Here's how NATURE.COM makes money* and how much!

*Please read our disclaimer before using our estimates.
Loading...

NATURE . COM {}

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Nature.com Make Money
  6. How Much Does Nature.com Make
  7. Keywords
  8. Topics
  9. Questions
  10. Schema
  11. External Links
  12. Analytics And Tracking
  13. Libraries
  14. Hosting Providers
  15. CDN Services

We are analyzing https://www.nature.com/articles/s41421-020-0167-x.

Title:
Inflammasome activation and regulation: toward a better understanding of complex mechanisms | Cell Discovery
Description:
Inflammasomes are cytoplasmic multiprotein complexes comprising a sensor protein, inflammatory caspases, and in some but not all cases an adapter protein connecting the two. They can be activated by a repertoire of endogenous and exogenous stimuli, leading to enzymatic activation of canonical caspase-1, noncanonical caspase-11 (or the equivalent caspase-4 and caspase-5 in humans) or caspase-8, resulting in secretion of IL-1β and IL-18, as well as apoptotic and pyroptotic cell death. Appropriate inflammasome activation is vital for the host to cope with foreign pathogens or tissue damage, while aberrant inflammasome activation can cause uncontrolled tissue responses that may contribute to various diseases, including autoinflammatory disorders, cardiometabolic diseases, cancer and neurodegenerative diseases. Therefore, it is imperative to maintain a fine balance between inflammasome activation and inhibition, which requires a fine-tuned regulation of inflammasome assembly and effector function. Recently, a growing body of studies have been focusing on delineating the structural and molecular mechanisms underlying the regulation of inflammasome signaling. In the present review, we summarize the most recent advances and remaining challenges in understanding the ordered inflammasome assembly and activation upon sensing of diverse stimuli, as well as the tight regulations of these processes. Furthermore, we review recent progress and challenges in translating inflammasome research into therapeutic tools, aimed at modifying inflammasome-regulated human diseases.
Website Age:
30 years and 10 months (reg. 1994-08-11).

Matching Content Categories {📚}

  • Education
  • Science
  • Health & Fitness

Content Management System {📝}

What CMS is nature.com built with?

Custom-built

No common CMS systems were detected on Nature.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of nature.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Nature.com Make Money? {💸}


Display Ads {🎯}


The website utilizes display ads within its content to generate revenue. Check the next section for further revenue estimates.

Ads are managed by yourbow.com. Particular relationships are as follows:

Direct Advertisers (10)
google.com, pmc.com, doceree.com, yourbow.com, audienciad.com, onlinemediasolutions.com, advibe.media, aps.amazon.com, getmediamx.com, onomagic.com

Reseller Advertisers (38)
conversantmedia.com, rubiconproject.com, pubmatic.com, appnexus.com, openx.com, smartadserver.com, lijit.com, sharethrough.com, video.unrulymedia.com, google.com, yahoo.com, triplelift.com, onetag.com, sonobi.com, contextweb.com, 33across.com, indexexchange.com, media.net, themediagrid.com, adform.com, richaudience.com, sovrn.com, improvedigital.com, freewheel.tv, smaato.com, yieldmo.com, amxrtb.com, adyoulike.com, adpone.com, criteo.com, smilewanted.com, 152media.info, e-planning.net, smartyads.com, loopme.com, opera.com, mediafuse.com, betweendigital.com

How Much Does Nature.com Make? {💰}


Display Ads {🎯}

$63,100 per month
Our calculations suggest that Nature.com earns between $42,042 and $115,616 monthly online from display advertisements.

Keywords {🔍}

pubmed, inflammasome, nlrp, article, scholar, google, cas, activation, central, caspase, cell, inflammasomes, aim, nlrc, protein, signaling, pyrin, immunol, assembly, immune, asc, nat, nature, regulation, human, inflammation, innate, mechanisms, dna, inflammatory, noncanonical, domain, infection, host, immunity, ilβ, activity, bacterial, studies, nlrpb, cells, apoptosis, including, disease, pyroptosis, intestinal, mice, regulates, death, response,

Topics {✒️}

nature portfolio privacy policy intrinsic “nf-κb-p62-mitophagy” pathway ketone body beta-hydroxy-butirate advertising therapeutic tools asc-mediated nuclear-factor-kappa enhancing tlr-4–trif–ifnar signaling crystal-induced il-1β secretion278 iapp‐induced il‐1β production social media trif/ripk1/fadd-dependent pathways ketone body β-hydroxybutyrate mitosis-related serine-threonine kinase transcription factor nf-kappab reprints pore-induced intracellular traps microrna-based post-transcriptional control beta-sulfonyl nitrile compound nlrp3-mediated il-1beta activation short double-stranded rna tlr4-independent endotoxic shock mir-122-5p/brcc3 axis free cytosolic double-stranded deubiquitinating enzyme brca1/brca2 double-stranded dna backbone nlrp3 il-1/il-18 axis noncanonical nf-kappab signaling multi-factorial diseases involving hepatic ischemia/reperfusion injury173 caspase-1 cleaves pro-il-1β urate crystal-induced peritonitis nf-κb-mediated expression bone marrow-derived cells210 sesn2/sestrin2 suppresses sepsis extreme c-terminal side ischemia–reperfusion injured myocardium144 irf1-directed antiviral responses gsdma-induced cell death33 crystal-induced nlrp3 responses golgi-mediated protein kinase drive anti-viral responses central nervous system volume-regulated anion channels sun yat‐sen university sun yat-sen university inflammasome-dependent immune responses ischemia-reperfusion injured heart low-grade inflammation sustained trans-golgi network

Questions {❓}

  • Mitochondrial DNA signals driving immune responses: Why, How, Where?
  • NLRP3 inflammasome activation: the convergence of multiple signalling pathways on ROS production?
  • The HIN-200 family: more than interferon-inducible genes?
  • What role does pyroptosis play in microbial infection?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Inflammasome activation and regulation: toward a better understanding of complex mechanisms
         description:Inflammasomes are cytoplasmic multiprotein complexes comprising a sensor protein, inflammatory caspases, and in some but not all cases an adapter protein connecting the two. They can be activated by a repertoire of endogenous and exogenous stimuli, leading to enzymatic activation of canonical caspase-1, noncanonical caspase-11 (or the equivalent caspase-4 and caspase-5 in humans) or caspase-8, resulting in secretion of IL-1β and IL-18, as well as apoptotic and pyroptotic cell death. Appropriate inflammasome activation is vital for the host to cope with foreign pathogens or tissue damage, while aberrant inflammasome activation can cause uncontrolled tissue responses that may contribute to various diseases, including autoinflammatory disorders, cardiometabolic diseases, cancer and neurodegenerative diseases. Therefore, it is imperative to maintain a fine balance between inflammasome activation and inhibition, which requires a fine-tuned regulation of inflammasome assembly and effector function. Recently, a growing body of studies have been focusing on delineating the structural and molecular mechanisms underlying the regulation of inflammasome signaling. In the present review, we summarize the most recent advances and remaining challenges in understanding the ordered inflammasome assembly and activation upon sensing of diverse stimuli, as well as the tight regulations of these processes. Furthermore, we review recent progress and challenges in translating inflammasome research into therapeutic tools, aimed at modifying inflammasome-regulated human diseases.
         datePublished:2020-06-09T00:00:00Z
         dateModified:2020-06-09T00:00:00Z
         pageStart:1
         pageEnd:22
         license:http://creativecommons.org/licenses/by/4.0/
         sameAs:https://doi.org/10.1038/s41421-020-0167-x
         keywords:
            Cell signalling
            NOD-like receptors
            Life Sciences
            general
            Cell Biology
            Stem Cells
            Cell Culture
            Cell Cycle Analysis
            Cell Physiology
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41421-020-0167-x/MediaObjects/41421_2020_167_Fig1_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41421-020-0167-x/MediaObjects/41421_2020_167_Fig2_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41421-020-0167-x/MediaObjects/41421_2020_167_Fig3_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41421-020-0167-x/MediaObjects/41421_2020_167_Fig4_HTML.png
         isPartOf:
            name:Cell Discovery
            issn:
               2056-5968
            volumeNumber:6
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer Singapore
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Danping Zheng
               affiliation:
                     name:Weizmann Institute of Science
                     address:
                        name:Immunology Department, Weizmann Institute of Science, Rehovot, Israel
                        type:PostalAddress
                     type:Organization
                     name:Sun Yat-sen University
                     address:
                        name:Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Timur Liwinski
               affiliation:
                     name:Weizmann Institute of Science
                     address:
                        name:Immunology Department, Weizmann Institute of Science, Rehovot, Israel
                        type:PostalAddress
                     type:Organization
                     name:University Medical Center Hamburg-Eppendorf
                     address:
                        name:1st Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Eran Elinav
               url:http://orcid.org/0000-0002-5775-2110
               affiliation:
                     name:Weizmann Institute of Science
                     address:
                        name:Immunology Department, Weizmann Institute of Science, Rehovot, Israel
                        type:PostalAddress
                     type:Organization
                     name:Cancer-Microbiome Division Deutsches Krebsforschungszentrum (DKFZ)
                     address:
                        name:Cancer-Microbiome Division Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:1
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Inflammasome activation and regulation: toward a better understanding of complex mechanisms
      description:Inflammasomes are cytoplasmic multiprotein complexes comprising a sensor protein, inflammatory caspases, and in some but not all cases an adapter protein connecting the two. They can be activated by a repertoire of endogenous and exogenous stimuli, leading to enzymatic activation of canonical caspase-1, noncanonical caspase-11 (or the equivalent caspase-4 and caspase-5 in humans) or caspase-8, resulting in secretion of IL-1β and IL-18, as well as apoptotic and pyroptotic cell death. Appropriate inflammasome activation is vital for the host to cope with foreign pathogens or tissue damage, while aberrant inflammasome activation can cause uncontrolled tissue responses that may contribute to various diseases, including autoinflammatory disorders, cardiometabolic diseases, cancer and neurodegenerative diseases. Therefore, it is imperative to maintain a fine balance between inflammasome activation and inhibition, which requires a fine-tuned regulation of inflammasome assembly and effector function. Recently, a growing body of studies have been focusing on delineating the structural and molecular mechanisms underlying the regulation of inflammasome signaling. In the present review, we summarize the most recent advances and remaining challenges in understanding the ordered inflammasome assembly and activation upon sensing of diverse stimuli, as well as the tight regulations of these processes. Furthermore, we review recent progress and challenges in translating inflammasome research into therapeutic tools, aimed at modifying inflammasome-regulated human diseases.
      datePublished:2020-06-09T00:00:00Z
      dateModified:2020-06-09T00:00:00Z
      pageStart:1
      pageEnd:22
      license:http://creativecommons.org/licenses/by/4.0/
      sameAs:https://doi.org/10.1038/s41421-020-0167-x
      keywords:
         Cell signalling
         NOD-like receptors
         Life Sciences
         general
         Cell Biology
         Stem Cells
         Cell Culture
         Cell Cycle Analysis
         Cell Physiology
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41421-020-0167-x/MediaObjects/41421_2020_167_Fig1_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41421-020-0167-x/MediaObjects/41421_2020_167_Fig2_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41421-020-0167-x/MediaObjects/41421_2020_167_Fig3_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41421-020-0167-x/MediaObjects/41421_2020_167_Fig4_HTML.png
      isPartOf:
         name:Cell Discovery
         issn:
            2056-5968
         volumeNumber:6
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer Singapore
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Danping Zheng
            affiliation:
                  name:Weizmann Institute of Science
                  address:
                     name:Immunology Department, Weizmann Institute of Science, Rehovot, Israel
                     type:PostalAddress
                  type:Organization
                  name:Sun Yat-sen University
                  address:
                     name:Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Timur Liwinski
            affiliation:
                  name:Weizmann Institute of Science
                  address:
                     name:Immunology Department, Weizmann Institute of Science, Rehovot, Israel
                     type:PostalAddress
                  type:Organization
                  name:University Medical Center Hamburg-Eppendorf
                  address:
                     name:1st Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Eran Elinav
            url:http://orcid.org/0000-0002-5775-2110
            affiliation:
                  name:Weizmann Institute of Science
                  address:
                     name:Immunology Department, Weizmann Institute of Science, Rehovot, Israel
                     type:PostalAddress
                  type:Organization
                  name:Cancer-Microbiome Division Deutsches Krebsforschungszentrum (DKFZ)
                  address:
                     name:Cancer-Microbiome Division Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:1
["Periodical","PublicationVolume"]:
      name:Cell Discovery
      issn:
         2056-5968
      volumeNumber:6
Organization:
      name:Springer Singapore
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Weizmann Institute of Science
      address:
         name:Immunology Department, Weizmann Institute of Science, Rehovot, Israel
         type:PostalAddress
      name:Sun Yat-sen University
      address:
         name:Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
         type:PostalAddress
      name:Weizmann Institute of Science
      address:
         name:Immunology Department, Weizmann Institute of Science, Rehovot, Israel
         type:PostalAddress
      name:University Medical Center Hamburg-Eppendorf
      address:
         name:1st Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
         type:PostalAddress
      name:Weizmann Institute of Science
      address:
         name:Immunology Department, Weizmann Institute of Science, Rehovot, Israel
         type:PostalAddress
      name:Cancer-Microbiome Division Deutsches Krebsforschungszentrum (DKFZ)
      address:
         name:Cancer-Microbiome Division Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Danping Zheng
      affiliation:
            name:Weizmann Institute of Science
            address:
               name:Immunology Department, Weizmann Institute of Science, Rehovot, Israel
               type:PostalAddress
            type:Organization
            name:Sun Yat-sen University
            address:
               name:Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
               type:PostalAddress
            type:Organization
      name:Timur Liwinski
      affiliation:
            name:Weizmann Institute of Science
            address:
               name:Immunology Department, Weizmann Institute of Science, Rehovot, Israel
               type:PostalAddress
            type:Organization
            name:University Medical Center Hamburg-Eppendorf
            address:
               name:1st Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
               type:PostalAddress
            type:Organization
      name:Eran Elinav
      url:http://orcid.org/0000-0002-5775-2110
      affiliation:
            name:Weizmann Institute of Science
            address:
               name:Immunology Department, Weizmann Institute of Science, Rehovot, Israel
               type:PostalAddress
            type:Organization
            name:Cancer-Microbiome Division Deutsches Krebsforschungszentrum (DKFZ)
            address:
               name:Cancer-Microbiome Division Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Immunology Department, Weizmann Institute of Science, Rehovot, Israel
      name:Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
      name:Immunology Department, Weizmann Institute of Science, Rehovot, Israel
      name:1st Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
      name:Immunology Department, Weizmann Institute of Science, Rehovot, Israel
      name:Cancer-Microbiome Division Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany

External Links {🔗}(1044)

Analytics and Tracking {📊}

  • Google Tag Manager

Libraries {📚}

  • Prism.js
  • Zoom.js

Emails and Hosting {✉️}

Mail Servers:

  • mxa-002c5801.gslb.pphosted.com
  • mxb-002c5801.gslb.pphosted.com

Name Servers:

  • pdns1.ultradns.net
  • pdns2.ultradns.net
  • pdns3.ultradns.org
  • pdns4.ultradns.org
  • pdns5.ultradns.info
  • pdns6.ultradns.co.uk

CDN Services {📦}

  • Crossref

6.82s.