We are analyzing https://link.springer.com/article/10.1007/s00018-017-2458-4.

Title:
The multi-faceted role of retinoid X receptor in bone remodeling | Cellular and Molecular Life Sciences
Description:
Retinoid X receptors (RXRs) form a unique subclass within the nuclear receptor (NR) superfamily of ligand-dependent transcription factors. RXRs are obligatory partners for a number of other NRs, placing RXRs in a coordinating role at the crossroads of multiple signaling pathways. In addition, RXRs can function as self-sufficient homodimers. Recent advances have revealed RXRs as novel regulators of osteoclastogenesis and bone remodeling. This review outlines the versatility of RXR action in the control of transcription of bone-forming osteoblasts and bone-resorbing osteoclasts, both through heterodimerization with other NRs and through RXR homodimerization. RXR signaling is currently a major therapeutic target and, therefore, knowledge of how RXR signaling affects bone remodeling creates enormous potential for the translation of basic research findings into successful clinical therapies to increase bone mass and improve bone quality.
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Keywords {🔍}

pubmed, article, google, scholar, cas, bone, receptor, central, retinoid, receptors, nuclear, rxr, acid, cell, cells, res, mol, biol, kim, differentiation, retinoic, osteoclast, remodeling, endocrinol, miner, role, vitamin, biochem, ricote, mice, metab, function, ligand, nat, clin, chen, chem, activation, formation, transcription, signaling, factor, peroxisome, regulation, genes, zhang, dois, doijbmr, ppargamma, lee,

Topics {✒️}

month download article/chapter peroxisome proliferator-activated receptor/retinoid peroxisome proliferator-activated receptors estrogen-induced bone-mass increase menendez-gutierrez mp receptor gamma-deficient mice menéndez-gutiérrez & mercedes ricote ppar-gamma regulates osteoclastogenesis article menéndez-gutiérrez extracellular matrix-related genes osteocyte-driven bone remodeling 9-cis retinoic acid 9-cis-retinoic acid xenobiotic receptor sxr nuclear receptor-independent pathways direct protein-protein interactions retinoid-induced bone thinning nuclear receptor heterodimers full article pdf ligand-dependent transcription factors nuclear hormone receptors multiple signaling pathways beta-catenin degradation trans retinoic acid enhanced bone resorption retinoic acid receptors relevant references owing receptor mafb specific rxr heterodimers thyroid hormone actions induced osteoclast differentiation rar signaling pathways bone marrow progenitors privacy choices/manage cookies receptor agonists bone remodelling basic research findings dna binding domain synergistic antitumor effect increase bone mass mesenchymal progenitor cells mesenchymal stem cells wnts’ fashion statement nuclear receptor expression cho sw article cellular de lera ar nur transcription factors srebp transcription factors unique response pathways

Questions {❓}

Wolf G (2006) Is 9-cis-retinoic acid the endogenous ligand for the retinoic acid-X receptor?

Schema {🗺️}

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         headline:The multi-faceted role of retinoid X receptor in bone remodeling
         description:Retinoid X receptors (RXRs) form a unique subclass within the nuclear receptor (NR) superfamily of ligand-dependent transcription factors. RXRs are obligatory partners for a number of other NRs, placing RXRs in a coordinating role at the crossroads of multiple signaling pathways. In addition, RXRs can function as self-sufficient homodimers. Recent advances have revealed RXRs as novel regulators of osteoclastogenesis and bone remodeling. This review outlines the versatility of RXR action in the control of transcription of bone-forming osteoblasts and bone-resorbing osteoclasts, both through heterodimerization with other NRs and through RXR homodimerization. RXR signaling is currently a major therapeutic target and, therefore, knowledge of how RXR signaling affects bone remodeling creates enormous potential for the translation of basic research findings into successful clinical therapies to increase bone mass and improve bone quality.
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      description:Retinoid X receptors (RXRs) form a unique subclass within the nuclear receptor (NR) superfamily of ligand-dependent transcription factors. RXRs are obligatory partners for a number of other NRs, placing RXRs in a coordinating role at the crossroads of multiple signaling pathways. In addition, RXRs can function as self-sufficient homodimers. Recent advances have revealed RXRs as novel regulators of osteoclastogenesis and bone remodeling. This review outlines the versatility of RXR action in the control of transcription of bone-forming osteoblasts and bone-resorbing osteoclasts, both through heterodimerization with other NRs and through RXR homodimerization. RXR signaling is currently a major therapeutic target and, therefore, knowledge of how RXR signaling affects bone remodeling creates enormous potential for the translation of basic research findings into successful clinical therapies to increase bone mass and improve bone quality.
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         Life Sciences
         Biochemistry
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