We are analyzing https://link.springer.com/article/10.1007/s10495-023-01866-w.

Title:
Neutrophil extracellular traps mediate TLR9/Merlin axis to resist ferroptosis and promote triple negative breast cancer progression | Apoptosis
Description:
Neutrophil and neutrophil extracellular traps (NETs) were reported to be associated with tumor development, but the exact role and concrete mechanisms are still poorly understood, especially in triple negative breast cancer (TNBC). In this study, our results exhibited that NETs formation in TNBC tissues was higher than that in non-TNBC tissues, and NETs formation was distinctly correlated with tumor size, ki67 level and lymph node metastasis in TNBC patients. Subsequent in vivo experiments demonstrated that NETs inhibition could suppress TNBC tumor growth and lung metastasis. Further in vitro experiments uncovered that oncogenic function of NETs on TNBC cells were possibly dependent on TLR9 expression. We also found that neutrophils from peripheral blood of TNBC patients with postoperative fever were prone to form NETs and could enhance the proliferation and invasion of TNBC cells. Mechanistically, we revealed that NETs could interact with TLR9 to decrease Merlin phosphorylation which contributed to TNBC cell ferroptosis resistance. Our work provides a novel insight into the mechanism of NETs promoting TNBC progression and blocking the key modulator of NETs might be a promising therapeutic strategy in TNBC.
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Keywords {🔍}

pubmed, article, cancer, google, scholar, cas, breast, neutrophil, extracellular, traps, central, nets, tnbc, cells, promote, data, ferroptosis, triple, negative, progression, shanghai, metastasis, information, cell, authors, res, signaling, china, university, privacy, cookies, content, role, access, nature, springer, publish, research, search, apoptosis, manuscript, yao, sheng, dong, song, study, patients, neutrophils, merlin, contributed,

Topics {✒️}

triple-negative breast cancer month download article/chapter huijuan dai & yueyao du promote pro-metastatic phenotype neutrophil extracellular traps nf-kappab article apoptosis aims breast cancer cells full article pdf decrease merlin phosphorylation merlin deficiency alters privacy choices/manage cookies reducing hippo signaling canonical hippo signaling tlr9 signaling cancer-related thrombosis lymph node metastasis cancers predispose neutrophils shanghai cancer institute neutrophil/lymphocyte ratio article yao related subjects huijuan dai yueyao du ren ji hospital gastric cancer patients vivo experiments demonstrated vitro experiments uncovered xuzhou medical university holds exclusive rights breast cancer cancer progression european economic area promising therapeutic strategy reis-filho js epithelial-mesenchymal transition gpx4-mediated ferroptosis redox management program shanghai jiaotong university ethics declarations conflict cancer cells conditions privacy policy check access instant access shanghai sailing program additional information publisher' tlr9 expression article log electronic supplementary material current evidence

Schema {🗺️}

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         headline:Neutrophil extracellular traps mediate TLR9/Merlin axis to resist ferroptosis and promote triple negative breast cancer progression
         description:Neutrophil and neutrophil extracellular traps (NETs) were reported to be associated with tumor development, but the exact role and concrete mechanisms are still poorly understood, especially in triple negative breast cancer (TNBC). In this study, our results exhibited that NETs formation in TNBC tissues was higher than that in non-TNBC tissues, and NETs formation was distinctly correlated with tumor size, ki67 level and lymph node metastasis in TNBC patients. Subsequent in vivo experiments demonstrated that NETs inhibition could suppress TNBC tumor growth and lung metastasis. Further in vitro experiments uncovered that oncogenic function of NETs on TNBC cells were possibly dependent on TLR9 expression. We also found that neutrophils from peripheral blood of TNBC patients with postoperative fever were prone to form NETs and could enhance the proliferation and invasion of TNBC cells. Mechanistically, we revealed that NETs could interact with TLR9 to decrease Merlin phosphorylation which contributed to TNBC cell ferroptosis resistance. Our work provides a novel insight into the mechanism of NETs promoting TNBC progression and blocking the key modulator of NETs might be a promising therapeutic strategy in TNBC.
         datePublished:2023-06-27T00:00:00Z
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      description:Neutrophil and neutrophil extracellular traps (NETs) were reported to be associated with tumor development, but the exact role and concrete mechanisms are still poorly understood, especially in triple negative breast cancer (TNBC). In this study, our results exhibited that NETs formation in TNBC tissues was higher than that in non-TNBC tissues, and NETs formation was distinctly correlated with tumor size, ki67 level and lymph node metastasis in TNBC patients. Subsequent in vivo experiments demonstrated that NETs inhibition could suppress TNBC tumor growth and lung metastasis. Further in vitro experiments uncovered that oncogenic function of NETs on TNBC cells were possibly dependent on TLR9 expression. We also found that neutrophils from peripheral blood of TNBC patients with postoperative fever were prone to form NETs and could enhance the proliferation and invasion of TNBC cells. Mechanistically, we revealed that NETs could interact with TLR9 to decrease Merlin phosphorylation which contributed to TNBC cell ferroptosis resistance. Our work provides a novel insight into the mechanism of NETs promoting TNBC progression and blocking the key modulator of NETs might be a promising therapeutic strategy in TNBC.
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