
NCBI . NLM . NIH . GOV {
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Title[redir]:
Inflammasome activation causes dual recruitment of NLRC4 and NLRP3 to the same macromolecular complex - PMC
Description:
The nucleotide-binding oligomerization domain-like receptor (NLR) family members, NLRC4 and NLRP3, activate the inflammasome to provide host defenses against infection. The precise molecular constituents of an inflammasome are unknown; however, it ...
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Keywords {🔍}
asc, inflammasome, nlrp, doi, nlrc, caspase, fig, infection, speck, pubmed, google, scholar, typhimurium, pmc, article, salmonella, activation, nlrs, free, structure, mice, bacterial, protein, infected, ring, endogenous, complex, superresolution, macrophages, recruitment, cell, bmms, immunol, domain, proilβ, nlr, host, data, cells, formed, microscopy, single, ilβ, multiple, day, formation, response, time, similar, analysis,
Topics {✒️}
sustained pro–il-1β processing proinflammatory cytokines pro–il-1β coordinate pro–il-1β processing caspase-1–specific fluorescent-labeled inhibitor nlrp3-mediated il-1β production il-1β production induced modulate il-1β production org/lookup/suppl/doi drive il-1β processing leucine-rich repeat pmc beta search pro–il-1β processing nucleotide-binding oligomerization domain pathogen-induced cell death process pro–il-1β pro–il-1β colocalize cleaved il-1β p17 stained pro–il-1β pro–il-1β formed driving salmonella-induced pyroptosis lps-primed thp-1 cells log phase-grown wt dna constructs encoding releasing macrophage-resident microbes ligand-mediated nlr activation fluorescent-labeled inhibitor direct submission article il-1β production license information pmcid cryo-em analysis suggests salmonella-induced inflammasome structure pro–il-1β receptor-specific inflammasomes consisting salmonella-induced asc speck supporting information online supplementary materials included bayesian localization microscopy pyhin [pyrin domain including time-dependent effects substrate-specific entity salmonella-infected macrophages revealed mouse naip1 detects protein–protein interactions drive inflammasome production human thp-1 macrophages nucleotide-binding domain full speck formation macromolecular protein complex exogenous overexpression system cell type dominance
Questions {❓}
- Activation of multiple NLRs in response to Salmonella infection occurs in vitro and in vivo, yet how is this activation achieved if cells only form a single inflammasome per cell?
- That is, in response to pathogens like Salmonella, which activate multiple NLRs, why does only a single ASC speck form?
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- What's the revenue for https://www.nlm.nih.gov/web_policies.html?
- Income figures for https://www.nih.gov/institutes-nih/nih-office-director/office-communications-public-liaison/freedom-information-act-office
- What is the monthly revenue of https://www.hhs.gov/vulnerability-disclosure-policy/index.html?
- Find out how much https://support.nlm.nih.gov/?pagename=cloudpmc-viewer%3Apmc%3Aarticle%3Ajournal earns monthly
- How profitable is https://www.nlm.nih.gov/accessibility.html?
- How much revenue does https://www.nlm.nih.gov/careers/careers.html bring in?
- What's the financial gain of https://www.nlm.nih.gov/?
- What are the earnings of https://www.nih.gov/?
- How much does https://www.hhs.gov/ bring in each month?
- How much does https://www.usa.gov/ generate monthly?
Analytics and Tracking {📊}
- Google Analytics
- Google Analytics 4
- Google Tag Manager
Libraries {📚}
- jQuery
- jQuery module (jquery-3.6.0)
- Zoom.js
Emails and Hosting {✉️}
Mail Servers:
- nihcesxway.hub.nih.gov
- nihcesxway2.hub.nih.gov
- nihcesxway3.hub.nih.gov
- nihcesxway4.hub.nih.gov
- nihcesxway5.hub.nih.gov
Name Servers:
- dns1-ncbi.ncbi.nlm.nih.gov
- dns2-ncbi.ncbi.nlm.nih.gov
- lhcns1.nlm.nih.gov
- lhcns2.nlm.nih.gov
CDN Services {📦}
- Ncbi