We are analyzing https://link.springer.com/article/10.1186/s12929-024-01047-0.

Title:
Beyond traditional translation: ncRNA derived peptides as modulators of tumor behaviors | Journal of Biomedical Science
Description:
Within the intricate tapestry of molecular research, noncoding RNAs (ncRNAs) were historically overshadowed by a pervasive presumption of their inability to encode proteins or peptides. However, groundbreaking revelations have challenged this notion, unveiling select ncRNAs that surprisingly encode peptides specifically those nearing a succinct 100 amino acids. At the forefront of this epiphany stand lncRNAs and circRNAs, distinctively characterized by their embedded small open reading frames (sORFs). Increasing evidence has revealed different functions and mechanisms of peptides/proteins encoded by ncRNAs in cancer, including promotion or inhibition of cancer cell proliferation, cellular metabolism (glucose metabolism and lipid metabolism), and promotion or concerted metastasis of cancer cells. The discoveries not only accentuate the depth of ncRNA functionality but also open novel avenues for oncological research and therapeutic innovations. The main difficulties in the study of these ncRNA-derived peptides hinge crucially on precise peptide detection and sORFs identification. Here, we illuminate cutting-edge methodologies, essential instrumentation, and dedicated databases tailored for unearthing sORFs and peptides. In addition, we also conclude the potential of clinical applications in cancer therapy.
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Keywords {🔍}

pubmed, article, google, scholar, cas, cancer, central, peptides, cell, wang, zhang, rnas, translation, noncoding, peptide, cells, rna, circular, tumor, encoded, chen, liu, human, yang, expression, zhou, metastasis, mol, proliferation, protein, small, pathway, ncrna, lncrna, open, ncrnas, ribosome, promotes, long, biol, sorfs, analysis, research, functions, potential, res, sci, zhao, role, functional,

Topics {✒️}

identify short-open-reading-frame-encoded peptides wnt/β-catenin signaling pathway wnt/beta-catenin signaling pathway inhibits pi3k/akt/nfjb pathway par-acylated parp1-dna complex lncrna-encoded pep-ap attenuates linc00961-encoded spar polypeptide encode cancer-suppressive peptides/proteins restricts lactate-pyruvate conversion parp/atr/cdk4/6 inhibitors sendai virus di-rnas article download pdf wnt/ β-catenin pathway wnt/β-catenin pathway lncrna afap1-as1 promotes illuminate cutting-edge methodologies myocardial ischemia-reperfusion injury framed k-mer features wnt/beta-catenin pathway smorf-encoded bioactive polypeptides circ-eif6 encodes eif6-224aa huh7 ribo-seq dataset peptide called coro1c-47aa open reading frame highly base-paired rod pi3k/akt/nfjb pathway open reading frames targetable tumor-specific antigens cell-type specific features tumor-specific immune response inhibit c-myc ubiquitin encode plant-related peptides inhibiting ereg/egfr signaling cancer-related micropeptides encoded rho/rac signaling pathway tissue-specific circular rnas apoptosis-related protein bax age-dependent neural accumulation testis-determining gene sry full access pri-mirna-31 suppresses autoimmunity clip6-ova complex prompted promoting mllt4-as1 transcription tumor-suppressor microprotein encoded b16/ova mouse model exert antitumor effects downstream jak/stat pathway crispr-based genetic screening acute myeloid leukemia graft-versus-host disease

Schema {🗺️}

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         headline:Beyond traditional translation: ncRNA derived peptides as modulators of tumor behaviors
         description:Within the intricate tapestry of molecular research, noncoding RNAs (ncRNAs) were historically overshadowed by a pervasive presumption of their inability to encode proteins or peptides. However, groundbreaking revelations have challenged this notion, unveiling select ncRNAs that surprisingly encode peptides specifically those nearing a succinct 100 amino acids. At the forefront of this epiphany stand lncRNAs and circRNAs, distinctively characterized by their embedded small open reading frames (sORFs). Increasing evidence has revealed different functions and mechanisms of peptides/proteins encoded by ncRNAs in cancer, including promotion or inhibition of cancer cell proliferation, cellular metabolism (glucose metabolism and lipid metabolism), and promotion or concerted metastasis of cancer cells. The discoveries not only accentuate the depth of ncRNA functionality but also open novel avenues for oncological research and therapeutic innovations. The main difficulties in the study of these ncRNA-derived peptides hinge crucially on precise peptide detection and sORFs identification. Here, we illuminate cutting-edge methodologies, essential instrumentation, and dedicated databases tailored for unearthing sORFs and peptides. In addition, we also conclude the potential of clinical applications in cancer therapy.
         datePublished:2024-06-14T00:00:00Z
         dateModified:2024-06-14T00:00:00Z
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      headline:Beyond traditional translation: ncRNA derived peptides as modulators of tumor behaviors
      description:Within the intricate tapestry of molecular research, noncoding RNAs (ncRNAs) were historically overshadowed by a pervasive presumption of their inability to encode proteins or peptides. However, groundbreaking revelations have challenged this notion, unveiling select ncRNAs that surprisingly encode peptides specifically those nearing a succinct 100 amino acids. At the forefront of this epiphany stand lncRNAs and circRNAs, distinctively characterized by their embedded small open reading frames (sORFs). Increasing evidence has revealed different functions and mechanisms of peptides/proteins encoded by ncRNAs in cancer, including promotion or inhibition of cancer cell proliferation, cellular metabolism (glucose metabolism and lipid metabolism), and promotion or concerted metastasis of cancer cells. The discoveries not only accentuate the depth of ncRNA functionality but also open novel avenues for oncological research and therapeutic innovations. The main difficulties in the study of these ncRNA-derived peptides hinge crucially on precise peptide detection and sORFs identification. Here, we illuminate cutting-edge methodologies, essential instrumentation, and dedicated databases tailored for unearthing sORFs and peptides. In addition, we also conclude the potential of clinical applications in cancer therapy.
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         ncRNA
         Protein
         Peptides
         circRNAs
         lncRNAs
         Cancer
         Biomedicine
         general
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         type:PostalAddress
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         type:PostalAddress
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               type:PostalAddress
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            name:The Second Affiliated Hospital of Nanjing Medical University
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            address:
               name:Department of Respiratory Endoscopy, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, P.R. China
               type:PostalAddress
            type:Organization
            name:Shanghai Medical College, Fudan University
            address:
               name:Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Zhaoxia Wang
      affiliation:
            name:The Second Affiliated Hospital of Nanjing Medical University
            address:
               name:Cancer Medical Center, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, P.R. China
               type:PostalAddress
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      name:Cancer Medical Center, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, P.R. China
      name:Cancer Medical Center, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, P.R. China
      name:Department of Respiratory Endoscopy, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, P.R. China
      name:Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China
      name:Cancer Medical Center, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, P.R. China

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