We are analyzing https://link.springer.com/article/10.1186/s12943-017-0707-7.

Title:
Neutrophils in cancer: prognostic role and therapeutic strategies | Molecular Cancer
Description:
Expression of high levels of immune cells including neutrophils has been associated with detrimental outcome in several solid tumors and new strategies to decrease their presence and activity are currently under clinical development. Here, we review some of the relevant literature of the role of neutrophils in different stages of the oncogenic process including tumor initiation, growth, proliferation or metastatic spreading and also focus on how neutrophil counts or the neutrophil-to-lymphocyte ratio may be used as a prognostic and predictive biomarker. Strategies to avoid the deleterious effects of neutrophils in cancer and to reduce their activity are discussed. Examples for such strategies include inhibition of CXCR1 and CXCR2 to decrease migration of neutrophils to tumoral areas or the inhibition of granulocyte colony stimulating factor to decrease the amount of neutrophils which has shown efficacy in preclinical models.
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Keywords {🔍}

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Topics {✒️}

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Schema {🗺️}

WebPage:
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         headline:Neutrophils in cancer: prognostic role and therapeutic strategies
         description:Expression of high levels of immune cells including neutrophils has been associated with detrimental outcome in several solid tumors and new strategies to decrease their presence and activity are currently under clinical development. Here, we review some of the relevant literature of the role of neutrophils in different stages of the oncogenic process including tumor initiation, growth, proliferation or metastatic spreading and also focus on how neutrophil counts or the neutrophil-to-lymphocyte ratio may be used as a prognostic and predictive biomarker. Strategies to avoid the deleterious effects of neutrophils in cancer and to reduce their activity are discussed. Examples for such strategies include inhibition of CXCR1 and CXCR2 to decrease migration of neutrophils to tumoral areas or the inhibition of granulocyte colony stimulating factor to decrease the amount of neutrophils which has shown efficacy in preclinical models.
         datePublished:2017-08-15T00:00:00Z
         dateModified:2017-08-15T00:00:00Z
         pageStart:1
         pageEnd:7
         license:http://creativecommons.org/publicdomain/zero/1.0/
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            Neutrophils
            Neutrophil-lymphocyte ratio
            Prognosis
            Target
            Cancer Research
            Oncology
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                     address:
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ScholarlyArticle:
      headline:Neutrophils in cancer: prognostic role and therapeutic strategies
      description:Expression of high levels of immune cells including neutrophils has been associated with detrimental outcome in several solid tumors and new strategies to decrease their presence and activity are currently under clinical development. Here, we review some of the relevant literature of the role of neutrophils in different stages of the oncogenic process including tumor initiation, growth, proliferation or metastatic spreading and also focus on how neutrophil counts or the neutrophil-to-lymphocyte ratio may be used as a prognostic and predictive biomarker. Strategies to avoid the deleterious effects of neutrophils in cancer and to reduce their activity are discussed. Examples for such strategies include inhibition of CXCR1 and CXCR2 to decrease migration of neutrophils to tumoral areas or the inhibition of granulocyte colony stimulating factor to decrease the amount of neutrophils which has shown efficacy in preclinical models.
      datePublished:2017-08-15T00:00:00Z
      dateModified:2017-08-15T00:00:00Z
      pageStart:1
      pageEnd:7
      license:http://creativecommons.org/publicdomain/zero/1.0/
      sameAs:https://doi.org/10.1186/s12943-017-0707-7
      keywords:
         Neutrophils
         Neutrophil-lymphocyte ratio
         Prognosis
         Target
         Cancer Research
         Oncology
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs12943-017-0707-7/MediaObjects/12943_2017_707_Fig1_HTML.gif
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                     type:PostalAddress
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            email:[email protected]
            type:Person
            name:Cristina Nieto-Jiménez
            affiliation:
                  name:Albacete University Hospital and Translational Research Unit
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                     name:Medical Oncology Department, Albacete University Hospital and Translational Research Unit, Albacete, Spain
                     type:PostalAddress
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            type:Person
            name:Atanasio Pandiella
            affiliation:
                  name:Centro de Investigación del Cáncer CSIC and CIBERONC
                  address:
                     name:Centro de Investigación del Cáncer CSIC and CIBERONC, Salamanca, Spain
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Arnoud J Templeton
            affiliation:
                  name:University of Basel
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         name:Centro de Investigación del Cáncer CSIC and CIBERONC, Salamanca, Spain
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            address:
               name:Medical Oncology Department, Albacete University Hospital and Translational Research Unit, Albacete, Spain
               type:PostalAddress
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      email:[email protected]
      name:Cristina Nieto-Jiménez
      affiliation:
            name:Albacete University Hospital and Translational Research Unit
            address:
               name:Medical Oncology Department, Albacete University Hospital and Translational Research Unit, Albacete, Spain
               type:PostalAddress
            type:Organization
      name:Atanasio Pandiella
      affiliation:
            name:Centro de Investigación del Cáncer CSIC and CIBERONC
            address:
               name:Centro de Investigación del Cáncer CSIC and CIBERONC, Salamanca, Spain
               type:PostalAddress
            type:Organization
      name:Arnoud J Templeton
      affiliation:
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            address:
               name:Division of Medical Oncology, St. Claraspital Basel and Faculty of Medicine, University of Basel, Basel, Switzerland
               type:PostalAddress
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      name:Medical Oncology Department, Albacete University Hospital and Translational Research Unit, Albacete, Spain
      name:Medical Oncology Department, Albacete University Hospital and Translational Research Unit, Albacete, Spain
      name:Centro de Investigación del Cáncer CSIC and CIBERONC, Salamanca, Spain
      name:Division of Medical Oncology, St. Claraspital Basel and Faculty of Medicine, University of Basel, Basel, Switzerland

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