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Title[redir]:
Cytoplasmic LPS activates caspase-11: implications in TLR4-independent endotoxic shock - PMC
Description:
Inflammatory caspases, such as caspase-1 and -11, mediate innate immune detection of pathogens. Caspase-11 induces pyroptosis, a form of programmed cell death, and specifically defends against bacterial pathogens that invade the cytosol. During ...
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Keywords {🔍}
caspase, lps, doi, fig, pubmed, google, scholar, lipid, mice, pmc, activation, primed, data, article, tlr, polyic, free, bmms, inflammasome, bacteria, cytotoxicity, shock, determined, hours, experiments, ctb, transfected, processing, pyroptosis, challenge, cytosolic, gramnegative, nature, minnesota, novicida, nlm, science, detection, cell, francisella, canonical, casp, lysates, macrophages, transfection, secretion, priming, pathway, ilβ, pathways,
Topics {✒️}
[pubmed] [google scholar] retrovirus-mediated gene transfer stimulate ifn-β production pmc beta search pathogen-induced cell death lps primed nlrc4−/−asc−/−casp11+/+ adaptor inducing interferon-β promote il-1β secretion vacuolar gram-negative bacteria caspase-1 processes il-1β peculiar tetra-acylated lipid immortalized casp1−/−casp11−/− bmms ifn-γ signaling overlap supplementary materials included inflammasome-dependent release canonical nlrp3 pathway anthrax lethal toxin induces multiple components canonical inflammasome agonists temperature-dependent alterations nih grants ai007273 triggers caspase-11 activation lactate dehydrogenase release hexa-acylated species gram-positive bacterium programmed cell death canonical inflammasome pathways gram-positive lysates caspase-11 induces pyroptosis endotoxic shock independent gram-negative bacteria secondary lps challenge gram-positive bacteria managing mouse colonies innate immune detection ice-interacting protease bacterial lysates packaged il-1β secretion cell host microbe caspase-11 activating factor hexa-acylated lipid publisher site pdf detecting cytoplasmic lps cytoplasmic lps independently complete cholera toxin divergent signaling pathways extracellular/vacuolar lps nlrc4−/− asc−/− mice caspase-1 processing dependent united states government
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- Bench-to-bedside review: Sepsis, severe sepsis and septic shock – does the nature of the infecting organism matter?
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