissue, expansion, regulation, studies, mouse, human, transcription, embryonic, size, regulates, suppressor, transcriptional,

Topics {✒️}

map/microtubule affinity-regulating kinases c-terminal coiled-coil domains g-protein-coupled receptor signaling scf{beta}-trcp e3 ligase salvador/warts/hippo signaling network restricting wnt/β-catenin signaling salt-inducible kinases wnt/β-catenin signaling results ras-transformed mcf10a-t1k tumour-suppressor genes nf2/merlin pmc beta search g-protein-coupled receptors g-protein-coupled receptor mediating tgf-β/bmp density-dependent cell–cell junctions casein kinase 1 adult fibroblast cultures ferm-domain protein expanded tgf-β/bmp pathways mst1/2-deficient intestinal epithelium apical–basal polarity proteins serine/threonine kinases mst1/2 wnt-induced intestinal regeneration tgf-beta-smad pathway upstream inhibitory kinases wnt/β-catenin signaling generate low-grade tumors salvador/warts/hippo pathway salvador-warts-hippo pathway widespread hepatocellular carcinoma ferm-domain proteins mer pdz binding motif signal-responsive transcriptional coregulators yap-responsive transcriptional reporter epidermal stem/progenitor cells ubiquitin-proteasome-dependent manner growth factor signaling disease-defining gene fusion transcriptional enhancer factor-1 tissue-specific stem cells liver stem/progenitor cells serum-derived sphingosine-1-phosphate ras association domain gs inhibits yap/taz tissue-specific stem cell pdz domain-dependent transcription factor choice growth inhibitory proteins sav1 ko livers hippo-yap pathway differ

Questions {❓}

• Does the stemness function of Hippo-YAP pathway differ from its more classic role in cell growth regulation?
• How is YAP/TAZ regulated by stemness signals?
• What are the molecular bases for the differential functions of YAP and TAZ in stem cells?
• What determines the specificity and complexity of the Hippo-YAP in tissue-specific stem cells?

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• How much money does https://doi.org/10.1016/j.cub.2010.02.035 make?
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• What's the profit of https://doi.org/10.1371/journal.pbio.1000624?
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• What's the financial gain of https://scholar.google.com/scholar_lookup?journal=Cell&title=Regulation%20of%20the%20Hippo-YAP%20pathway%20by%20G-protein-coupled%20receptor%20signaling&author=FX%20Yu&author=B%20Zhao&author=N%20Panupinthu&author=JL%20Jewell&author=I%20Lian&volume=150&publication_year=2012&pages=780-791&pmid=22863277&doi=10.1016/j.cell.2012.06.037&?
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• What's the monthly income of https://doi.org/10.1016/j.devcel.2011.08.028?
• How much does https://scholar.google.com/scholar_lookup?journal=Dev%20Cell&title=Tao-1%20phosphorylates%20Hippo/MST%20kinases%20to%20regulate%20the%20Hippo-Salvador-Warts%20tumor%20suppressor%20pathway&author=JC%20Boggiano&author=PJ%20Vanderzalm&author=RG%20Fehon&volume=21&publication_year=2011&pages=888-895&pmid=22075147&doi=10.1016/j.devcel.2011.08.028& earn?
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• How much revenue does https://doi.org/10.1371/journal.pbio.1001620 bring in?
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• What's the income of https://doi.org/10.1128/MCB.26.1.77-87.2006?
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• What's https://doi.org/10.1242/dev.010223's gross income?
• What are the earnings of https://scholar.google.com/scholar_lookup?journal=Development&title=Transcription%20factor%20TEAD4%20specifies%20the%20trophectoderm%20lineage%20at%20the%20beginning%20of%20mammalian%20development&author=R%20Yagi&author=MJ%20Kohn&author=I%20Karavanova&author=KJ%20Kaneko&author=D%20Vullhorst&volume=134&publication_year=2007&pages=3827-3836&pmid=17913785&doi=10.1242/dev.010223&?
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• What's the income generated by https://doi.org/10.1016/j.devcel.2009.02.003 each month?
• What's the revenue for https://scholar.google.com/scholar_lookup?journal=Dev%20Cell&title=The%20Hippo%20signaling%20pathway%20components%20Lats%20and%20Yap%20pattern%20Tead4%20activity%20to%20distinguish%20mouse%20trophectoderm%20from%20inner%20cell%20mass&author=N%20Nishioka&author=K%20Inoue&author=K%20Adachi&author=H%20Kiyonari&author=M%20Ota&volume=16&publication_year=2009&pages=398-410&pmid=19289085&doi=10.1016/j.devcel.2009.02.003&?
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• Learn how profitable https://scholar.google.com/scholar_lookup?journal=Curr%20Biol&title=The%20Hippo%20pathway%20member%20Nf2%20is%20required%20for%20inner%20cell%20mass%20specification&author=K%20Cockburn&author=S%20Biechele&author=J%20Garner&author=J%20Rossant&volume=23&publication_year=2013&pages=1195-1201&pmid=23791728&doi=10.1016/j.cub.2013.05.044& is on a monthly basis
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• Check the income stats for https://scholar.google.com/scholar_lookup?journal=Curr%20Biol&title=Polarity-dependent%20distribution%20of%20angiomotin%20localizes%20Hippo%20signaling%20in%20preimplantation%20embryos&author=Y%20Hirate&author=S%20Hirahara&author=K%20Inoue&author=A%20Suzuki&author=VB%20Alarcon&volume=23&publication_year=2013&pages=1181-1194&pmid=23791731&doi=10.1016/j.cub.2013.05.014&
• How profitable is https://doi.org/10.1073/pnas.0605266104?
• See how much https://scholar.google.com/scholar_lookup?journal=Proc%20Natl%20Acad%20Sci%20U%20S%20A&title=Glomerulocystic%20kidney%20disease%20in%20mice%20with%20a%20targeted%20inactivation%20of%20Wwtr1&author=Z%20Hossain&author=SM%20Ali&author=HL%20Ko&author=J%20Xu&author=CP%20Ng&volume=104&publication_year=2007&pages=1631-1636&pmid=17251353&doi=10.1073/pnas.0605266104& makes per month
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• What's https://doi.org/10.1073/pnas.1019603108's gross income?
• What are the earnings of https://scholar.google.com/scholar_lookup?journal=Proc%20Natl%20Acad%20Sci%20U%20S%20A&title=Yes-associated%20protein%20(YAP)%20transcriptional%20coactivator%20functions%20in%20balancing%20growth%20and%20differentiation%20in%20skin&author=H%20Zhang&author=HA%20Pasolli&author=E%20Fuchs&volume=108&publication_year=2011&pages=2270-2275&pmid=21262812&doi=10.1073/pnas.1019603108&?
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• How much does https://scholar.google.com/scholar_lookup?journal=PLoS%20ONE&title=Yes-associated%20protein%2065%20(YAP)%20expands%20neural%20progenitors%20and%20regulates%20Pax3%20expression%20in%20the%20neural%20plate%20border%20zone&author=ST%20Gee&author=SL%20Milgram&author=KL%20Kramer&author=FL%20Conlon&author=SA%20Moody&volume=6&publication_year=2011&pages=e20309&pmid=21687713&doi=10.1371/journal.pone.0020309& rake in every month?
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• Income figures for https://scholar.google.com/scholar_lookup?journal=Nat%20Genet&title=Delineation%20of%20a%20Fat%20tumor%20suppressor%20pathway&author=E%20Cho&author=Y%20Feng&author=C%20Rauskolb&author=S%20Maitra&author=R%20Fehon&volume=38&publication_year=2006&pages=1142-1150&pmid=16980976&doi=10.1038/ng1887&
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• How much revenue does https://doi.org/10.1161/01.res.0000053618.86362.df bring in?
• https://scholar.google.com/scholar_lookup?journal=Circ%20Res&title=Myocyte%20death,%20growth,%20and%20regeneration%20in%20cardiac%20hypertrophy%20and%20failure&author=B%20Nadal-Ginard&author=J%20Kajstura&author=A%20Leri&author=P%20Anversa&volume=92&publication_year=2003&pages=139-150&pmid=12574141&doi=10.1161/01.res.0000053618.86362.df& income
• Explore the financials of https://doi.org/10.1172/JCI17459
• What are the total earnings of https://scholar.google.com/scholar_lookup?journal=J%20Clin%20Invest&title=Activation%20of%20Mst1%20causes%20dilated%20cardiomyopathy%20by%20stimulating%20apoptosis%20without%20compensatory%20ventricular%20myocyte%20hypertrophy&author=S%20Yamamoto&author=G%20Yang&author=D%20Zablocki&author=J%20Liu&author=C%20Hong&volume=111&publication_year=2003&pages=1463-1474&pmid=12750396&doi=10.1172/JCI17459&?
• How much does https://doi.org/10.1161/CIRCRESAHA.108.180042 earn?
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• How much revenue does https://doi.org/10.1126/science.1199010 bring in?
• How much revenue does https://scholar.google.com/scholar_lookup?journal=Science&title=Hippo%20pathway%20inhibits%20Wnt%20signaling%20to%20restrain%20cardiomyocyte%20proliferation%20and%20heart%20size&author=T%20Heallen&author=M%20Zhang&author=J%20Wang&author=M%20Bonilla-Claudio&author=E%20Klysik&volume=332&publication_year=2011&pages=458-461&pmid=21512031&doi=10.1126/science.1199010& generate?
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• https://scholar.google.com/scholar_lookup?journal=Proc%20Natl%20Acad%20Sci%20U%20S%20A&title=YAP1,%20the%20nuclear%20target%20of%20Hippo%20signaling,%20stimulates%20heart%20growth%20through%20cardiomyocyte%20proliferation%20but%20not%20hypertrophy&author=A%20von%20Gise&author=Z%20Lin&author=K%20Schlegelmilch&author=LB%20Honor&author=GM%20Pan&volume=109&publication_year=2012&pages=2394-2399&pmid=22308401&doi=10.1073/pnas.1116136109&'s financial summary
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• Earnings of https://doi.org/10.1016/j.bbrc.2010.02.034
• What's the financial outcome of https://scholar.google.com/scholar_lookup?journal=Biochem%20Biophys%20Res%20Commun&title=Yap%20is%20a%20novel%20regulator%20of%20C2C12%20myogenesis&author=KI%20Watt&author=R%20Judson&author=P%20Medlow&author=K%20Reid&author=TB%20Kurth&volume=393&publication_year=2010&pages=619-624&pmid=20153295&doi=10.1016/j.bbrc.2010.02.034&?
• How much cash flow does https://doi.org/10.1096/fj.09-151324 have monthly?
• What's the profit of https://scholar.google.com/scholar_lookup?journal=FASEB%20J&title=TAZ%20as%20a%20novel%20enhancer%20of%20MyoD-mediated%20myogenic%20differentiation&author=H%20Jeong&author=S%20Bae&author=SY%20An&author=MR%20Byun&author=JH%20Hwang&volume=24&publication_year=2010&pages=3310-3320&pmid=20466877&doi=10.1096/fj.09-151324&?
• How much money does https://doi.org/10.1016/j.ceb.2012.12.006 make?
• What's the monthly money flow for https://scholar.google.com/scholar_lookup?journal=Curr%20Opin%20Cell%20Biol&title=The%20Hippo%20superhighway:%20signaling%20crossroads%20converging%20on%20the%20Hippo/Yap%20pathway%20in%20stem%20cells%20and%20development&author=ER%20Barry&author=FD%20Camargo&volume=25&publication_year=2013&pages=247-253&pmid=23312716&doi=10.1016/j.ceb.2012.12.006&?
• Monthly income for https://doi.org/10.1038/nrm3721
• What's https://scholar.google.com/scholar_lookup?journal=Nat%20Rev%20Mol%20Cell%20Biol&title=Adult%20intestinal%20stem%20cells:%20critical%20drivers%20of%20epithelial%20homeostasis%20and%20regeneration&author=N%20Barker&volume=15&publication_year=2014&pages=19-33&pmid=24326621&doi=10.1038/nrm3721&'s gross income?
• https://doi.org/10.1038/nrd4161's revenue stream
• https://scholar.google.com/scholar_lookup?journal=Nat%20Rev%20Drug%20Discov&title=The%20two%20faces%20of%20Hippo:%20targeting%20the%20Hippo%20pathway%20for%20regenerative%20medicine%20and%20cancer%20treatment&author=R%20Johnson&author=G%20Halder&volume=13&publication_year=2014&pages=63-79&pmid=24336504&doi=10.1038/nrd4161&'s revenue stream
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• How much money does https://scholar.google.com/scholar_lookup?journal=Genes%20Dev&title=The%20Hippo%20signaling%20pathway%20restricts%20the%20oncogenic%20potential%20of%20an%20intestinal%20regeneration%20program&author=J%20Cai&author=N%20Zhang&author=Y%20Zheng&author=RF%20de%20Wilde&author=A%20Maitra&volume=24&publication_year=2010&pages=2383-2388&pmid=21041407&doi=10.1101/gad.1978810& make?
• What is the earnings of https://doi.org/10.1073/pnas.1110428108?
• How much does https://scholar.google.com/scholar_lookup?journal=Proc%20Natl%20Acad%20Sci%20U%20S%20A&title=Mst1%20and%20Mst2%20protein%20kinases%20restrain%20intestinal%20stem%20cell%20proliferation%20and%20colonic%20tumorigenesis%20by%20inhibition%20of%20Yes-associated%20protein%20(Yap)%20overabundance&author=D%20Zhou&author=Y%20Zhang&author=H%20Wu&author=E%20Barry&author=Y%20Yin&volume=108&publication_year=2011&pages=E1312-E1320&pmid=22042863&doi=10.1073/pnas.1110428108& rake in every month?
• How much does https://doi.org/10.1038/nature11693 net monthly?
• Earnings of https://scholar.google.com/scholar_lookup?journal=Nature&title=Restriction%20of%20intestinal%20stem%20cell%20expansion%20and%20the%20regenerative%20response%20by%20YAP&author=ER%20Barry&author=T%20Morikawa&author=BL%20Butler&author=K%20Shrestha&author=R%20de%20la%20Rosa&volume=493&publication_year=2013&pages=106-110&pmid=23178811&doi=10.1038/nature11693&
• Profit of https://doi.org/10.1242/dev.060483
• https://scholar.google.com/scholar_lookup?journal=Development&title=The%20Hippo%20tumor%20suppressor%20pathway%20regulates%20intestinal%20stem%20cell%20regeneration&author=P%20Karpowicz&author=J%20Perez&author=N%20Perrimon&volume=137&publication_year=2010&pages=4135-4145&pmid=21098564&doi=10.1242/dev.060483&'s revenue stream
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• https://scholar.google.com/scholar_lookup?journal=Curr%20Biol&title=Warts%20and%20Yorkie%20mediate%20intestinal%20regeneration%20by%20influencing%20stem%20cell%20proliferation&author=BK%20Staley&author=KD%20Irvine&volume=20&publication_year=2010&pages=1580-1587&pmid=20727758&doi=10.1016/j.cub.2010.07.041&'s total income per month
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• How much revenue does https://scholar.google.com/scholar_lookup?journal=Dev%20Cell&title=The%20hippo%20signaling%20pathway%20in%20development%20and%20cancer&author=D%20Pan&volume=19&publication_year=2010&pages=491-505&pmid=20951342&doi=10.1016/j.devcel.2010.09.011& generate?
• Income figures for https://doi.org/10.1016/j.ceb.2008.10.001
• How much does https://scholar.google.com/scholar_lookup?journal=Curr%20Opin%20Cell%20Biol&title=The%20Hippo-YAP%20pathway:%20new%20connections%20between%20regulation%20of%20organ%20size%20and%20cancer&author=B%20Zhao&author=QY%20Lei&author=KL%20Guan&volume=20&publication_year=2008&pages=638-646&pmid=18955139&doi=10.1016/j.ceb.2008.10.001& bring in each month?
• What's the profit of https://doi.org/10.1016/j.cell.2006.05.030?
• See how much https://scholar.google.com/scholar_lookup?journal=Cell&title=Identification%20and%20validation%20of%20oncogenes%20in%20liver%20cancer%20using%20an%20integrative%20oncogenomic%20approach&author=L%20Zender&author=MS%20Spector&author=W%20Xue&author=P%20Flemming&author=C%20Cordon-Cardo&volume=125&publication_year=2006&pages=1253-1267&pmid=16814713&doi=10.1016/j.cell.2006.05.030& makes per month
• https://doi.org/10.1016/j.humpath.2008.04.012's financial summary
• Explore the financials of https://scholar.google.com/scholar_lookup?journal=Hum%20Pathol&title=Expression%20of%20Yes-associated%20protein%20in%20common%20solid%20tumors&author=AA%20Steinhardt&author=MF%20Gayyed&author=AP%20Klein&author=J%20Dong&author=A%20Maitra&volume=39&publication_year=2008&pages=1582-1589&pmid=18703216&doi=10.1016/j.humpath.2008.04.012&
• Revenue of https://doi.org/10.1158/0008-5472.CAN-07-2696
• How much profit is https://scholar.google.com/scholar_lookup?journal=Cancer%20Res&title=A%20role%20for%20TAZ%20in%20migration,%20invasion,%20and%20tumorigenesis%20of%20breast%20cancer%20cells&author=SW%20Chan&author=CJ%20Lim&author=K%20Guo&author=CP%20Ng&author=I%20Lee&volume=68&publication_year=2008&pages=2592-2598&pmid=18413727&doi=10.1158/0008-5472.CAN-07-2696& making per month?
• What's https://doi.org/10.1016/j.cell.2011.09.048's gross income?
• Monthly income for https://scholar.google.com/scholar_lookup?journal=Cell&title=The%20Hippo%20transducer%20TAZ%20confers%20cancer%20stem%20cell-related%20traits%20on%20breast%20cancer%20cells&author=M%20Cordenonsi&author=F%20Zanconato&author=L%20Azzolin&author=M%20Forcato&author=A%20Rosato&volume=147&publication_year=2011&pages=759-772&pmid=22078877&doi=10.1016/j.cell.2011.09.048&
• Profit of https://doi.org/10.1101/gad.176800.111
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• https://doi.org/10.1073/pnas.0605579103's total income per month
• What's the revenue for https://scholar.google.com/scholar_lookup?journal=Proc%20Natl%20Acad%20Sci%20U%20S%20A&title=Transforming%20properties%20of%20YAP,%20a%20candidate%20oncogene%20on%20the%20chromosome%2011q22%20amplicon&author=M%20Overholtzer&author=J%20Zhang&author=GA%20Smolen&author=B%20Muir&author=W%20Li&volume=103&publication_year=2006&pages=12405-12410&pmid=16894141&doi=10.1073/pnas.0605579103&?
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• How much does https://doi.org/10.1038/5965 rake in every month?
• What's the financial gain of https://scholar.google.com/scholar_lookup?journal=Nat%20Genet&title=Mice%20deficient%20of%20Lats1%20develop%20soft-tissue%20sarcomas,%20ovarian%20tumours%20and%20pituitary%20dysfunction&author=MA%20St%20John&author=W%20Tao&author=X%20Fei&author=R%20Fukumoto&author=ML%20Carcangiu&volume=21&publication_year=1999&pages=182-186&pmid=9988269&doi=10.1038/5965&?
• Profit of https://doi.org/10.1158/1078-0432.CCR-04-1773
• What's the income of https://scholar.google.com/scholar_lookup?journal=Clin%20Cancer%20Res&title=Down-regulation%20of%20LATS1%20and%20LATS2%20mRNA%20expression%20by%20promoter%20hypermethylation%20and%20its%20association%20with%20biologically%20aggressive%20phenotype%20in%20human%20breast%20cancers&author=Y%20Takahashi&author=Y%20Miyoshi&author=C%20Takahata&author=N%20Irahara&author=T%20Taguchi&volume=11&publication_year=2005&pages=1380-1385&pmid=15746036&doi=10.1158/1078-0432.CCR-04-1773&?
• What's the total monthly financial gain of https://doi.org/10.1016/j.neures.2006.09.006?
• Financial intake of https://scholar.google.com/scholar_lookup?journal=Neurosci%20Res&title=Promoter%20hypermethylation-mediated%20down-regulation%20of%20LATS1%20and%20LATS2%20in%20human%20astrocytoma&author=Z%20Jiang&author=X%20Li&author=J%20Hu&author=W%20Zhou&author=Y%20Jiang&volume=56&publication_year=2006&pages=450-458&pmid=17049657&doi=10.1016/j.neures.2006.09.006&
• https://doi.org/10.1002/mc.20317's total income per month
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• What's the financial gain of https://doi.org/10.1097/GIM.0b013e3181ac9a27?
• https://scholar.google.com/scholar_lookup?journal=Genet%20Med&title=Neurofibromatosis%202%20%5BBilateral%20acoustic%20neurofibromatosis,%20central%20neurofibromatosis,%20NF2,%20neurofibromatosis%20type%20II%5D&author=DG%20Evans&volume=11&publication_year=2009&pages=599-610&pmid=19652604&doi=10.1097/GIM.0b013e3181ac9a27&'s revenue stream
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• How much does https://scholar.google.com/scholar_lookup?journal=Lung%20Cancer&title=Functional%20inactivation%20of%20NF2/merlin%20in%20human%20mesothelioma&author=C%20Thurneysen&author=I%20Opitz&author=S%20Kurtz&author=W%20Weder&author=RA%20Stahel&volume=64&publication_year=2009&pages=140-147&pmid=18835652&doi=10.1016/j.lungcan.2008.08.014& gross monthly?
• What's https://doi.org/10.1073/pnas.92.24.10854's gross income?
• What are the earnings of https://scholar.google.com/scholar_lookup?journal=Proc%20Natl%20Acad%20Sci%20U%20S%20A&title=High%20frequency%20of%20inactivating%20mutations%20in%20the%20neurofibromatosis%20type%202%20gene%20(NF2)%20in%20primary%20malignant%20mesotheliomas&author=AB%20Bianchi&author=SI%20Mitsunaga&author=JQ%20Cheng&author=WM%20Klein&author=SC%20Jhanwar&volume=92&publication_year=1995&pages=10854-10858&pmid=7479897&doi=10.1073/pnas.92.24.10854&?
• Income figures for https://doi.org/10.1126/scitranslmed.3002409
• How much income does https://scholar.google.com/scholar_lookup?journal=Sci%20Transl%20Med&title=Identification%20of%20a%20disease-defining%20gene%20fusion%20in%20epithelioid%20hemangioendothelioma&author=MR%20Tanas&author=A%20Sboner&author=AM%20Oliveira&author=MR%20Erickson-Johnson&author=J%20Hespelt&volume=3&publication_year=2011&pages=98ra82&pmid=21885404&doi=10.1126/scitranslmed.3002409& have?
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• Earnings of https://doi.org/10.1038/ng.950
• How much does https://scholar.google.com/scholar_lookup?journal=Nat%20Genet&title=Exon%20capture%20analysis%20of%20G%20protein-coupled%20receptors%20identifies%20activating%20mutations%20in%20GRM3%20in%20melanoma&author=TD%20Prickett&author=X%20Wei&author=I%20Cardenas-Navia&author=JK%20Teer&author=JC%20Lin&volume=43&publication_year=2011&pages=1119-1126&pmid=21946352&doi=10.1038/ng.950& pull in?
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• How much does https://www.nlm.nih.gov/web_policies.html gross monthly?
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• How much does https://www.usa.gov/ bring in each month?

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