
NCBI . NLM . NIH . GOV {
}
Title[redir]:
G-protein-coupled Receptor Agonist BV8/Prokineticin-2 and STAT3 Protein Form a Feed-forward Loop in Both Normal and Malignant Myeloid Cells - PMC
Description:
Background: Signaling pathways underlying BV8-mediated oncogenesis remain unknown. Results: BV8-STAT3 forms a feed-forward loop in both normal and malignant myeloid cells and promotes tumor growth. Conclusion: JAK2/STAT3 signaling plays critical ...
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Keywords {🔍}
cells, stat, myeloid, tumor, cell, expression, doi, shrna, leukemia, pubmed, google, scholar, jak, activation, control, mice, fig, human, signaling, expressing, pmc, angiogenesis, growth, cancer, realtime, levels, western, blotting, article, mouse, malignant, viability, medium, showing, free, activity, receptors, azd, cdb, protein, reduced, ngml, rtpcr, gproteincoupled, receptor, normal, role, rpmi, splenic, tumors,
Topics {✒️}
g-protein-coupled receptor s1pr1 quantitative real-time rt-pcr map kinase/pi-3-kinase pathways g-protein-coupled receptor signaling real-time rt-pcr showed sphingosine-1-phosphate receptor 1 orphan g-protein-coupled receptors bv8/receptor-mediated stat3 activation endocrine gland-derived vegf bv8-stat3 feed-forward loop g-csf-induced bv8 expression treating mx1-cre/jak2flox/flox jak2-dependent bv8-stat3 signaling real-time rt-pcr g-protein-coupled receptor mx1-cre/stat3flox/flox mice myeloid-derived leukemia cells real-time pcr showed stat3-induced s1pr1 expression myeloid cell-dependent angiogenesis chromo-4 real-time detector sphingosine-1-phosphate real-time pcr assay tumor cell-derived bv8 g-protein-coupled receptors putative stat-binding site myeloid-derived human cancers stat3-mediated myc expression granulocyte colony-stimulating factor dimethyl sulfoxide hypoxia inducible factor-1α protein-coupled receptors activated acute myeloid leukemia introduction bv8/prokineticin-2 gene-specific primer sets cd11b+gr1+ myeloid cells endocrine gland endothelium cell lymphoma-extra large bv8-induced stat3 activation pooled puromycin-resistant cells pmc beta search jak2-deficient myeloid cells annexin v-positive population bv8-indcued stat3 activation tumor cell proliferation/survival tumor cell invasion/mobilization stat3 shrna-expressing cells pro-proliferation/survival genes control shrna-expressing cells b16 tumor-bearing mice
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