JNEUROINFLAMMATION . BIOMEDCENTRAL . COM {}

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We are analyzing https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-024-03222-4.

Title:
Microenvironmental regulation of tumor-associated neutrophils in malignant glioma: from mechanism to therapy | Journal of Neuroinflammation | Full Text
Description:
Glioma is the most common primary intracranial tumor in adults, with high incidence, recurrence, and mortality rates. Tumor-associated neutrophils (TANs) are essential components of the tumor microenvironment (TME) in glioma and play a crucial role in glioma cell proliferation, invasion and proneural-mesenchymal transition. Besides the interactions between TANs and tumor cells, the multi-dimensional crosstalk between TANs and other components within TME have been reported to participate in glioma progression. More importantly, several therapies targeting TANs have been developed and relevant preclinical and clinical studies have been conducted in cancer therapy. In this review, we introduce the origin of TANs and the functions of TANs in malignant behaviors of glioma, highlighting the microenvironmental regulation of TANs. Moreover, we focus on summarizing the TANs-targeted methods in cancer therapy, aiming to provide insights into the mechanisms and therapeutic opportunities of TANs in the malignant glioma microenvironment.
Website Age:
25 years and 10 months (reg. 1999-08-06).

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✈️ Decent Traffic: 20k - 50k visitors per month

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Keywords {🔍}

pubmed, tans, glioma, article, google, scholar, tumor, cells, neutrophils, cas, cancer, central, neutrophil, cell, role, therapy, progression, glioblastoma, angiogenesis, tme, studies, promote, microenvironment, immune, tumors, signaling, proliferation, recruitment, patients, resistance, expression, wang, growth, promoting, fig, tcell, tams, factor, receptor, tumorassociated, mmp, nets, treatment, malignant, antitumor, produce, promotes, survival, shown, cxcr,

Topics {✒️}

fak/erk/mlck/yap signaling pathway granulocyte-macrophage colony-stimulating factor pd-1/pd-l1 axis represents hmgb1/rage/nf-κb axis pd-1/pd-l1 axis pd-1/pd-l1 axis [107 granulocyte colony-stimulating factor tlr9/merlin signaling axis pd-1/pd-l1 pathway endocrine gland-derived vegf platelet-derived growth factor pd-1+cd8+ t-cell niche emerging pd-l1 antibodies tans-based anti-tumor therapies transforming growth factor-β car-neutrophil mediated delivery triple-negative breast cancer dual-responsive biohybrid neutrobots highly express hla-dr+ suppresses anti-tumoral activities pd-l1 antibody durvalumab hmgb1/rage/il-8 axis myeloid-derived suppressor cells pd-l1 blockade activate t-cell directly writing-original manuscript preparation develop pro-tumorigenic properties pd-1+cd8+ t-cell hypoxia-inducible-factor pathway anti-angiogenic agents pd-l1 reduces increasing lipid-based ros neutrophil-based micro-robot hla-dr+ tans exert resisting anti-angiogenic therapy activate t-cell cytotoxicity anti-il-8 monoclonal antibody single-cell rna sequencing accelerating t-cell aging heteroaryl-substituted pyrazole inhibitors tumor-microenvironment responsive nanodrugs antigen-presenting cell features tumor necrosis factor-α persistent interleukin-1beta signaling additional information publisher high hla-dr expression newly published article hyperactive nf-κb signaling neutrophil-exosome system targeting central nervous system

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Tumor-associated neutrophils: friend or foe?

Schema {🗺️}

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